OpenURL Connection Search

Select item for more details and to access through your institution.

Drugging the undruggable RAS: Mission Possible?
Published in:
Nature Reviews Drug Discovery, 2014, v. 13, n. 11, p. 828, doi. 10.1038/nrd4389
By:
- Cox, Adrienne D.;
- Fesik, Stephen W.;
- Kimmelman, Alec C.;
- Luo, Ji;
- Der, Channing J.
Publication type:
Article
Geranylgeranyltransferase I as a target for anti-cancer drugs.
Published in:
Journal of Clinical Investigation, 2007, v. 117, n. 5, p. 1223, doi. 10.1172/JCI32108
By:
- Philips, Mark R.;
- Cox, Adrienne D.
Publication type:
Article
Guanine nucleotide exchange factors: Activators of Ras superfamily proteins.
Published in:
Molecular Reproduction & Development, 1995, v. 42, n. 4, p. 468, doi. 10.1002/mrd.1080420415
By:
- Overbeck, Ashley F.;
- Brtva, Teresa R.;
- Cox, Adrienne D.;
- Graham, Suzanne M.;
- Huff, Shayne Y.;
- Khosravi-Far, Roya;
- Quilliam, Lawrence A.;
- Solski, Patricia A.;
- Der, Channing J.
Publication type:
Article
Application of a MYC degradation screen identifies sensitivity to CDK9 inhibitors in KRAS-mutant pancreatic cancer.
Published in:
Science Signaling, 2019, v. 12, n. 590, p. 1, doi. 10.1126/scisignal.aav7259
By:
- Blake, Devon R.;
- Vaseva, Angelina V.;
- Hodge, Richard G.;
- Kline, McKenzie P.;
- Gilbert, Thomas S. K.;
- Tyagi, Vikas;
- Huang, Daowei;
- Whiten, Gabrielle C.;
- Larson, Jacob E.;
- Wang, Xiaodong;
- Pearce, Kenneth H.;
- Herring, Laura E.;
- Graves, Lee M.;
- Frye, Stephen V.;
- Emanuele, Michael J.;
- Cox, Adrienne D.;
- Der, Channing J.
Publication type:
Article
Evaluation of the selectivity and sensitivity of isoform- and mutation-specific RAS antibodies.
Published in:
Science Signaling, 2017, v. 10, n. 498, p. 1, doi. 10.1126/scisignal.aao3332
By:
- Waters, Andrew M.;
- Ozkan-Dagliyan, Irem;
- Vaseva, Angelina V.;
- Fer, Nicole;
- Strathern, Leslie A.;
- Hobbs, G. Aaron;
- Tessier-Cloutier, Basile;
- Gillette, William K.;
- Bagni, Rachel;
- Whiteley, Gordon R.;
- Hartley, James L.;
- McCormick, Frank;
- Cox, Adrienne D.;
- Houghton, Peter J.;
- Huntsman, David G.;
- Philips, Mark R.;
- Der, Channing J.
Publication type:
Article
Up-front polytherapy for ALK-positive lung cancer.
Published in:
Nature Medicine, 2015, v. 21, n. 9, p. 974, doi. 10.1038/nm.3942
By:
- Zhou, Bingying;
- Cox, Adrienne D
Publication type:
Article
The C. elegans Chp/Wrch Ortholog CHW-1 Contributes to LIN-18/Ryk and LIN-17/Frizzled Signaling in Cell Polarity.
Published in:
PLoS ONE, 2015, v. 10, n. 7, p. 1, doi. 10.1371/journal.pone.0133226
By:
- IIIKidd, Ambrose R.;
- Muñiz-Medina, Vanessa;
- Der, Channing J.;
- Cox, Adrienne D.;
- Reiner, David J.
Publication type:
Article
Src-Mediated Phosphorylation of the Tyrosine Phosphatase PRL-3 Is Required for PRL-3 Promotion of Rho Activation, Motility and Invasion
Published in:
PLoS ONE, 2013, v. 8, n. 5, p. 1, doi. 10.1371/journal.pone.0064309
By:
- Fiordalisi, James J.;
- Dewar, Brian J.;
- Graves, Lee M.;
- Madigan, James P.;
- Cox, Adrienne D.
Publication type:
Article
Role of TC21/R-Ras2 in enhanced migration of neurofibromin-deficient Schwann cells.
Published in:
Oncogene, 2004, v. 23, n. 2, p. 368, doi. 10.1038/sj.onc.1207075
By:
- Yuan Huang;
- Rangwala, Fatima;
- Fulkerson, Patricia C.;
- Bo Ling;
- Reed, Erin;
- Cox, Adrienne D.;
- Kamholz, John;
- Ratner, Nancy
Publication type:
Article
The dark side of Ras: regulation of apoptosis.
Published in:
Oncogene, 2003, v. 22, n. 56, p. 8999, doi. 10.1038/sj.onc.1207111
By:
- Cox, Adrienne D.;
- Der, Channing J.
Publication type:
Article
R-Ras C-terminal sequences are sufficient to confer R-Ras specificity to H-Ras.
Published in:
Oncogene, 2002, v. 21, n. 28, p. 4448, doi. 10.1038/sj.onc.1205538
By:
- Hansen, Malene;
- Rusyn, Elena V.;
- Hughes, Paul E.;
- Ginsberg, Mark H.;
- Cox, Adrienne D.;
- Willumsen, Berthe M.
Publication type:
Article
RALA and RALBP1 regulate mitochondrial fission at mitosis.
Published in:
Nature Cell Biology, 2011, v. 13, n. 9, p. 1108, doi. 10.1038/ncb2310
By:
- Kashatus, David F.;
- Lim, Kian-Huat;
- Brady, Donita C.;
- Pershing, Nicole L. K.;
- Cox, Adrienne D.;
- Counter, Christopher M.
Publication type:
Article
Ras signalling on the endoplasmic reticulum and the Golgi.
Published in:
Nature Cell Biology, 2002, v. 4, n. 5, p. 343, doi. 10.1038/ncb783
By:
- Chiu, Vi K.;
- Bivona, Trever;
- Hach, Angela;
- Sajous, J. Bernard;
- Silletti, Joseph;
- Wiener, Heidi;
- Johnson, Ronald L.;
- Cox, Adrienne D.;
- Philips, Mark R.
Publication type:
Article
Rit, a non-lipid-modified Ras-related protein, transforms NIH3T3 cells without activating the ERK, JNK, p38 MAPK or PI3K/Akt pathways.
Published in:
Oncogene, 2000, v. 19, n. 41, p. 4685, doi. 10.1038/sj.onc.1203836
By:
- Rusyn, Elena V;
- Reynolds, Evangeline R;
- Shao, Haipeng;
- Grana, Theresa M;
- Chan, Tung O;
- Andres, Douglas A;
- Cox, Adrienne D
Publication type:
Article
Ras, but not Src, transformation of RIE-1 epithelial cells is dependent on activation of the mitogen-activated protein kinase cascade.
Published in:
Oncogene, 1998, v. 16, n. 20, p. 2565, doi. 10.1038/sj.onc.1201784
By:
- Oldham, Sean M.;
- Cox, Adrienne D.;
- Reynolds, Evangeline R.;
- Sizemore, Nywana S.;
- Coffey, Jr., Robert J.;
- Der, Channing J.
Publication type:
Article
R-Ras is regulated by activators and effectors distinct from those that control Ras function.
Published in:
Oncogene, 1997, v. 14, n. 2, p. 133, doi. 10.1038/sj.onc.1200815
By:
- Huff, Shayne Y;
- Quilliam, Lawrence A;
- Cox, Adrienne D;
- Der, Channing J
Publication type:
Article
The oncogenic kinase Pim-1 is modulated by K-Ras signaling and mediates transformed growth and radioresistance in human pancreatic ductal adenocarcinoma cells.
Published in:
Carcinogenesis, 2011, v. 32, n. 4, p. 488
By:
- Xu, Dapeng;
- Allsop, Stephen A.;
- Witherspoon, Sam M.;
- Snider, Jared L.;
- Yeh, Jen Jen;
- Fiordalisi, James J.;
- White, Catherine D.;
- Williams, Daniel;
- Cox, Adrienne D.;
- Baines, Antonio T.
Publication type:
Article
Phospholipase C? activates Ras on the Golgi apparatus by means of RasGRP1.
Published in:
Nature, 2003, v. 424, n. 6949, p. 694, doi. 10.1038/nature01806
By:
- Bivona, Trever G.;
- Pérez de Castro, Ignacio;
- Ahearn, Ian M.;
- Grana, Theresa M.;
- Chiu, Vi K.;
- Lockyer, Peter J.;
- Cullen, Peter J.;
- Pellicer, Angel;
- Cox, Adrienne D.;
- Philips, Mark R.
Publication type:
Article
RHOA<sup>L57V</sup> drives the development of diffuse gastric cancer through IGF1R-PAK1-YAP1 signaling.
Published in:
Science Signaling, 2023, v. 16, n. 816, p. 1, doi. 10.1126/scisignal.adg5289
By:
- Schaefer, Antje;
- Hodge, Richard G.;
- Zhang, Haisheng;
- Hobbs, G. Aaron;
- Dilly, Julien;
- Huynh, Minh V.;
- Goodwin, Craig M.;
- Zhang, Feifei;
- Diehl, J. Nathaniel;
- Pierobon, Mariaelena;
- Baldelli, Elisa;
- Javaid, Sehrish;
- Guthrie, Karson;
- Rashid, Naim U.;
- Petricoin, Emanuel F.;
- Cox, Adrienne D.;
- Hahn, William C.;
- Aguirre, Andrew J.;
- Bass, Adam J.;
- Der, Channing J.
Publication type:
Article
Functional and biological heterogeneity of KRAS<sup>Q61</sup> mutations.
Published in:
Science Signaling, 2022, v. 15, n. 746, p. 1, doi. 10.1126/scisignal.abn2694
By:
- Huynh, Minh V.;
- Hobbs, G. Aaron;
- Schaefer, Antje;
- Pierobon, Mariaelena;
- Carey, Leiah M.;
- Diehl, J. Nathaniel;
- DeLiberty, Jonathan M.;
- Thurman, Ryan D.;
- Cooke, Adelaide R.;
- Goodwin, Craig M.;
- Cook, Joshua H.;
- Lin, Lin;
- Waters, Andrew M.;
- Rashid, Naim U.;
- Petricoin III, Emanuel F.;
- Campbell, Sharon L.;
- Haigis, Kevin M.;
- Simeone, Diane M.;
- Lyssiotis, Costas A.;
- Cox, Adrienne D.
Publication type:
Article
Protein localization: Can too much lipid glue stop Ras?
Published in:
Nature Chemical Biology, 2010, v. 6, n. 7, p. 483, doi. 10.1038/nchembio.399
By:
- Cox, Adrienne D.
Publication type:
Article
TLN-4601 suppresses growth and inducesapoptosis of pancreatic carcinoma cells throughinhibition of Ras-ERK MAPK signaling.
Published in:
Journal of Molecular Signaling, 2010, v. 5, p. 18, doi. 10.1186/1750-2187-5-18
By:
- Campbell, Paul M.;
- Boufaied, Nadia;
- Fiordalisi, James J.;
- Cox, Adrienne D.;
- Falardeau, Pierre;
- Der, Channing J.;
- Gourdeau, Henriette
Publication type:
Article
Genetic and functional characterization of putative Ras/Raf interaction inhibitors in C. elegans and mammalian cells.
Published in:
Journal of Molecular Signaling, 2010, v. 5, p. 1, doi. 10.1186/1750-2187-5-2
By:
- González-Pérez, Vanessa;
- Reiner, David J.;
- Alan, Jamie K.;
- Mitchell, Cicely;
- Edwards, Lloyd J.;
- Khazak, Vladimir;
- Der, Channing J.;
- Cox, Adrienne D.
Publication type:
Article

Found: 23