Found: 20
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C9ORF72-derived poly-GA DPRs undergo endocytic uptake in iAstrocytes and spread to motor neurons.
- Published in:
- Life Science Alliance, 2022, v. 5, n. 9, p. 1, doi. 10.26508/lsa.202101276
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- Publication type:
- Article
Deficiency of the copper chaperone for superoxide dismutase increases amyloid-β production.
- Published in:
- 2010
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- Publication type:
- journal article
Deficiency of the Copper Chaperone for Superoxide Dismutase Increases Amyloid-β Production.
- Published in:
- Journal of Alzheimer's Disease, 2010, v. 21, n. 4, p. 1101, doi. 10.3233/JAD-2010-100717
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- Publication type:
- Article
Direct evidence for axonal transport defects in a novel mouse model of mutant spastin-induced hereditary spastic paraplegia (HSP) and human HSP patients.
- Published in:
- Journal of Neurochemistry, 2009, v. 110, n. 1, p. 34, doi. 10.1111/j.1471-4159.2009.06104.x
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- Publication type:
- Article
Amyotrophic lateral sclerosis-associated mutant VAPBP56S perturbs calcium homeostasis to disrupt axonal transport of mitochondria.
- Published in:
- Human Molecular Genetics, 2012, v. 21, n. 9, p. 1979, doi. 10.1093/hmg/dds011
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- Publication type:
- Article
VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis.
- Published in:
- Human Molecular Genetics, 2012, v. 21, n. 6, p. 1299, doi. 10.1093/hmg/ddr559
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- Publication type:
- Article
Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content.
- Published in:
- Human Molecular Genetics, 2007, v. 16, n. 22, p. 2720, doi. 10.1093/hmg/ddm226
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- Publication type:
- Article
Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations.
- Published in:
- Nature Communications, 2014, v. 5, n. 10, p. 5245, doi. 10.1038/ncomms6245
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- Publication type:
- Article
ER-mitochondria associations are regulated by the VAPB-PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43.
- Published in:
- Nature Communications, 2014, v. 5, n. 6, p. 3996, doi. 10.1038/ncomms4996
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- Publication type:
- Article
Astrocyte adenosine deaminase loss increases motor neuron toxicity in amyotrophic lateral sclerosis.
- Published in:
- 2019
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- Publication type:
- journal article
An interaction between synapsin and C9orf72 regulates excitatory synapses and is impaired in ALS/FTD.
- Published in:
- Acta Neuropathologica, 2022, v. 144, n. 3, p. 437, doi. 10.1007/s00401-022-02470-z
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- Publication type:
- Article
Axonal Transport Defects in a Mitofusin 2 Loss of Function Model of Charcot-Marie-Tooth Disease in Zebrafish.
- Published in:
- PLoS ONE, 2013, v. 8, n. 6, p. 1, doi. 10.1371/journal.pone.0067276
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- Publication type:
- Article
Loss of TMEM106B exacerbates C9ALS/FTD DPR pathology by disrupting autophagosome maturation.
- Published in:
- Frontiers in Cellular Neuroscience, 2022, v. 16, p. 01, doi. 10.3389/fncel.2022.1061559
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- Publication type:
- Article
ALS/ FTD-associated FUS activates GSK-3β to disrupt the VAPB- PTPIP51 interaction and ER-mitochondria associations.
- Published in:
- EMBO Reports, 2016, v. 17, n. 9, p. 1326, doi. 10.15252/embr.201541726
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- Publication type:
- Article
A cell-penetrant peptide blocking C9ORF72-repeat RNA nuclear export reduces the neurotoxic effects of dipeptide repeat proteins.
- Published in:
- Science Translational Medicine, 2023, v. 15, n. 685, p. 1, doi. 10.1126/scitranslmed.abo3823
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- Publication type:
- Article
Amyotrophic lateral sclerosis-associated mutant SOD1 inhibits anterograde axonal transport of mitochondria by reducing Miro1 levels.
- Published in:
- Human Molecular Genetics, 2017, v. 26, n. 23, p. 4668, doi. 10.1093/hmg/ddx348
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- Publication type:
- Article
C9ORF72 hexanucleotide repeat exerts toxicity in a stable, inducible motor neuronal cell model, which is rescued by partial depletion of Pten.
- Published in:
- Human Molecular Genetics, 2017, v. 26, n. 6, p. 1133, doi. 10.1093/hmg/ddx022
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- Publication type:
- Article
Protein Homeostasis in Amyotrophic Lateral Sclerosis: Therapeutic Opportunities?
- Published in:
- Frontiers in Molecular Neuroscience, 2017, v. 10, p. 1, doi. 10.3389/fnmol.2017.00123
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- Publication type:
- Article
The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy.
- Published in:
- EMBO Journal, 2016, v. 35, n. 15, p. 1656, doi. 10.15252/embj.201694401
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- Publication type:
- Article
A comparison of in vitro properties of resting SOD1 transgenic microglia reveals evidence of reduced neuroprotective function.
- Published in:
- 2011
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- Publication type:
- journal article