Works by DeGrado, William

Results: 110

ProBASS—a language model with sequence and structural features for predicting the effect of mutations on binding affinity Open Access.

Published in:

Bioinformatics, 2025, v. 41, n. 5, p. 1, doi. 10.1093/bioinformatics/btaf270

By:

Gurusinghe, Sagara N S;
Wu, Yibing;
DeGrado, William;
Shifman, Julia M

Publication type:

Article

Innentitelbild: Design of a Three-Helix Bundle Capable of Binding Heavy Metals in a Triscysteine Environment (Angew. Chem. 9/2011).

Published in:

Angewandte Chemie, 2011, v. 123, n. 9, p. 1990, doi. 10.1002/ange.201100297

By:

Chakraborty, Saumen;
Yudenfreund Kravitz, Joslyn;
Thulstrup, Peter W.;
Hemmingsen, Lars;
DeGrado, William F.;
Pecoraro, Vincent L.

Publication type:

Article

Design of a Three-Helix Bundle Capable of Binding Heavy Metals in a Triscysteine Environment.

Published in:

Angewandte Chemie, 2011, v. 123, n. 9, p. 2097, doi. 10.1002/ange.201006413

By:

Chakraborty, Saumen;
Yudenfreund Kravitz, Joslyn;
Thulstrup, Peter W.;
Hemmingsen, Lars;
DeGrado, William F.;
Pecoraro, Vincent L.

Publication type:

Article

Spectroscopic and metal binding properties of a de novo metalloprotein binding a tetrazinc cluster.

Published in:

Biopolymers, 2018, v. 109, n. 10, p. N.PAG, doi. 10.1002/bip.23229

By:

Chino, Marco;
Zhang, Shao‐Qing;
Pirro, Fabio;
Leone, Linda;
Maglio, Ornella;
Lombardi, Angela;
DeGrado, William F.

Publication type:

Article

A long‐lived Aβ oligomer resistant to fibrillization.

Published in:

Biopolymers, 2018, v. 109, n. 8, p. N.PAG, doi. 10.1002/bip.23096

By:

Nick, Mimi;
Wu, Yibing;
Schmidt, Nathan W.;
Prusiner, Stanley B.;
Stöhr, Jan;
DeGrado, William F.

Publication type:

Article

A long‐lived Aβ oligomer resistant to fibrillization.

Published in:

Biopolymers, 2018, v. 109, n. 8, p. 1, doi. 10.1002/bip.23096

By:

Nick, Mimi;
Wu, Yibing;
Schmidt, Nathan W.;
Prusiner, Stanley B.;
Stöhr, Jan;
DeGrado, William F.

Publication type:

Article

The Structure of a Designed Diiron(III) Protein: Implications for Cofactor Stabilization and Catalysis.

Published in:

Angewandte Chemie International Edition, 2006, v. 45, n. 30, p. 4951, doi. 10.1002/anie.200600042

By:

Wade, Herschel;
Stayrook, Steven E.;
DeGrado, William F.

Publication type:

Article

Cover Picture: The Design and Evaluation of Heparin-Binding Foldamers (Angew. Chem. Int. Ed. 41/2005).

Published in:

Angewandte Chemie International Edition, 2005, v. 44, n. 41, p. 6599, doi. 10.1002/anie.200590137

By:

Sungwook Choi;
Dylan J. Clements;
Vojislava Pophristic;
Ivaylo Ivanov;
Satyavani Vemparala;
Joel S. Bennett;
Michael L. Klein;
Jeffrey D. Winkler;
William F. DeGrado

Publication type:

Article

The Design and Evaluation of Heparin-Binding FoldamersWe thank the National Institutes of Health (grant no. 65803), PolyMedix, Inc., and Burroughs Wellcome Fund (fellowship to I.I) for financial support.

Published in:

Angewandte Chemie International Edition, 2005, v. 44, n. 41, p. 6685, doi. 10.1002/anie.200501279

By:

Sungwook Choi;
Dylan J. Clements;
Vojislava Pophristic;
Ivaylo Ivanov;
Satyavani Vemparala;
Joel S. Bennett;
Michael L. Klein;
Jeffrey D. Winkler;
William F. DeGrado

Publication type:

Article

Artificial diiron proteins: From structure to function.

Published in:

Biopolymers, 2005, v. 80, n. 2/3, p. 264, doi. 10.1002/bip.20230

By:

Calhoun, Jennifer R.;
Nastri, Flavia;
Maglio, Ornella;
Pavone, Vincenzo;
Lombardi, Angela;
DeGrado, William F.

Publication type:

Article

Solid-supported membrane technology for the investigation of the influenza A virus M2 channel activity.

Published in:

Pflügers Archiv: European Journal of Physiology, 2010, v. 459, n. 4, p. 593, doi. 10.1007/s00424-009-0760-1

By:

Balannik, Victoria;
Obrdlik, Petr;
Inayat, Samsoon;
Steensen, Catrin;
Jun Wang;
Rausch, Joshua M.;
DeGrado, William F.;
Kelety, Bela;
Pinto, Lawrence H.

Publication type:

Article

High-density grids for efficient data collection from multiple crystals.

Published in:

Acta Crystallographica: Section D, Structural Biology, 2016, v. 72, n. 1, p. 2, doi. 10.1107/S2059798315020847

By:

Baxter, Elizabeth L.;
Aguila, Laura;
Alonso-Mori, Roberto;
Barnes, Christopher O.;
Bonagura, Christopher A.;
Brehmer, Winnie;
Brunger, Axel T.;
Calero, Guillermo;
Caradoc-Davies, Tom T.;
Chatterjee, Ruchira;
Degrado, William F.;
Fraser, James S.;
Ibrahim, Mohamed;
Kern, Jan;
Kobilka, Brian K.;
Kruse, Andrew C.;
Larsson, Karl M.;
Lemke, Heinrik T.;
Lyubimov, Artem Y.;
Manglik, Aashish

Publication type:

Article

Emergence of distinct and heterogeneous strains of amyloid beta with advanced Alzheimer's disease pathology in Down syndrome.

Published in:

Acta Neuropathologica Communications, 2021, v. 9, n. 1, p. 1, doi. 10.1186/s40478-021-01298-0

By:

Maxwell, Alison M.;
Yuan, Peng;
Rivera, Brianna M.;
Schaaf, Wilder;
Mladinov, Mihovil;
Prasher, Vee P.;
Robinson, Andrew C.;
DeGrado, William F.;
Condello, Carlo

Publication type:

Article

Allosteric mechanism of signal transduction in the two-component system histidine kinase PhoQ.

Published in:

eLife, 2021, p. 1, doi. 10.7554/eLife.73336

By:

Mensa, Bruk;
Polizzi, Nicholas F.;
Molnar, Kathleen S.;
Natale, Andrew M.;
Lemmin, Thomas;
DeGrado, William F.

Publication type:

Article

Inhibitors of the Influenza A Virus M2 Proton Channel Discovered Using a High-Throughput Yeast Growth Restoration Assay.

Published in:

PLoS ONE, 2013, v. 8, n. 2, p. 1, doi. 10.1371/journal.pone.0055271

By:

Balgi, Aruna D.;
Wang, Jun;
Cheng, Daphne Y. H.;
Ma, Chunlong;
Pfeifer, Tom A.;
Shimizu, Yoko;
Anderson, Hilary J.;
Pinto, Lawrence H.;
Lamb, Robert A.;
DeGrado, William F.;
Roberge, Michel

Publication type:

Article

An Assay Suitable for High Throughput Screening of Anti-Influenza Drugs.

Published in:

PLoS ONE, 2013, v. 8, n. 1, p. 1, doi. 10.1371/journal.pone.0054070

By:

Lili Mao;
Wang, Jun;
DeGrado, William F.;
Inouye, Masayori

Publication type:

Article

Engineered single- and multi-cell chemotaxis pathways in E. coli.

Published in:

Molecular Systems Biology, 2009, v. 5, n. 1, p. 283, doi. 10.1038/msb.2009.41

By:

Goldberg, Shalom D;
Derr, Paige;
DeGrado, William F;
Goulian, Mark

Publication type:

Article

Artificial di-iron proteins: solution characterization of four helix bundles containing two distinct types of inter-helical loops.

Published in:

Journal of Biological Inorganic Chemistry (JBIC), 2005, v. 10, n. 5, p. 539, doi. 10.1007/s00775-005-0002-8

By:

Maglio, Ornella;
Nastri, Flavia;
Calhoun, Jennifer R.;
Lahr, Stephen;
Wade, Herschel;
Pavone, Vincenzo;
DeGrado, William F.;
Lombardi, Angela

Publication type:

Article

P4‐233: AGED ALZHEIMER'S DISEASE BRAINS EXHIBIT NUMEROUS Aβ BUT ONLY FEW TAU PRIONS.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P1531, doi. 10.1016/j.jalz.2018.07.054

By:

Condello, Carlo;
Aoyagi, Atsushi;
Stöhr, Jan;
Lee, Joanne C.;
Rivera, Brianna M.;
Woerman, Amanda L.;
Halliday, Glenda M.;
van Duinen, Sjoerd;
Ingelsson, Martin;
Lannfelt, Lars;
Graff, Caroline;
Bird, Thomas D.;
Dirk Keene, C.;
Seeley, William W.;
DeGrado, William F.;
Prusiner, Stanley B.

Publication type:

Article

Spontaneous and specific chemical cross-linking in live cells to capture and identify protein interactions.

Published in:

Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-02409-z

By:

Bing Yang;
Shibing Tang;
Cheng Ma;
Shang-Tong Li;
Guang-Can Shao;
Bobo Dang;
DeGrado, William F.;
Meng-Qiu Dong;
Peng George Wang;
Sheng Ding;
Lei Wang

Publication type:

Article

Artificial Diiron Enzymes with a De Novo Designed Four-Helix Bundle Structure.

Published in:

2015

By:

Chino, Marco;
Maglio, Ornella;
Nastri, Flavia;
Pavone, Vincenzo;
DeGrado, William F.;
Lombardi, Angela

Publication type:

Other

Artificial Diiron Enzymes with a De Novo Designed Four-Helix Bundle Structure (Eur. J. Inorg. Chem. 21/2015).

Published in:

European Journal of Inorganic Chemistry, 2015, v. 2015, n. 21, p. n/a, doi. 10.1002/ejic.201590084

By:

Chino, Marco;
Maglio, Ornella;
Nastri, Flavia;
Pavone, Vincenzo;
DeGrado, William F.;
Lombardi, Angela

Publication type:

Article

Artificial Diiron Enzymes with a De Novo Designed Four-Helix Bundle Structure.

Published in:

European Journal of Inorganic Chemistry, 2015, v. 2015, n. 21, p. 3371, doi. 10.1002/ejic.201500470

By:

Chino, Marco;
Maglio, Ornella;
Nastri, Flavia;
Pavone, Vincenzo;
DeGrado, William F.;
Lombardi, Angela

Publication type:

Article

Volatile anesthetic modulation of oligomerization equilibria in a hexameric model peptide

Published in:

FEBS Letters, 2004, v. 578, n. 1/2, p. 140, doi. 10.1016/j.febslet.2004.10.087

By:

Ghirlanda, Giovanna;
Hilcove, Simon A.;
Pidikiti, Ravindernath;
Johansson, Jonas S.;
Lear, James D.;
DeGrado, William F.;
Eckenhoff, Roderic G.

Publication type:

Article

Mutagenesis data in the automated prediction of transmembrane helix dimers.

Published in:

Proteins, 2007, v. 67, n. 2, p. 375, doi. 10.1002/prot.21265

By:

Metcalf, Douglas G.;
Law, Peter B.;
DeGrado, William F.

Publication type:

Article

α-α linking motifs and interhelical orientations.

Published in:

Proteins, 2005, v. 61, n. 2, p. 325, doi. 10.1002/prot.20522

By:

Engel, Donald E.;
DeGrado, William F.

Publication type:

Article

Empirical lipid propensities of amino acid residues in multispan alpha helical membrane proteins.

Published in:

Proteins, 2005, v. 59, n. 3, p. 496, doi. 10.1002/prot.20456

By:

Adamian, Larisa;
Nanda, Vikas;
DeGrado, William F.;
Liang, Jie

Publication type:

Article

Automated use of mutagenesis data in structure prediction.

Published in:

Proteins, 2005, v. 59, n. 3, p. 454, doi. 10.1002/prot.20382

By:

Nanda, Vikas;
DeGrado, William F.

Publication type:

Article

Structural consequences of an amino acid deletion in the B1 domain of protein G.

Published in:

Proteins, 2000, v. 41, n. 3, p. 323, doi. 10.1002/1097-0134(20001115)41:3<323::AID-PROT50>3.0.CO;2-R

By:

O'Neil, Karyn T.;
Bach, Alvin C.;
DeGrado, William F.

Publication type:

Article

The role of helix formation in the folding of a fully α-helical coiled coil.

Published in:

Proteins, 1996, v. 24, n. 4, p. 427, doi. 10.1002/(SICI)1097-0134(199604)24:4<427::AID-PROT2>3.0.CO;2-B

By:

Sosnick, Tobin R.;
Jackson, Sharon;
Wilk, Rosemarie R.;
Englander, S. Walter;
DeGrado, William F.

Publication type:

Article

Thermodynamic genetics of the folding of the B1 immunoglobulin-binding domain from streptococcal protein G.

Published in:

Proteins, 1995, v. 21, n. 1, p. 11, doi. 10.1002/prot.340210103

By:

O'Neil, Karyn T.;
Hoess, Ronald H.;
Raleigh, Daniel P.;
DeGrado, William F.

Publication type:

Article

Identification of novel peptide antagonists for GPIIb/IIIa from a conformationally constrained phage peptide library.

Published in:

Proteins, 1992, v. 14, n. 4, p. 509, doi. 10.1002/prot.340140411

By:

O'Neil, Karyn T.;
Hoess, Ronald H.;
Jackson, Sharon A.;
Ramachandran, Narayana Swamy;
Mousa, Shaker A.;
DeGrado, William F.

Publication type:

Article

Calmodulin binding to α<sub>1</sub>-purothionin: Soloution binding and modeling of the complex.

Published in:

Proteins, 1992, v. 14, n. 2, p. 127, doi. 10.1002/prot.340140202

By:

Rao, Usha;
Teeter, Martha M.;
Erickson-Viitanen, Susan;
DeGrado, William F.

Publication type:

Article

The interaction of calmodulin with fluorescent and photoreactive model peptides: Evidence for a short interdomain separation.

Published in:

Proteins, 1989, v. 6, n. 3, p. 284, doi. 10.1002/prot.340060311

By:

O'Neil, K. T.;
DeGrado, William F.

Publication type:

Article

Editor's Note.

Published in:

Proteins, 1989, v. 6, n. 3, p. 215, doi. 10.1002/prot.340060302

By:

DeGrado, William F.

Publication type:

Article

In memorium: Emil Thomas Kaiser, 1938-1988.

Published in:

Proteins, 1988, v. 4, n. 1, p. i, doi. 10.1002/prot.340040102

By:

DeGrado, William

Publication type:

Article

The Role of Hydrophobicity in the Antimicrobial and Hemolytic Activities of Polymethacrylate Derivatives.

Published in:

Chemistry - A European Journal, 2009, v. 15, n. 5, p. 1123, doi. 10.1002/chem.200801523

By:

Kuroda, Kenichi;
Caputo, Gregory A.;
DeGrado, William F.

Publication type:

Article

Controlling the Conformation of Arylamides: Computational Studies of Intramolecular Hydrogen Bonds between Amides and Ethers or Thioethers.

Published in:

Chemistry - A European Journal, 2004, v. 10, n. 20, p. 5008, doi. 10.1002/chem.200400176

By:

Robert J. Doerksen;
Bin Chen;
Dahui Liu;
Gregory N. Tew;
William F. DeGrado;
Michael L. Klein

Publication type:

Article

Catalytic molten globules.

Published in:

Nature, 1993, v. 365, n. 6446, p. 488, doi. 10.1038/365488a0

By:

DeGrado, William F.

Publication type:

Article

Use of phage display to probe the evolution of binding specificity and affinity in integrins.

Published in:

Protein Engineering, 2003, v. 16, n. 1, p. 65, doi. 10.1093/proeng/gzg002

By:

Li, Renhao;
Hoess, Ronald H.;
Bennett, Joel S.;
DeGrado, William F.

Publication type:

Article

De novo protein design, a retrospective.

Published in:

Quarterly Reviews of Biophysics, 2020, v. 53, p. 1, doi. 10.1017/S0033583519000131

By:

Korendovych, Ivan V.;
DeGrado, William F.

Publication type:

Article

Asparagine-mediated self-association of a model transmembrane helix.

Published in:

Nature Structural Biology, 2000, v. 7, n. 2, p. 161

By:

Choma, Christin;
Gratkowski, Holly;
Lear, James D.;
DeGrado, William F.

Publication type:

Article

A Real-Time All-Atom Structural Search Engine for Proteins.

Published in:

PLoS Computational Biology, 2014, v. 10, n. 7, p. 1, doi. 10.1371/journal.pcbi.1003750

By:

Gonzalez, Gabriel;
Hannigan, Brett;
DeGrado, William F.

Publication type:

Article

Assembly of the Transmembrane Domain of E. coli PhoQ Histidine Kinase: Implications for Signal Transduction from Molecular Simulations.

Published in:

PLoS Computational Biology, 2013, v. 9, n. 1, p. 1, doi. 10.1371/journal.pcbi.1002878

By:

Lemmin, Thomas;
Soto, Cinque S.;
Clinthorne, Graham;
DeGrado, William F.;
Dal Peraro, Matteo

Publication type:

Article

Integrin α2β1 regulates collagen I tethering to modulate hyperresponsiveness in reactive airway disease models.

Published in:

2021

By:

Sean Liu;
Uyen Ngo;
Xin-Zi Tang;
Xin Ren;
Wenli Qiu;
Xiaozhu Huang;
DeGrado, William;
Allen, Christopher D. C.;
Hyunil Jo;
Sheppard, Dean;
Sundaram, Aparna B.;
Liu, Sean;
Ngo, Uyen;
Tang, Xin-Zi;
Ren, Xin;
Qiu, Wenli;
Huang, Xiaozhu;
Allen, Christopher Dc;
Jo, Hyunil

Publication type:

journal article

Targeting integrin α5β1 ameliorates severe airway hyperresponsiveness in experimental asthma.

Published in:

2017

By:

Sundaram, Aparna;
Chun Chen;
Khalifeh-Soltani, Amin;
Atakilit, Amha;
Xin Ren;
Wenli Qiu;
Hyunil Jo;
DeGrado, William;
Xiaozhu Huang;
Sheppard, Dean;
Chen, Chun;
Ren, Xin;
Qiu, Wenli;
Jo, Hyunil;
Huang, Xiaozhu

Publication type:

journal article

4-Cyanoindole-2′-deoxyribonucleoside as a Dual Fluorescence and Infrared Probe of DNA Structure and Dynamics.

Published in:

Molecules, 2019, v. 24, n. 3, p. 602, doi. 10.3390/molecules24030602

By:

Ahmed, Ismail A.;
Acharyya, Arusha;
Eng, Christina M.;
Rodgers, Jeffrey M.;
DeGrado, William F.;
Jo, Hyunil;
Gai, Feng;
Fang, Chong

Publication type:

Article

Sliding Helix and Change of Coordination Geometry in a Model Di-Mn<sup>II</sup> Protein.

Published in:

Angewandte Chemie International Edition, 2003, v. 42, n. 4, p. 417, doi. 10.1002/anie.200390127

By:

DeGrado, William F.;
Di Costanzo, Luigi;
Geremia, Silvano;
Lombardi, Angela;
Pavone, Vincenzo;
Randaccio, Lucio

Publication type:

Article

Fluorinated Coiled-Coil Proteins Prepared In Vivo Display Enhanced Thermal and Chemical Stability.

Published in:

Angewandte Chemie International Edition, 2001, v. 40, n. 8, p. 1494, doi. 10.1002/1521-3773(20010417)40:8<1494::AID-ANIE1494>3.0.CO;2-X

By:

Tang, Yi;
Ghirlanda, Giovanna;
Petka, Wendy A.;
Nakajima, Tadashi;
DeGrado, William F.;
Tirrell, David A.

Publication type:

Article

Predicted calmodulin-binding sequence in the γ subunit of phosphorylase b kinase.

Published in:

Proteins, 1987, v. 2, n. 1, p. 20, doi. 10.1002/prot.340020104

By:

Degrado, William F.;
Erickson-Viitanen, Susan;
Wolfe, Henry R.;
O'Neil, Karyn T.

Publication type:

Article