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Characterization of the skeletal muscle arginine methylome in health and disease reveals remodeling in amyotrophic lateral sclerosis.
- Published in:
- FASEB Journal, 2024, v. 38, n. 10, p. 1, doi. 10.1096/fj.202400045R
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- Publication type:
- Article
Evidence for disrupted copper availability in human spinal cord supports Cu<sup>II</sup>(atsm) as a treatment option for sporadic cases of ALS.
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- Scientific Reports, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41598-024-55832-w
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- Publication type:
- Article
Microglial ferroptotic stress causes non-cell autonomous neuronal death.
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- Molecular Neurodegeneration, 2024, v. 19, n. 1, p. 1, doi. 10.1186/s13024-023-00691-8
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- Publication type:
- Article
Evidence for decreased copper associated with demyelination in the corpus callosum of cuprizone-treated mice.
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- Metallomics, 2024, v. 16, n. 1, p. 1, doi. 10.1093/mtomcs/mfad072
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- Publication type:
- Article
Fundamental Neurochemistry Review: Copper availability as a potential therapeutic target in progressive supranuclear palsy: Insight from other neurodegenerative diseases.
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- Journal of Neurochemistry, 2023, v. 167, n. 3, p. 337, doi. 10.1111/jnc.15978
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- Publication type:
- Article
Cu<sup>II</sup>(atsm) significantly decreases microglial reactivity in patients with sporadic amyotrophic lateral sclerosis.
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- Neuropathology & Applied Neurobiology, 2023, v. 49, n. 5, p. 1, doi. 10.1111/nan.12938
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- Publication type:
- Article
Proteome-wide systems genetics identifies UFMylation as a regulator of skeletal muscle function.
- Published in:
- eLife, 2023, p. 1, doi. 10.7554/eLife.82951
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- Article
RIEMANNIAN CUBICS CLOSE TO GEODESICS AT THE BOUNDARIES.
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- Journal of Geometric Mechanics, 2022, v. 14, n. 4, p. 545, doi. 10.3934/jgm.2022003
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- Publication type:
- Article
Altered SOD1 maturation and post-translational modification in amyotrophic lateral sclerosis spinal cord.
- Published in:
- 2022
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- Publication type:
- journal article
Iron overload and impaired iron handling contribute to the dystrophic pathology in models of Duchenne muscular dystrophy.
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- Journal of Cachexia, Sarcopenia & Muscle, 2022, v. 13, n. 3, p. 1541, doi. 10.1002/jcsm.12950
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- Article
Lithium administered to pregnant, lactating and neonatal rats: entry into developing brain.
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- Fluids & Barriers of the CNS, 2021, v. 18, n. 1, p. 1, doi. 10.1186/s12987-021-00285-w
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- Article
Sex-dependent effects of amyloid precursor-like protein 2 in the SOD1-G37R transgenic mouse model of MND.
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- Cellular & Molecular Life Sciences, 2021, v. 78, n. 19/20, p. 6605, doi. 10.1007/s00018-021-03924-5
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- Publication type:
- Article
CuATSM improves motor function and extends survival but is not tolerated at a high dose in SOD1<sup>G93A</sup> mice with a C57BL/6 background.
- Published in:
- Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-98317-w
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- Publication type:
- Article
Regular Physical Exercise Modulates Iron Homeostasis in the 5xFAD Mouse Model of Alzheimer's Disease.
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- International Journal of Molecular Sciences, 2021, v. 22, n. 16, p. 8715, doi. 10.3390/ijms22168715
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- Publication type:
- Article
SLN124, a GalNac‐siRNA targeting transmembrane serine protease 6, in combination with deferiprone therapy reduces ineffective erythropoiesis and hepatic iron‐overload in a mouse model of β‐thalassaemia.
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- British Journal of Haematology, 2021, v. 194, n. 1, p. 200, doi. 10.1111/bjh.17428
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- Article
Superoxide Dismutase 1 in Health and Disease: How a Frontline Antioxidant Becomes Neurotoxic.
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- Angewandte Chemie, 2021, v. 133, n. 17, p. 9299, doi. 10.1002/ange.202000451
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- Publication type:
- Article
Superoxide Dismutase 1 in Health and Disease: How a Frontline Antioxidant Becomes Neurotoxic.
- Published in:
- Angewandte Chemie International Edition, 2021, v. 60, n. 17, p. 9215, doi. 10.1002/anie.202000451
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- Publication type:
- Article
Iron accumulation in skeletal muscles of old mice is associated with impaired regeneration after ischaemia–reperfusion damage.
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- Journal of Cachexia, Sarcopenia & Muscle, 2021, v. 12, n. 2, p. 476, doi. 10.1002/jcsm.12685
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- Publication type:
- Article
Copper-ATSM as a Treatment for ALS: Support from Mutant SOD1 Models and Beyond.
- Published in:
- Life (2075-1729), 2020, v. 10, n. 11, p. 271, doi. 10.3390/life10110271
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- Publication type:
- Article
Cu<sup>II</sup> (atsm) inhibits ferroptosis: Implications for treatment of neurodegenerative disease.
- Published in:
- 2020
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- Publication type:
- journal article
A versatile quantitative microdroplet elemental imaging method optimised for integration in biochemical workflows for low-volume samples.
- Published in:
- Analytical & Bioanalytical Chemistry, 2019, v. 411, n. 3, p. 603, doi. 10.1007/s00216-018-1362-6
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- Publication type:
- Article
TDP-43 mutations causing amyotrophic lateral sclerosis are associated with altered expression of RNA-binding protein hnRNP K and affect the Nrf2 antioxidant pathway.
- Published in:
- Human Molecular Genetics, 2017, v. 26, n. 9, p. 1732, doi. 10.1093/hmg/ddx093
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- Publication type:
- Article
Cu<sup>II</sup>(atsm) improves the neurological phenotype and survival of SOD1<sup>G93A</sup> mice and selectively increases enzymatically active SOD1 in the spinal cord.
- Published in:
- Scientific Reports, 2017, p. 42292, doi. 10.1038/srep42292
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- Publication type:
- Article
Enhancing survival motor neuron expression extends lifespan and attenuates neurodegeneration in mutant TDP-43 mice.
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- Human Molecular Genetics, 2016, v. 25, n. 18, p. 4080, doi. 10.1093/hmg/ddw247
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- Publication type:
- Article
N-acetylcysteine modulates glutamatergic dysfunction and depressive behavior in Huntington's disease.
- Published in:
- Human Molecular Genetics, 2016, v. 25, n. 14, p. 2923, doi. 10.1093/hmg/ddw144
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- Publication type:
- Article
Prion protein 'gamma-cleavage': characterizing a novel endoproteolytic processing event.
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- Cellular & Molecular Life Sciences, 2016, v. 73, n. 3, p. 667, doi. 10.1007/s00018-015-2022-z
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- Publication type:
- Article
Editorial: Metals and neurodegeneration: restoring the balance.
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- 2015
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- Publication type:
- Editorial
Editorial: Metals and neurodegeneration: restoring the balance.
- Published in:
- 2015
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- Publication type:
- Editorial
Metal-deficient SOD1 in amyotrophic lateral sclerosis.
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- Journal of Molecular Medicine, 2015, v. 93, n. 5, p. 481, doi. 10.1007/s00109-015-1273-3
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- Publication type:
- Article
Phosphorylation of hnRNP K by cyclin-dependent kinase 2 controls cytosolic accumulation of TDP-43.
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- Human Molecular Genetics, 2015, v. 24, n. 6, p. 1655, doi. 10.1093/hmg/ddu578
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- Publication type:
- Article
Deregulation of subcellular biometal homeostasis through loss of the metal transporter, Zip7, in a childhood neurodegenerative disorder.
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- Acta Neuropathologica Communications, 2014, v. 2, n. 1, p. 1, doi. 10.1186/2051-5960-2-25
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- Publication type:
- Article
Localized changes to glycogen synthase kinase-3 and collapsin response mediator protein-2 in the Huntington's disease affected brain.
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- Human Molecular Genetics, 2014, v. 23, n. 15, p. 4051, doi. 10.1093/hmg/ddu119
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- Publication type:
- Article
Deregulation of biometal homeostasis: the missing link for neuronal ceroid lipofuscinoses?
- Published in:
- Metallomics, 2014, v. 6, n. 4, p. 932, doi. 10.1039/c4mt00032c
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- Publication type:
- Article
Neuroprotective Copper Bis(thiosemicarbazonato) Complexes Promote Neurite Elongation.
- Published in:
- PLoS ONE, 2014, v. 9, n. 2, p. 1, doi. 10.1371/journal.pone.0090070
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- Publication type:
- Article
ALS-Associated TDP-43 Induces Endoplasmic Reticulum Stress, Which Drives Cytoplasmic TDP-43 Accumulation and Stress Granule Formation.
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- PLoS ONE, 2013, v. 8, n. 11, p. 1, doi. 10.1371/journal.pone.0081170
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- Publication type:
- Article
Phosphorylation of hnRNP K controls cytosolic accumulation of TDP-43.
- Published in:
- 2013
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- Publication type:
- Abstract
Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress.
- Published in:
- PLoS ONE, 2013, v. 8, n. 6, p. 1, doi. 10.1371/journal.pone.0067433
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- Publication type:
- Article
Mild Oxidative Stress Induces Redistribution of BACE1 in Non-Apoptotic Conditions and Promotes the Amyloidogenic Processing of Alzheimer’s Disease Amyloid Precursor Protein.
- Published in:
- PLoS ONE, 2013, v. 8, n. 4, p. 1, doi. 10.1371/journal.pone.0061246
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- Publication type:
- Article
CONTINUOUS AND DISCRETE EMBEDDED OPTIMAL CONTROL PROBLEMS AND THEIR APPLICATION TO THE ANALYSIS OF CLEBSCH OPTIMAL CONTROL PROBLEMS AND MECHANICAL SYSTEMS.
- Published in:
- Journal of Geometric Mechanics, 2013, v. 5, n. 1, p. 1, doi. 10.3934/jgm.2013.5.1
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- Publication type:
- Article
Increased Zinc and Manganese in Parallel with Neurodegeneration, Synaptic Protein Changes and Activation of Akt/GSK3 Signaling in Ovine CLN6 Neuronal Ceroid Lipofuscinosis.
- Published in:
- PLoS ONE, 2013, v. 8, n. 3, p. 1, doi. 10.1371/journal.pone.0058644
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- Publication type:
- Article
Inhibition of TDP-43 Accumulation by Bis(thiosemicarbazonato)-Copper Complexes.
- Published in:
- PLoS ONE, 2012, v. 7, n. 8, p. 1, doi. 10.1371/journal.pone.0042277
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- Publication type:
- Article
The Alzheimer's therapeutic PBT2 promotes amyloid-β degradation and GSK3 phosphorylation via a metal chaperone activity.
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- Journal of Neurochemistry, 2011, v. 119, n. 1, p. 220, doi. 10.1111/j.1471-4159.2011.07402.x
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- Publication type:
- Article
TDP-43 aggregation during chronic oxidative stress is mediated by c-Jun N-terminal kinase and can be inhibited by a potentially therapeutic metallo-complex
- Published in:
- 2011
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- Publication type:
- Abstract
The Alzheimer's therapeutic PBT2 achieves cognitive benefit by combining neuroprotection with neurorestoration: studies in animal models of Alzheimer's disease and Huntington's disease
- Published in:
- 2011
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- Publication type:
- Abstract
Therapeutic benefits of copper-bis (thiosemicarbazonato) complexes in neurodegenerative disorders
- Published in:
- 2011
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- Publication type:
- Abstract
Mechanism for the protective effect of pyrrolidine dithiocarbamate against oxidative stress in AD: induction of the Nrf2-ARE pathway
- Published in:
- 2011
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- Publication type:
- Abstract
Water-soluble Bis(thiosemicarbazonato)copper(ii) Complexes.
- Published in:
- Australian Journal of Chemistry, 2011, v. 64, n. 3, p. 14, doi. 10.1071/CH10463
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- Publication type:
- Article
Metal Ionophore Treatment Restores Dendritic Spine Density and Synaptic Protein Levels in a Mouse Model of Alzheimer's Disease.
- Published in:
- PLoS ONE, 2011, v. 6, n. 3, p. 1, doi. 10.1371/journal.pone.0017669
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- Publication type:
- Article
Cell cycle arrest in cultured neuroblastoma cells exposed to a bis(thiosemicarbazonato) metal complex.
- Published in:
- BioMetals, 2011, v. 24, n. 1, p. 117, doi. 10.1007/s10534-010-9380-7
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- Publication type:
- Article
Glycogen Synthase Kinase-3.
- Published in:
- 2011
- By:
- Publication type:
- Editorial