Found: 26

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  • A Trem2<sup>R47H</sup> mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaques.

    Published in:
    Molecular Neurodegeneration, 2023, v. 18, n. 1, p. 1, doi. 10.1186/s13024-023-00598-4
    By:
    • Tran, Kristine M.;
    • Kawauchi, Shimako;
    • Kramár, Enikö A.;
    • Rezaie, Narges;
    • Liang, Heidi Yahan;
    • Sakr, Jasmine S.;
    • Gomez-Arboledas, Angela;
    • Arreola, Miguel A.;
    • Cunha, Celia da;
    • Phan, Jimmy;
    • Wang, Shuling;
    • Collins, Sherilyn;
    • Walker, Amber;
    • Shi, Kai-Xuan;
    • Neumann, Jonathan;
    • Filimban, Ghassan;
    • Shi, Zechuan;
    • Milinkeviciute, Giedre;
    • Javonillo, Dominic I.;
    • Tran, Katelynn
    Publication type:
    Article

  • Amyloid propagation in a sporadic model of Alzheimer's disease: Development of new models and analysis methods/seeding and spreading of proteinopathies.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.045657
    By:
    • Huynh, Kelly Do;
    • Nguyen, Marie Minh Thu;
    • Cheung, Alwin;
    • Tran, Janine Pham;
    • Nuñez‐Diaz, Cristina;
    • Forner, Stefania;
    • Martini, Alessandra Cadete;
    • Trujillo‐Estrada, Laura;
    • Da Cunha, Celia;
    • Shahnawaz, Mohammad;
    • Soto, Claudio;
    • Moreno‐Gonzalez, Ines;
    • Gutierrez, Antonia;
    • LaFerla, Frank;
    • Baglietto‐Vargas, David
    Publication type:
    Article

  • P4‐522: TYPE 2 DIABETES MELLITUS INDUCES TAU‐INDEPENDENT COGNITIVE AND SYNAPTIC DEFICITS IN A MOUSE MODEL.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P1514, doi. 10.1016/j.jalz.2019.08.069
    By:
    • Trujillo-Estrada, Laura;
    • Kuang, Run R.;
    • Da Cunha, Celia;
    • Forner, Stefania;
    • Martini, Alessandra Cadete;
    • Nguyen, Caroline;
    • Baglietto-Vargas, David;
    • LaFerla, Frank
    Publication type:
    Article

  • P3‐069: HUMAN WILD TYPE Aβ KNOCK‐IN MICE AS A BASIS TO STUDY SPORADIC ALZHEIMER'S DISEASE.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P953, doi. 10.1016/j.jalz.2019.06.3096
    By:
    • Baglietto-Vargas, David;
    • Forner, Stefania;
    • Cai, Lena;
    • Martini, Alessandra Cadete;
    • Trujillo-Estrada, Laura;
    • Jiang, Shan;
    • Kramár, Enikö;
    • Nuñez-Diaz, Cristina;
    • Shahnawaz, Mohammad;
    • Matheos, Dina P.;
    • Ma, Xinyi;
    • Da Cunha, Celia;
    • Soto, Claudio;
    • Gutierrez, Antonia;
    • Moreno-Gonzalez, Ines;
    • MacGregor, Grant R.;
    • Green, Kim N.;
    • Wood, Marcelo A.;
    • Mortazavi, Ali;
    • Tenner, Andrea
    Publication type:
    Article

  • Intra- and extracellular β-amyloid overexpression via adeno-associated virus-mediated gene transfer impairs memory and synaptic plasticity in the hippocampus.

    Published in:
    Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-52324-0
    By:
    • Forner, Stefania;
    • Martini, Alessandra C.;
    • Prieto, G. Aleph;
    • Dang, Cindy T.;
    • Rodriguez-Ortiz, Carlos J.;
    • Reyes-Ruiz, Jorge Mauricio;
    • Trujillo-Estrada, Laura;
    • da Cunha, Celia;
    • Andrews, Elizabeth J.;
    • Phan, Jimmy;
    • Vu Ha, Jordan;
    • Chang, Allissa V. Z. D.;
    • Levites, Yona;
    • Cruz, Pedro E.;
    • Ager, Rahasson;
    • Medeiros, Rodrigo;
    • Kitazawa, Masashi;
    • Glabe, Charles G.;
    • Cotman, Carl W.;
    • Golde, Todd
    Publication type:
    Article

  • Systematic Phenotyping and Characterization of the 3xTg-AD Mouse Model of Alzheimer's Disease.

    Published in:
    Frontiers in Neuroscience, 2022, v. 15, p. 1, doi. 10.3389/fnins.2021.785276
    By:
    • Javonillo, Dominic I.;
    • Tran, Kristine M.;
    • Phan, Jimmy;
    • Hingco, Edna;
    • Kramár, Enikö A.;
    • da Cunha, Celia;
    • Forner, Stefania;
    • Kawauchi, Shimako;
    • Milinkeviciute, Giedre;
    • Gomez-Arboledas, Angela;
    • Neumann, Jonathan;
    • Banh, Crystal E.;
    • Huynh, Michelle;
    • Matheos, Dina P.;
    • Rezaie, Narges;
    • Alcantara, Joshua A.;
    • Mortazavi, Ali;
    • Wood, Marcelo A.;
    • Tenner, Andrea J.;
    • MacGregor, Grant R.
    Publication type:
    Article

  • Systematic phenotyping and characterization of the 5xFAD mouse model of Alzheimer's disease.

    Published in:
    Scientific Data, 2021, v. 8, n. 1, p. 1, doi. 10.1038/s41597-021-01054-y
    By:
    • Forner, Stefania;
    • Kawauchi, Shimako;
    • Balderrama-Gutierrez, Gabriela;
    • Kramár, Enikö A.;
    • Matheos, Dina P.;
    • Phan, Jimmy;
    • Javonillo, Dominic I.;
    • Tran, Kristine M.;
    • Hingco, Edna;
    • da Cunha, Celia;
    • Rezaie, Narges;
    • Alcantara, Joshua A.;
    • Baglietto-Vargas, David;
    • Jansen, Camden;
    • Neumann, Jonathan;
    • Wood, Marcelo A.;
    • MacGregor, Grant R.;
    • Mortazavi, Ali;
    • Tenner, Andrea J.;
    • LaFerla, Frank M.
    Publication type:
    Article

  • Tau underlies synaptic and cognitive deficits for type 1, but not type 2 diabetes mouse models.

    Published in:
    Aging Cell, 2019, v. 18, n. 3, p. 1, doi. 10.1111/acel.12919
    By:
    • Trujillo‐Estrada, Laura;
    • Nguyen, Cassidy;
    • da Cunha, Celia;
    • Cai, Lena;
    • Forner, Stefania;
    • Martini, Alessandra C.;
    • Ager, Rahasson R.;
    • Prieto, Gilberto Aleph;
    • Cotman, Carl W.;
    • Baglietto‐Vargas, David;
    • LaFerla, Frank M.
    Publication type:
    Article

  • EDUCAÇÃO MEDIADA POR TECNOLOGIAS DIGITAIS: novas perspectivas e desafios.

    Published in:
    Revista Plurais - Virtual, 2021, v. 11, n. 1, p. 10
    By:
    • Cunha, Regina Célia Alves da;
    • Suanno, João Henrique
    Publication type:
    Article

  • The Abca7<sup>V1613M</sup> variant reduces Aβ generation, plaque load, and neuronal damage.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. 7, p. 4914, doi. 10.1002/alz.13783
    By:
    • Butler, Claire A.;
    • Mendoza Arvilla, Adrian;
    • Milinkeviciute, Giedre;
    • Da Cunha, Celia;
    • Kawauchi, Shimako;
    • Rezaie, Narges;
    • Liang, Heidi Y.;
    • Javonillo, Dominic;
    • Thach, Annie;
    • Wang, Shuling;
    • Collins, Sherilyn;
    • Walker, Amber;
    • Shi, Kai‐Xuan;
    • Neumann, Jonathan;
    • Gomez‐Arboledas, Angela;
    • Henningfield, Caden M.;
    • Hohsfield, Lindsay A.;
    • Mapstone, Mark;
    • Tenner, Andrea J.;
    • LaFerla, Frank M.
    Publication type:
    Article

  • BIN1<sup>K358R</sup> suppresses glial response to plaques in mouse model of Alzheimer's disease.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. 4, p. 2922, doi. 10.1002/alz.13767
    By:
    • Garcia‐Agudo, Laura Fernandez;
    • Shi, Zechuan;
    • Smith, Ian F.;
    • Kramár, Enikö A.;
    • Tran, Katelynn;
    • Kawauchi, Shimako;
    • Wang, Shuling;
    • Collins, Sherilyn;
    • Walker, Amber;
    • Shi, Kai‐Xuan;
    • Neumann, Jonathan;
    • Liang, Heidi Yahan;
    • Da Cunha, Celia;
    • Milinkeviciute, Giedre;
    • Morabito, Samuel;
    • Miyoshi, Emily;
    • Rezaie, Narges;
    • Gomez‐Arboledas, Angela;
    • Arvilla, Adrian Mendoza;
    • Ghaemi, Daryan Iman
    Publication type:
    Article

  • Genetic diversity promotes resilience in a mouse model of Alzheimer's disease.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. 4, p. 2794, doi. 10.1002/alz.13753
    By:
    • Soni, Neelakshi;
    • Hohsfield, Lindsay A.;
    • Tran, Kristine M.;
    • Kawauchi, Shimako;
    • Walker, Amber;
    • Javonillo, Dominic;
    • Phan, Jimmy;
    • Matheos, Dina;
    • Da Cunha, Celia;
    • Uyar, Asli;
    • Milinkeviciute, Giedre;
    • Gomez‐Arboledas, Angela;
    • Tran, Katelynn;
    • Kaczorowski, Catherine C.;
    • Wood, Marcelo A.;
    • Tenner, Andrea J.;
    • LaFerla, Frank M.;
    • Carter, Gregory W.;
    • Mortazavi, Ali;
    • Swarup, Vivek
    Publication type:
    Article

  • Visceral adipose tissue triggers tau pathogenesis in transgenic mice.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.076287
    By:
    • Bettinetti‐Luque, Miriam;
    • Trujillo‐Estrada, Laura;
    • Andreo‐Lopez, Juana;
    • Cantero‐Molina, Francisco;
    • Da Cunha, Celia;
    • Sanchez‐Mejias, Elisabeth;
    • LaFerla, Frank;
    • Gutierrez, Antonia;
    • Baglietto‐Vargas, David
    Publication type:
    Article

  • A CLU/APOJ GWAS AD risk variant suppresses the astrocytic response to plaques and reduces axonal and neuritic damage in 5xFAD mice.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.080373
    By:
    • Milinkeviciute, Giedre;
    • Tran, Katelynn;
    • Da Cunha, Celia;
    • Mendoza‐Arvilla, Adrian;
    • Garcia‐Agudo, Laura Fernandez;
    • Neumann, Jonathan;
    • Walker, Amber;
    • Kawauchi, Shimako;
    • Tenner, Andrea J;
    • LaFerla, Frank;
    • MacGregor, Grant R;
    • Green, Kim N
    Publication type:
    Article

  • Human and mouse seeds differentially affect Aβ aggregation by modulating the inflammatory response.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.074787
    By:
    • Andreo‐Lopez, Juana;
    • Cantero‐Molina, Francisco;
    • Bettinetti‐Luque, Miriam;
    • Huynh, Kelly Do;
    • Nguyen, Marie Minh Thu;
    • Cheung, Alwin;
    • Tran, Janine Pham;
    • Da Cunha, Celia;
    • Trujillo‐Estrada, Laura;
    • Nuñez‐Diaz, Cristina;
    • Martini, Alessandra Cadete;
    • Forner, Stefania;
    • Gutierrez, Antonia;
    • LaFerla, Frank;
    • Baglietto‐Vargas, David
    Publication type:
    Article

  • A CLU/APOJ GWAS AD risk variant suppresses the astrocytic response to plaques and reduces axonal and neuritic damage in 5xFAD mice.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.080373
    By:
    • Milinkeviciute, Giedre;
    • Tran, Katelynn;
    • Da Cunha, Celia;
    • Mendoza‐Arvilla, Adrian;
    • Garcia‐Agudo, Laura Fernandez;
    • Neumann, Jonathan;
    • Walker, Amber;
    • Kawauchi, Shimako;
    • Tenner, Andrea J;
    • LaFerla, Frank;
    • MacGregor, Grant R;
    • Green, Kim N
    Publication type:
    Article

  • Human and mouse seeds differentially affect Aβ aggregation by modulating the inflammatory response.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.074787
    By:
    • Andreo‐Lopez, Juana;
    • Cantero‐Molina, Francisco;
    • Bettinetti‐Luque, Miriam;
    • Huynh, Kelly Do;
    • Nguyen, Marie Minh Thu;
    • Cheung, Alwin;
    • Tran, Janine Pham;
    • Da Cunha, Celia;
    • Trujillo‐Estrada, Laura;
    • Nuñez‐Diaz, Cristina;
    • Martini, Alessandra Cadete;
    • Forner, Stefania;
    • Gutierrez, Antonia;
    • LaFerla, Frank;
    • Baglietto‐Vargas, David
    Publication type:
    Article

  • Fat and the brain: its connection and implication in AD pathogenesis.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.062317
    By:
    • Bettinetti‐Luque, Miriam;
    • Trujillo‐Estrada, Laura;
    • Andreo‐Lopez, Juana;
    • Cantero‐Molina, Francisco;
    • Da Cunha, Celia;
    • Sanchez‐Mejias, Elisabeth;
    • LaFerla, Frank;
    • Gutierrez, Antonia;
    • Baglietto‐Vargas, David
    Publication type:
    Article

  • Human amyloid seeds induce a more profound pathology than seeds from old 3x‐Tg‐AD mice.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.062277
    By:
    • Andreo‐Lopez, Juana;
    • Cantero‐Molina, Francisco;
    • Bettinetti‐Luque, Miriam;
    • Huynh, Kelly Do;
    • Nguyen, Marie Minh Thu;
    • Cheung, Alwin;
    • Tran, Janine Pham;
    • Da Cunha, Celia;
    • Trujillo‐Estrada, Laura;
    • Nuñez‐Diaz, Cristina;
    • Martini, Alessandra Cadete;
    • Forner, Stefania;
    • Gutierrez, Antonia;
    • LaFerla, Frank;
    • Baglietto‐Vargas, David
    Publication type:
    Article

  • BIN1 K358R variant in 5xFAD mice ameliorates AB pathology and microgliosis.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 4, p. 1, doi. 10.1002/alz.066218
    By:
    • Tran, Katelynn;
    • Milinkeviciute, Giedre;
    • Tran, Kristine M;
    • Phan, Jimmy;
    • Da Cunha, Celia;
    • Javonillo, Dominic I;
    • Kawauchi, Shimako;
    • Tenner, Andrea J;
    • LaFerla, Frank;
    • MacGregor, Grant R;
    • Green, Kim N
    Publication type:
    Article

  • Trem2<sup>R47H NSS</sup>; 5xFAD mice display age/disease progression‐dependent changes in plaques and plaque‐associated microglia, and increased plasma neurofilament light chain.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 4, p. 1, doi. 10.1002/alz.062610
    By:
    • Tran, Kristine M;
    • Kawauchi, Shimako;
    • Javonillo, Dominic I;
    • Da Cunha, Celia;
    • Phan, Jimmy;
    • Rezaie, Narges;
    • Liang, Heidi Yahan;
    • Milinkeviciute, Giedre;
    • Gomez‐Arboledas, Angela;
    • Forner, Stefania;
    • Mortazavi, Ali;
    • Tenner, Andrea J;
    • LaFerla, Frank;
    • MacGregor, Grant R;
    • Green, Kim N
    Publication type:
    Article

  • The Clu‐rs2279590_h2kb variant increases axonal and neuritic damage in 5xFAD mice.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 3, p. 1, doi. 10.1002/alz.066214
    By:
    • Milinkeviciute, Giedre;
    • Tran, Katelynn;
    • Tran, Kristine M;
    • Phan, Jimmy;
    • Da Cunha, Celia;
    • Javonillo, Dominic I;
    • Neumann, Jonathan;
    • Alcantara, Joshua A;
    • Walker, Amber;
    • Kawauchi, Shimako;
    • Tenner, Andrea J;
    • LaFerla, Frank;
    • MacGregor, Grant R;
    • Green, Kim N
    Publication type:
    Article

  • ABCA7*V1599M variant in 5xFAD mice mediates differences in amyloid‐beta pathology and reactive gliosis.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 3, p. 1, doi. 10.1002/alz.065930
    By:
    • Butler, Claire Ann;
    • Javonillo, Dominic I;
    • Houchin, Lauren A;
    • Kawauchi, Shimako;
    • Phan, Jimmy;
    • Da Cunha, Celia;
    • Tran, Katelynn;
    • Milinkeviciute, Giedre;
    • Tenner, Andrea J;
    • LaFerla, Frank;
    • MacGregor, Grant R;
    • Green, Kim N
    Publication type:
    Article

  • Late‐onset AD risk mutation PICALM<sup>H458R</sup> prevents plaque generation in 5xFAD mice.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 3, p. 1, doi. 10.1002/alz.063718
    By:
    • Gomez‐Arboledas, Angela;
    • Tran, Kristine M;
    • Javonillo, Dominic I;
    • Phan, Jimmy;
    • Milinkeviciute, Giedre;
    • Da Cunha, Celia;
    • Forner, Stefania;
    • Kawauchi, Shimako;
    • Tenner, Andrea J;
    • LaFerla, Frank;
    • MacGregor, Grant R;
    • Green, Kim N
    Publication type:
    Article

  • Accumulation of periodic‐acid Schiff granules is increased in the presence of humanized amyloid beta.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, n. 3, p. 1, doi. 10.1002/alz.055658
    By:
    • Forner, Stefania;
    • Javonillo, Dominic I;
    • Tran, Kristine M;
    • Phan, Jimmy;
    • Da Cunha, Celia;
    • Baglietto‐Vargas, David;
    • Kawauchi, Shimako;
    • Tenner, Andrea J;
    • LaFerla, Frank;
    • MacGregor, Grant R;
    • Green, Kim N
    Publication type:
    Article

  • Amyloid propagation in a sporadic model of Alzheimer disease.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, n. 3, p. 1, doi. 10.1002/alz.051813
    By:
    • Andreo‐Lopez, Juana;
    • Cantero‐Molina, Francisco;
    • Bettinetti‐Luque, Miriam;
    • Huynh, Kelly Do;
    • Nguyen, Marie Minh Thu;
    • Cheung, Alwin;
    • Tran, Janine Pham;
    • Da Cunha, Celia;
    • Trujillo‐Estrada, Laura;
    • Nuñez‐Diaz, Cristina;
    • Martini, Alessandra Cadete;
    • Forner, Stefania;
    • Gutierrez, Antonia;
    • LaFerla, Frank;
    • Baglietto‐Vargas, David
    Publication type:
    Article