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Excess ribosomal protein production unbalances translation in a model of Fragile X Syndrome.
Published in:
Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-30979-0
By:
- Seo, Sang S.;
- Louros, Susana R.;
- Anstey, Natasha;
- Gonzalez-Lozano, Miguel A.;
- Harper, Callista B.;
- Verity, Nicholas C.;
- Dando, Owen;
- Thomson, Sophie R.;
- Darnell, Jennifer C.;
- Kind, Peter C.;
- Li, Ka Wan;
- Osterweil, Emily K.
Publication type:
Article
Distinct neuroinflammatory signatures exist across genetic and sporadic amyotrophic lateral sclerosis cohorts.
Published in:
Brain: A Journal of Neurology, 2023, v. 146, n. 12, p. 5124, doi. 10.1093/brain/awad243
By:
- Rifai, Olivia M;
- O'Shaughnessy, Judi;
- Dando, Owen R;
- Munro, Alison F;
- Sewell, Michael D E;
- Abrahams, Sharon;
- Waldron, Fergal M;
- Sibley, Christopher R;
- Gregory, Jenna M
Publication type:
Article
Synaptic resilience is associated with maintained cognition during ageing.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 6, p. 2560, doi. 10.1002/alz.12894
By:
- King, Declan;
- Holt, Kris;
- Toombs, Jamie;
- HE, Xin;
- Dando, Owen;
- Okely, Judith A;
- Tzioras, Makis;
- Rose, Jamie;
- Gunn, Ciaran;
- Correia, Adele;
- Montero, Carmen;
- McAlister, Hannah;
- Tulloch, Jane;
- Lamont, Douglas;
- Taylor, Adele M;
- Harris, Sarah E;
- Redmond, Paul;
- Cox, Simon R;
- Henstridge, Christopher M;
- Deary, Ian J
Publication type:
Article
A role for astrocytes and microglia in synapse loss in Alzheimer’s disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, p. 1, doi. 10.1002/alz.052532
By:
- Tzioras, Makis;
- Daniels, Michael;
- Davies, Caitlin;
- Hooley, Monique;
- He, Xin;
- Dando, Owen R.;
- Hardingham, Giles;
- McColl, Barry;
- Spires‐Jones, Tara L.
Publication type:
Article
Neuronal Activity and Its Role in Controlling Antioxidant Genes.
Published in:
International Journal of Molecular Sciences, 2020, v. 21, n. 6, p. 1933, doi. 10.3390/ijms21061933
By:
- Qiu, Jing;
- Dando, Owen;
- Febery, James A.;
- Fowler, Jill H.;
- Chandran, Siddharthan;
- Hardingham, Giles E.
Publication type:
Article
Mutant C9orf72 human iPSC‐derived astrocytes cause non‐cell autonomous motor neuron pathophysiology.
Published in:
Glia, 2020, v. 68, n. 5, p. 1046, doi. 10.1002/glia.23761
By:
- Zhao, Chen;
- Devlin, Anna‐Claire;
- Chouhan, Amit K.;
- Selvaraj, Bhuvaneish T.;
- Stavrou, Maria;
- Burr, Karen;
- Brivio, Veronica;
- He, Xin;
- Mehta, Arpan R.;
- Story, David;
- Shaw, Christopher E.;
- Dando, Owen;
- Hardingham, Giles E.;
- Miles, Gareth B.;
- Chandran, Siddharthan
Publication type:
Article
Evidence for evolutionary divergence of activity-dependent gene expression in developing neurons.
Published in:
eLife, 2016, p. 1, doi. 10.7554/eLife.20337
By:
- Jing Qiu;
- McQueen, Jamie;
- Bilican, Bilada;
- Dando, Owen;
- Magnani, Dario;
- Punovuori, Karolina;
- Selvaraj, Bhuvaneish T.;
- Livesey, Matthew;
- Haghi, Ghazal;
- Heron, Samuel;
- Burr, Karen;
- Patani, Rickie;
- Rajan, Rinku;
- Sheppard, Olivia;
- Kind, Peter C.;
- Simpson, T. Ian;
- Tybulewicz, Victor L. J.;
- Wyllie, David J. A.;
- Fisher, Elizabeth M. C.;
- Lowell, Sally
Publication type:
Article
Enhanced hippocampal LTP but normal NMDA receptor and AMPA receptor function in a rat model of CDKL5 deficiency disorder.
Published in:
Molecular Autism, 2024, v. 15, n. 1, p. 1, doi. 10.1186/s13229-024-00601-9
By:
- Simões de Oliveira, Laura;
- O'Leary, Heather E.;
- Nawaz, Sarfaraz;
- Loureiro, Rita;
- Davenport, Elizabeth C.;
- Baxter, Paul;
- Louros, Susana R.;
- Dando, Owen;
- Perkins, Emma;
- Peltier, Julien;
- Trost, Matthias;
- Osterweil, Emily K.;
- Hardingham, Giles E.;
- Cousin, Michael A.;
- Chattarji, Sumantra;
- Booker, Sam A.;
- Benke, Tim A.;
- Wyllie, David J. A;
- Kind, Peter C.
Publication type:
Article
Experience-dependent changes in hippocampal spatial activity and hippocampal circuit function are disrupted in a rat model of Fragile X Syndrome.
Published in:
Molecular Autism, 2022, v. 13, n. 1, p. 1, doi. 10.1186/s13229-022-00528-z
By:
- Asiminas, Antonis;
- Booker, Sam A.;
- Dando, Owen R.;
- Kozic, Zrinko;
- Arkell, Daisy;
- Inkpen, Felicity H.;
- Sumera, Anna;
- Akyel, Irem;
- Kind, Peter C.;
- Wood, Emma R.
Publication type:
Article
Imbalance of flight–freeze responses and their cellular correlates in the Nlgn3−/y rat model of autism.
Published in:
Molecular Autism, 2022, v. 13, n. 1, p. 1, doi. 10.1186/s13229-022-00511-8
By:
- Anstey, Natasha J.;
- Kapgal, Vijayakumar;
- Tiwari, Shashank;
- Watson, Thomas C.;
- Toft, Anna K. H.;
- Dando, Owen R.;
- Inkpen, Felicity H.;
- Baxter, Paul S.;
- Kozić, Zrinko;
- Jackson, Adam D.;
- He, Xin;
- Nawaz, Mohammad Sarfaraz;
- Kayenaat, Aiman;
- Bhattacharya, Aditi;
- Wyllie, David J. A.;
- Chattarji, Sumantra;
- Wood, Emma R.;
- Hardt, Oliver;
- Kind, Peter C.
Publication type:
Article
Astrocyte-oligodendrocyte interaction regulates central nervous system regeneration.
Published in:
Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-39046-8
By:
- Molina-Gonzalez, Irene;
- Holloway, Rebecca K.;
- Jiwaji, Zoeb;
- Dando, Owen;
- Kent, Sarah A.;
- Emelianova, Katie;
- Lloyd, Amy F.;
- Forbes, Lindsey H.;
- Mahmood, Ayisha;
- Skripuletz, Thomas;
- Gudi, Viktoria;
- Febery, James A.;
- Johnson, Jeffrey A.;
- Fowler, Jill H.;
- Kuhlmann, Tanja;
- Williams, Anna;
- Chandran, Siddharthan;
- Stangel, Martin;
- Howden, Andrew J. M.;
- Hardingham, Giles E.
Publication type:
Article
Altered dendritic spine function and integration in a mouse model of fragile X syndrome.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-11891-6
By:
- Booker, Sam A.;
- Domanski, Aleksander P. F.;
- Dando, Owen R.;
- Jackson, Adam D.;
- Isaac, John T. R.;
- Hardingham, Giles E.;
- Wyllie, David J. A.;
- Kind, Peter C.
Publication type:
Article
Synaptic gene expression changes in frontotemporal dementia due to the MAPT 10 + 16 mutation.
Published in:
Neuropathology & Applied Neurobiology, 2024, v. 50, n. 4, p. 1, doi. 10.1111/nan.13006
By:
- Dando, Owen;
- McGeachan, Robert;
- McQueen, Jamie;
- Baxter, Paul;
- Rockley, Nathan;
- McAlister, Hannah;
- Prasad, Adharsh;
- He, Xin;
- King, Declan;
- Rose, Jamie;
- Jones, Phillip B.;
- Tulloch, Jane;
- Chandran, Siddharthan;
- Smith, Colin;
- Hardingham, Giles;
- Spires‐Jones, Tara L.
Publication type:
Article
Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism.
Published in:
Nature Communications, 2017, v. 8, n. 5, p. 15132, doi. 10.1038/ncomms15132
By:
- Hasel, Philip;
- Dando, Owen;
- Jiwaji, Zoeb;
- Baxter, Paul;
- Todd, Alison C.;
- Heron, Samuel;
- Márkus, Nóra M.;
- McQueen, Jamie;
- Hampton, David W.;
- Torvell, Megan;
- Tiwari, Sachin S.;
- McKay, Sean;
- Eraso-Pichot, Abel;
- Zorzano, Antonio;
- Masgrau, Roser;
- Galea, Elena;
- Chandran, Siddharthan;
- Wyllie, David J. A.;
- Simpson, T. Ian;
- Hardingham, Giles E.
Publication type:
Article
Sustained correction of associative learning deficits after brief, early treatment in a rat model of Fragile X Syndrome.
Published in:
Science Translational Medicine, 2019, v. 11, n. 494, p. 1, doi. 10.1126/scitranslmed.aao0498
By:
- Asiminas, Antonis;
- Jackson, Adam D.;
- Louros, Susana R.;
- Till, Sally M.;
- Spano, Teresa;
- Dando, Owen;
- Bear, Mark F.;
- Chattarji, Sumantra;
- Hardingham, Giles E.;
- Osterweil, Emily K.;
- Wyllie, David J. A.;
- Wood, Emma R.;
- Kind, Peter C.
Publication type:
Article
Identifying foetal forebrain interneurons as a target for monogenic autism risk factors and the polygenic 16p11.2 microdeletion.
Published in:
BMC Neuroscience, 2023, v. 24, n. 1, p. 1, doi. 10.1186/s12868-022-00771-3
By:
- Yang, Yifei;
- Booker, Sam A.;
- Clegg, James M.;
- Quintana-Urzainqui, Idoia;
- Sumera, Anna;
- Kozic, Zrinko;
- Dando, Owen;
- Martin Lorenzo, Sandra;
- Herault, Yann;
- Kind, Peter C.;
- Price, David J.;
- Pratt, Thomas
Publication type:
Article
Laboratory Automated Interrogation of Data: an interactive web application for visualization of multilevel data from biological experiments.
Published in:
Brain Communications, 2024, v. 6, n. 2, p. 1, doi. 10.1093/braincomms/fcae074
By:
- Dando, Owen R;
- Kozic, Zrinko;
- Booker, Sam A;
- Hardingham, Giles E;
- Kind, Peter C
Publication type:
Article
Microarray profiling emphasizes transcriptomic differences between hippocampal in vivo tissue and in vitro cultures.
Published in:
Brain Communications, 2021, v. 3, n. 3, p. 1, doi. 10.1093/braincomms/fcab152
By:
- King, Declan;
- Skehel, Paul A.;
- Dando, Owen;
- Emelianova, Katie;
- Barron, Rona;
- Wishart, Thomas M.
Publication type:
Article
Recapitulation of the EEF1A2 D252H neurodevelopmental disorder-causing missense mutation in mice reveals a toxic gain of function.
Published in:
Human Molecular Genetics, 2020, v. 29, n. 10, p. 1592, doi. 10.1093/hmg/ddaa042
By:
- Davies, Faith C J;
- Hope, Jilly E;
- McLachlan, Fiona;
- Marshall, Grant F;
- Kaminioti-Dumont, Laura;
- Qarkaxhija, Vesa;
- Nunez, Francis;
- Dando, Owen;
- Smith, Colin;
- Wood, Emma;
- MacDonald, Josephine;
- Hardt, Oliver;
- Abbott, Catherine M
Publication type:
Article
Characterisation of CDKL5 Transcript Isoforms in Human and Mouse.
Published in:
PLoS ONE, 2016, v. 11, n. 6, p. 1, doi. 10.1371/journal.pone.0157758
By:
- Hector, Ralph D.;
- Dando, Owen;
- Landsberger, Nicoletta;
- Kilstrup-Nielsen, Charlotte;
- Kind, Peter C.;
- Bailey, Mark E. S.;
- Cobb, Stuart R.
Publication type:
Article
Expression of mRNA Encoding Mcu and Other Mitochondrial Calcium Regulatory Genes Depends on Cell Type, Neuronal Subtype, and Ca2+ Signaling.
Published in:
PLoS ONE, 2016, v. 11, n. 2, p. 1, doi. 10.1371/journal.pone.0148164
By:
- Márkus, Nóra M.;
- Hasel, Philip;
- Qiu, Jing;
- Bell, Karen F. S.;
- Heron, Samuel;
- Kind, Peter C.;
- Dando, Owen;
- Simpson, T. Ian;
- Hardingham, Giles E.
Publication type:
Article
Mitochondrial bioenergetic deficits in C9orf72 amyotrophic lateral sclerosis motor neurons cause dysfunctional axonal homeostasis.
Published in:
Acta Neuropathologica, 2021, v. 141, n. 2, p. 257, doi. 10.1007/s00401-020-02252-5
By:
- Mehta, Arpan R.;
- Gregory, Jenna M.;
- Dando, Owen;
- Carter, Roderick N.;
- Burr, Karen;
- Nanda, Jyoti;
- Story, David;
- McDade, Karina;
- Smith, Colin;
- Morton, Nicholas M.;
- Mahad, Don J.;
- Hardingham, Giles E.;
- Chandran, Siddharthan;
- Selvaraj, Bhuvaneish T.
Publication type:
Article
Ionotropic GABA and glycine receptor subunit composition in human pluripotent stem cell-derived excitatory cortical neurones.
Published in:
Journal of Physiology, 2014, v. 592, n. 19, p. 4353, doi. 10.1113/jphysiol.2014.278994
By:
- James, Owain T.;
- Livesey, Matthew R.;
- Qiu, Jing;
- Dando, Owen;
- Bilican, Bilada;
- Haghi, Ghazal;
- Rajan, Rinku;
- Burr, Karen;
- Hardingham, Giles E.;
- Chandran, Siddharthan;
- Kind, Peter C.;
- Wyllie, David J. A.
Publication type:
Article
Author Correction: Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism.
Published in:
Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/ncomms16176
By:
- Hasel, Philip;
- Dando, Owen;
- Jiwaji, Zoeb;
- Baxter, Paul;
- Todd, Alison C.;
- Heron, Samuel;
- Márkus, Nóra M.;
- McQueen, Jamie;
- Hampton, David W.;
- Torvell, Megan;
- Tiwari, Sachin S.;
- McKay, Sean;
- Eraso-Pichot, Abel;
- Zorzano, Antonio;
- Masgrau, Roser;
- Galea, Elena;
- Chandran, Siddharthan;
- Wyllie, David J. A.;
- Simpson, T. Ian;
- Hardingham, Giles E.
Publication type:
Article
Author Correction: Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism.
Published in:
Nature Communications, 2018, v. 9, p. 16176, doi. 10.1038/ncomms16176
By:
- Hasel, Philip;
- Dando, Owen;
- Jiwaji, Zoeb;
- Baxter, Paul;
- Todd, Alison C.;
- Heron, Samuel;
- Márkus, Nóra M.;
- McQueen, Jamie;
- Hampton, David W.;
- Torvell, Megan;
- Tiwari, Sachin S.;
- McKay, Sean;
- Eraso-Pichot, Abel;
- Zorzano, Antonio;
- Masgrau, Roser;
- Galea, Elena;
- Chandran, Siddharthan;
- Wyllie, David J. A.;
- Simpson, T. Ian;
- Hardingham, Giles E.
Publication type:
Article
C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca2+-permeable AMPA receptor-mediated excitotoxicity.
Published in:
Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-017-02729-0
By:
- Selvaraj, Bhuvaneish T.;
- Livesey, Matthew R.;
- Chen Zhao;
- Gregory, Jenna M.;
- James, Owain T.;
- Cleary, Elaine M.;
- Chouhan, Amit K.;
- Gane, Angus B.;
- Perkins, Emma M.;
- Dando, Owen;
- Lillico, Simon G.;
- Youn-Bok Lee;
- Nishimura, Agnes L.;
- Poreci, Urjana;
- Thankamony, Sai;
- Pray, Meryll;
- Vasistha, Navneet A.;
- Magnani, Dario;
- Borooah, Shyamanga;
- Burr, Karen
Publication type:
Article
Differential splicing choices made by neurons and astrocytes and their importance when investigating signal-dependent alternative splicing in neural cells.
Published in:
Frontiers in Molecular Neuroscience, 2023, p. 1, doi. 10.3389/fnmol.2023.1214439
By:
- Baxter, Paul S.;
- Dando, Owen;
- Hardingham, Giles E.
Publication type:
Article
Inhibiting CSF1R alleviates cerebrovascular white matter disease and cognitive impairment.
Published in:
Glia, 2024, v. 72, n. 2, p. 375, doi. 10.1002/glia.24481
By:
- Askew, Katharine E.;
- Beverley, Joshua;
- Sigfridsson, Emma;
- Szymkowiak, Stefan;
- Emelianova, Katherine;
- Dando, Owen;
- Hardingham, Giles E.;
- Duncombe, Jessica;
- Hennessy, Edel;
- Koudelka, Juraj;
- Samarasekera, Neshika;
- Salman, Rustam Al‐Shahi;
- Smith, Colin;
- Tavares, Adriana A. S.;
- Gomez‐Nicola, Diego;
- Kalaria, Raj N.;
- McColl, Barry W.;
- Horsburgh, Karen
Publication type:
Article
Mixed-species RNA-seq for elucidation of non-cell-autonomous control of gene transcription.
Published in:
Nature Protocols, 2018, v. 13, n. 10, p. 2176, doi. 10.1038/s41596-018-0029-2
By:
- Qiu, Jing;
- Dando, Owen;
- Baxter, Paul S.;
- Hasel, Philip;
- Heron, Samuel;
- Simpson, T. Ian;
- Hardingham, Giles E.
Publication type:
Article
Altered network properties in C9ORF72 repeat expansion cortical neurons are due to synaptic dysfunction.
Published in:
Molecular Neurodegeneration, 2021, v. 16, n. 1, p. 1, doi. 10.1186/s13024-021-00433-8
By:
- Perkins, Emma M.;
- Burr, Karen;
- Banerjee, Poulomi;
- Mehta, Arpan R.;
- Dando, Owen;
- Selvaraj, Bhuvaneish T.;
- Suminaite, Daumante;
- Nanda, Jyoti;
- Henstridge, Christopher M.;
- Gillingwater, Thomas H.;
- Hardingham, Giles E.;
- Wyllie, David J. A.;
- Chandran, Siddharthan;
- Livesey, Matthew R.
Publication type:
Article

Found: 30

Excess ribosomal protein production unbalances translation in a model of Fragile X Syndrome.

Distinct neuroinflammatory signatures exist across genetic and sporadic amyotrophic lateral sclerosis cohorts.

Synaptic resilience is associated with maintained cognition during ageing.

A role for astrocytes and microglia in synapse loss in Alzheimer’s disease.

Neuronal Activity and Its Role in Controlling Antioxidant Genes.

Mutant C9orf72 human iPSC‐derived astrocytes cause non‐cell autonomous motor neuron pathophysiology.

Evidence for evolutionary divergence of activity-dependent gene expression in developing neurons.

Enhanced hippocampal LTP but normal NMDA receptor and AMPA receptor function in a rat model of CDKL5 deficiency disorder.

Experience-dependent changes in hippocampal spatial activity and hippocampal circuit function are disrupted in a rat model of Fragile X Syndrome.

Imbalance of flight–freeze responses and their cellular correlates in the Nlgn3<sup>−/y</sup> rat model of autism.

Astrocyte-oligodendrocyte interaction regulates central nervous system regeneration.

Altered dendritic spine function and integration in a mouse model of fragile X syndrome.

Synaptic gene expression changes in frontotemporal dementia due to the MAPT 10 + 16 mutation.

Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism.

Sustained correction of associative learning deficits after brief, early treatment in a rat model of Fragile X Syndrome.

Identifying foetal forebrain interneurons as a target for monogenic autism risk factors and the polygenic 16p11.2 microdeletion.

Laboratory Automated Interrogation of Data: an interactive web application for visualization of multilevel data from biological experiments.

Microarray profiling emphasizes transcriptomic differences between hippocampal in vivo tissue and in vitro cultures.

Recapitulation of the EEF1A2 D252H neurodevelopmental disorder-causing missense mutation in mice reveals a toxic gain of function.

Characterisation of CDKL5 Transcript Isoforms in Human and Mouse.

Expression of mRNA Encoding Mcu and Other Mitochondrial Calcium Regulatory Genes Depends on Cell Type, Neuronal Subtype, and Ca<sup>2+</sup> Signaling.

Mitochondrial bioenergetic deficits in C9orf72 amyotrophic lateral sclerosis motor neurons cause dysfunctional axonal homeostasis.

Ionotropic GABA and glycine receptor subunit composition in human pluripotent stem cell-derived excitatory cortical neurones.

Author Correction: Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism.

Author Correction: Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism.

C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca<sup>2+</sup>-permeable AMPA receptor-mediated excitotoxicity.

Differential splicing choices made by neurons and astrocytes and their importance when investigating signal-dependent alternative splicing in neural cells.

Inhibiting CSF1R alleviates cerebrovascular white matter disease and cognitive impairment.

Mixed-species RNA-seq for elucidation of non-cell-autonomous control of gene transcription.

Altered network properties in C9ORF72 repeat expansion cortical neurons are due to synaptic dysfunction.