Works by Dörrie, Jan

Results: 58

Transcriptional Targeting of Mature Dendritic Cells with Adenoviral Vectors via a Modular Promoter System for Antigen Expression and Functional Manipulation.

Published in:

2016

By:

Knippertz, Ilka;
Deinzer, Andrea;
Dörrie, Jan;
Schaft, Niels;
Nettelbeck, Dirk M.;
Steinkasserer, Alexander;
Dörrie, Jan

Publication type:

journal article

Electroporated Antigen-Encoding mRNA Is Not a Danger Signal to Human Mature Monocyte-Derived Dendritic Cells.

Published in:

2015

By:

Hoyer, Stefanie;
Gerer, Kerstin F.;
Pfeiffer, Isabell A.;
Prommersberger, Sabrina;
Höfflin, Sandra;
Jaitly, Tanushree;
Beltrame, Luca;
Cavalieri, Duccio;
Schuler, Gerold;
Vera, Julio;
Schaft, Niels;
Dörrie, Jan;
Höfflin, Sandra;
Dörrie, Jan

Publication type:

journal article

Chimeric Antigen Receptor (CAR) T Cells Releasing Soluble SLAMF6 Isoform 2 Gain Superior Anti-Cancer Cell Functionality in an Auto-Stimulatory Fashion.

Published in:

Cells (2073-4409), 2025, v. 14, n. 12, p. 901, doi. 10.3390/cells14120901

By:

Harrer, Dennis Christoph;
Schlierkamp-Voosen, Tim;
Barden, Markus;
Pan, Hong;
Xydia, Maria;
Herr, Wolfgang;
Dörrie, Jan;
Schaft, Niels;
Abken, Hinrich

Publication type:

Article

Single-Molecule RNA Sequencing Reveals IFNγ-Induced Differential Expression of Immune Escape Genes in Merkel Cell Polyomavirus–Positive MCC Cell Lines.

Published in:

Frontiers in Microbiology, 2021, v. 12, p. 1, doi. 10.3389/fmicb.2021.785662

By:

Sauerer, Tatjana;
Lischer, Christopher;
Weich, Adrian;
Berking, Carola;
Vera, Julio;
Dörrie, Jan

Publication type:

Article

Generation of an Oncolytic Herpes Simplex Virus 1 Expressing Human MelanA.

Published in:

Frontiers in Immunology, 2019, p. N.PAG, doi. 10.3389/fimmu.2019.00002

By:

Boscheinen, Jan B.;
Thomann, Sabrina;
Knipe, David M.;
DeLuca, Neal;
Schuler-Thurner, Beatrice;
Gross, Stefanie;
Dörrie, Jan;
Schaft, Niels;
Bach, Christian;
Rohrhofer, Anette;
Werner-Klein, Melanie;
Schmidt, Barbara;
Schuster, Philipp

Publication type:

Article

The Role of the Large T Antigen in the Molecular Pathogenesis of Merkel Cell Carcinoma.

Published in:

Genes, 2024, v. 15, n. 9, p. 1127, doi. 10.3390/genes15091127

By:

Myrda, Julia;
Bremm, Franziska;
Schaft, Niels;
Dörrie, Jan

Publication type:

Article

Stability and activity of MCSP-specific chimeric antigen receptors (CARs) depend on the scFv antigen-binding domain and the protein backbone.

Published in:

Cancer Immunology, Immunotherapy, 2015, v. 64, n. 12, p. 1623, doi. 10.1007/s00262-015-1767-4

By:

Krug, Christian;
Birkholz, Katrin;
Paulus, Alexander;
Schwenkert, Michael;
Schmidt, Patrick;
Hoffmann, Nicole;
Hombach, Andreas;
Fey, Georg;
Abken, Hinrich;
Schuler, Gerold;
Schuler-Thurner, Beatrice;
Dörrie, Jan;
Schaft, Niels

Publication type:

Article

A GMP-compliant protocol to expand and transfect cancer patient T cells with mRNA encoding a tumor-specific chimeric antigen receptor.

Published in:

Cancer Immunology, Immunotherapy, 2014, v. 63, n. 10, p. 999, doi. 10.1007/s00262-014-1572-5

By:

Krug, Christian;
Wiesinger, Manuel;
Abken, Hinrich;
Schuler-Thurner, Beatrice;
Schuler, Gerold;
Dörrie, Jan;
Schaft, Niels

Publication type:

Article

CD8+ T-cell priming and boosting: more antigen-presenting DC, or more antigen per DC?

Published in:

Cancer Immunology, Immunotherapy, 2013, v. 62, n. 12, p. 1769, doi. 10.1007/s00262-013-1481-z

By:

Schaft, Niels;
Wellner, Verena;
Wohn, Christian;
Schuler, Gerold;
Dörrie, Jan

Publication type:

Article

Dendritic cell vaccination and other strategies to tip the balance of the immune system.

Published in:

Cancer Immunology, Immunotherapy, 2008, v. 57, n. 6, p. 913, doi. 10.1007/s00262-007-0443-8

By:

Schaft, Niels;
Birkholz, Katrin;
Hofmann, Christian;
Schmid, Martina;
Theiner, Gabi;
Dörrie, Jan

Publication type:

Article

Dendritic cell vaccination and other strategies to tip the balance of the immune system.

Published in:

2008

By:

Schaft, Niels;
Birkholz, Katrin;
Hofmann, Christian;
Schmid, Martina;
Theiner, Gabi;
Dörrie, Jan

Publication type:

Correction Notice

Introduction of functional chimeric E/L-selectin by RNA electroporation to target dendritic cells from blood to lymph nodes.

Published in:

Cancer Immunology, Immunotherapy, 2008, v. 57, n. 4, p. 467, doi. 10.1007/s00262-007-0385-1

By:

Dörrie, Jan;
Schaft, Niels;
Müller, Ina;
Wellner, Verena;
Schunder, Tanja;
Hänig, Jens;
Oostingh, Gertie J.;
Schön, Michael P.;
Robert, Caroline;
Kämpgen, Eckhart;
Schuler, Gerold

Publication type:

Article

Strategies for immune intervention; from bench to bedside.

Published in:

Cancer Immunology, Immunotherapy, 2007, v. 56, n. 10, p. 1677, doi. 10.1007/s00262-007-0311-6

By:

Dörrie, Jan;
Birkholz, Katrin;
Schaft, Niels

Publication type:

Article

A new way to generate cytolytic tumor-specific T cells: electroporation of RNA coding for a T cell receptor into T lymphocytes.

Published in:

Cancer Immunology, Immunotherapy, 2006, v. 55, n. 9, p. 1132, doi. 10.1007/s00262-005-0098-2

By:

Schaft, Niels;
Dörrie, Jan;
Müller, Ina;
Beck, Verena;
Baumann, Stefanie;
Schunder, Tanja;
Kämpgen, Eckhart;
Schuler, Gerold

Publication type:

Article

Strategies for immune intervention.

Published in:

Cancer Immunology, Immunotherapy, 2006, v. 55, n. 5, p. 612, doi. 10.1007/s00262-005-0113-7

By:

Schaft, Niels;
Dörrie, Jan

Publication type:

Article

The siRNA‐mediated downregulation of PD‐1 alone or simultaneously with CTLA‐4 shows enhanced in vitro CAR‐T‐cell functionality for further clinical development towards the potential use in immunotherapy of melanoma.

Published in:

Experimental Dermatology, 2018, v. 27, n. 7, p. 769, doi. 10.1111/exd.13678

By:

Simon, Bianca;
Harrer, Dennis C.;
Schuler‐Thurner, Beatrice;
Schaft, Niels;
Schuler, Gerold;
Dörrie, Jan;
Uslu, Ugur

Publication type:

Article

Combining a chimeric antigen receptor and a conventional T-cell receptor to generate T cells expressing two additional receptors ( TETARs) for a multi-hit immunotherapy of melanoma.

Published in:

Experimental Dermatology, 2016, v. 25, n. 11, p. 872, doi. 10.1111/exd.13095

By:

Uslu, Ugur;
Schuler, Gerold;
Dörrie, Jan;
Schaft, Niels

Publication type:

Article

Individualized neoantigen peptide immunization of a metastatic pancreatic cancer patient: a case report of combined tumor and liquid biopsy.

Published in:

Frontiers in Immunology, 2024, p. 1, doi. 10.3389/fimmu.2024.1414737

By:

Roehnisch, Tim;
Carmen Martos-Contreras, Mari;
Manoochehri, Mehdi;
Nogueira, Mauro;
Bremm, Franziska;
Dörrie, Jan;
Christoph, Jan;
Kunz, Meik;
Schönharting, Wolfgang

Publication type:

Article

Mild hyperthermia enhances human monocyte-derived dendritic cell functions and offers potential for applications in vaccination strategies.

Published in:

International Journal of Hyperthermia, 2011, v. 27, n. 6, p. 591, doi. 10.3109/02656736.2011.589234

By:

Knippertz, Ilka;
Stein, Marcello F.;
Dörrie, Jan;
Schaft, Niels;
Müller, Ina;
Deinzer, Andrea;
Steinkasserer, Alexander;
Nettelbeck, Dirk M.

Publication type:

Article

Transfer of mRNA Encoding Invariant NKT Cell Receptors Imparts Glycolipid Specific Responses to T Cells and γδT Cells.

Published in:

PLoS ONE, 2015, v. 10, n. 6, p. 1, doi. 10.1371/journal.pone.0131477

By:

Shimizu, Kanako;
Shinga, Jun;
Yamasaki, Satoru;
Kawamura, Masami;
Dörrie, Jan;
Schaft, Niels;
Sato, Yusuke;
Iyoda, Tomonori;
Fujii, Shin-ichiro

Publication type:

Article

Human Adenovirus-Specific γ/δ and CD8+ T Cells Generated by T-Cell Receptor Transfection to Treat Adenovirus Infection after Allogeneic Stem Cell Transplantation.

Published in:

PLoS ONE, 2014, v. 9, n. 10, p. 1, doi. 10.1371/journal.pone.0109944

By:

Dörrie, Jan;
Krug, Christian;
Hofmann, Christian;
Müller, Ina;
Wellner, Verena;
Knippertz, Ilka;
Schierer, Stephan;
Thomas, Simone;
Zipperer, Elke;
Printz, Dieter;
Fritsch, Gerhard;
Schuler, Gerold;
Schaft, Niels;
Geyeregger, Rene

Publication type:

Article

Just One Position-Independent Lysine Residue Can Direct MelanA into Proteasomal Degradation following N-Terminal Fusion of Ubiquitin.

Published in:

PLoS ONE, 2013, v. 8, n. 2, p. 1, doi. 10.1371/journal.pone.0055567

By:

Setz, Christian;
Friedrich, Melanie;
Hahn, Sabine;
Dörrie, Jan;
Schaft, Niels;
Schuler, Gerold;
Schubert, Ulrich

Publication type:

Article

Redirecting T Cells to Ewing's Sarcoma Family of Tumors by a Chimeric NKG2D Receptor Expressed by Lentiviral Transduction or mRNA Transfection.

Published in:

PLoS ONE, 2012, v. 7, n. 2, p. 1, doi. 10.1371/journal.pone.0031210

By:

Lehner, Manfred;
Götz, Gabriel;
Proff, Julia;
Schaft, Niels;
Dörrie, Jan;
Full, Florian;
Ensser, Armin;
Muller, Yves A.;
Cerwenka, Adelheid;
Abken, Hinrich;
Parolini, Ornella;
Ambros, Peter F.;
Kovar, Heinrich;
Holter, Wolfgang

Publication type:

Article

Guidelines for mouse and human DC generation.

Published in:

European Journal of Immunology, 2023, v. 53, n. 11, p. 1, doi. 10.1002/eji.202249816

By:

Lutz, Manfred B.;
Ali, Shafaqat;
Audiger, Cindy;
Autenrieth, Stella E.;
Berod, Luciana;
Bigley, Venetia;
Cyran, Laura;
Dalod, Marc;
Dörrie, Jan;
Dudziak, Diana;
Flórez‐Grau, Georgina;
Giusiano, Lucila;
Godoy, Gloria J.;
Heuer, Marion;
Krug, Anne B.;
Lehmann, Christian H. K.;
Mayer, Christian T.;
Naik, Shalin H.;
Scheu, Stefanie;
Schreibelt, Gerty

Publication type:

Article

Concurrent interaction of DCs with CD4+ and CD8+ T cells improves secondary CTL expansion: It takes three to tango.

Published in:

European Journal of Immunology, 2014, v. 44, n. 12, p. 3543, doi. 10.1002/eji.201444477

By:

Hoyer, Stefanie;
Prommersberger, Sabrina;
Pfeiffer, Isabell A.;
Schuler‐Thurner, Beatrice;
Schuler, Gerold;
Dörrie, Jan;
Schaft, Niels

Publication type:

Article

Triggering of NF-κB in cytokine-matured human DCs generates superior DCs for T-cell priming in cancer immunotherapy.

Published in:

European Journal of Immunology, 2014, v. 44, n. 11, p. 3413, doi. 10.1002/eji.201344417

By:

Pfeiffer, Isabell A.;
Hoyer, Stefanie;
Gerer, Kerstin F.;
Voll, Reinhard E.;
Knippertz, Ilka;
Gückel, Eva;
Schuler, Gerold;
Schaft, Niels;
Dörrie, Jan

Publication type:

Article

Strong and sustained effector function of memory- versus naïve-derived T cells upon T-cell receptor RNA transfer: Implications for cellular therapy.

Published in:

European Journal of Immunology, 2012, v. 42, n. 12, p. 3442, doi. 10.1002/eji.201242666

By:

Thomas, Simone;
Klobuch, Sebastian;
Besold, Katrin;
Plachter, Bodo;
Dörrie, Jan;
Schaft, Niels;
Theobald, Matthias;
Herr, Wolfgang

Publication type:

Article

Norm- and hypo-fractionated radiotherapy is capable of activating human dendritic cells.

Published in:

Journal of Immunotoxicology, 2014, v. 11, n. 4, p. 328, doi. 10.3109/1547691X.2014.880533

By:

Kulzer, Lorenz;
Rubner, Yvonne;
Deloch, Lisa;
Allgäuer, Andrea;
Frey, Benjamin;
Fietkau, Rainer;
Dörrie, Jan;
Schaft, Niels;
Gaipl, Udo S.

Publication type:

Article

Decitabine-Mediated Upregulation of CSPG4 in Ovarian Carcinoma Cells Enables Targeting by CSPG4-Specific CAR-T Cells.

Published in:

Cancers, 2022, v. 14, n. 20, p. 5033, doi. 10.3390/cancers14205033

By:

Harrer, Dennis Christoph;
Schenkel, Charlotte;
Berking, Carola;
Herr, Wolfgang;
Abken, Hinrich;
Dörrie, Jan;
Schaft, Niels

Publication type:

Article

Clinical-Scale Production of CAR-T Cells for the Treatment of Melanoma Patients by mRNA Transfection of a CSPG4-Specific CAR under Full GMP Compliance.

Published in:

Cancers, 2019, v. 11, n. 8, p. 1198, doi. 10.3390/cancers11081198

By:

Wiesinger, Manuel;
März, Johannes;
Kummer, Mirko;
Schuler, Gerold;
Dörrie, Jan;
Schuler-Thurner, Beatrice;
Schaft, Niels

Publication type:

Article

Autophagic degradation of lamins facilitates the nuclear egress of herpes simplex virus type 1.

Published in:

Journal of Cell Biology, 2019, v. 218, n. 2, p. 508, doi. 10.1083/jcb.201801151

By:

Turan, Aykut;
Grosche, Linda;
Krawczyk, Adalbert;
Mühl-Zürbes, Petra;
Drassner, Christina;
Düthorn, Alexandra;
Kummer, Mirko;
Hasenberg, Mike;
Voortmann, Sylvia;
Jastrow, Holger;
Dörrie, Jan;
Schaft, Niels;
Kraner, Max;
Döhner, Katinka;
Sodeik, Beate;
Steinkasserer, Alexander;
Heilingloh, Christiane Silke

Publication type:

Article

Immune checkpoint blockade can synergize with radiation therapy, even in tumors resistant to checkpoint monotherapy.

Published in:

EMBO Molecular Medicine, 2017, v. 9, n. 2, p. 135, doi. 10.15252/emmm.201607219

By:

Dörrie, Jan

Publication type:

Article

RNA-transfection of γ/δ T cells with a chimeric antigen receptor or an α/β T-cell receptor: a safer alternative to genetically engineered α/β T cells for the immunotherapy of melanoma.

Published in:

2017

By:

Harrer, Dennis C.;
Simon, Bianca;
Shin-ichiro Fujii;
Kanako Shimizu;
Uslu, Ugur;
Schuler, Gerold;
Gerer, Kerstin F.;
Hoyer, Stefanie;
Dörrie, Jan;
Schaft, Niels;
Fujii, Shin-Ichiro;
Shimizu, Kanako

Publication type:

journal article

Proteomic Response of Human Umbilical Vein Endothelial Cells to Histamine Stimulation.

Published in:

Proteomics, 2017, v. 17, n. 21, p. n/a, doi. 10.1002/pmic.201700116

By:

Emirbayer, Pelin Esma;
Sinha, Ankit;
Ignatchenko, Vladimir;
Hoyer, Stefanie;
Dörrie, Jan;
Schaft, Niels;
Pischetsrieder, Monika;
Kislinger, Thomas

Publication type:

Article

Breaking Entry-and Species Barriers: LentiBOOST ® Plus Polybrene Enhances Transduction Efficacy of Dendritic Cells and Monocytes by Adenovirus 5.

Published in:

Viruses (1999-4915), 2022, v. 14, n. 1, p. 92, doi. 10.3390/v14010092

By:

Strack, Astrid;
Deinzer, Andrea;
Thirion, Christian;
Schrödel, Silke;
Dörrie, Jan;
Sauerer, Tatjana;
Steinkasserer, Alexander;
Knippertz, Ilka

Publication type:

Article

Preclinical evaluation of NF-κB-triggered dendritic cells expressing the viral oncogenic driver of Merkel cell carcinoma for therapeutic vaccination.

Published in:

Therapeutic Advances in Medical Oncology, 2017, v. 9, n. 7, p. 451, doi. 10.1177/1758834017712630

By:

Gerer, Kerstin F.;
Erdmann, Michael;
Hadrup, Sine R.;
Lyngaa, Rikke;
Martin, Lena-Marie;
Voll, Reinhard E.;
Schuler-Thurner, Beatrice;
Schuler, Gerold;
Schaft, Niels;
Hoyer, Stefanie;
Dörrie, Jan

Publication type:

Article

Avelumab mediates antibody‐dependent cellular cytotoxicity against monocyte‐derived dendritic cells through natural killer cells.

Published in:

MedComm, 2025, v. 6, n. 3, p. 1, doi. 10.1002/mco2.70111

By:

Sauerer, Tatjana;
Bremm, Franziska;
Beenen, Amke C.;
Heger, Lukas;
Dudziak, Diana;
Bosch, Naomi C.;
Erdmann, Michael;
Berking, Carola;
Schaft, Niels;
Dörrie, Jan

Publication type:

Article

Loading of CAR‐T cells with magnetic nanoparticles for controlled targeting suppresses inflammatory cytokine release and switches tumor cell death mechanism.

Published in:

MedComm, 2025, v. 6, n. 1, p. 1, doi. 10.1002/mco2.70039

By:

Pfister, Felix;
Carnell, Lucas R.;
Löffler, Lisa;
Boosz, Philipp;
Schaft, Niels;
Dörrie, Jan;
Stein, René;
Lenz, Malte;
Spiecker, Erdmann;
Huber, Christian M.;
Haddadin, Sami;
Berking, Carola;
Alexiou, Christoph;
Janko, Christina

Publication type:

Article

Generation of CD8 T cells expressing two additional T-cell receptors (TETARs) for personalised melanoma therapy.

Published in:

Cancer Biology & Therapy, 2015, v. 16, n. 9, p. 1323, doi. 10.1080/15384047.2015.1070981

By:

Höfflin, Sandra;
Prommersberger, Sabrina;
Uslu, Ugur;
Schuler, Gerold;
Schmidt, Christopher W;
Lennerz, Volker;
Dörrie, Jan;
Schaft, Niels

Publication type:

Article

Non-Coding RNA in Tumor Cells and Tumor-Associated Myeloid Cells—Function and Therapeutic Potential.

Published in:

International Journal of Molecular Sciences, 2024, v. 25, n. 13, p. 7275, doi. 10.3390/ijms25137275

By:

Binder, Amanda Katharina;
Bremm, Franziska;
Dörrie, Jan;
Schaft, Niels

Publication type:

Article

Tumor Antigens beyond the Human Exome.

Published in:

International Journal of Molecular Sciences, 2024, v. 25, n. 9, p. 4673, doi. 10.3390/ijms25094673

By:

Emilius, Lisabeth;
Bremm, Franziska;
Binder, Amanda Katharina;
Schaft, Niels;
Dörrie, Jan

Publication type:

Article

CARs and Drugs: Pharmacological Ways of Boosting CAR-T-Cell Therapy.

Published in:

2023

By:

Harrer, Dennis Christoph;
Dörrie, Jan;
Schaft, Niels

Publication type:

Literature Review

Beyond Cancer: Regulation and Function of PD-L1 in Health and Immune-Related Diseases.

Published in:

2022

By:

Beenen, Amke C.;
Sauerer, Tatjana;
Schaft, Niels;
Dörrie, Jan

Publication type:

Literature Review

BRAF and MEK Inhibitors Affect Dendritic-Cell Maturation and T-Cell Stimulation.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 21, p. 11951, doi. 10.3390/ijms222111951

By:

Hoyer, Stefanie;
Eberlein, Valentina;
Schuler, Gerold;
Berking, Carola;
Heinzerling, Lucie;
Schaft, Niels;
Dörrie, Jan

Publication type:

Article

A Chimeric IL-15/IL-15Rα Molecule Expressed on NFκB-Activated Dendritic Cells Supports Their Capability to Activate Natural Killer Cells †.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 19, p. 10227, doi. 10.3390/ijms221910227

By:

Bosch, Naomi C.;
Martin, Lena-Marie;
Voskens, Caroline J.;
Berking, Carola;
Seliger, Barbara;
Schuler, Gerold;
Schaft, Niels;
Dörrie, Jan

Publication type:

Article

T-Cell Responses in Merkel Cell Carcinoma: Implications for Improved Immune Checkpoint Blockade and Other Therapeutic Options.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 16, p. 8679, doi. 10.3390/ijms22168679

By:

Gehrcken, Laura;
Sauerer, Tatjana;
Schaft, Niels;
Dörrie, Jan

Publication type:

Article

CARs: Beyond T Cells and T Cell-Derived Signaling Domains.

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 10, p. 3525, doi. 10.3390/ijms21103525

By:

Sievers, Nico M.;
Dörrie, Jan;
Schaft, Niels

Publication type:

Article

CSPG4 as Target for CAR-T-Cell Therapy of Various Tumor Entities–Merits and Challenges.

Published in:

International Journal of Molecular Sciences, 2019, v. 20, n. 23, p. 5942, doi. 10.3390/ijms20235942

By:

Harrer, Dennis C.;
Dörrie, Jan;
Schaft, Niels

Publication type:

Article

CSPG4-Specific CAR T Cells for High-Risk Childhood B Cell Precursor Leukemia.

Published in:

International Journal of Molecular Sciences, 2019, v. 20, n. 11, p. 2764, doi. 10.3390/ijms20112764

By:

Harrer, Dennis C.;
Schuler, Gerold;
Dörrie, Jan;
Schaft, Niels

Publication type:

Article

The Generation of CAR-Transfected Natural Killer T Cells for the Immunotherapy of Melanoma.

Published in:

International Journal of Molecular Sciences, 2018, v. 19, n. 8, p. 2365, doi. 10.3390/ijms19082365

By:

Simon, Bianca;
Wiesinger, Manuel;
März, Johannes;
Wistuba-Hamprecht, Kilian;
Weide, Benjamin;
Schuler-Thurner, Beatrice;
Schuler, Gerold;
Dörrie, Jan;
Uslu, Ugur

Publication type:

Article