Works by Dalby, Kevin N.

Results: 42

Reversible Covalent Inhibition of eEF-2K by Carbonitriles.

Published in:

ChemBioChem, 2014, v. 15, n. 16, p. 2435, doi. 10.1002/cbic.201402321

By:

Devkota, Ashwini K.;
Edupuganti, Ramakrishna;
Yan, Chunli;
Shi, Yue;
Jose, Jiney;
Wang, Qiantao;
Kaoud, Tamer S.;
Cho, Eun Jeong;
Ren, Pengyu;
Dalby, Kevin N.

Publication type:

Article

Development of cell‐based high throughput luminescence assay for drug discovery in inhibiting OCT4/DNA‐PKcs and OCT4–MK2 interactions.

Published in:

Biotechnology & Bioengineering, 2021, v. 118, n. 5, p. 1987, doi. 10.1002/bit.27712

By:

Mohiuddin, Ismail S.;
Wei, Sung‐Jen;
Yang, In‐Hyoung;
Martinez, Gloria M.;
Yang, Shengping;
Cho, Eun J.;
Dalby, Kevin N.;
Kang, Min H.

Publication type:

Article

A collagen glucosyltransferase drives lung adenocarcinoma progression in mice.

Published in:

Communications Biology, 2021, v. 4, n. 1, p. 1, doi. 10.1038/s42003-021-01982-w

By:

Guo, Hou-Fu;
Bota-Rabassedas, Neus;
Terajima, Masahiko;
Leticia Rodriguez, B.;
Gibbons, Don L.;
Chen, Yulong;
Banerjee, Priyam;
Tsai, Chi-Lin;
Tan, Xiaochao;
Liu, Xin;
Yu, Jiang;
Tokmina-Roszyk, Michal;
Stawikowska, Roma;
Fields, Gregg B.;
Miller, Mitchell D.;
Wang, Xiaoyan;
Lee, Juhoon;
Dalby, Kevin N.;
Creighton, Chad J.;
Phillips, George N.

Publication type:

Article

The HIF-1α/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair.

Published in:

Bone Research, 2024, v. 12, n. 1, p. 1, doi. 10.1038/s41413-024-00320-0

By:

Kang, Heeseog;
Strong, Amy L.;
Sun, Yuxiao;
Guo, Lei;
Juan, Conan;
Bancroft, Alec C.;
Choi, Ji Hae;
Pagani, Chase A.;
Fernandes, Aysel A.;
Woodard, Michael;
Lee, Juhoon;
Ramesh, Sowmya;
James, Aaron W.;
Hudson, David;
Dalby, Kevin N.;
Xu, Lin;
Tower, Robert J.;
Levi, Benjamin

Publication type:

Article

Droplet-based screening of phosphate transfer catalysis reveals how epistasis shapes MAP kinase interactions with substrates.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-28396-4

By:

Scheele, Remkes A.;
Lindenburg, Laurens H.;
Petek, Maya;
Schober, Markus;
Dalby, Kevin N.;
Hollfelder, Florian

Publication type:

Article

MELK: a potential novel therapeutic target for TNBC and other aggressive malignancies.

Published in:

Expert Opinion on Therapeutic Targets, 2017, v. 21, n. 9, p. 849, doi. 10.1080/14728222.2017.1363183

By:

Pitner, Mary Kathryn;
Taliaferro, Juliana M.;
Dalby, Kevin N.;
Bartholomeusz, Chandra

Publication type:

Article

Computational insights into the binding of IN17 inhibitors to MELK.

Published in:

Journal of Molecular Modeling, 2019, v. 25, n. 6, p. N.PAG, doi. 10.1007/s00894-019-4036-1

By:

Harger, Matthew;
Lee, Ju-Hyeon;
Walker, Brandon;
Taliaferro, Juliana M.;
Edupuganti, Ramakrishna;
Dalby, Kevin N.;
Ren, Pengyu

Publication type:

Article

Kinetic mechanism for p38 MAP kinase α.

Published in:

FEBS Journal, 2005, v. 272, n. 18, p. 4631, doi. 10.1111/j.1742-4658.2005.04827.x

By:

Szafranska, Anna E.;
Dalby, Kevin N.

Publication type:

Article

GRK3 is a poor prognosticator and serves as a therapeutic target in advanced gastric adenocarcinoma.

Published in:

Journal of Experimental & Clinical Cancer Research (17569966), 2022, v. 41, n. 1, p. 1, doi. 10.1186/s13046-022-02463-6

By:

Li, Yuan;
Fan, Yibo;
Xu, Jinbang;
Huo, Longfei;
Scott, Ailing W.;
Jin, Jiankang;
Yang, Boxuan;
Shao, Shan;
Ma, Lang;
Wang, Ying;
Yao, Xiaodan;
Pool Pizzi, Melissa;
Sewastjanow Da Silva, Matheus;
Zhang, Guoliang;
Zhuo, Lijuan;
Cho, Eun Jeong;
Dalby, Kevin N.;
Shanbhag, Namita D.;
Wang, Zhenning;
Li, Wenliang

Publication type:

Article

Short Arrestin-3-Derived Peptides Activate JNK3 in Cells.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 15, p. 8679, doi. 10.3390/ijms23158679

By:

Perry-Hauser, Nicole A.;
Kaoud, Tamer S.;
Stoy, Henriette;
Zhan, Xuanzhi;
Chen, Qiuyan;
Dalby, Kevin N.;
Iverson, Tina M.;
Gurevich, Vsevolod V.;
Gurevich, Eugenia V.

Publication type:

Article

JNK Signaling in Stem Cell Self-Renewal and Differentiation.

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 7, p. 2613, doi. 10.3390/ijms21072613

By:

Semba, Takashi;
Sammons, Rachel;
Wang, Xiaoping;
Xie, Xuemei;
Dalby, Kevin N.;
Ueno, Naoto T.

Publication type:

Article

193-nm photodissociation of singly and multiply charged peptide anions for acidic proteome characterization.

Published in:

Proteomics, 2011, v. 11, n. 7, p. 1329, doi. 10.1002/pmic.201000565

By:

Madsen, James A.;
Kaoud, Tamer S.;
Dalby, Kevin N.;
Brodbelt, Jennifer S.

Publication type:

Article

Structural dynamics of the complex of calmodulin with a minimal functional construct of eukaryotic elongation factor 2 kinase and the role of Thr348 autophosphorylation.

Published in:

Protein Science: A Publication of the Protein Society, 2021, v. 30, n. 6, p. 1221, doi. 10.1002/pro.4087

By:

Piserchio, Andrea;
Long, Kimberly;
Lee, Kwangwoon;
Kumar, Eric A.;
Abzalimov, Rinat;
Dalby, Kevin N.;
Ghose, Ranajeet

Publication type:

Article

The role of calcium in the interaction between calmodulin and a minimal functional construct of eukaryotic elongation factor 2 kinase.

Published in:

Protein Science: A Publication of the Protein Society, 2019, v. 28, n. 12, p. 2089, doi. 10.1002/pro.3753

By:

Lee, Kwangwoon;
Kumar, Eric A.;
Dalby, Kevin N.;
Ghose, Ranajeet

Publication type:

Article

Virtual screening using molecular simulations.

Published in:

Proteins, 2011, v. 79, n. 6, p. 1940, doi. 10.1002/prot.23018

By:

Yang, Tianyi;
Wu, Johnny C.;
Yan, Chunli;
Wang, Yuanfeng;
Luo, Ray;
Gonzales, Michael B.;
Dalby, Kevin N.;
Ren, Pengyu

Publication type:

Article

A Fluorescence-Based Assay for p38α Recruitment Site Binders: Identification of Rooperol as a Novel p38α Kinase Inhibitor.

Published in:

ChemBioChem, 2013, v. 14, n. 1, p. 66, doi. 10.1002/cbic.201200529

By:

Li, Jing;
Kaoud, Tamer S.;
LeVieux, Jake;
Gilbreath, Brad;
Moharana, Swapna;
Dalby, Kevin N.;
Kerwin, Sean M.

Publication type:

Article

Targeting the prodeath and prosurvival functions of autophagy as novel therapeutic strategies in cancer.

Published in:

Autophagy, 2010, v. 6, n. 3, p. 322, doi. 10.4161/auto.6.3.11625

By:

Dalby, Kevin N.;
Tekedereli, Ibrahim;
Lopez-Berestein, Gabriel;
Ozpolat, Bulent

Publication type:

Article

Charge-Site-Dependent Dissociation of Hydrogen-Rich Radical Peptide Cations upon Vacuum UV Photoexcitation.

Published in:

Chemistry - A European Journal, 2012, v. 18, n. 17, p. 5374, doi. 10.1002/chem.201103534

By:

Madsen, James A.;
Cheng, Ryan R.;
Kaoud, Tamer S.;
Dalby, Kevin N.;
Makarov, Dmitrii E.;
Brodbelt, Jennifer S.

Publication type:

Article

Differential Sensing of MAP Kinases Using SOX-Peptides.

Published in:

Angewandte Chemie, 2014, v. 126, n. 51, p. 14288, doi. 10.1002/ange.201408256

By:

Zamora ‐ Olivares, Diana;
Kaoud, Tamer S.;
Jose, Jiney;
Ellington, Andrew;
Dalby, Kevin N.;
Anslyn, Eric V.

Publication type:

Article

Cover Image, Volume 58, Issue 9.

Published in:

Molecular Carcinogenesis, 2019, v. 58, n. 9, p. i, doi. 10.1002/mc.23094

By:

Sammons, Rachel M.;
Ghose, Ranajeet;
Tsai, Kenneth Y.;
Dalby, Kevin N.

Publication type:

Article

Targeting ERK beyond the boundaries of the kinase active site in melanoma.

Published in:

Molecular Carcinogenesis, 2019, v. 58, n. 9, p. 1551, doi. 10.1002/mc.23047

By:

Sammons, Rachel M.;
Ghose, Ranajeet;
Tsai, Kenneth Y.;
Dalby, Kevin N.

Publication type:

Article

A tunable assay for modulators of genome-destabilizing DNA structures.

Published in:

Nucleic Acids Research, 2019, v. 47, n. 13, p. 1, doi. 10.1093/nar/gkz237

By:

del Mundo, Imee M.A.;
Eun Jeong Cho;
Dalby, Kevin N.;
Vasquez, Karen M.

Publication type:

Article

Author Correction: Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe<sup>2+</sup>-binding.

Published in:

Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-05295-1

By:

Hou-Fu Guo;
Chi-Lin Tsai;
Masahiko Terajima;
Xiaochao Tan;
Banerjee, Priyam;
Miller, Mitchell D.;
Xin Liu;
Jiang Yu;
Byemerwa, Jovita;
Alvarado, Sarah;
Kaoud, Tamer S.;
Dalby, Kevin N.;
Bota-Rabassedas, Neus;
Yulong Chen;
Mitsuo Yamauchi;
Tainer, John A.;
Phillips Jr., George N.;
Kurie, Jonathan M.

Publication type:

Article

Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe<sup>2+</sup>-binding.

Published in:

Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-02859-z

By:

Hou-Fu Guo;
Chi-Lin Tsai;
Masahiko Terajima;
Xiaochao Tan;
Banerjee, Priyam;
Miller, Mitchell D.;
Xin Liu;
Jiang Yu;
Byemerwa, Jovita;
Alvarado, Sarah;
Kaoud, Tamer S.;
Dalby, Kevin N.;
Bota-Rabassedas, Neus;
Yulong Chen;
Mitsuo Yamauchi;
Tainer, John A.;
Phillips Jr., George N.;
Kurie, Jonathan M.

Publication type:

Article

Evidence of the Regulation of JNK2 through Oligomerization.

Published in:

FASEB Journal, 2013, v. 27, p. 789.22, doi. 10.1096/fasebj.27.1_supplement.789.22

By:

Kaoud, Tamer S;
Riggs, Austin F.;
Dalby, Kevin N.

Publication type:

Article

Arrestin‐3 binding to JNK1alpha1/JNK2alpha2: modulation of JNK1 and JNK2 activity via scaffolding.

Published in:

FASEB Journal, 2013, v. 27, p. 1042.6, doi. 10.1096/fasebj.27.1_supplement.1042.6

By:

Kook, Seunghyi;
Zhan, Xuanzhi;
Kaoud, Tamer S;
Dalby, Kevin N;
Gurevich, Vsevolod V;
Gurevich, Eugenia V

Publication type:

Article

JNK3 binding to arrestin‐3 differentially affects recruitment of upstream MAP kinase kinases.

Published in:

FASEB Journal, 2013, v. 27, p. 1042.4, doi. 10.1096/fasebj.27.1_supplement.1042.4

By:

Zhan, Xuanzhi;
Kaoud, Tamer S;
Kook, Seunghyi;
Dalby, Kevin N.;
Gurevich, Vsevold V.

Publication type:

Article

Dopamine depletion and subsequent treatment withl-DOPA, but not the long-lived dopamine agonist pergolide, enhances activity of the Akt pathway in the rat striatum.

Published in:

Journal of Neurochemistry, 2007, v. 102, n. 3, p. 699, doi. 10.1111/j.1471-4159.2007.04586.x

By:

Bychkov, Evgeny;
Ahmed, M. Rafiuddin;
Dalby, Kevin N.;
Gurevich, Eugenia V.

Publication type:

Article

Construction of human activity-based phosphorylation networks.

Published in:

Molecular Systems Biology, 2013, v. 9, n. 1, p. 1, doi. 10.1038/msb.2013.12

By:

Newman, Robert H;
Hu, Jianfei;
Rho, Hee‐Sool;
Xie, Zhi;
Woodard, Crystal;
Neiswinger, John;
Cooper, Christopher;
Shirley, Matthew;
Clark, Hillary M;
Hu, Shaohui;
Hwang, Woochang;
Seop Jeong, Jun;
Wu, George;
Lin, Jimmy;
Gao, Xinxin;
Ni, Qiang;
Goel, Renu;
Xia, Shuli;
Ji, Hongkai;
Dalby, Kevin N

Publication type:

Article

Steady State and Time‐Dependent Fluorescent Peptide Assays for Protein Kinases.

Published in:

Current Protocols, 2024, v. 4, n. 3, p. 1, doi. 10.1002/cpz1.998

By:

Sammons, Rae M.;
Devkota, Ashwini K.;
Kaoud, Tamer S.;
Warthaka, Mangalika;
Cho, Eun Jeong;
Dalby, Kevin N.

Publication type:

Article

Arrestin‐3‐Dependent Activation of c‐Jun N‐Terminal Kinases (JNKs).

Published in:

Current Protocols, 2023, v. 3, n. 9, p. 1, doi. 10.1002/cpz1.839

By:

Zhan, Xuanzhi;
Kaoud, Tamer S.;
Dalby, Kevin N.;
Gurevich, Eugenia V.;
Gurevich, Vsevolod V.

Publication type:

Article

Differential functions of ERK1 and ERK2 in lung metastasis processes in triple-negative breast cancer.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-65250-3

By:

Gagliardi, Maria;
Pitner, Mary Kathryn;
Park, Jihyun;
Xie, Xuemei;
Saso, Hitomi;
Larson, Richard A.;
Sammons, Rachel M.;
Chen, Huiqin;
Wei, Caimiao;
Masuda, Hiroko;
Chauhan, Gaurav;
Kondo, Kimie;
Tripathy, Debu;
Ueno, Naoto T.;
Dalby, Kevin N.;
Debeb, Bisrat G.;
Bartholomeusz, Chandra

Publication type:

Article

Targeted Silencing of Elongation Factor 2 Kinase Suppresses Growth and Sensitizes Tumors to Doxorubicin in an Orthotopic Model of Breast Cancer.

Published in:

PLoS ONE, 2012, v. 7, n. 7, p. 1, doi. 10.1371/journal.pone.0041171

By:

Tekedereli, Ibrahim;
Alpay, S. Neslihan;
Tavares, Clint D. J.;
Cobanoglu, Zehra E.;
Kaoud, Tamer S.;
Sahin, Ibrahim;
Sood, Anil K.;
Lopez-Berestein, Gabriel;
Dalby, Kevin N.;
Ozpolat, Bulent

Publication type:

Article

The Effect of Arrestin Conformation on the Recruitment of c-Raf1, MEK1, and ERK1/2 Activation.

Published in:

PLoS ONE, 2011, v. 6, n. 12, p. 1, doi. 10.1371/journal.pone.0028723

By:

Coffa, Sergio;
Breitman, Maya;
Hanson, Susan M.;
Callaway, Kari;
Kook, Seunghyi;
Dalby, Kevin N.;
Gurevich, Vsevolod V.

Publication type:

Article

A Model of a MAPK·Substrate Complex in an Active Conformation: A Computational and Experimental Approach.

Published in:

PLoS ONE, 2011, v. 6, n. 4, p. 1, doi. 10.1371/journal.pone.0018594

By:

Sunbae Lee;
Warthaka, Mangalika;
Chunli Yan;
Kaoud, Tamer S.;
Piserchio, Andrea;
Ghose, Ranajeet;
Ren, Pengyu;
Dalby, Kevin N.

Publication type:

Article

Identification of the JNK-Active Triple-Negative Breast Cancer Cluster Associated With an Immunosuppressive Tumor Microenvironment.

Published in:

2022

By:

Semba, Takashi;
Wang, Xiaoping;
Xie, Xuemei;
Cohen, Evan N;
Reuben, James M;
Dalby, Kevin N;
Long, James P;
Phi, Lan Thi Hanh;
Tripathy, Debu;
Ueno, Naoto T

Publication type:

journal article

Differential Sensing of MAP Kinases Using SOX-Peptides.

Published in:

Angewandte Chemie International Edition, 2014, v. 53, n. 51, p. 14064, doi. 10.1002/anie.201408256

By:

Zamora‐Olivares, Diana;
Kaoud, Tamer S.;
Jose, Jiney;
Ellington, Andrew;
Dalby, Kevin N.;
Anslyn, Eric V.

Publication type:

Article

Peptide mini-scaffold facilitates JNK3 activation in cells.

Published in:

Scientific Reports, 2016, p. 21025, doi. 10.1038/srep21025

By:

Zhan, Xuanzhi;
Stoy, Henriette;
Kaoud, Tamer S.;
Perry, Nicole A.;
Chen, Qiuyan;
Perez, Alejandro;
Els-Heindl, Sylvia;
Slagis, Jack V.;
Iverson, Tina M.;
Beck-Sickinger, Annette G.;
Gurevich, Eugenia V.;
Dalby, Kevin N.;
Gurevich, Vsevolod V.

Publication type:

Article

Structural and Dynamic Features of F-recruitment Site Driven Substrate Phosphorylation by ERK2.

Published in:

Scientific Reports, 2015, p. 11127, doi. 10.1038/srep11127

By:

Piserchio, Andrea;
Ramakrishan, Venkatesh;
Wang, Hsin;
Kaoud, Tamer S.;
Arshava, Boris;
Dutta, Kaushik;
Dalby, Kevin N.;
Ghose, Ranajeet

Publication type:

Article

Phage display identifies novel peptides that bind extracellular-regulated protein kinase 2 to compete with transcription factor binding.

Published in:

Journal of Physical Organic Chemistry, 2004, v. 17, n. 6/7, p. 461, doi. 10.1002/poc.762

By:

Rainey, Mark A.;
Linse, Klaus D.;
Dalby, Kevin N.

Publication type:

Article

Modulating multi-functional ERK complexes by covalent targeting of a recruitment site in vivo.

Published in:

Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-12996-8

By:

Kaoud, Tamer S.;
Johnson, William H.;
Ebelt, Nancy D.;
Piserchio, Andrea;
Zamora-Olivares, Diana;
Van Ravenstein, Sabrina X.;
Pridgen, Jacey R.;
Edupuganti, Ramakrishna;
Sammons, Rachel;
Cano, Micael;
Warthaka, Mangalika;
Harger, Matthew;
Tavares, Clint D. J.;
Park, Jihyun;
Radwan, Mohamed F.;
Ren, Pengyu;
Anslyn, Eric V.;
Tsai, Kenneth Y.;
Ghose, Ranajeet;
Dalby, Kevin N.

Publication type:

Article

Unexpected inhibition of the lipid kinase PIKfyve reveals an epistatic role for p38 MAPKs in endolysosomal fission and volume control.

Published in:

Cell Death & Disease, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41419-024-06423-0

By:

Wible, Daric J.;
Parikh, Zalak;
Cho, Eun Jeong;
Chen, Miao-Der;
Jeter, Collene R.;
Mukhopadhyay, Somshuvra;
Dalby, Kevin N.;
Varadarajan, Shankar;
Bratton, Shawn B.

Publication type:

Article