Works by Cruts, Marc

Results: 73

Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21.

Published in:

Nature, 2006, v. 442, n. 7105, p. 920, doi. 10.1038/nature05017

By:

Cruts, Marc;
Gijselinck, Ilse;
van der Zee, Julie;
Engelborghs, Sebastiaan;
Wils, Hans;
Pirici, Daniel;
Rademakers, Rosa;
Vandenberghe, Rik;
Dermaut, Bart;
Martin, Jean-Jacques;
van Duijn, Cornelia;
Peeters, Karin;
Sciot, Raf;
Santens, Patrick;
De Pooter, Tim;
Mattheijssens, Maria;
Van den Broeck, Marleen;
Cuijt, Ivy;
Vennekens, Krist'l;
De Deyn, Peter P.

Publication type:

Article

Genetic association of the presenilin-1 regulatory region with early-onset Alzheimer's disease in a population-based sample.

Published in:

European Journal of Human Genetics, 1999, v. 7, n. 7, p. 801, doi. 10.1038/sj.ejhg.5200373

By:

Duijn, Cornelia M van;
Cruts, Marc;
Theuns, Jessie;
Van Gassen, Geert;
Backhovens, Hubert;
van den Broeck, Marleen;
Wehnert, Anita;
Serneels, Sally;
Hofman, Albert;
Van Broeckhoven, Christine

Publication type:

Article

Frontotemporal Lobar Degeneration with Ubiquitin-Positive Inclusions: A Molecular Genetic Update.

Published in:

Neurodegenerative Diseases, 2007, v. 4, n. 2/3, p. 227, doi. 10.1159/000101847

By:

van der Zee, Julie;
Gijselinck, Ilse;
Pirici, Daniel;
Kumar-Singh, Samir;
Cruts, Marc;
Van Broeckhoven, Christine

Publication type:

Article

Course of objective memory impairment in non-demented subjects attending a memory clinic and predictors of outcome.

Published in:

International Journal of Geriatric Psychiatry, 2000, v. 15, n. 4, p. 363, doi. 10.1002/(SICI)1099-1166(200004)15:4<363::AID-GPS129>3.0.CO;2-4

By:

Visser, Pieter Jelle;
Verhey, Frans R. J.;
Ponds, Rudolf W. H. M.;
Cruts, Marc;
Van Broeckhoven, Christine L.;
Jolles, Jellemer

Publication type:

Article

Reduced secreted clusterin as a mechanism for Alzheimer-associated CLU mutations.

Published in:

Molecular Neurodegeneration, 2015, v. 10, n. 1, p. 1, doi. 10.1186/s13024-015-0024-9

By:

Bettens, Karolien;
Vermeulen, Steven;
Van Cauwenberghe, Caroline;
Heeman, Bavo;
Asselbergh, Bob;
Robberecht, Caroline;
Engelborghs, Sebastiaan;
Vandenbulcke, Mathieu;
Vandenberghe, Rik;
De Deyn, Peter Paul;
Cruts, Marc;
Van Broeckhoven, Christine;
Sleegers, Kristel

Publication type:

Article

Novel PSEN1 Mutation in a Bulgarian Patient With Very Early-Onset Alzheimer's Disease, Spastic Paraparesis, and Extrapyramidal Signs.

Published in:

2009

By:

Traykov, Latchezar Dintchov;
Mehrabian, Shima;
Van den Broeck, Marleen;
Raycheva, Margarita Radoslavova;
Cruts, Marc;
Jordanova, Albena Kirilova;
Van Broeckhoven, Christine

Publication type:

Case Study

High-density SNP haplotyping suggests altered regulation of tau gene expression in progressive supranuclear palsy.

Published in:

Human Molecular Genetics, 2005, v. 14, n. 21, p. 3281, doi. 10.1093/hmg/ddi361

By:

Rademakers, Rosa;
Melquist, Stacey;
Cruts, Marc;
Theuns, Jessie;
Del-Favero, Jurgen;
Poorkaj, Parvoneh;
Baker, Matt;
Sleegers, Kristel;
Crook, Richard;
De Pooter, Tim;
Kacem, Samira Bel;
Adamson, Jennifer;
Van den Bossche, Dirk;
Van den Broeck, Marleen;
Gass, Jennifer;
Corsmit, Ellen;
De Rijk, Peter;
Thomas, Natalie;
Engelborghs, Sebastiaan;
Heckman, Michael

Publication type:

Article

Genomic architecture of human 17q21 linked to frontotemporal dementia uncovers a highly homologous family of low-copy repeats in the tau region.

Published in:

Human Molecular Genetics, 2005, v. 14, n. 13, p. 1753, doi. 10.1093/hmg/ddi182

By:

Cruts, Marc;
Rademakers, Rosa;
Gijselinck, Ilse;
van der Zee, Julie;
Dermaut, Bart;
de Pooter, Tim;
de Rijk, Peter;
Del-Favero, Jurgen;
van Broeckhoven, Christine

Publication type:

Article

Alzheimer-associated C allele of the promoter polymorphism −22C>T causes a critical neuron-specific decrease of presenilin 1 expression.

Published in:

Human Molecular Genetics, 2003, v. 12, n. 8, p. 869, doi. 10.1093/hmg/ddg098

By:

Theuns, Jessie;
Remacle, Jacques;
Killick, Richard;
Corsmit, Ellen;
Vennekens, Krist'l;
Huylebroeck, Danny;
Cruts, Marc;
Broeckhoven, Christine Van

Publication type:

Article

Aberrant splicing in the presenilin-1 intron 4 mutation causes presenile Alzheimer's disease by increased ABeta42 secretion.

Published in:

Human Molecular Genetics, 1999, v. 8, n. 8, p. 1529, doi. 10.1093/hmg/8.8.1529

By:

Jonghe, Chris De;
Cruts, Marc;
Rogaeva, Ekaterina A.;
Tysoe, Carolyn;
Singleton, Andrew;
Vanderstichele, Hugo;
Meschino, Wendy;
Dermaut, Bart;
Vanderhoeven, Inge;
Backhovens, Hubert;
Vanmechelen, Eugeen;
Morris, Christopher M.;
Hardy, John;
Rubinsztein, David C.;
St. George-Hyslop, Peter H.;
Van Broeckhoven, Christine

Publication type:

Article

Estimation of the genetic contribution of presenilin-1 and -2 mutations in a population-based study of presenile Alzheimer disease.

Published in:

Human Molecular Genetics, 1998, v. 7, n. 1, p. 43, doi. 10.1093/hmg/7.1.43

By:

Cruts, Marc;
van Duijn, Cornelia M.;
Backhovens, Hubert;
Van den Broeck, Marleen;
Wehnert, Anita;
Serneels, Sally;
Sherrington, Robin;
Hutton, Michael;
Hardy, John;
St George‐Hyslop, Peter H.;
Hofman, Albert;
Van Broeckhoven, Christine

Publication type:

Article

Molecular genetic analysis of familial early-onset Alzheimer's disease linked to chromosome 14q24.3.

Published in:

Human Molecular Genetics, 1995, v. 4, n. 12, p. 2363

By:

Cruts, Marc;
Backhovens, Hubert;
Wang, Sheng-Yue;
Van Gassen, Geert;
Theuns, Jessie;
De Jonghe, Chris;
Wehnert, Anita;
De Voecht, Joke;
De Winter, Goedele;
Cras, Patrick;
Bruyland, Marc;
Datson, Nicole;
Weissenbach, Jean;
Dunnen, Johan T.den;
Martin, Jean-Jaques;
Hendriks, Lydia;
Van Broeckhoven, Christine

Publication type:

Article

Genetic and physical characterization of the early-onset Alzheimer's disease AD3 locus on chromosome 14q24.3.

Published in:

Human Molecular Genetics, 1995, v. 4, n. 8, p. 1355

By:

Cruts, Marc;
Backhovens, Hubert;
Theuns, Jessie;
Clark, Robert F.;
Le Paslier, Denis;
Weissenbach, Jean;
Goate, Alison M.;
Martin, Jean-Jaques;
Van Broeckhoven, Christine

Publication type:

Article

A yeast artificial chromosome contig from human chromosome 14q24 spanning the Alzheimer's disease locus AD3.

Published in:

Human Molecular Genetics, 1995, v. 4, n. 8, p. 1347

By:

Clark, Robert F.;
Cruts, Marc;
Korenblat, Kevin M.;
He, Chengshi;
Talbot, Christopher;
Van Broeckhoven, Christine;
Goate, Alison M.

Publication type:

Article

Reduced functional brain activity response in cognitively intact apolipoprotein E ɛ4 carriers.

Published in:

Brain: A Journal of Neurology, 2006, v. 129, n. 5, p. 1240, doi. 10.1093/brain/awl054

By:

Johanna Lind;
Jonas Persson;
Martin Ingvar;
Anne Larsson;
Marc Cruts;
Christine Van Broeckhoven;
Rolf Adolfsson;
Lars Bäckman;
Lars-Göran Nilsson;
Karl Magnus Petersson;
Lars Nyberg

Publication type:

Article

Reduced functional brain activity response in cognitively intact apolipoprotein E ɛ4 carriers.

Published in:

Brain: A Journal of Neurology, 2006, v. 129, n. 5, p. 1240, doi. 10.1093/brain/awl054

By:

Johanna Lind;
Jonas Persson;
Martin Ingvar;
Anne Larsson;
Marc Cruts;
Christine Van Broeckhoven;
Rolf Adolfsson;
Lars Bäckman;
Lars-Göran Nilsson;
Karl Magnus Petersson;
Lars Nyberg

Publication type:

Article

A Belgian ancestral haplotype harbours a highly prevalent mutation for 17q21-linked tau-negative FTLD.

Published in:

Brain: A Journal of Neurology, 2006, v. 129, n. 4, p. 841, doi. 10.1093/brain/awl029

By:

Julie van der Zee;
Rosa Rademakers;
Sebastiaan Engelborghs;
Ilse Gijselinck;
Veerle Bogaerts;
Rik Vandenberghe;
Patrick Santens;
Jo Caekebeke;
Tim De Pooter;
Karin Peeters;
Ursula Lübke;
Marleen Van den Broeck;
Jean-Jacques Martin;
Marc Cruts;
Peter P. De Deyn;
Christine Van Broeckhoven;
Bart Dermaut

Publication type:

Article

Rescue of Progranulin Deficiency Associated with Frontotemporal Lobar Degeneration by Alkalizing Reagents and Inhibition of Vacuolar ATPase.

Published in:

Journal of Neuroscience, 2011, v. 31, n. 5, p. 1885, doi. 10.1523/JNEUROSCI.5757-10.2011

By:

Capell, Anja;
Liebscher, Sabine;
Fellerer, Katrin;
Brouwers, Nathalie;
Willem, Michael;
Lammich, Sven;
Gijselinck, Ilse;
Bittner, Tobias;
Carlson, Aaron M.;
Sasse, Florenz;
Kunze, Brigitte;
Steinmetz, Heinrich;
Jansen, Rolf;
Dormann, Dorothee;
Sleegers, Kristel;
Cruts, Marc;
Herms, Jochen;
Van Broeckhoven, Christine;
Haass, Christian

Publication type:

Article

A novel presenilin 1 mutation associated with Pick's disease but not β-amyloid plaques.

Published in:

Annals of Neurology, 2004, v. 55, n. 5, p. 617

By:

Bart Dermaut;
Samir Kumar-Singh;
Sebastian Engelborghs;
Jessie Theuns;
Rosa Rademakers;
Jos Saerens;
Barbara A. Pickut;
Karin Peeters;
Marleen Van Den Broeck;
Krist'l Vennekens;
Stephen Claes;
Marc Cruts;
Patrick Cras;
Jean-Jacques Martin;
Christine Van Broeckhoven

Publication type:

Article

Early cognitive decline is associated with prion protein codon 129 polymorphism.

Published in:

Annals of Neurology, 2003, v. 54, n. 2, p. 275

By:

Esther A. Croes;
Bart Dermaut;
Jeanine J. Houwing-Duistermaat;
Marleen Van den Broeck;
Marc Cruts;
Monique M. B. Breteler;
Albert Hofman;
Christine van Broeckhoven

Publication type:

Article

PRNP Val129 homozygosity increases risk for early-onset Alzheimer's disease.

Published in:

Annals of Neurology, 2003, v. 53, n. 3, p. 409

By:

Bart Dermaut;
Esther A. Croes;
Rosa Rademakers;
Marleen Van Den Broeck;
Marc Cruts;
Albert Hofman;
Cornelia M. Van Duijn;
Christine Van Broeckhoven

Publication type:

Article

Call for participation in the neurogenetics consortium within the Human Variome Project.

Published in:

Neurogenetics, 2011, v. 12, n. 3, p. 169, doi. 10.1007/s10048-011-0287-4

By:

Haworth, Andrea;
Bertram, Lars;
Carrera, Paola;
Elson, Joanna;
Braastad, Corey;
Cox, Diane;
Cruts, Marc;
Dunnen, Johann;
Farrer, Matthew;
Fink, John;
Hamed, Sherifa;
Houlden, Henry;
Johnson, Dennis;
Nuytemans, Karen;
Palau, Francesc;
Rayan, Dipa;
Robinson, Peter;
Salas, Antonio;
Schüle, Birgitt;
Sweeney, Mary

Publication type:

Article

NanoPack: visualizing and processing long-read sequencing data.

Published in:

Bioinformatics, 2018, v. 34, n. 15, p. 2666, doi. 10.1093/bioinformatics/bty149

By:

Coster, Wouter De;
D’Hert, Svenn;
Schultz, Darrin T;
Cruts, Marc;
Broeckhoven, Christine Van

Publication type:

Article

Visualization of MAPT inversion on stretched chromosomes of tau-negative frontotemporal dementia patients.

Published in:

Human Mutation, 2006, v. 27, n. 10, p. 1057, doi. 10.1002/humu.20391

By:

Gijselinck, Ilse;
Bogaerts, Veerle;
Rademakers, Rosa;
van der Zee, Julie;
Van Broeckhoven, Christine;
Cruts, Marc

Publication type:

Article

Mean age-of-onset of familial alzheimer disease caused by presenilin mutations correlates with both increased Aβ42 and decreased Aβ40.

Published in:

Human Mutation, 2006, v. 27, n. 7, p. 686, doi. 10.1002/humu.20336

By:

Kumar-Singh, Samir;
Theuns, Jessie;
Van Broeck, Bianca;
Pirici, Daniel;
Vennekens, Krist'l;
Corsmit, Ellen;
Cruts, Marc;
Dermaut, Bart;
Wang, Rong;
Van Broeckhoven, Christine

Publication type:

Article

Missense mutation in exon 11 (codon 378) of the presenilin-1 gene in a French family with early-onset Alzheimer's disease and transmission study by mismatch enhanced allele specific amplification.

Published in:

Human Mutation, 1998, v. 11, n. 6, p. 481, doi. 10.1002/(SICI)1098-1004(1998)11:6<481::AID-HUMU13>3.0.CO;2-N

By:

Besançon, Roger;
Lorenzi, Alberta;
Cruts, Marc;
Radawiec, Sandrine;
Sturtz, Franck;
Broussolle, Emmanuel;
Chazot, Guy;
Broeckhoven, Christine Van;
Chamba, Geneviève;
Vandenberghe, Antoon

Publication type:

Article

Presenilin mutations in Alzheimer's disease.

Published in:

Human Mutation, 1998, v. 11, n. 3, p. 183, doi. 10.1002/(SICI)1098-1004(1998)11:3<183::AID-HUMU1>3.0.CO;2-J

By:

Cruts, Marc;
Van Broeckhoven, Christine

Publication type:

Article

Sequencing an Ashkenazi reference panel supports population-targeted personal genomics and illuminates Jewish and European origins.

Published in:

Nature Communications, 2014, v. 5, n. 9, p. 4835, doi. 10.1038/ncomms5835

By:

Carmi, Shai;
Hui, Ken Y.;
Kochav, Ethan;
Liu, Xinmin;
Xue, James;
Grady, Fillan;
Guha, Saurav;
Upadhyay, Kinnari;
Ben-Avraham, Dan;
Mukherjee, Semanti;
Bowen, B. Monica;
Thomas, Tinu;
Vijai, Joseph;
Cruts, Marc;
Froyen, Guy;
Lambrechts, Diether;
Plaisance, Stéphane;
Van Broeckhoven, Christine;
Van Damme, Philip;
Van Marck, Herwig

Publication type:

Article

Bidirectional transcripts of the expanded <i>C9orf72</i> hexanucleotide repeat are translated into aggregating dipeptide repeat proteins.

Published in:

Acta Neuropathologica, 2013, v. 126, n. 6, p. 881, doi. 10.1007/s00401-013-1189-3

By:

Mori, Kohji;
Arzberger, Thomas;
Grässer, Friedrich A.;
Gijselinck, Ilse;
May, Stephanie;
Rentzsch, Kristin;
Weng, Shih-Ming;
Schludi, Martin H.;
van der Zee, Julie;
Cruts, Marc;
Van Broeckhoven, Christine;
Kremmer, Elisabeth;
Kretzschmar, Hans A.;
Haass, Christian;
Edbauer, Dieter

Publication type:

Article

hnRNP A3 binds to GGGGCC repeats and is a constituent of p62-positive/TDP43-negative inclusions in the hippocampus of patients with C9orf72 mutations.

Published in:

Acta Neuropathologica, 2013, v. 125, n. 3, p. 413, doi. 10.1007/s00401-013-1088-7

By:

Mori, Kohji;
Lammich, Sven;
Mackenzie, Ian;
Forné, Ignasi;
Zilow, Sonja;
Kretzschmar, Hans;
Edbauer, Dieter;
Janssens, Jonathan;
Kleinberger, Gernot;
Cruts, Marc;
Herms, Jochen;
Neumann, Manuela;
Broeckhoven, Christine;
Arzberger, Thomas;
Haass, Christian

Publication type:

Article

The genetics and neuropathology of frontotemporal lobar degeneration.

Published in:

Acta Neuropathologica, 2012, v. 124, n. 3, p. 353, doi. 10.1007/s00401-012-1029-x

By:

Sieben, Anne;
Van Langenhove, Tim;
Engelborghs, Sebastiaan;
Martin, Jean-Jacques;
Boon, Paul;
Cras, Patrick;
De Deyn, Peter-Paul;
Santens, Patrick;
Van Broeckhoven, Christine;
Cruts, Marc

Publication type:

Article

Contribution of TARDBP to Alzheimer's Disease Genetic Etiology.

Published in:

Journal of Alzheimer's Disease, 2010, v. 21, n. 2, p. 423, doi. 10.3233/JAD-2010-100198

By:

Brouwers, Nathalie;
Bettens, Karolien;
Gijselinck, Ilse;
Engelborghs, Sebastiaan;
Pickut, Barbara A.;
Van Miegroet, Helen;
Montoya, Ana Gil;
Mattheijssens, Maria;
Peeters, Karin;
De Deyn, Peter P.;
Cruts, Marc;
Sleegers, Kristel;
Van Broeckhoven, Christine

Publication type:

Article

Extended FTLD pedigree segregating a Belgian <italic>GRN</italic>-null mutation: neuropathological heterogeneity in one family.

Published in:

Alzheimer's Research & Therapy, 2018, v. 10, p. 1, doi. 10.1186/s13195-017-0334-y

By:

Sieben, Anne;
Van Mossevelde, Sara;
Wauters, Eline;
Engelborghs, Sebastiaan;
van der Zee, Julie;
Van Langenhove, Tim;
Santens, Patrick;
Praet, Marleen;
Boon, Paul;
Miatton, Marijke;
Van Hoecke, Sofie;
Vandenbulcke, Mathieu;
Vandenberghe, Rik;
Cras, Patrick;
Cruts, Marc;
De Deyn, Peter Paul;
Van Broeckhoven, Christine;
Martin, Jean-Jacques

Publication type:

Article

Clinical features of TBK1 carriers compared with C9orf72, GRN and non-mutation carriers in a Belgian cohort.

Published in:

2016

By:

Van Mossevelde, Sara;
van der Zee, Julie;
Gijselinck, Ilse;
Engelborghs, Sebastiaan;
Sieben, Anne;
Van Langenhove, Tim;
De Bleecker, Jan;
Baets, Jonathan;
Vandenbulcke, Mathieu;
Van Laere, Koen;
Ceyssens, Sarah;
Van den Broeck, Marleen;
Peeters, Karin;
Mattheijssens, Maria;
Cras, Patrick;
Vandenberghe, Rik;
De Jonghe, Peter;
Martin, Jean-Jacques;
De Deyn, Peter P.;
Cruts, Marc

Publication type:

journal article

TMEM106B is associated with frontotemporal lobar degeneration in a clinically diagnosed patient cohort.

Published in:

Brain: A Journal of Neurology, 2011, v. 134, n. 3, p. 808, doi. 10.1093/brain/awr007

By:

van der Zee, Julie;
Van Langenhove, Tim;
Kleinberger, Gernot;
Sleegers, Kristel;
Engelborghs, Sebastiaan;
Vandenberghe, Rik;
Santens, Patrick;
Van den Broeck, Marleen;
Joris, Geert;
Brys, Jolien;
Mattheijssens, Maria;
Peeters, Karin;
Cras, Patrick;
De Deyn, Peter P.;
Cruts, Marc;
Van Broeckhoven, Christine

Publication type:

Article

APP duplication is sufficient to cause early onset Alzheimer's dementia with cerebral amyloid angiopathy.

Published in:

Brain: A Journal of Neurology, 2006, v. 129, n. 11, p. 2977, doi. 10.1093/brain/awl203

By:

Kristel Sleegers;
Nathalie Brouwers;
Ilse Gijselinck;
Jessie Theuns;
Dirk Goossens;
Jan Wauters;
Jurgen Del-Favero;
Marc Cruts;
Cornelia M. van Duijn;
Christine Van Broeckhoven

Publication type:

Article

Serum biomarker for progranulin-associated frontotemporal lobar degeneration.

Published in:

Annals of Neurology, 2009, v. 65, n. 5, p. 603, doi. 10.1002/ana.21621

By:

Sleegers, Kristel;
Brouwers, Nathalie;
Van Damme, Philip;
Engelborghs, Sebastiaan;
Gijselinck, Ilse;
van der Zee, Julie;
Peeters, Karin;
Mattheijssens, Maria;
Cruts, Marc;
Vandenberghe, Rik;
De Deyn, Peter P.;
Robberecht, Wim;
Van Broeckhoven, Christine

Publication type:

Article

Correction to: Bidirectional transcripts of the expanded C9orf72 hexanucleotide repeat are translated into aggregating dipeptide repeat proteins.

Published in:

2024

By:

Mori, Kohji;
Arzberger, Thomas;
Grässer, Friedrich A.;
Gijselinck, Ilse;
May, Stephanie;
Rentzsch, Kristin;
Weng, Shih‑Ming;
Schludi, Martin H.;
van der Zee, Julie;
Cruts, Marc;
Van Broeckhoven, Christine;
Kremmer, Elisabeth;
Kretzschmar, Hans A.;
Haass, Christian;
Edbauer, Dieter

Publication type:

Correction Notice

Novel APP mutation V715A associated with presenile Alzheimer’s disease in a German family.

Published in:

Journal of Neurology, 2003, v. 250, n. 11, p. 1374, doi. 10.1007/s00415-003-0182-5

By:

Cruts, Marc;
Dermaut, Bart;
Rademakers, Rosa;
Van den Broeck, Marleen;
Stögbauer, Florian;
Van Broeckhoven, Christine

Publication type:

Article

Diagnostic accuracy of the Preclinical AD Scale (PAS) in cognitively mildly impaired subjects.

Published in:

Journal of Neurology, 2002, v. 249, n. 3, p. 312, doi. 10.1007/s004150200011

By:

Visser, Pieter Jelle;
Verhey, Frans R. J.;
Scheltens, Philip;
Cruts, Marc;
Ponds, Rudolf W. H. M.;
Van Broeckhoven, Christine L.;
Jolles, Jellemer

Publication type:

Article

Familial Creutzfeldt-Jakob disease in a patient carrying both a presenilin 1 missense substitution and a prion protein gene insertion.

Published in:

Journal of Neurology, 2000, v. 247, n. 5, p. 364, doi. 10.1007/s004150050603

By:

Dermaut, Bart;
Cruts, Marc;
Backhovens, Hubert;
Lübcke, Ursula;
Van Everbroeck, Bart;
Sciot, Raf;
Dom, René;
Martin, Jean-Jacques;
Van Broeckhoven, Christine;
Cras, Patrick

Publication type:

Article

Massive parallel gene panel sequencing in a belgian ftld cohort of causal genes associated with diverse neurodegenerative brain diseases.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2015, v. 11, n. 7, p. P251, doi. 10.1016/j.jalz.2015.07.311

By:

van der Zee, Julie;
Robberecht, Caroline;
Dillen, Lubina;
Sleegers, Kristel;
Cruts, Marc;
Van Broeckhoven, Christine

Publication type:

Article

Loss-of-function mutations in TBK1 are frequently associated with frontotemporal lobar degeneration in a belgian patient cohort.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2015, v. 11, n. 7, p. P333, doi. 10.1016/j.jalz.2015.08.157

By:

Gijselinck, Ilse;
Van Mossevelde, Sara;
Sieben, Anne;
Heeman, Bavo;
Engelborghs, Sebastiaan;
Vandenbulcke, Mathieu;
Cuijt, Ivy;
Van den Broeck, Marleen;
Peeters, Karin;
Mattheijssens, Maria;
Vandenberghe, Rik;
De Jonghe, Peter;
Cras, Patrick;
De Deyn, Peter P.;
Martin, Jean-Jacques;
Cruts, Marc;
Van Broeckhoven, Christine

Publication type:

Article

Geographical frequency of the FTLD-ALS causing C9orf72 repeat expansion mutation in an extended cohort ascertained within the European consortium on early-onset dementia

Published in:

2012

By:

van der Zee, Julie;
Gijselinck, Ilse;
Dillen, Lubina;
Van Langenhove, Tim;
Sieben, Anne;
Martin, Jean-Jacques;
Cruts, Marc;
Van Broeckhoven, Christine

Publication type:

Abstract

Genomic characterization of the C9orf72 promoter repeat in FTLD and ALS patients

Published in:

2012

By:

Gijselinck, Ilse;
Van Langenhove, Tim;
van der Zee, Julie;
Philtjens, Stéphanie;
Engelborghs, Sebastiaan;
De Jonghe, Peter;
Vandenberghe, Rik;
Santens, Patrick;
De Bleecker, Jan;
Bäumer, Veerle;
Maes, Githa;
Dillen, Lubina;
Cras, Patrick;
Robberecht, Wim;
De Deyn, Peter;
Van Broeckhoven, Christine;
Cruts, Marc

Publication type:

Abstract

The clinical presentation of C9orf72-associated frontotemporal lobar degeneration in an extended Flanders-Belgian cohort

Published in:

2012

By:

Van Langenhove, Tim;
van der Zee, Julie;
Gijselinck, Ilse;
Engelborghs, Sebastiaan;
Vandenberghe, Rik;
Sieben, Anne;
Santens, Patrick;
De Jonghe, Peter;
Cras, Patrick;
De Deyn, Peter P.;
Cruts, Marc;
Van Broeckhoven, Christine

Publication type:

Abstract

Risk For Alzheimer's Associated With A Copy Number Variation In The Complement Receptor 1 Increasing C3b/C4b Binding Sites

Published in:

2011

By:

Brouwers, Nathalie;
Van Cauwenberghe, Caroline;
Engelborghs, Sebastiaan;
Lambert, Jean-Charles;
Bettens, Karolien;
Le Bastard, Nathalie;
Pasquier, Florence;
Vandenberghe, Rik;
De Deyn, Peter;
Cruts, Marc;
Amouyel, Philippe;
Sleegers, Kristel;
Van Broeckhoven, Christine

Publication type:

Abstract

Association of intermediate-length polyQ expansions in ATXN2 with ALS but not FTLD in a flanders-belgian cohort

Published in:

2011

By:

Van Langenhove, Tim;
Engelborghs, Sebastiaan;
Vandenberghe, Rik;
Santens, Patrick;
Cras, Patrick;
Nuytten, Dirk;
De Jonghe, Peter;
De Deyn, Peter P.;
Cruts, Marc;
Van Broeckhoven, Christine;
van der Zee, Julie

Publication type:

Abstract

TMEM106B the first common risk factor for FTLD: Replication in a clinically diagnosed cohort of FTLD patients

Published in:

2010

By:

van der Zee, Julie;
Van Langenhove, Tim;
Kleinberger, Gernot;
Sleegers, Kristel;
Engelborghs, Sebastiaan;
Vandenberghe, Rik;
Santens, Patrick;
Cras, Patrick;
De Deyn, Peter P.;
Cruts, Marc;
Van Broeckhoven, Christine

Publication type:

Abstract

P3-206: Genetic variability at the progranulin locus contributes to risk for Alzheimer's disease

Published in:

2008

By:

Brouwers, Nathalie;
Sleegers, Kristel;
Engelborghs, Sebastiaan;
Maurer-Stroh, Sébastian;
Gijselinck, Ilse;
van der Zee, Julie;
Pickut, Barbara;
Van den Broeck, Marleen;
Mattheijssens, Maria;
Peeters, Karin;
Schymkowitz, Joost;
Rousseau, Frédéric;
Martin, Jean-Jacques;
Cruts, Marc;
De Deyn, Peter Paul;
Van Broeckhoven, Christine

Publication type:

Abstract