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Polymeric Nanoparticles for Drug Delivery in Osteoarthritis.
Published in:
Pharmaceutics, 2022, v. 14, n. 12, p. 2639, doi. 10.3390/pharmaceutics14122639
By:
- Pontes, Adriano P.;
- Welting, Tim J. M.;
- Rip, Jaap;
- Creemers, Laura B.
Publication type:
Article
Prospective Evaluation of Local Sustained Release of Celecoxib in Dogs with Low Back Pain.
Published in:
Pharmaceutics, 2021, v. 13, n. 8, p. 1178, doi. 10.3390/pharmaceutics13081178
By:
- Wiersema, Tijn;
- Tellegen, Anna R.;
- Beukers, Martijn;
- van Stralen, Marijn;
- Wouters, Erik;
- van de Vooren, Mandy;
- Woike, Nina;
- Mihov, George;
- Thies, Jens C.;
- Creemers, Laura B.;
- Tryfonidou, Marianna A.;
- Meij, Björn P.
Publication type:
Article
Single-Stage Cell-Based Cartilage Regeneration Using a Combination of Chondrons and Mesenchymal Stromal Cells: Comparison With Microfracture.
Published in:
American Journal of Sports Medicine, 2013, v. 41, n. 9, p. 2158, doi. 10.1177/0363546513494181
By:
- Bekkers, Joris E.J.;
- Tsuchida, Anika I.;
- van Rijen, Mattie H.P.;
- Vonk, Lucienne A.;
- Dhert, Wouter J.A.;
- Creemers, Laura B.;
- Saris, Daniel B.F.
Publication type:
Article
Articular Cartilage Evaluation After TruFit Plug Implantation Analyzed by Delayed Gadolinium-Enhanced MRI of Cartilage (dGEMRIC)
Published in:
2013
By:
- Bekkers, Joris E.J.;
- Bartels, Lambertus W.;
- Vincken, Koen L.;
- Dhert, Wouter J.A.;
- Creemers, Laura B.;
- Saris, Daniel B.F.
Publication type:
Journal Article
Articular Cartilage Evaluation After TruFit Plug Implantation Analyzed by Delayed Gadolinium-Enhanced MRI of Cartilage (dGEMRIC).
Published in:
American Journal of Sports Medicine, 2013, v. 41, n. 6, p. 1290, doi. 10.1177/0363546513483536
By:
- Bekkers, Joris E.J.;
- Bartels, Lambertus W.;
- Vincken, Koen L.;
- Dhert, Wouter J.A.;
- Creemers, Laura B.;
- Saris, Daniel B.F.
Publication type:
Article
Patient Profiling in Cartilage Regeneration.
Published in:
American Journal of Sports Medicine, 2009, v. 37, n. 1, p. 58S, doi. 10.1177/0363546509349765
By:
- de Windt, Tommy S.;
- Bekkers, Joris E. J.;
- Creemers, Laura B.;
- Dhert, Wouter J. A.;
- Saris, Daniël B. F.
Publication type:
Article
Bone Morphogenetic Proteins for Nucleus Pulposus Regeneration.
Published in:
International Journal of Molecular Sciences, 2020, v. 21, n. 8, p. 2720, doi. 10.3390/ijms21082720
By:
- Krouwels, Anita;
- Iljas, Juvita D.;
- Kragten, Angela H. M.;
- Dhert, Wouter J. A.;
- Öner, F. Cumhur;
- Tryfonidou, Marianna A.;
- Creemers, Laura B.
Publication type:
Article
Celecoxib alleviates nociceptor sensitization mediated by interleukin-1beta-primed annulus fibrosus cells.
Published in:
European Spine Journal, 2023, v. 32, n. 6, p. 2048, doi. 10.1007/s00586-023-07672-x
By:
- Ma, Junxuan;
- Häne, Surya;
- Eglauf, Janick;
- Pfannkuche, Judith;
- Soubrier, Astrid;
- Li, Zhen;
- Peroglio, Marianna;
- Hoppe, Sven;
- Benneker, Lorin;
- Lang, Gernot;
- Wangler, Sebastian;
- Alini, Mauro;
- Creemers, Laura B.;
- Grad, Sibylle;
- Häckel, Sonja
Publication type:
Article
Proinflammatory intervertebral disc cell and organ culture models induced by tumor necrosis factor alpha.
Published in:
JOR Spine, 2020, v. 3, n. 3, p. 1, doi. 10.1002/jsp2.1104
By:
- Du, Jie;
- Pfannkuche, Judith‐J.;
- Lang, Gernot;
- Häckel, Sonja;
- Creemers, Laura B.;
- Alini, Mauro;
- Grad, Sibylle;
- Li, Zhen
Publication type:
Article
Hedgehog proteins and parathyroid hormone‐related protein are involved in intervertebral disc maturation, degeneration, and calcification.
Published in:
JOR Spine, 2019, v. 2, n. 4, p. N.PAG, doi. 10.1002/jsp2.1071
By:
- Bach, Frances C.;
- Rooij, Kim M.;
- Riemers, Frank M.;
- Snuggs, Joseph W.;
- Jong, Willem A. M.;
- Zhang, Ying;
- Creemers, Laura B.;
- Chan, Danny;
- Le Maitre, Christine;
- Tryfonidou, Marianna A.
Publication type:
Article
Successful fishing for nucleus pulposus progenitor cells of the intervertebral disc across species.
Published in:
JOR Spine, 2018, v. 1, n. 2, p. 1, doi. 10.1002/jsp2.1018
By:
- Sakai, Daisuke;
- Schol, Jordy;
- Bach, Frances C.;
- Tekari, Adel;
- Sagawa, Nobuho;
- Nakamura, Yoshihiko;
- Chan, Samantha C.W.;
- Nakai, Tomoko;
- Creemers, Laura B.;
- Frauchiger, Daniela A.;
- May, Rahel D.;
- Grad, Sibylle;
- Watanabe, Masahiko;
- Tryfonidou, Marianna A.;
- Gantenbein, Benjamin
Publication type:
Article
Intra-articular Administration of Triamcinolone Acetonide in a Murine Cartilage Defect Model Reduces Inflammation but Inhibits Endogenous Cartilage Repair.
Published in:
American Journal of Sports Medicine, 2022, v. 50, n. 6, p. 1668, doi. 10.1177/03635465221083693
By:
- Wesdorp, Marinus A.;
- Capar, Serdar;
- Bastiaansen-Jenniskens, Yvonne M.;
- Kops, Nicole;
- Creemers, Laura B.;
- Verhaar, Jan A.N.;
- Van Osch, Gerjo J.V.M.;
- Wei, Wu
Publication type:
Article
Inflammatory profiles in canine intervertebral disc degeneration.
Published in:
BMC Veterinary Research, 2016, v. 12, p. 1, doi. 10.1186/s12917-016-0635-6
By:
- Willems, Nicole;
- Tellegen, Anna R.;
- Bergknut, Niklas;
- Creemers, Laura B.;
- Wolfswinkel, Jeannette;
- Freudigmann, Christian;
- Benz, Karin;
- Grinwis, Guy C. M.;
- Tryfonidou, Marianna A.;
- Meij, Björn P.
Publication type:
Article
Of Mice, Men and Elephants: The Relation between Articular Cartilage Thickness and Body Mass.
Published in:
PLoS ONE, 2013, v. 8, n. 2, p. 1, doi. 10.1371/journal.pone.0057683
By:
- Malda, Jos;
- de Grauw, Janny C.;
- Benders, Kim E. M.;
- Kik, Marja J. L.;
- van de Lest, Chris H. A.;
- Creemers, Laura B.;
- Dhert, Wouter J. A.;
- van Weeren, P. René
Publication type:
Article
Concise Review: Unraveling Stem Cell Cocultures in Regenerative Medicine: Which Cell Interactions Steer Cartilage Regeneration and How?
Published in:
Stem Cells Translational Medicine, 2014, v. 3, n. 6, p. 723, doi. 10.5966/sctm.2013-0207
By:
- DE WINDT, TOMMY S.;
- HENDRIKS, JEANINE A. A.;
- XING ZHAO;
- VONK, LUCIENNE A.;
- CREEMERS, LAURA B.;
- DHERT, WOUTER J. A.;
- RANDOLPH, MARK A.;
- SARIS, DANIEL B. F.
Publication type:
Article
The function of CD146 in human annulus fibrosus cells and mechanism of the regulation by TGF‐β.
Published in:
Journal of Orthopaedic Research, 2022, v. 40, n. 7, p. 1661, doi. 10.1002/jor.25190
By:
- Du, Jie;
- Guo, Wei;
- Häckel, Sonja;
- Hoppe, Sven;
- Garcia, João P.;
- Alini, Mauro;
- Tryfonidou, Marianna A.;
- Creemers, Laura B.;
- Grad, Sibylle;
- Li, Zhen
Publication type:
Article
Comparison of annulus fibrosus cell collagen remodeling rates in a microtissue system.
Published in:
Journal of Orthopaedic Research, 2021, v. 39, n. 9, p. 1955, doi. 10.1002/jor.24921
By:
- Tromp, Isabel N.;
- Foolen, Jasper;
- van Doeselaar, Marina;
- Zhang, Ying;
- Chan, Danny;
- Kruyt, Moyo C.;
- Creemers, Laura B.;
- Castelein, Rene M.;
- Ito, Keita
Publication type:
Article
Dog as a Model for Osteoarthritis: The FGF4 Retrogene Insertion May Matter.
Published in:
Journal of Orthopaedic Research, 2019, v. 37, n. 12, p. 2550, doi. 10.1002/jor.24432
By:
- Tellegen, Anna R.;
- Dessing, Aileen J.;
- Houben, Kaat;
- Riemers, Frank M.;
- Creemers, Laura B.;
- Mastbergen, Simon C.;
- Meij, Björn P.;
- Miranda‐Bedate, Alberto;
- Tryfonidou, Marianna A.
Publication type:
Article
Safety of intradiscal injection and biocompatibility of polyester amide microspheres in a canine model predisposed to intervertebral disc degeneration.
Published in:
Journal of Biomedical Materials Research, Part B: Applied Biomaterials, 2017, v. 105, n. 4, p. 707, doi. 10.1002/jbm.b.33579
By:
- Willems, Nicole;
- Mihov, George;
- Grinwis, Guy C.M.;
- van Dijk, Maarten;
- Schumann, Detlef;
- Bos, Clemens;
- Strijkers, Gustav J.;
- Dhert, Wouter J.A.;
- Meij, Björn P.;
- Creemers, Laura B.;
- Tryfonidou, Marianna A.
Publication type:
Article
Increased caveolin-1 in intervertebral disc degeneration facilitates repair.
Published in:
Arthritis Research & Therapy, 2016, v. 18, p. 1, doi. 10.1186/s13075-016-0960-y
By:
- Bach, Frances C.;
- Ying Zhang;
- Miranda-Bedate, Alberto;
- Verdonschot, Lucy C.;
- Bergknut, Niklas;
- Creemers, Laura B.;
- Ito, Keita;
- Sakai, Daisuke;
- Chan, Danny;
- Meij, Björn P.;
- Tryfonidou, Marianna A.
Publication type:
Article
Nerves are more abundant than blood vessels in the degenerate human intervertebral disc.
Published in:
Arthritis Research & Therapy, 2015, v. 17, p. 1, doi. 10.1186/s13075-015-0889-6
By:
- Binch, Abbie L. A.;
- Cole, Ashley A.;
- Breakwell, Lee M.;
- Michael, Antony L. R.;
- Chiverton, Neil;
- Creemers, Laura B.;
- Cross, Alison K.;
- Le Maitre, Christine L.
Publication type:
Article
Biocompatibility and intradiscal application of a thermoreversible celecoxib-loaded poly-N-isopropylacrylamide MgFe-layered double hydroxide hydrogel in a canine model.
Published in:
Arthritis Research & Therapy, 2015, v. 17, n. 1, p. 1, doi. 10.1186/s13075-015-0727-x
By:
- Willems, Nicole;
- Hsiao-yin Yang;
- Langelaan, Marloes L. P.;
- Tellegen, Anna R.;
- Grinwis, Guy C. M.;
- Kranenburg, Hendrik-Jan C.;
- Riemers, Frank M.;
- Plomp, Saskia G. M.;
- Craenmehr, Eric G. M.;
- Dhert, Wouter J. A.;
- Papen-Botterhuis, Nicole E.;
- Meij, Björn P.;
- Creemers, Laura B.;
- Tryfonidou, Marianna A.
Publication type:
Article
Intradiscal application of rhBMP-7 does not induce regeneration in a canine model of spontaneous intervertebral disc degeneration.
Published in:
Arthritis Research & Therapy, 2015, v. 17, n. 1, p. 1, doi. 10.1186/s13075-015-0625-2
By:
- Willems, Nicole;
- Bach, Frances C.;
- Plomp, Saskia G. M.;
- van Rijen, Mattie H. P.;
- Wolfswinkel, Jeannette;
- Grinwis, Guy C. M.;
- Bos, Clemens;
- Strijkers, Gustav J.;
- Dhert, Wouter J. A.;
- Meij, Björn P.;
- Creemers, Laura B.;
- Tryfonidou, Marianna A.
Publication type:
Article
Cytokine profiles in the joint depend on pathology, but are different between synovial fluid, cartilage tissue and cultured chondrocytes.
Published in:
Arthritis Research & Therapy, 2014, v. 16, n. 5, p. 1, doi. 10.1186/s13075-014-0441-0
By:
- Tsuchida, Anika I.;
- Beekhuizen, Michiel;
- 't Hart, Marieke C.;
- Radstake, Timothy R. D. J.;
- Dhert, Wouter J. A.;
- Saris, Daniel B. F.;
- van Osch, Gerjo J. V. M.;
- Creemers, Laura B.
Publication type:
Article
Gene expression profiling of early intervertebral disc degeneration reveals a down-regulation of canonical Wnt signaling and caveolin-1 expression: implications for development of regenerative strategies.
Published in:
Arthritis Research & Therapy, 2013, v. 15, n. 1, p. 1, doi. 10.1186/ar4157
By:
- Smolders, Lucas A.;
- Meij, Björn P.;
- Onis, David;
- Riemers, Frank M.;
- Bergknut, Niklas;
- Wubbolts, Richard;
- Grinwis, Guy C. M.;
- Houweling, Martin;
- Groot Koerkamp, Marian J. A.;
- van Leenen, Dik;
- Holstege, Frank C. P.;
- Hazewinkel, Herman A. W.;
- Creemers, Laura B.;
- Penning, Louis C.;
- Tryfonidou, Marianna A.
Publication type:
Article
Interleukin-6 is elevated in synovial fluid of patients with focal cartilage defects and stimulates cartilage matrix production in an in vitro regeneration model.
Published in:
Arthritis Research & Therapy, 2012, v. 14, n. 6, p. 1, doi. 10.1186/ar4107
By:
- Tsuchida, Anika I.;
- Beekhuizen, Michiel;
- Rutgers, Marijn;
- van Osch, Gerjo J. V. M.;
- Bekkers, Joris E. J.;
- Bot, Arjan G. J.;
- Geurts, Bernd;
- Dhert, Wouter J.A.;
- Saris, Daniel B.F.;
- Creemers, Laura B.
Publication type:
Article
Harmonization and standardization of nucleus pulposus cell extraction and culture methods.
Published in:
JOR Spine, 2023, v. 6, n. 1, p. 1, doi. 10.1002/jsp2.1238
By:
- Basatvat, Shaghayegh;
- Bach, Frances C.;
- Barcellona, Marcos N.;
- Binch, Abbie L.;
- Buckley, Conor T.;
- Bueno, Brian;
- Chahine, Nadeen O.;
- Chee, Ana;
- Creemers, Laura B.;
- Dudli, Stefan;
- Fearing, Bailey;
- Ferguson, Stephen J.;
- Gansau, Jennifer;
- Gantenbein, Benjamin;
- Gawri, Rahul;
- Glaeser, Juliane D.;
- Grad, Sibylle;
- Guerrero, Julien;
- Haglund, Lisbet;
- Hernandez, Paula A.
Publication type:
Article
Hyperosmolar expansion medium improves nucleus pulposus cell phenotype.
Published in:
JOR Spine, 2022, v. 5, n. 3, p. 1, doi. 10.1002/jsp2.1219
By:
- Laagland, Lisanne T.;
- Bach, Frances C.;
- Creemers, Laura B.;
- Le Maitre, Christine L.;
- Poramba‐Liyanage, Deepani W.;
- Tryfonidou, Marianna A.
Publication type:
Article
Local controlled release of corticosteroids extends surgically induced joint instability by inhibiting tissue healing.
Published in:
2019
By:
- Rudnik‐Jansen, Imke;
- Tellegen, Anna R.;
- Pouran, Behdad;
- Schrijver, Karin;
- Meij, Björn P.;
- Emans, Pieter J.;
- Gendt, Erin;
- Thomas, Rachel E.;
- Kik, Marja J.L.;
- Visser, Huub M.;
- Weinans, Harrie;
- Egas, Annelies;
- Maarseveen, Erik;
- Woike, Nina;
- Mihov, George;
- Thies, Jens;
- Tryfonidou, Marianna A.;
- Creemers, Laura B.;
- Rudnik-Jansen, Imke;
- de Gendt, Erin
Publication type:
journal article
Polymeric Nanoparticles Enable mRNA Transfection and Its Translation in Intervertebral Disc and Human Joint Cells, Except for M1 Macrophages.
Published in:
Pharmaceutics, 2024, v. 16, n. 4, p. 438, doi. 10.3390/pharmaceutics16040438
By:
- Muenzebrock, Katrin Agnes;
- Ho, Fiona Y. W.;
- Pontes, Adriano P.;
- Jorquera-Cordero, Carla;
- Utomo, Lizette;
- Garcia, Joao Pedro;
- Willems, Paul C.;
- Welting, Tim J. M.;
- Rip, Jaap;
- Creemers, Laura B.
Publication type:
Article
Association between Oncostatin M Expression and Inflammatory Phenotype in Experimental Arthritis Models and Osteoarthritis Patients.
Published in:
Cells (2073-4409), 2021, v. 10, n. 3, p. 508, doi. 10.3390/cells10030508
By:
- Garcia, Joao Pedro;
- Utomo, Lizette;
- Rudnik-Jansen, Imke;
- Du, Jie;
- Zuithoff, Nicolaas P.A.;
- Krouwels, Anita;
- van Osch, Gerjo J.V.M.;
- Creemers, Laura B.;
- Colombini, Alessandra
Publication type:
Article
Intradiscal application of a PCLA–PEG–PCLA hydrogel loaded with celecoxib for the treatment of back pain in canines: What's in it for humans?
Published in:
Journal of Tissue Engineering & Regenerative Medicine, 2018, v. 12, n. 3, p. 642, doi. 10.1002/term.2483
By:
- Tellegen, Anna R.;
- Willems, Nicole;
- Beukers, Martijn;
- Grinwis, Guy C. M.;
- Plomp, Saskia G. M.;
- Bos, Clemens;
- van Dijk, Maarten;
- de Leeuw, Mike;
- Creemers, Laura B.;
- Tryfonidou, Marianna A.;
- Meij, Björn P.
Publication type:
Article
Osteogenic protein 1 does not stimulate a regenerative effect in cultured human degenerated nucleus pulposus tissue.
Published in:
Journal of Tissue Engineering & Regenerative Medicine, 2017, v. 11, n. 7, p. 2127, doi. 10.1002/term.2111
By:
- Dijk, Bart G. M.;
- Potier, Esther;
- Dijk, Maarten;
- Creemers, Laura B.;
- Ito, Keita
Publication type:
Article
Osteoarthritis treatment using autologous conditioned serum after placebo.
Published in:
Acta Orthopaedica, 2015, v. 86, n. 1, p. 114, doi. 10.3109/17453674.2014.950467
By:
- Rutgers, Marijn;
- Creemers, Laura B;
- Yang, Kiem Gie Auw;
- Raijmakers, Natasja J H;
- Dhert, Wouter J A;
- Saris, Daniel B F
Publication type:
Article
PLGA Nanoparticles Grafted with Hyaluronic Acid to Improve Site-Specificity and Drug Dose Delivery in Osteoarthritis Nanotherapy.
Published in:
Nanomaterials (2079-4991), 2022, v. 12, n. 13, p. 2248, doi. 10.3390/nano12132248
By:
- Zerrillo, Luana;
- Gigliobianco, Maria Rosa;
- D'Atri, Domenico;
- Garcia, Joao Pedro;
- Baldazzi, Fabio;
- Ridwan, Yanto;
- Fuentes, Gastón;
- Chan, Alan;
- Creemers, Laura B.;
- Censi, Roberta;
- Di Martino, Piera;
- Cruz, Luis J.
Publication type:
Article
Link-N: The missing link towards intervertebral disc repair is species-specific.
Published in:
PLoS ONE, 2017, v. 12, n. 11, p. 1, doi. 10.1371/journal.pone.0187831
By:
- Bach, Frances C.;
- Laagland, Lisanne T.;
- Grant, Michael P.;
- Creemers, Laura B.;
- Ito, Keita;
- Meij, Björn P.;
- Mwale, Fackson;
- Tryfonidou, Marianna A.
Publication type:
Article
Replacement of the medial tibial plateau by a metallic implant in a goat model.
Published in:
Journal of Orthopaedic Research, 2010, v. 28, n. 4, p. 429, doi. 10.1002/jor.21021
By:
- Custers, Roel J.H.;
- Saris, Daniel B.F.;
- Creemers, Laura B.;
- Verbout, Ab J.;
- van Rijen, Mattie H.P.;
- Mastbergen, Simon C.;
- Lafeber, Floris P.;
- Dhert, Wouter J.A.
Publication type:
Article
Cartilage damage caused by metal implants applied for the treatment of established localized cartilage defects in a rabbit model.
Published in:
Journal of Orthopaedic Research, 2009, v. 27, n. 1, p. 84, doi. 10.1002/jor.20709
By:
- Custers, Roel J.H.;
- Creemers, Laura B.;
- van Rijen, Mattie H.P.;
- Verbout, Ab J.;
- Saris, Daniel B.F.;
- Dhert, Wouter J.A.
Publication type:
Article
Antimicrobial activity of platelet-leukocyte gel against Staphylococcus aureus.
Published in:
Journal of Orthopaedic Research, 2008, v. 26, n. 3, p. 404, doi. 10.1002/jor.20519
By:
- Moojen, Dirk Jan F.;
- Everts, Peter A.M.;
- Schure, Rose-Minke;
- Overdevest, Ed P.;
- van Zundert, André;
- Knape, Johannes T.A.;
- Castelein, René M.;
- Creemers, Laura B.;
- Dhert, Wouter J.A.
Publication type:
Article

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