Works by De Clercq, Erik

Results: 302

Antivirals and antiviral strategies.

Published in:

Nature Reviews Microbiology, 2004, v. 2, n. 9, p. 704, doi. 10.1038/nrmicro975

By:

Clercq, Erik De

Publication type:

Article

Expression of HIV-1 integrase in CEM cells inhibits HIV-1 replication.

Published in:

Journal of Gene Medicine, 2004, v. 6, n. 3, p. 268, doi. 10.1002/jgm.520

By:

Johan van Griensven;
Xiaojing Zhan;
Bénédicte Van Maele;
Wim Pluymers;
Martine Michiels;
Erik De Clercq;
Peter Cherepanov;
Zeger Debyser

Publication type:

Article

Assessment of the in vitro broad-spectrum antiviral activity of some selected antitumor metallocene and metallocenium complexes.

Published in:

Applied Organometallic Chemistry, 1989, v. 3, n. 6, p. 491, doi. 10.1002/aoc.590030605

By:

Ward, Sarah G;
Taylor, R Craig;
Köpf-Maier, Petra;
Köpf, Hartmut;
Balzarini, Jan;
De Clercq, Erik

Publication type:

Article

Assessment of the in vitro broad-spectrum antiviral activity of some selected antitumor organotin complexes.

Published in:

Applied Organometallic Chemistry, 1989, v. 3, n. 5, p. 431, doi. 10.1002/aoc.590030509

By:

Ward, Sarah G;
Taylor, R Craig;
Crowe, Alan J;
Balzarini, Jan;
De Clercq, Erik

Publication type:

Article

Deciphering the enigmas of non‐nucleoside reverse transcriptase inhibitors (NNRTIs): A medicinal chemistry expedition towards combating HIV drug resistance.

Published in:

Medicinal Research Reviews, 2025, v. 45, n. 2, p. 426, doi. 10.1002/med.22080

By:

Zhang, Kun;
Zhang, Yu‐Jie;
Li, Min;
Pannecouque, Christophe;
De Clercq, Erik;
Wang, Shuai;
Chen, Fen‐Er

Publication type:

Article

A medicinal chemist who reshaped the antiviral drug industry: John Charles Martin (1951–2021).

Published in:

Medicinal Research Reviews, 2022, v. 42, n. 2, p. 647, doi. 10.1002/med.21858

By:

Li, Guangdi;
De Clercq, Erik

Publication type:

Article

Molecular design opportunities presented by solvent‐exposed regions of target proteins.

Published in:

Medicinal Research Reviews, 2019, v. 39, n. 6, p. 2194, doi. 10.1002/med.21581

By:

Jiang, Xiangyi;
Yu, Ji;
Zhou, Zhongxia;
Kongsted, Jacob;
Song, Yuning;
Pannecouque, Christophe;
De Clercq, Erik;
Kang, Dongwei;
Poongavanam, Vasanthanathan;
Liu, Xinyong;
Zhan, Peng

Publication type:

Article

A Cutting-Edge View on the Current State of Antiviral Drug Development.

Published in:

Medicinal Research Reviews, 2013, v. 33, n. 6, p. 1249, doi. 10.1002/med.21281

By:

De Clercq, Erik

Publication type:

Article

The Acyclic Nucleoside Phosphonates (ANPs): Antonín Holý's Legacy.

Published in:

Medicinal Research Reviews, 2013, v. 33, n. 6, p. 1278, doi. 10.1002/med.21283

By:

De Clercq, Erik

Publication type:

Article

Highlights in Antiviral Drug Research: Antivirals at the Horizon.

Published in:

Medicinal Research Reviews, 2013, v. 33, n. 6, p. 1215, doi. 10.1002/med.21256

By:

Clercq, Erik De

Publication type:

Article

Organic Chemist Whose Inventions Reshaped the Antiviral Drug World.

Published in:

Medicinal Research Reviews, 2013, v. 33, n. 1, p. 1, doi. 10.1002/med.21274

By:

De Clercq, Erik

Publication type:

Article

Tenofovir: Quo Vadis Anno 2012 (Where Is It Going in the Year 2012)?

Published in:

Medicinal Research Reviews, 2012, v. 32, n. 4, p. 765, doi. 10.1002/med.21267

By:

De Clercq, Erik

Publication type:

Article

Yet another ten stories on antiviral drug discovery (part D): Paradigms, paradoxes, and paraductions.

Published in:

Medicinal Research Reviews, 2010, v. 30, n. 4, p. 667, doi. 10.1002/med.20173

By:

De Clercq, Erik

Publication type:

Article

The next ten stories on antiviral drug discovery (part E): advents, advances, and adventures.

Published in:

Medicinal Research Reviews, 2011, v. 31, n. 1, p. 118, doi. 10.1002/med.20179

By:

De Clercq, Erik

Publication type:

Article

Another ten stories in antiviral drug discovery (part C): 'Old' and 'new' antivirals, strategies, and perspectives.

Published in:

Medicinal Research Reviews, 2009, v. 29, n. 4, p. 611, doi. 10.1002/med.20153

By:

De Clercq, Erik

Publication type:

Article

Antiviral drug discovery: Ten more compounds, and ten more stories (part B).

Published in:

Medicinal Research Reviews, 2009, v. 29, n. 4, p. 571, doi. 10.1002/med.20149

By:

De Clercq, Erik

Publication type:

Article

The discovery of antiviral agents: Ten different compounds, ten different stories.

Published in:

Medicinal Research Reviews, 2008, v. 28, n. 6, p. 929, doi. 10.1002/med.20128

By:

De Clercq, Erik

Publication type:

Article

Selective inhibitors of picornavirus replication.

Published in:

Medicinal Research Reviews, 2008, v. 28, n. 6, p. 823, doi. 10.1002/med.20125

By:

De Palma, Armando M.;
Vliegen, Inge;
De Clercq, Erik;
Neyts, Johan

Publication type:

Article

Anti-influenza virus agents: Synthesis and mode of action.

Published in:

Medicinal Research Reviews, 2008, v. 28, n. 1, p. 1, doi. 10.1002/med.20096

By:

Lagoja, Irene M.;
De Clercq, Erik

Publication type:

Article

The regulation of HIV-1 transcription: Molecular targets for chemotherapeutic intervention.

Published in:

Medicinal Research Reviews, 2006, v. 26, n. 5, p. 595, doi. 10.1002/med.20081

By:

Stevens, Miguel;
De Clercq, Erik;
Balzarini, Jan

Publication type:

Article

( E)-5-(2-bromovinyl)-2′-deoxyuridine (BVDU).

Published in:

Medicinal Research Reviews, 2005, v. 25, n. 1, p. 1, doi. 10.1002/med.20011

By:

Clercq, Erik De

Publication type:

Article

Highly potent and selective inhibition of varicella-zoster virus replication by bicyclic furo[2,3-d]pyrimidine nucleoside analogues (This work was presented at the Symposium on Non-HIV Antivirals at the 224th American Chemical Society Meeting at Boston, MA, August 1822, 2002.)

Published in:

Medicinal Research Reviews, 2003, v. 23, n. 3, p. 253, doi. 10.1002/med.10035

By:

Erik De Clercq

Publication type:

Article

New anti-HIV agents and targets.

Published in:

Medicinal Research Reviews, 2002, v. 22, n. 6, p. 531, doi. 10.1002/med.10021

By:

Clercq, Erik De

Publication type:

Article

Current lead natural products for the chemotherapy of human immunodeficiency virus (HIV) infection.

Published in:

Medicinal Research Reviews, 2000, v. 20, n. 5, p. 323, doi. 10.1002/1098-1128(200009)20:5<323::AID-MED1>3.0.CO;2-A

By:

De Clercq, Erik

Publication type:

Article

The HIV-1 Reverse Transcription (RT) Process as Target for RT Inhibitors.

Published in:

Medicinal Research Reviews, 2000, v. 20, n. 2, p. 129, doi. 10.1002/(SICI)1098-1128(200003)20:2<129::AID-MED2>3.0.CO;2-A

By:

Jonckheere, Heidi;
Anné, Jozef;
De Clercq, Erik

Publication type:

Article

Non-nucleoside reverse transcriptase inhibitors (NNRTIs) for the treatment of human immunodeficiency virus type 1 (HIV-1) infections: Strategies to overcome drug resistance development.

Published in:

Medicinal Research Reviews, 1996, v. 16, n. 2, p. 125, doi. 10.1002/(SICI)1098-1128(199603)16:2<125::AID-MED1>3.0.CO;2-2

By:

De Clercq, Erik

Publication type:

Article

HIV-1-specific RT inhibitors: Highly selective inhibitors of human immunodeficiency virus type 1 that are specifically targeted at the viral reverse transcriptase.

Published in:

Medicinal Research Reviews, 1993, v. 13, n. 3, p. 229, doi. 10.1002/med.2610130303

By:

De Clercq, Erik

Publication type:

Article

Antibody seroconversion in asymptomatic and symptomatic patients infected with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2).

Published in:

Clinical & Translational Immunology, 2020, v. 9, n. 9, p. 1, doi. 10.1002/cti2.1182

By:

Jiang, Chuanhao;
Wang, Yali;
Hu, Min;
Wen, Lingjun;
Wen, Chuan;
Wang, Yang;
Zhu, Weihong;
Tai, Shi;
Jiang, Zhongbiao;
Xiao, Kui;
Faria, Nuno Rodrigues;
De Clercq, Erik;
Xu, Junmei;
Li, Guangdi

Publication type:

Article

Anti-retrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine (pmea) in vivo increases when it is less frequently administered.

Published in:

International Journal of Cancer, 1990, v. 46, n. 2, p. 337, doi. 10.1002/ijc.2910460233

By:

Balzarini, Jan;
Naesens, Lieve;
Clercq, Erik De

Publication type:

Article

Inhibitory effects of 9-(2-Phosphonylmethoxyethyl)adenine and 3′-azido-2′,3′-dideoxythymidine on tumor development in mice inoculated intracerebrally with moloney murine sarcoma virus.

Published in:

International Journal of Cancer, 1990, v. 45, n. 3, p. 486, doi. 10.1002/ijc.2910450319

By:

Balzarini, Jan;
Sobis, Halina;
Naesens, Lieve;
Vandeputte, Michel;
De Clercq, Erik

Publication type:

Article

Comparative inhibitory effects of suramin and other selected compounds on the infectivity and replication of human T-cell lymphotropic virus (HTLV-III)/lymphadenopathy-associated virus (LAV).

Published in:

International Journal of Cancer, 1986, v. 37, n. 3, p. 451, doi. 10.1002/ijc.2910370318

By:

Balzarini, Jan;
Mitsuya, Hiroaki;
De Clercq, Erik;
Broder, Samuel

Publication type:

Article

Antinociceptive and antitumor activity of novel synthetic mononuclear Ruthenium (II) compounds.

Published in:

Journal of Research in Medical Sciences, 2013, v. 18, n. 3, p. 215

By:

Shyam Sunder, A.;
Dhulipala, Satyavati;
Thota, Sreekanth;
Yerra, Rajeshwar;
Balzarini, Jan;
De Clercq, Erik

Publication type:

Article

Hope and hype.

Published in:

2006

By:

De Clercq, Erik

Publication type:

Book Review

Liposome-encapsulated (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine for long-acting therapy of viral retinitis.

Published in:

1996

By:

Kuppermann, Baruch D.;
Assil, Kerry K.;
Vuong, Chou;
Besen, Gilberto;
Wiley, Clayton A.;
De Clercq, Erik;
Bergeron-Lynn, Germaine;
Connor, James D.;
Pursley, Michael;
Munguia, David;
Freeman, William R.;
Kuppermann, B D;
Assil, K K;
Vuong, C;
Besen, G;
Wiley, C A;
De Clercq, E;
Bergeron-Lynn, G;
Connor, J D;
Pursley, M

Publication type:

journal article

Antiviral Effects of Plasma and Milk Proteins: Lactoferrin Shows Potent Activity against Both Human Immunodeficiency Virus and Human Cytomegalovirus Replication In Vitro.

Published in:

Journal of Infectious Diseases, 1995, v. 172, n. 2, p. 380, doi. 10.1093/infdis/172.2.380

By:

Harmsen, Martin C.;
Swart, Pieter J.;
Béthune, Marie-Pierre de;
Pauwels, Rudi;
Clercq, Erik De;
The, T. Bauw;
Meijer, Dirk K. F.

Publication type:

Article

Absence of Infectious Retinitis after Injection of Human Cytomegalovirus into Rabbit Eyes.

Published in:

Journal of Infectious Diseases, 1995, v. 171, n. 4, p. 782, doi. 10.1093/infdis/171.4.782

By:

Tatebayashi, Misako;
Neyts, Johan;
Besen, Gilberto;
Flores-Aguilar, Marisa;
Smith, Irene L.;
Wiley, Clayton A.;
Spector, Stephen A.;
Lynn, Germaine Bergeron;
Maudgal, Prabhat C.;
Clercq, Erik De;
Gangan, Pacifico A.;
Chavez, Eugenio;
Russack, Valentina;
Freeman, William R.

Publication type:

Article

Long-Acting Therapy of Viral Retinitis with (S)-1-(3-Hydroxy-2-Phosphonylmethoxypropyl) cytosine.

Published in:

Journal of Infectious Diseases, 1994, v. 169, n. 3, p. 642, doi. 10.1093/infdis/169.3.642

By:

Aguilar, Marisa Flores;
Huang, Jen-Shang;
Wiley, Gayton A.;
Clercq, Erik De;
Vuong, Chau;
Bergeron-Lynn, Germaine;
Chandler, Beverly;
Munguia, David;
Freeman, William R.

Publication type:

Article

Comparative Inhibitory Effects of Various Nucleoside and Nonnucleoside Analogues on Replication of Influenza Virus Types A and B In Vitro and In Ovo.

Published in:

Journal of Infectious Diseases, 1993, v. 168, n. 3, p. 641, doi. 10.1093/infdis/168.3.641

By:

Hosoya, Mitsuaki;
Shigeta, Shiro;
Ishii, Takanori;
Suzuki, Hitoshi;
Clercq, Erik De

Publication type:

Article

Comparative Inhibitory Effects of Nucleoside Analogues on Different Clinical Isolates of Human Cytomegalovirus In Vitro.

Published in:

Journal of Infectious Diseases, 1991, v. 163, n. 2, p. 270, doi. 10.1093/infdis/163.2.270

By:

Shigeta, Shiro;
Konno, Kenji;
Baba, Masanori;
Yokota, Tomoyuki;
De Clercq, Erik

Publication type:

Article

Novel Sulfated Polysaccharides: Dissociation of Anti-Human Immunodeficiency Virus Activity from Antithrombin Activity.

Published in:

Journal of Infectious Diseases, 1990, v. 161, n. 2, p. 208

By:

Baba, Masanori;
De Clercq, Erik;
Schols, Dominique;
Pauwels, Rudi;
Snoeck, Robert;
Van Boeckel, Constant;
Van Dedem, Gijs;
Kraaijeveld, Nelly;
Hobbelen, Paul;
Ottenheijm, Harry;
Den Hollander, Frank

Publication type:

Article

Differential Effects of E-5-(2-Bromovinyl)-2'-Deoxyuridine on Infections with Herpes Simplex Virus Type 1 and Type 2 in Hairless Mice.

Published in:

Journal of Infectious Diseases, 1981, v. 145, n. 1, p. 130

By:

Clercq, Erik De;
Zhang, Zhen-Xi

Publication type:

Article

E-5-(2-Bromovinyl)-2′-Deoxyuridine vs. Interferon in the Systemic Treatment of Infection with Herpes Simplex Virus of Athymic Nude Mice.

Published in:

Journal of Infectious Diseases, 1981, v. 143, n. 6, p. 846

By:

De Clercq, Erik;
Zhen-Xi, Zhang;
Descamps, Johan;
Huygen, Kris

Publication type:

Article

Design and synthesis of Fsp<sup>3</sup>‐enriched spirocyclic‐substituted diarylpyrimidine derivatives as novel HIV‐1 NNRTIs.

Published in:

Chemical Biology & Drug Design, 2024, v. 103, n. 3, p. 1, doi. 10.1111/cbdd.14510

By:

Sang, Zihao;
Zhang, Tao;
Wang, Zhao;
De Clercq, Erik;
Pannecouque, Christophe;
Kang, Dongwei;
Zhan, Peng;
Liu, Xinyong

Publication type:

Article

Potential antivirals and antiviral strategies against SARS coronavirus infections.

Published in:

2006

By:

De Clercq, Erik

Publication type:

journal article

Pyridazines 92. Synthesis of dialkyldipyridazinodiazepinones as potential HIV-1 reverse transcriptase inhibitors.

Published in:

Journal of Heterocyclic Chemistry, 2001, v. 38, n. 1, p. 125, doi. 10.1002/jhet.5570380117

By:

Heinisch, Gottfried;
Matuszczak, Barbara;
Spielmann, Elisabeth;
Witvrouw, Myriam;
Pannecouque, Christophe;
De Clercq, Erik

Publication type:

Article

Synthesis of 2-carbamoylmethyl-6-β-D-ribofuranosylpyridine with the aid of a Pd(0)-catalyzed reaction.

Published in:

Journal of Heterocyclic Chemistry, 1993, v. 30, n. 5, p. 1245, doi. 10.1002/jhet.5570300513

By:

De Vos, Eric;
Esmans, Eddy L.;
Alderweireldt, Frank C.;
Balzarini, Jan;
De Clercq, Erik

Publication type:

Article

3′-(1,2,3-Triazol-1-yl)-2′,3′-dideoxythymidine and 3′-(1,2,3-triazol-1-yl)-2′,3′-dideoxyuridine.

Published in:

Journal of Heterocyclic Chemistry, 1989, v. 26, n. 6, p. 1635, doi. 10.1002/jhet.5570260624

By:

Wigerinck, Piet;
Van Aerschot, Arthur;
Claes, Paul;
Balzarini, Jan;
De Clercq, Erik;
Herdewijn, Piet

Publication type:

Article

Synthesis of 3-Nitrosoimidazo[1,2- a]pyridine Derivatives as Potential Antiretroviral Agents.

Published in:

Archiv der Pharmazie, 2001, v. 334, n. 7, p. 224, doi. 10.1002/1521-4184(200107)334:7<224::AID-ARDP224>3.0.CO;2-7

By:

Chaouni-Benabdallah, Aziz;
Galtier, Christophe;
Allouchi, Hassan;
Kherbeche, Abdelhak;
Debouzy, Jean-Claude;
Teulade, Jean-Claude;
Chavignon, Olivier;
Witvrouw, Myriam;
Pannecouque, Christophe;
Balzarini, Jan;
de Clercq, Erik;
Enguehard, Cécile;
Gueiffier, Alain

Publication type:

Article

Synthesis and Antiviral and Cytostatic Activities of Carbocyclic Nucleosides Incorporating a Modified Cyclobutane Ring.

Published in:

Archiv der Pharmazie, 1999, v. 332, n. 10, p. 348, doi. 10.1002/(SICI)1521-4184(199910)332:10<348::AID-ARDP348>3.0.CO;2-H

By:

Figueira, M. José;
Blanco, J. Manuel;
Caamaño, Olga;
Fernández, Franco;
García-Mera, Xerardo;
López, Carmen;
Andrei, Graciela;
Snoeck, Robert;
Padalko, Elisabeth;
Neyts, Johan;
Balzarini, Jan;
Clercq, Erik De

Publication type:

Article

Inhibition of Human Immunodeficiency Virus Type (HIV-1) Replication by some Diversely Functionalized Spirocyclopropyl Derivatives.

Published in:

Archiv der Pharmazie, 1999, v. 332, n. 5, p. 163, doi. 10.1002/(SICI)1521-4184(19995)332:5<163::AID-ARDP163>3.0.CO;2-2

By:

Witvrouw, Myriam;
Pannecouque, Christophe;
De Clercq, Erik;
Fernández-Alvarez, Eldiberto;
Marco, José L.

Publication type:

Article