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A Single-Dose Placebo-Controlled Study of AMG 162, a Fully Human Monoclonal Antibody to RANKL, in Postmenopausal Women.
Published in:
Journal of Bone & Mineral Research, 2005, v. 20, n. 12, p. 2274, doi. 10.1359/jbmr.2005.20.12.2274
By:
- Bekker, Pirow J;
- Holloway, Donna L;
- Rasmussen, Amy S;
- Murphy, Robyn;
- Martin, Steven W;
- Leese, Philip T;
- Holmes, Gregory B;
- Dunstan, Colin R;
- DePaoli, Alex M
Publication type:
Article
A Single-Dose Placebo-Controlled Study of AMG 162, a Fully Human Monoclonal Antibody to RANKL, in Postmenopausal Women.
Published in:
Journal of Bone & Mineral Research, 2004, v. 19, n. 7, p. 1059, doi. 10.1359/JBMR.040305
By:
- Bekker, Pirow J;
- Holloway, Donna L;
- Rasmussen, Amy S;
- Murphy, Robyn;
- Martin, Steven W;
- Leese, Philip T;
- Holmes, Gregory B;
- Dunstan, Colin R;
- DePaoli, Alex M
Publication type:
Article
The effects of recombinant human leptin on visceral fat, dyslipidemia, and insulin resistance in patients with human immunodeficiency virus-associated lipoatrophy and hypoleptinemia.
Published in:
2009
By:
- Mulligan, Kathleen;
- Khatami, Hootan;
- Schwarz, Jean-Marc;
- Sakkas, Giorgos K;
- DePaoli, Alex M;
- Tai, Viva W;
- Wen, Michael J;
- Lee, Grace A;
- Grunfeld, Carl;
- Schambelan, Morris
Publication type:
journal article
Efficacy and Safety of Leptin-Replacement Therapy and Possible Mechanisms of Leptin Actions in Patients with Generalized Lipodystrophy.
Published in:
Journal of Clinical Endocrinology & Metabolism, 2007, v. 92, n. 2, p. 532, doi. 10.1210/jc.2006-1546
By:
- Ebihara, Ken;
- Toru Kusakabe;
- Masakazu Hirata;
- Hiroaki Masuzaki;
- Fumiko Miyanaga;
- Nozomi Kobayashi;
- Tomohiro Tanaka;
- Hideki Chusho;
- Takashi Miyazawa;
- Tatsuya Hayashi;
- Kiminori Hosoda;
- Yoshihiro Ogawa;
- DePaoli, Alex M.;
- Masanori Fukushima;
- Kazuwa Nakao
Publication type:
Article
Leptin Replacement Therapy Modulates Circulating Lymphocyte Subsets and Cytokine Responsiveness in Severe Lipodystrophy.
Published in:
Journal of Clinical Endocrinology & Metabolism, 2006, v. 91, n. 2, p. 624, doi. 10.1210/jc.2005-1220
By:
- Oral, Elif Arioglu;
- Javor, Edward D.;
- Li Ding;
- Uzel, Gulbu;
- Cochran, Elaine K.;
- Young, Janice Ryan;
- DePaoli, Alex M.;
- Holland, Steven M.;
- Gorden, Phillip
Publication type:
Article
Effect of Leptin Replacement on Brain Structure in Genetically Leptin-Deficient Adults.
Published in:
Journal of Clinical Endocrinology & Metabolism, 2005, v. 90, n. 5, p. 2851, doi. 10.1210/jc.2004-1979
By:
- Matochik, John A.;
- London, Edythe D.;
- Yildiz, Bulent O.;
- Ozata, Metin;
- Caglayan, Sinan;
- DePaoli, Alex M.;
- Ma-Li Wong;
- Licinio, Julio
Publication type:
Article
Recombinant Methionyl Human Leptin Administration to Achieve High Physiologic or Pharmacologic Leptin Levels Does Not Alter Circulating Inflammatory Marker Levels in Humans with Leptin Sufficiency or Excess.
Published in:
Journal of Clinical Endocrinology & Metabolism, 2005, v. 90, n. 3, p. 1618, doi. 10.1210/jc.2004-1921
By:
- Chan, Jean L.;
- Bullen, John;
- Stoyneva, Violeta;
- DePaoli, Alex M.;
- Addy, Carol;
- Mantzoros, Christos S.
Publication type:
Article
Endocrine and Metabolic Effects of Physiologic r-metHuLeptin Administration during Acute Caloric Deprivation in Normal-Weight Women.
Published in:
Journal of Clinical Endocrinology & Metabolism, 2004, v. 89, n. 11, p. 5402, doi. 10.1210/jc.2004-1102
By:
- SCHURGIN, SUNITA;
- CANAVAN, BRIDGET;
- KOUTKIA, POLYXENI;
- DEPAOLI, ALEX M.;
- GRINSPOON, STEVEN
Publication type:
Article
Effects of Exogenous Leptin on Satiety and Satiation in Patients with Lipodystrophy and Leptin Insufficiency.
Published in:
Journal of Clinical Endocrinology & Metabolism, 2004, v. 89, n. 9, p. 4258, doi. 10.1210/jc.2003-031868
By:
- MCDUFFIE, JENNIFER R.;
- RIGGS, PATTI A.;
- CALIS, KARIM A.;
- FREEDMAN, RENEE J.;
- ORAL, ELIF A.;
- DEPAOLI, ALEX M.;
- YANOVSK, JACK A.
Publication type:
Article
Congenital leptin deficiency due to homozygosity for the Delta133G mutation: report of another case and evaluation of response to four years of leptin therapy.
Published in:
2004
By:
- Gibson, William T;
- Farooqi, I Sadaf;
- Moreau, Mary;
- DePaoli, Alex M;
- Lawrence, Elizabeth;
- O'Rahilly, Stephen;
- Trussell, Rebecca A
Publication type:
journal article
Effects of exogenous leptin on satiety and satiation in patients with lipodystrophy and leptin insufficiency.
Published in:
2004
By:
- McDuffie, Jennifer R;
- Riggs, Patti A;
- Calis, Karim A;
- Freedman, Renee J;
- Oral, Elif A;
- DePaoli, Alex M;
- Yanovski, Jack A
Publication type:
journal article
Proteinuric Nephropathy in Acquired and Congenital Generalized Lipodystrophy: Baseline Characteristics and Course during Recombinant Leptin Therapy.
Published in:
Journal of Clinical Endocrinology & Metabolism, 2004, v. 89, n. 7, p. 3199, doi. 10.1210/jc.2003-032140
By:
- JAVOR, EDWARD D.;
- ANN MORAN, STEPHANIE;
- YOUNG, JANICE RYAN;
- COCHRAN, ELAINE K.;
- DEPAOLI, ALEX M.;
- ORAL, ELIF ARIOGLU;
- TURMAN, MARTIN A.;
- BLACKETT, PIERS R.;
- SAVAGE, DAVID B.;
- O’RAHILLY, STEPHEN;
- BALOW, JAMES E.;
- GORDEN, PHILLIP
Publication type:
Article
Leptin Hormonal Kinetics in the Fed State: Effects of Adiposity, Age, and Gender on Endogenous Leptin Production and Clearance Rates.
Published in:
Journal of Clinical Endocrinology & Metabolism, 2004, v. 89, n. 6, p. 2672, doi. 10.1210/jc.2003-031931
By:
- WONG, SHEKMAN L.;
- DEPAOLI, ALEX M.;
- LEE, JENNIFER H.;
- MANTZOROS, CHRISTOS S.
Publication type:
Article
Effect of Leptin Replacement on Pituitary Hormone Regulation in Patients with Severe Lipodystrophy.
Published in:
Journal of Clinical Endocrinology & Metabolism, 2002, v. 87, n. 7, p. 3110, doi. 10.1210/jcem.87.7.8591
By:
- ORAL, ELIF ARIOGLU;
- RUIZ, ELAINE;
- ANDEWELT, ALEXA;
- SEBRING, NANCY;
- WAGNER, ANTHONY J.;
- DEPAOLI, ALEX M.;
- GORDEN, PHILLIP
Publication type:
Article
Leptin administration to overweight and obese subjects for 6 months increases free leptin concentrations but does not alter circulating hormones of the thyroid and IGF axes during weight loss induced by a mild hypocaloric diet.
Published in:
European Journal of Endocrinology, 2011, v. 165, n. 2, p. 249, doi. 10.1530/EJE-11-0252
By:
- Shetty, Greeshma K.;
- Matarese, Giuseppe;
- Magkos, Faidon;
- Moon, Hyun-Seuk;
- Liu, Xiaowen;
- Brennan, Aoife M.;
- Mylvaganam, Geetha;
- Sykoutri, Despina;
- DePaoli, Alex M.;
- Mantzoros, Christos S.
Publication type:
Article
Blood Pressure and Vascular Effects of Leptin in Humans.
Published in:
Metabolic Syndrome & Related Disorders, 2007, v. 5, n. 3, p. 270, doi. 10.1089/met.2006.0023
By:
- Robert D. Brook;
- Robert L. Bard;
- Peter F. Bodary;
- Daniel T. Eitzman;
- Sanjay Rajagopalan;
- Yan Sun;
- Alex M. Depaoli
Publication type:
Article
Blood Pressure and Vascular Effects of Leptin in Humans.
Published in:
Metabolic Syndrome & Related Disorders, 2007, v. 5, n. 1, p. 63
By:
- Robert D. Brook;
- Robert L. Bard;
- Peter F. Bodary;
- Daniel T. Eitzman;
- Sanjay Rajagopalan;
- Yan Sun;
- Alex M. Depaoli
Publication type:
Article
Effect of leptin replacement on intrahepatic and intramyocellular lipid content in patients with generalized lipodystrophy.
Published in:
2003
By:
- Simha, Vinaya;
- Szczepaniak, Lidia S.;
- Wagner, Anthony J.;
- Depaoli, Alex M.;
- Garg, Abhimanyu
Publication type:
journal article
A nontumorigenic variant of FGF19 treats cholestatic liver diseases.
Published in:
Science Translational Medicine, 2014, v. 6, n. 247, p. 1, doi. 10.1126/scitranslmed.3009098
By:
- Jian Luo;
- Brian Ko;
- Elliott, Michael;
- Mei Zhou;
- Lindhout, Darrin A.;
- Van Phung;
- To, Carmen;
- Learned, R. Marc;
- Hui Tian;
- DePaoli, Alex M.;
- Lei Ling
Publication type:
Article
Long-Term Efficacy of Leptin Replacement in Patients With Generalized Lipodystrophy.
Published in:
Diabetes, 2005, v. 54, n. 7, p. 1994, doi. 10.2337/diabetes.54.7.1994
By:
- Javor, Edward D.;
- Cochran, Elaine K.;
- Musso, Carla;
- Young, Janice Ryan;
- DePaoli, Alex M.;
- Gorden, Phillip
Publication type:
Article
Evolution of β-Cell Dysfunction in the Male Zucker Diabetic Fatty Rat.
Published in:
Diabetes, 1995, v. 44, n. 12, p. 1447, doi. 10.2337/diab.44.12.1447
By:
- Tokuyama, Yoshiharu;
- Sturis, Jeppe;
- DePaoli, Alex M.;
- Takeda, Jun;
- Stoffel, Markus;
- Jiping Tang;
- Xiaohong Sun;
- Polonsky, Kenneth S.;
- Bell, Graeme I.
Publication type:
Article
Expression of calcium channel mRNAs in rat pancreatic islets and downregulation after glucose infusion.
Published in:
1993
By:
- Iwashima, Yasunori;
- Pugh, William;
- Depaoli, Alex M.;
- Takeda, Jun;
- Seino, Susumu;
- Bell, Graeme I.;
- Polonsky, Kenneth S.;
- Iwashima, Y;
- Pugh, W;
- Depaoli, A M;
- Takeda, J;
- Seino, S;
- Bell, G I;
- Polonsky, K S
Publication type:
journal article
Can a Selective PPAR[gamma] Modulator Improve Glycemic Control in Patients With Type 2 Diabetes With Fewer Side Effects Compared With Pioglitazone?
Published in:
2014
By:
- DePaoli, Alex M;
- Higgins, Linda S;
- Henry, Robert R;
- Mantzoros, Christos;
- Dunn, Fredrick L;
- INT131-007 Study Group
Publication type:
Journal Article
Can a Selective PPARγ Modulator Improve Glycemic Control in Patients With Type 2 Diabetes With Fewer Side Effects Compared With Pioglitazone?
Published in:
Diabetes Care, 2014, v. 37, n. 7, p. 1918, doi. 10.2337/dc13-2480
By:
- DePaoli, Alex M.;
- Higgins, Linda S.;
- Henry, Robert R.;
- Mantzoros, Christos;
- Dunn, Fredrick L.
Publication type:
Article
Circulating Citrate Is Associated with Liver Fibrosis in Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis.
Published in:
International Journal of Molecular Sciences, 2023, v. 24, n. 17, p. 13332, doi. 10.3390/ijms241713332
By:
- Amjad, Waseem;
- Shalaurova, Irina;
- Garcia, Erwin;
- Gruppen, Eke G.;
- Dullaart, Robin P. F.;
- DePaoli, Alex M.;
- Jiang, Z. Gordon;
- Lai, Michelle;
- Connelly, Margery A.
Publication type:
Article
FGF19 Analog as a Surgical Factor Mimetic That Contributes to Metabolic Effects Beyond Glucose Homeostasis.
Published in:
2019
By:
- DePaoli, Alex M.;
- Mei Zhou;
- Kaplan, Daniel D.;
- Hunt, Steven C.;
- Adams, Ted D.;
- Learned, R. Marc;
- Hui Tian;
- Lei Ling;
- Zhou, Mei;
- Tian, Hui;
- Ling, Lei
Publication type:
journal article
Recombinant Human Leptin Treatment Does Not Improve Insulin Action in Obese Subjects With Type 2 Diabetes.
Published in:
Diabetes, 2011, v. 60, n. 5, p. 1474, doi. 10.2337/db10-1302
By:
- Mittendorfer, Bettina;
- Horowitz, Jeffrey F.;
- DePaoli, Alex M.;
- McCamish, Mark A.;
- Patterson, Bruce W.;
- Klein, Samuel
Publication type:
Article

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