Works by De Lepeleire, Inge

Results: 34

Quantification, Variability, and Reproducibility of Basal Skeletal Muscle Glucose Uptake in Healthy Humans Using 18F-FDG PET/CT.

Published in:

Journal of Nuclear Medicine, 2015, v. 56, n. 10, p. 1520, doi. 10.2967/jnumed.115.159715

By:

Gheysens, Olivier;
Postnov, Andrey;
Deroose, Christophe M.;
Vandermeulen, Corinne;
de Hoon, Jan;
Declercq, Ruben;
Dennie, Justin;
Mixson, Lori;
De Lepeleire, Inge;
Van Laere, Koen;
Klimas, Michael;
Chakravarthy, Manu V.

Publication type:

Article

11C-MK-8278 PET as a Tool for Pharmacodynamic Brain Occupancy of Histamine 3 Receptor Inverse Agonists.

Published in:

Journal of Nuclear Medicine, 2014, v. 55, n. 1, p. 65, doi. 10.2967/jnumed.113.122515

By:

Van Laere, Koenraad J.;
Sanabria-Bohórquez, Sandra M.;
Mozley, David P.;
Burns, Donald H.;
Hamill, Terence G.;
Van Hecken, Anne;
De Lepeleire, Inge;
Koole, Michel;
Bormans, Guy;
de Hoon, Jan;
Depré, Marleen;
Cerchio, Kristine;
Plalcza, John;
Lingling Han;
Renger, John;
Hargreaves, Richard J.;
Iannone, Robert

Publication type:

Article

Whole-Body Biodistribution and Radiation Dosimetry of the Human Cannabinoid Type-1 Receptor Ligand 18F-MK-9470 in Healthy Subjects.

Published in:

Journal of Nuclear Medicine, 2008, v. 49, n. 3, p. 439, doi. 10.2967/jnumed.107.047290

By:

Van Laere, Koen;
Koole, Michel;
Bohorquez, Sandra M. Sanabria;
Goffin, Karolien;
Guenther, Ilonka;
Belanger, Marie J.;
Cote, Josee;
Rothenberg, Paul;
De Lepeleire, Inge;
Grachev, Igor D.;
Hargreaves, Richard J.;
Bormans, Guy;
Burns, H. Donald

Publication type:

Article

Reproducibility of the Determination of 13C‐Labeling of Glutamate and Glutamine in the Human Brain Using selPOCE‐MRS at 7 T Upon [U‐13C]–Labeled Glucose Infusion.

Published in:

NMR in Biomedicine, 2025, v. 38, n. 5, p. 1, doi. 10.1002/nbm.70026

By:

Ahmadian, Narjes;
Jacobs, Sarah M.;
Gosselink, Mark;
van der Kemp, Wybe J. M.;
Hoogduin, Hans;
Coppoli, Anastasia;
Mason, Graeme F.;
de Graaf, Robin A.;
Norouzizadeh, Helia;
Mahon, Chantal;
Eijsden, Pieter van;
Tiessen, Renger;
Cerneus, Dirk;
Miller, Corin O.;
Lepeleire, Inge De;
Basile, Anthony S.;
Klomp, Dennis W. J.;
Prompers, Jeanine J.;
Wiegers, Evita C.

Publication type:

Article

Prolonged Oral Treatment with MK-677, a Novel Growth Hormone Secretagogue, Improves Sleep Quality in Man.

Published in:

Neuroendocrinology, 1997, v. 66, n. 4, p. 278, doi. 10.1159/000127249

By:

Copinschi, Georges;
Leproult, Rachel;
Van Onderbergen, Anne;
Caufriez, Anne;
Cole, Katrina Y.;
Schilling, Lisa M.;
Mendel, Carl M.;
De Lepeleire, Inge;
Bolognese, James A.;
Van Cauter, Eve

Publication type:

Article

A randomized clinical trial comparing point-of-care platelet function assays and bleeding time in healthy subjects treated with aspirin or clopidogrel.

Published in:

Platelets, 2012, v. 23, n. 4, p. 249, doi. 10.3109/09537104.2011.604806

By:

Chen, Fabian;
Maridakis, Victor;
O'neill, Edward A.;
Beals, Chan;
Radziszewski, Waldemar;
de Lepeleire, Inge;
Van Dyck, Kristien;
Depré, Marleen;
Bolognese, James A.;
de Hoon, Jan;
Jacquemin, Marc

Publication type:

Article

The effects of laropiprant, a selective prostaglandin D2 receptor 1 antagonist, on the antiplatelet activity of clopidogrel or aspirin.

Published in:

Platelets, 2011, v. 22, n. 7, p. 495, doi. 10.3109/09537104.2011.565433

By:

Dallob, Aimee;
Luo, Wen-Lin;
Luk, Julie Mabalot;
Ratcliffe, Lisa;
Johnson-Levonas, Amy O.;
Schwartz, Jules I.;
Dishy, Victor;
Kraft, Walter K.;
De Hoon, Jan N.;
Van Hecken, Anne;
De Lepeleire, Inge;
Radziszewski, Waldemar;
Wagner, John A.;
Lai, Eseng

Publication type:

Article

Image-derived input function for [11C]flumazenil kinetic analysis in human brain.

Published in:

2003

By:

Sanabria-Bohórquez, Sandra M;
Maes, Alex;
Dupont, Patrick;
Bormans, Guy;
de Groot, Tjibbe;
Coimbra, Alexandre;
Eng, WaiSi;
Laethem, Tine;
De Lepeleire, Inge;
Gambale, Jay;
Vega, Jose M;
Burns, H Donald

Publication type:

journal article

Image-Derived Input Function for [11C]Flumazenil Kinetic Analysis in Human Brain

Published in:

Molecular Imaging & Biology, 2003, v. 5, n. 2, p. 72, doi. 10.1016/S1536-1632(03)00046-5

By:

Sanabria-Bohórquez, Sandra M.;
Maes, Alex;
Dupont, Patrick;
Bormans, Guy;
Groot, Tjibbe de;
Coimbra, Alexandre;
Eng, WaiSi;
Laethem, Tine;
Lepeleire, Inge De;
Gambale, Jay;
Vega, Jose M.;
Burns, H. Donald

Publication type:

Article

Characterizing the PK/ PD relationship for inhibition of capsaicin-induced dermal vasodilatation by MK-3207, an oral calcitonin gene related peptide receptor antagonist.

Published in:

British Journal of Clinical Pharmacology, 2015, v. 79, n. 5, p. 831, doi. 10.1111/bcp.12547

By:

Li, Chi‐Chung;
Vermeersch, Steve;
Denney, William S.;
Kennedy, William P.;
Palcza, John;
Gipson, Adrianna;
Han, Tae H.;
Blanchard, Rebecca;
De Lepeleire, Inge;
Depré, Marleen;
Murphy, M. Gail;
Van Dyck, Kristien;
Hoon, Jan N.

Publication type:

Article

Effect of Single Oral Doses of Sitagliptin, a Dipeptidyl Peptidase-4 Inhibitor, on Incretin and Plasma Glucose Levels after an Oral Glucose Tolerance Test in Patients with Type 2 Diabetes.

Published in:

Journal of Clinical Endocrinology & Metabolism, 2006, v. 91, n. 11, p. 4612, doi. 10.1210/jc.2006-1009

By:

Herman, Gary A.;
Bergman, Arthur;
Stevens, Catherine;
Kotey, Paul;
Bingming Yi;
Peng Zhao;
Dietrich, Bruno;
Golor, George;
Schrodter, Andreas;
Keymeulen, Bart;
Lasseter, Kenneth C.;
Kipnes, Mark S.;
Snyder, Karen;
Hilliard, Deborah;
Tanen, Michael;
Cilissen, Caroline;
De Smet, Marina;
de Lepeleire, Inge;
Van Dyck, Kristien;
Wang, Amy Q.

Publication type:

Article

Effect of MK-386, a Novel Inhibitor of Type 15~ Reductase, Alone and in Combination with Finasteride, on Serum Dihydrotestosterone Concentrations in Men.

Published in:

Journal of Clinical Endocrinology & Metabolism, 1996, v. 81, n. 8, p. 2942, doi. 10.1210/jc.81.8.2942

By:

SCHWARTZ, JULES I.;
VAN HECKEN, ANNE;
DE SCHEPPER, PAUL J.;
DE LEPELEIRE, INGE;
LASSETER, KENNETH C.;
SHAMBLEN, E. COOPER;
WINCHELL, GREGORY A.;
CONSTANZER, MARVIN L.;
CHAVEZ, CYNTHIA M.;
WANG, DANIEL Z.;
EBEL, DAVID L.;
JUSTICE, STEVEN J.;
GERTZ, BARRY J.

Publication type:

Article

Kinetic analysis of the cannabinoid-1 receptor PET tracer [18F]MK-9470 in human brain.

Published in:

European Journal of Nuclear Medicine & Molecular Imaging, 2010, v. 37, n. 5, p. 920, doi. 10.1007/s00259-009-1340-5

By:

Sanabria-Bohórquez, Sandra Marina;
Hamill, Terence G.;
Goffin, Karolien;
de Lepeleire, Inge;
Bormans, Guy;
Burns, H. Donald;
van Laere, Koen

Publication type:

Article

Safety, tolerability, and pharmacokinetics of single‐ and multiple‐dose administration of islatravir (MK‐8591) in adults without HIV.

Published in:

CTS: Clinical & Translational Science, 2021, v. 14, n. 5, p. 1935, doi. 10.1111/cts.13048

By:

Matthews, Randolph P.;
Ankrom, Wendy;
Friedman, Evan;
Jackson Rudd, Deanne;
Liu, Yang;
Mogg, Robin;
Panebianco, Deborah;
De Lepeleire, Inge;
Petkova, Magdalena;
Grobler, Jay A.;
Stoch, Selwyn Aubrey;
Iwamoto, Marian

Publication type:

Article

Clinical Evaluation of Brain CB-1 Receptor Occupancy of a Novel CB-1R Inverse Agonist Using CB-1R PET.

Published in:

Diabetes, 2007, v. 56, p. A693

By:

Addy, Carol;
Rothenberg, Paul;
Burns, Donald;
Sanabria, Sandra;
Wai-Si Eng;
De Lepeleire, Inge;
Dyck, Kristien Van;
Cote, Josee;
Rosko, Kim;
Bormans, Guy;
De Hoon, Jan;
Mortelmans, Luc;
Dupont, Patrick;
Depre, Marleen;
Van Hecken, Anne;
Stoch, Aubrey;
Gottesdiener, Keith;
Hargreaves, Richard;
Wagner, John;
Van Laere, Koen

Publication type:

Article

The potent calcitonin gene-related peptide receptor antagonist, telcagepant, does not affect nitroglycerin-induced vasodilation in healthy men.

Published in:

British Journal of Clinical Pharmacology, 2011, v. 71, n. 5, p. 708, doi. 10.1111/j.1365-2125.2010.03869.x

By:

Van der Schueren, Bart J.;
Blanchard, Rebecca;
Murphy, M. Gail;
Palcza, John;
De Lepeleire, Inge;
Van Hecken, Anne;
Depré, Marleen;
de Hoon, Jan N.

Publication type:

Article

Inhibition of capsaicin-induced increase in dermal blood flow by the oral CGRP receptor antagonist, telcagepant (MK-0974).

Published in:

British Journal of Clinical Pharmacology, 2010, v. 69, n. 1, p. 15, doi. 10.1111/j.1365-2125.2009.03543.x

By:

Sinclair, Simon R.;
Kane, Stefanie A.;
Van der Schueren, Bart J.;
Alan Xiao;
Willson, Kenneth J.;
Boyle, Janet;
de Lepeleire, Inge;
Yang Xu;
Hickey, Lisa;
Denney, William S.;
Chi-Chung Li;
Palcza, John;
Vanmolkot, Floris H. M.;
Depré, Marleen;
Van Hecken, Anne;
Murphy, M. Gail;
Ho, Tony W.;
de Hoon, Jay N.

Publication type:

Article

Lack of Erectogenic Activity of a Novel Selective Melanocortin-4 Receptor Agonist in a Clinical Experimental Model.

Published in:

Journal of Clinical Pharmacology, 2008, v. 48, n. 10, p. 1237, doi. 10.1177/0091270008320925

By:

Krishna, Rajesh;
Wong, Peggy;
Stevens, Catherine;
de Lepeleire, Inge;
van Dyck, Kristien;
Rosen, Raymond C.;
Gendrano III, Isaias Noel;
Peeters, Mathieu;
Wagner, John A.;
Herman, Gary A.

Publication type:

Article

Multiple-Dose Pharmacokinetics, Pharmacodynamics, and Safety of Taranabant, a Novel Selective Cannabinoid-1 Receptor Inverse Agonist, in Healthy Male Volunteers.

Published in:

Journal of Clinical Pharmacology, 2008, v. 48, n. 6, p. 734, doi. 10.1177/0091270008317591

By:

Addy, Carol;
Rothenberg, Paul;
Susie Li;
Majumdar, Anup;
Agrawal, Nancy;
Hankun Li;
Ling Zhong;
Jinyu Yuan;
Maes, Andrea;
Dunbar, Stephanie;
Cote, Josee;
Rosko, Kim;
Van Dyck, Kristien;
De Lepeleire, Inge;
De Hoon, Jan;
Van Hecken, Anne;
Depré, Marleen;
Knops, Annemie;
Gottesdiener, Keith;
Stoch, Aubrey

Publication type:

Article

Pharmacokinetics of Aprepitant After Single and Multiple Oral Doses in Healthy Volunteers.

Published in:

Journal of Clinical Pharmacology, 2006, v. 46, n. 3, p. 291, doi. 10.1177/0091270005283467

By:

Majumdar, Anup K.;
Howard, Laura;
Goldberg, Michael R.;
Hickey, Lisa;
Constanzer, Marvin;
Rothenberg, Paul L.;
Crumley, Tami M.;
Panebianco, Deborah;
Bradstreet, Thomas E.;
Bergman, Arthur J.;
Waldman, Scott A.;
Greenberg, Howard E.;
Butler, Kathleen;
Knops, A.;
De Lepeleire, Inge;
Michiels, Nicole;
Petty, Kevin J.

Publication type:

Article

Comparative Inhibitory Activity of Rofecoxib, Meloxicam, Diclofenac, Ibuprofen, and Naproxen on COX-2 versus COX-1 in Healthy Volunteers.

Published in:

Journal of Clinical Pharmacology, 2000, v. 40, n. 10, p. 1109, doi. 10.1177/009127000004001005

By:

Van Hecken, Anne;
Schwartz, Jules I.;
Depré, Marleen;
De Lepeleire, Inge;
Dallob, Aimee;
Tanaka, Wesley;
Wynants, Kathleen;
Buntinx, Agnes;
Arnout, Jef;
Wong, Peggy H.;
Ebel, David L.;
Gertz, Barry J.;
De Schepper, Paul J.

Publication type:

Article

Effect of Multiple Doses of Montelukast, a CysLT1 Receptor Antagonist, on Digoxin Pharmacokinetics in Healthy Volunteers.

Published in:

Journal of Clinical Pharmacology, 1999, v. 39, n. 9, p. 941, doi. 10.1177/009127009903900908

By:

Depré, Marleen;
Van Hecken, Anne;
Verbesselt, René;
Wynants, Katleen;
De Lepeleire, Inge;
Freeman, Amanda;
Holland, Sherry;
Shahane, Aditi;
Gertz, Barry;
De Schepper, Paul J.

Publication type:

Article

Effect of Montelukast on the Pharmacokinetics and Pharmacodynamics of Warfarin in Healthy Volunteers.

Published in:

Journal of Clinical Pharmacology, 1999, v. 39, n. 5, p. 495, doi. 10.1177/009127009903900509

By:

Van Hecken, Anne;
Depré, Marleen;
Verbesselt, René;
Wynants, Kathleen;
De Lepeleire, Inge;
Arnout, Jef;
Wong, Peggy H.;
Freeman, Amanda;
Holland, Sherry;
Gertz, Barry;
De Schepper, Paul J.

Publication type:

Article

Characterization of rofecoxib as a cyclooxygenase-2 isoform inhibitor and demonstration of analgesia in the dental pain model*.

Published in:

Clinical Pharmacology & Therapeutics, 1999, v. 65, n. 3, p. 336, doi. 10.1016/S0009-9236(99)70113-X

By:

Ehrich, Elliot W.;
Dallob, Aimee;
De Lepeleire, Inge;
Van Hecken, Anne;
Riendeau, Denis;
Yuan, Weiying;
Porras, Arturo;
Wittreich, Johanna;
Seibold, James R.;
De Schepper, Paul;
Mehlisch, Donald R.;
Gertz, Barry J.

Publication type:

Article

Montelukast causes prolonged, potent leukotriene D4-receptor antagonism in the airways of patients with asthma*.

Published in:

Clinical Pharmacology & Therapeutics, 1997, v. 61, n. 1, p. 83, doi. 10.1016/S0009-9236(97)90184-3

By:

De Lepeleire, Inge;
Reiss, Theodore F.;
Rochette, Felicien;
Botto, Albert;
Zhang, Ji;
Kundu, Sudeep;
Decramer, Marc

Publication type:

Article

Rhinovirus‐16 induced temporal interferon responses in nasal epithelium links with viral clearance and symptoms.

Published in:

Clinical & Experimental Allergy, 2019, v. 49, n. 12, p. 1587, doi. 10.1111/cea.13481

By:

Ravi, Abilash;
Chang, Meiping;
Pol, Marianne;
Yang, Shan;
Aliprantis, Antonios;
Thornton, Bob;
Carayannopoulos, Leonidas N.;
Bautmans, An;
Robberechts, Martine;
De Lepeleire, Inge;
Singh, Dave;
Hohlfeld, Jens M.;
Sterk, Peter J.;
Krug, Norbert;
Lutter, René

Publication type:

Article

Effect of Diltiazem, a Moderate CYP3A Inhibitor, on the Pharmacokinetics of Anacetrapib, a Potent Cholesteryl Ester Transfer Protein Inhibitor, in Healthy Subjects.

Published in:

Journal of Clinical Pharmacology, 2011, v. 51, n. 3, p. 436, doi. 10.1177/0091270010368676

By:

Garg, Amit;
Maes, Andrea;
Corr, Christy;
Jin, Bo;
Wadhwa, Tarun;
Handa, Nikhil;
Van Dyck, Kristien;
De Lepeleire, Inge;
Shah, Jinesh;
Wagner, John A.;
Krishna, Rajesh

Publication type:

Article

IC‐P‐150: [C‐11]MK‐6884 PET: CHARACTERIZING BRAIN M4 RECEPTORS IN HEALTHY ELDERLY VOLUNTEERS AND ACETYLCHOLINESTERASE INHIBITORS‐TREATED AD PATIENTS.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P121, doi. 10.1016/j.jalz.2019.06.4264

By:

Wang, Yuchuan;
Li, Wenping;
Lohith, Talakad G.;
Bormans, Guy;
Koole, Michel;
Van Laere, Koen;
Serdons, Kim;
de Hoon, Jan;
Declercq, Ruben;
De Lepeleire, Inge;
Pascual, Maria B.;
Zanotti-Fregonara, Paolo;
Yu, Meixiang;
Arbones, Victoria;
Masdeu, Joseph C.;
Cheng, Amy;
Anderson, Matt S.;
Hostetler, Eric D.;
Basile, Anthony S.

Publication type:

Article

IC‐P‐150: [C‐11]MK‐6884 PET: CHARACTERIZING BRAIN M4 RECEPTORS IN HEALTHY ELDERLY VOLUNTEERS AND ACETYLCHOLINESTERASE INHIBITORS‐TREATED AD PATIENTS.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P121, doi. 10.1016/j.jalz.2019.06.4264

By:

Wang, Yuchuan;
Li, Wenping;
Lohith, Talakad G.;
Bormans, Guy;
Koole, Michel;
Van Laere, Koen;
Serdons, Kim;
de Hoon, Jan;
Declercq, Ruben;
De Lepeleire, Inge;
Pascual, Maria B.;
Zanotti-Fregonara, Paolo;
Yu, Meixiang;
Arbones, Victoria;
Masdeu, Joseph C.;
Cheng, Amy;
Anderson, Matt S.;
Hostetler, Eric D.;
Basile, Anthony S.

Publication type:

Article

Preliminary evaluation of the amyloid PET Radioligand [18F]MK-3328 in Alzheimer's Disease patients

Published in:

2011

By:

Sanabria-Bohorquez, Sandra;
Hostetler, Eric;
Van Laere, Koen;
Koole, Michel;
Bormans, Guy;
Serdons, Kim;
de Hoon, Jan;
Vandenberghe, Rik;
Versijpt, Jan;
De Lepeleire, Inge;
Reynders, Tom;
Tamagnan, Gilles;
Marek, Kenneth;
Seibyl, John;
Jennings, Danna;
Barret, Olivier;
Koren, Andrei;
Rosen, Laura;
Hargreaves, Richard;
Evelhoch, Jeffrey

Publication type:

Abstract

Development of the amyloid PET radioligand [18F]MK-3328

Published in:

2010

By:

Sanabria-Bohorquez, Sandra;
Van Laere, Koen;
Koole, Michel;
Bormans, Guy;
Serdons, Kim;
de Hoon, Jan;
Vandenberghe, Rik;
De Lepeleire, Inge;
Reynders, Tom;
Zeng, Zhizhen;
Williams, David;
Rosen, Laura;
Hargreaves, Richard;
Sur, Cyrille;
Forman, Mark;
Hostetler, Eric

Publication type:

Abstract

Orexin 2 Receptor Antagonism is Sufficient to Promote NREM and REM Sleep from Mouse to Man.

Published in:

Scientific Reports, 2016, p. 27147, doi. 10.1038/srep27147

By:

Gotter, Anthony L.;
Forman, Mark S.;
Harrell, Charles M.;
Stevens, Joanne;
Svetnik, Vladimir;
Yee, Ka Lai;
Li, Xiaodong;
Roecker, Anthony J.;
Fox, Steven V.;
Tannenbaum, Pamela L.;
Garson, Susan L.;
Lepeleire, Inge De;
Calder, Nicole;
Rosen, Laura;
Struyk, Arie;
Coleman, Paul J.;
Herring, W. Joseph;
Renger, John J.;
Winrow, Christopher J.

Publication type:

Article

Pharmacokinetics and pharmacodynamics of MK-383, a selective non-peptide platelet glycoprotein-IIb/IIIa receptor antagonist, in healthy men.

Published in:

Clinical Pharmacology & Therapeutics, 1994, v. 56, n. 4, p. 377, doi. 10.1038/clpt.1994.152

By:

Barrett, Jeffrey S;
Murphy, Gail;
Peerlinck, Kathelijne;
Lepeleire, Inge De;
Gould, Robert J;
Panebianco, Deborah;
Hand, Elizabeth;
Deckmyn, Hans;
Vermylen, Jos;
Arnout, Jef

Publication type:

Article

Pharmacokinetics and pharmacodynamics of multiple oral doses of MK-0591, a 5-lipoxygenase-activating protein inhibitor.

Published in:

Clinical Pharmacology & Therapeutics, 1994, v. 56, n. 1, p. 22, doi. 10.1038/clpt.1994.96

By:

Depré, Marken;
Friedman, Beth;
Van Hecken, Anne;
De Lepeleire, Inge;
Tanaka, Wesley;
Dallob, Aimee;
Shingo, Sumiko;
Porras, Arturo;
Lin, Charles;
De Schepper, Paul J

Publication type:

Article

Works by De Lepeleire, Inge

Quantification, Variability, and Reproducibility of Basal Skeletal Muscle Glucose Uptake in Healthy Humans Using <sup>18</sup>F-FDG PET/CT.

<sup>11</sup>C-MK-8278 PET as a Tool for Pharmacodynamic Brain Occupancy of Histamine 3 Receptor Inverse Agonists.

Whole-Body Biodistribution and Radiation Dosimetry of the Human Cannabinoid Type-1 Receptor Ligand <sup>18</sup>F-MK-9470 in Healthy Subjects.

Reproducibility of the Determination of <sup>13</sup>C‐Labeling of Glutamate and Glutamine in the Human Brain Using selPOCE‐MRS at 7 T Upon [U‐<sup>13</sup>C]–Labeled Glucose Infusion.

Prolonged Oral Treatment with MK-677, a Novel Growth Hormone Secretagogue, Improves Sleep Quality in Man.

A randomized clinical trial comparing point-of-care platelet function assays and bleeding time in healthy subjects treated with aspirin or clopidogrel.

The effects of laropiprant, a selective prostaglandin D<sub>2</sub> receptor 1 antagonist, on the antiplatelet activity of clopidogrel or aspirin.

Image-derived input function for [11C]flumazenil kinetic analysis in human brain.

Image-Derived Input Function for [<sup>11</sup>C]Flumazenil Kinetic Analysis in Human Brain

Characterizing the PK/ PD relationship for inhibition of capsaicin-induced dermal vasodilatation by MK-3207, an oral calcitonin gene related peptide receptor antagonist.

Effect of Single Oral Doses of Sitagliptin, a Dipeptidyl Peptidase-4 Inhibitor, on Incretin and Plasma Glucose Levels after an Oral Glucose Tolerance Test in Patients with Type 2 Diabetes.

Effect of MK-386, a Novel Inhibitor of Type 15~ Reductase, Alone and in Combination with Finasteride, on Serum Dihydrotestosterone Concentrations in Men.

Kinetic analysis of the cannabinoid-1 receptor PET tracer [<sup>18</sup>F]MK-9470 in human brain.

Safety, tolerability, and pharmacokinetics of single‐ and multiple‐dose administration of islatravir (MK‐8591) in adults without HIV.

Clinical Evaluation of Brain CB-1 Receptor Occupancy of a Novel CB-1R Inverse Agonist Using CB-1R PET.

The potent calcitonin gene-related peptide receptor antagonist, telcagepant, does not affect nitroglycerin-induced vasodilation in healthy men.

Inhibition of capsaicin-induced increase in dermal blood flow by the oral CGRP receptor antagonist, telcagepant (MK-0974).

Lack of Erectogenic Activity of a Novel Selective Melanocortin-4 Receptor Agonist in a Clinical Experimental Model.

Multiple-Dose Pharmacokinetics, Pharmacodynamics, and Safety of Taranabant, a Novel Selective Cannabinoid-1 Receptor Inverse Agonist, in Healthy Male Volunteers.

Pharmacokinetics of Aprepitant After Single and Multiple Oral Doses in Healthy Volunteers.

Comparative Inhibitory Activity of Rofecoxib, Meloxicam, Diclofenac, Ibuprofen, and Naproxen on COX-2 versus COX-1 in Healthy Volunteers.

Effect of Multiple Doses of Montelukast, a CysLT1 Receptor Antagonist, on Digoxin Pharmacokinetics in Healthy Volunteers.

Effect of Montelukast on the Pharmacokinetics and Pharmacodynamics of Warfarin in Healthy Volunteers.

Characterization of rofecoxib as a cyclooxygenase-2 isoform inhibitor and demonstration of analgesia in the dental pain model<sup>*</sup>.

Montelukast causes prolonged, potent leukotriene D<sub>4</sub>-receptor antagonism in the airways of patients with asthma<sup>*</sup>.

Rhinovirus‐16 induced temporal interferon responses in nasal epithelium links with viral clearance and symptoms.

Effect of Diltiazem, a Moderate CYP3A Inhibitor, on the Pharmacokinetics of Anacetrapib, a Potent Cholesteryl Ester Transfer Protein Inhibitor, in Healthy Subjects.

IC‐P‐150: [C‐11]MK‐6884 PET: CHARACTERIZING BRAIN M4 RECEPTORS IN HEALTHY ELDERLY VOLUNTEERS AND ACETYLCHOLINESTERASE INHIBITORS‐TREATED AD PATIENTS.

IC‐P‐150: [C‐11]MK‐6884 PET: CHARACTERIZING BRAIN M4 RECEPTORS IN HEALTHY ELDERLY VOLUNTEERS AND ACETYLCHOLINESTERASE INHIBITORS‐TREATED AD PATIENTS.

Preliminary evaluation of the amyloid PET Radioligand [18F]MK-3328 in Alzheimer's Disease patients

Development of the amyloid PET radioligand [<sup>18</sup>F]MK-3328

Orexin 2 Receptor Antagonism is Sufficient to Promote NREM and REM Sleep from Mouse to Man.

Pharmacokinetics and pharmacodynamics of MK-383, a selective non-peptide platelet glycoprotein-IIb/IIIa receptor antagonist, in healthy men.

Pharmacokinetics and pharmacodynamics of multiple oral doses of MK-0591, a 5-lipoxygenase-activating protein inhibitor.