Works by Cowman, Alan F.

Results: 101

Structure–activity analysis of imino‐pyrimidinone‐fused pyrrolidines aids the development of dual plasmepsin V and plasmepsin X inhibitors.

Published in:

FEBS Journal, 2025, v. 292, n. 11, p. 2843, doi. 10.1111/febs.70038

By:

Hodder, Anthony N.;
Sleebs, Brad E.;
Adams, Greg;
Rezazadeh, Sina;
Ngo, Anna;
Jarman, Kate;
Scally, Stephen;
Czabotar, Peter;
Wang, Hongwu;
McCauley, John A.;
Olsen, David B.;
Cowman, Alan F.

Publication type:

Article

Moving in and renovating: exporting proteins from Plasmodium into host erythrocytes.

Published in:

Nature Reviews Microbiology, 2010, v. 8, n. 9, p. 617, doi. 10.1038/nrmicro2420

By:

Goldberg, Daniel E.;
Cowman, Alan F.

Publication type:

Article

Inhibition of Plasmepsin V Activity Demonstrates Its Essential Role in Protein Export, PfEMP1 Display, and Survival of Malaria Parasites.

Published in:

PLoS Biology, 2014, v. 12, n. 7, p. 1, doi. 10.1371/journal.pbio.1001897

By:

Sleebs, Brad E.;
Lopaticki, Sash;
Marapana, Danushka S.;
O'Neill, Matthew T.;
Rajasekaran, Pravin;
Gazdik, Michelle;
Günther, Svenja;
Whitehead, Lachlan W.;
Lowes, Kym N.;
Barfod, Lea;
Hviid, Lars;
Shaw, Philip J.;
Hodder, Anthony N.;
Smith, Brian J.;
Cowman, Alan F.;
Boddey, Justin A.

Publication type:

Article

Sir2 Paralogues Cooperate to Regulate Virulence Genes and Antigenic Variation in Plasmodium falciparum.

Published in:

PLoS Biology, 2009, v. 7, n. 4, p. 0771, doi. 10.1371/journal.pbio.1000084

By:

Tonkin, Christopher J.;
Carret, Céline K.;
Duraisingh, Manoj T.;
Voss, Till S.;
Ralph, Stuart A.;
Hommel, Mirja;
Duffy, Michael F.;
da Silva, Liliana Mancio;
Scherf, Artur;
Ivens, Alasdair;
Speed, Terence P.;
Beeson, James G.;
Cowman, Alan F.

Publication type:

Article

Immune sera recognize on erythrocytes a Plasmodium falciparum antigen composed of repeated amino acid sequences.

Published in:

Nature, 1984, v. 310, n. 5980, p. 789, doi. 10.1038/310789a0

By:

Coppel, Ross L.;
Cowman, Alan F.;
Anders, Robin F.;
Bianco, Albert E.;
Saint, Robert B.;
Lingelbach, Klaus R.;
Kemp, David J.;
Brown, Graham V.

Publication type:

Article

Isolate-specific S-antigen of Plasmodium falciparum contains a repeated sequence of eleven amino acids.

Published in:

Nature, 1983, v. 306, n. 5945, p. 751, doi. 10.1038/306751a0

By:

Coppel, Ross L.;
Cowman, Alan F.;
Lingelbach, Klaus R.;
Brown, Graham V.;
Saint, Robert B.;
Kemp, David J.;
Anders, Robin F.

Publication type:

Article

Production of RNA for secreted immunoglobulin μ chains does not require transcriptional termination 5′ to the μ<sub>M</sub> exons.

Published in:

Nature, 1983, v. 301, n. 5895, p. 84, doi. 10.1038/301084a0

By:

Kemp, David J.;
Morahan, Grant;
Cowman, Alan F.;
Harris, Alan W.

Publication type:

Article

Targeted mutagenesis of Plasmodium falciparum erythrocyte membrane protein 3 (PfEMP3) disrupts cytoadherence of malaria-infected red blood cells.

Published in:

2000

By:

Waterkeyn, Jacqueline G.;
Wickham, Mark E.;
Davern, Kathleen M.;
Cooke, Brian M.;
Coppel, Ross L.;
Reeder, John C.;
Culvenor, Janetta G.;
Waller, Ross F.;
Cowman, Alan F.

Publication type:

Arts/Entertainment Review

RAP1 controls rhoptry targeting of RAP2 in the malaria parasite Plasmodium falciparum.

Published in:

EMBO Journal, 2000, v. 19, n. 11, p. 2435, doi. 10.1093/emboj/19.11.2435

By:

Baldi, Deborah L.;
Andrews, Katherine T.;
Waller, Ross F.;
Roos, David S.;
Howard, Randall F.;
Crabb, Brendan S.;
Cowman, Alan F.

Publication type:

Article

Protein trafficking to the plastid of Plasmodium falciparum is via the secretory pathway.

Published in:

EMBO Journal, 2000, v. 19, n. 8, p. 1794, doi. 10.1093/emboj/19.8.1794

By:

Waller, Ross F.;
Reed, Michael B.;
Cowman, Alan F.;
McFadden, Geoffrey I.

Publication type:

Article

Allelic exchange at the endogenous genomic locus in Plasmodium falciparum proves the role of dihydropteroate synthase in sulfadoxine-resistant malaria.

Published in:

EMBO Journal, 1998, v. 17, n. 14, p. 3807, doi. 10.1093/emboj/17.14.3807

By:

Triglia, Tony;
Ping Wang;
Sims, Paul F. G.;
Hyde, John E.;
Cowman, Alan F.

Publication type:

Article

Molecular profiling reveals features of clinical immunity and immunosuppression in asymptomatic P. falciparum malaria.

Published in:

Molecular Systems Biology, 2022, v. 18, n. 4, p. 1, doi. 10.15252/msb.202110824

By:

Studniberg, Stephanie I;
Ioannidis, Lisa J;
Utami, Retno A S;
Trianty, Leily;
Liao, Yang;
Abeysekera, Waruni;
Li‐Wai‐Suen, Connie S N;
Pietrzak, Halina M;
Healer, Julie;
Puspitasari, Agatha M;
Apriyanti, Dwi;
Coutrier, Farah;
Poespoprodjo, Jeanne R;
Kenangalem, Enny;
Andries, Benediktus;
Prayoga, Pak;
Sariyanti, Novita;
Smyth, Gordon K;
Cowman, Alan F;
Price, Ric N

Publication type:

Article

Malaria parasite proteins that remodel the host erythrocyte.

Published in:

Nature Reviews Microbiology, 2009, v. 7, n. 5, p. 341, doi. 10.1038/nrmicro2110

By:

Maier, Alexander G.;
Cooke, Brian M.;
Cowman, Alan F.;
Tilley, Leann

Publication type:

Article

Regulation of apicomplexan actin-based motility.

Published in:

Nature Reviews Microbiology, 2006, v. 4, n. 8, p. 621, doi. 10.1038/nrmicro1465

By:

Baum, Jake;
Papenfuss, Anthony T.;
Baum, Buzz;
Speed, Terence P.;
Cowman, Alan F.

Publication type:

Article

A var gene promoter controls allelic exclusion of virulence genes in Plasmodium falciparum malaria.

Published in:

Nature, 2006, v. 439, n. 7079, p. 1004, doi. 10.1038/nature04407

By:

Voss, Till S.;
Healer, Julie;
Marty, Allison J.;
Duffy, Michael F.;
Thompson, Jennifer K.;
Beeson, James G.;
Reeder, John C.;
Crabb, Brendan S.;
Cowman, Alan F.

Publication type:

Article

Alterations in local chromatin environment are involved in silencing and activation of subtelomeric var genes in Plasmodium falciparum.

Published in:

Molecular Microbiology, 2007, v. 66, n. 1, p. 139, doi. 10.1111/j.1365-2958.2007.05899.x

By:

Voss, Till S.;
Tonkin, Christopher J.;
Marty, Allison J.;
Thompson, Jennifer K.;
Healer, Julie;
Crabb, Brendan S.;
Cowman, Alan F.

Publication type:

Article

Evidence that Plasmodium falciparum chromosome end clusters are cross-linked by protein and are the sites of both virulence gene silencing and activation.

Published in:

Molecular Microbiology, 2006, v. 62, n. 1, p. 72, doi. 10.1111/j.1365-2958.2006.05364.x

By:

Marty, Allison J.;
Thompson, Jennifer K.;
Duffy, Michael F.;
Voss, Till S.;
Cowman, Alan F.;
Crabb, Brendan S.

Publication type:

Article

Trafficking determinants for PfEMP3 export and assembly under the Plasmodium falciparum-infected red blood cell membrane.

Published in:

2006

By:

Knuepfer, Ellen;
Rug, Melanie;
Klonis, Nectarios;
Tilley, Leann;
Cowman, Alan F.

Publication type:

Correction Notice

Trafficking determinants for PfEMP3 export and assembly under the Plasmodium falciparum-infected red blood cell membrane.

Published in:

Molecular Microbiology, 2005, v. 58, n. 4, p. 1039, doi. 10.1111/j.1365-2958.2005.04895.x

By:

Knuepfer, Ellen;
Rug, Melanie;
Klonis, Nectarios;
Tilley, Leann;
Cowman, Alan F.

Publication type:

Article

Development of the endoplasmic reticulum, mitochondrion and apicoplast during the asexual life cycle of Plasmodium falciparum.

Published in:

Molecular Microbiology, 2005, v. 57, n. 2, p. 405, doi. 10.1111/j.1365-2958.2005.04699.x

By:

van Dooren, Giel G.;
Marti, Matthias;
Tonkin, Christopher J.;
Stimmler, Luciana M.;
Cowman, Alan F.;
McFadden, Geoffrey I.

Publication type:

Article

Reticulocyte-binding protein homologue 1 is required for sialic acid-dependent invasion into human erythrocytes byPlasmodium falciparum.

Published in:

Molecular Microbiology, 2005, v. 55, n. 1, p. 162, doi. 10.1111/j.1365-2958.2004.04388.x

By:

Triglia, Tony;
Duraisingh, Manoj T.;
Good, Robert T.;
Cowman, Alan F.

Publication type:

Article

Allelic polymorphisms in apical membrane antigen-1 are responsible for evasion of antibody-mediated inhibition in Plasmodium falciparum.

Published in:

Molecular Microbiology, 2004, v. 52, n. 1, p. 159, doi. 10.1111/j.1365-2958.2003.03974.x

By:

Healer, Julie;
Murphy, Vince;
Hodder, Anthony N.;
Masciantonio, Rosella;
Gemmill, Alan W.;
Anders, Robin F.;
Cowman, Alan F.;
Batchelor, Adrian

Publication type:

Article

Truncation of merozoite surface protein 3 disrupts its trafficking and that of acidic–basic repeat protein to the surface of Plasmodium falciparum merozoites.

Published in:

Molecular Microbiology, 2002, v. 43, n. 6, p. 1401, doi. 10.1046/j.1365-2958.2002.02834.x

By:

Mills, Kerry E;
Pearce, J. Andrew;
Crabb, Brendan S;
Cowman, Alan F

Publication type:

Article

Transcription of multiple var genes by individual, trophozoite-stagePlasmodium falciparum cells expressing a chondroitin sulphate A binding phenotype.

Published in:

Molecular Microbiology, 2002, v. 43, n. 5, p. 1285, doi. 10.1046/j.1365-2958.2002.02822.x

By:

Duffy, Michael F;
Brown, Graham V;
Basuki, Wanny;
Krejany, Efrosinia O;
Noviyanti, Rintis;
Cowman, Alan F;
Reeder, John C

Publication type:

Article

A novel ligand from Plasmodium falciparum that binds to a sialic acid-containing receptor on the surface of human erythrocytes.

Published in:

Molecular Microbiology, 2001, v. 41, n. 1, p. 47, doi. 10.1046/j.1365-2958.2001.02484.x

By:

Thompson, Jennifer K.;
Triglia, Tony;
Reed, Michael B.;
Cowman, Alan F.

Publication type:

Article

Apical membrane antigen 1 plays a central role in erythrocyte invasion by Plasmodium species.

Published in:

Molecular Microbiology, 2000, v. 38, n. 4, p. 706, doi. 10.1046/j.1365-2958.2000.02175.x

By:

Triglia, Tony;
Healer, Julie;
Caruana, Sonia R.;
Hodder, Anthony N.;
Anders, Robin F.;
Crabb, Brendan S.;
Cowman, Alan F.

Publication type:

Article

Molecular genetics and comparative genomics reveal RNAi is not functional in malaria parasites.

Published in:

Nucleic Acids Research, 2009, v. 37, n. 11, p. 3788, doi. 10.1093/nar/gkp239

By:

Baum, Jake;
Papenfuss, Anthony T.;
Mair, Gunnar R.;
Janse, Chris J.;
Vlachou, Dina;
Waters, Andrew P.;
Cowman, Alan F.;
Crabb, Brendan S.;
de Koning-Ward, Tania F.

Publication type:

Article

4D analysis of malaria parasite invasion offers insights into erythrocyte membrane remodeling and parasitophorous vacuole formation.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-23626-7

By:

Geoghegan, Niall D.;
Evelyn, Cindy;
Whitehead, Lachlan W.;
Pasternak, Michal;
McDonald, Phoebe;
Triglia, Tony;
Marapana, Danushka S.;
Kempe, Daryan;
Thompson, Jennifer K.;
Mlodzianoski, Michael J.;
Healer, Julie;
Biro, Maté;
Cowman, Alan F.;
Rogers, Kelly L.

Publication type:

Article

Targets of antibodies against Plasmodium falciparum-infected erythrocytes in malaria immunity.

Published in:

Journal of Clinical Investigation, 2012, v. 122, n. 9, p. 3227, doi. 10.1172/JCI62182

By:

Jo-Anne Chan;
Howell, Katherine B.;
Reiling, Linda;
Ataide, Ricardo;
Mackintosh, Claire L.;
Fowkes, Freya J. I.;
Petter, Michaela;
Chesson, Joanne M.;
Langer, Christine;
Warimwe, George M.;
Duffy, Michael F.;
Rogerson, Stephen J.;
Bull, Peter C.;
Cowman, Alan F.;
Marsh, Kevin;
Beeson, James G.

Publication type:

Article

Variation in use of erythrocyte invasion pathways by Plasmodium falciparum mediates evasion of human inhibitory antibodies.

Published in:

2008

By:

Persson, Kristina E. M.;
McCallum, Fiona J.;
Reiling, Linda;
Lister, Nicole A.;
Stubbs, Janine;
Cowman, Alan F.;
Marsh, Kevin;
Beeson, James G.

Publication type:

journal article

Generation of long mRNA for membrane immunoglobulin γ2a chains by differential splicing.

Published in:

Nature, 1981, v. 293, n. 5831, p. 406, doi. 10.1038/293406a0

By:

Tyler, Brett M.;
Cowman, Alan F.;
Adams, Jerry M.;
Harris, Alan W.

Publication type:

Article

Safety, infectivity and immunogenicity of a genetically attenuated blood-stage malaria vaccine.

Published in:

2021

By:

Webster, Rebecca;
Sekuloski, Silvana;
Odedra, Anand;
Woolley, Stephen;
Jennings, Helen;
Amante, Fiona;
Trenholme, Katharine R.;
Healer, Julie;
Cowman, Alan F.;
Eriksson, Emily M.;
Sathe, Priyanka;
Penington, Jocelyn;
Blanch, Adam J.;
Dixon, Matthew W. A.;
Tilley, Leann;
Duffy, Michael F.;
Craig, Alister;
Storm, Janet;
Chan, Jo-Anne;
Evans, Krystal

Publication type:

journal article

An old enemy, a new battle plan.

Published in:

EMBO Reports, 2001, v. 2, n. 2, p. 77, doi. 10.1093/embo-reports/kve032

By:

Cowman, Alan F.;
Duraisingh, Manoj T.

Publication type:

Article

RhopH2 and RhopH3 export enables assembly of the RhopH complex on P. falciparum-infected erythrocyte membranes.

Published in:

Communications Biology, 2022, v. 5, n. 1, p. 1, doi. 10.1038/s42003-022-03290-3

By:

Pasternak, Michał;
Verhoef, Julie M. J.;
Wong, Wilson;
Triglia, Tony;
Mlodzianoski, Michael J.;
Geoghegan, Niall;
Evelyn, Cindy;
Wardak, Ahmad Z.;
Rogers, Kelly;
Cowman, Alan F.

Publication type:

Article

Signal-mediated export of proteins from the malaria parasite to the host erythrocyte.

Published in:

Journal of Cell Biology, 2005, v. 171, n. 4, p. 587, doi. 10.1083/jcb.200508051

By:

Marti, Matthias;
Baum, Jake;
Rug, Melanie;
Tilley, Leann;
Cowman, Alan F.

Publication type:

Article

The cytoplasmic domain of the Plasmodium falciparum ligand EBA-175 is essential for invasion but not protein traffcking.

Published in:

Journal of Cell Biology, 2003, v. 162, n. 2, p. 317, doi. 10.1083/jcb.200301046

By:

Gilberger, Tim-Wolf;
Thompson, Jennifer K.;
Reed, Michael B.;
Good, Robert T.;
Cowman, Alan F.

Publication type:

Article

Role of Plasmepsin V in Export of Diverse Protein Families from the Plasmodium falciparum Exportome.

Published in:

Traffic, 2013, v. 14, n. 5, p. 532, doi. 10.1111/tra.12053

By:

Boddey, Justin A.;
Carvalho, Teresa G.;
Hodder, Anthony N.;
Sargeant, Tobias J.;
Sleebs, Brad E.;
Marapana, Danushka;
Lopaticki, Sash;
Nebl, Thomas;
Cowman, Alan F.

Publication type:

Article

Role of the Plasmodium Export Element in Trafficking Parasite Proteins to the Infected Erythrocyte.

Published in:

Traffic, 2009, v. 10, n. 3, p. 285, doi. 10.1111/j.1600-0854.2008.00864.x

By:

Boddey, Justin A.;
Moritz, Robert L.;
Simpson, Richard J.;
Cowman, Alan F.

Publication type:

Article

Plasmepsin X activates the PCRCR complex of Plasmodium falciparum by processing PfRh5 for erythrocyte invasion.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-37890-2

By:

Triglia, Tony;
Scally, Stephen W.;
Seager, Benjamin A.;
Pasternak, Michał;
Dagley, Laura F.;
Cowman, Alan F.

Publication type:

Article

Plasmepsin X activates the PCRCR complex of Plasmodium falciparum by processing PfRh5 for erythrocyte invasion.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-37890-2

By:

Triglia, Tony;
Scally, Stephen W.;
Seager, Benjamin A.;
Pasternak, Michał;
Dagley, Laura F.;
Cowman, Alan F.

Publication type:

Article

Unveiling malaria's "cloak of invisibility": The role of PfSET10 in the genetic control of P. falciparum virulence.

Published in:

Virulence, 2012, v. 3, n. 5, p. 449, doi. 10.4161/viru.20994

By:

Volz, Jennifer C.;
Cowman, Alan F.

Publication type:

Article

Alveolins, a New Family of Cortical Proteins that Define the Protist Infrakingdom Alveolata.

Published in:

Molecular Biology & Evolution, 2008, v. 25, n. 6, p. 1219, doi. 10.1093/molbev/msn070

By:

Gould, Sven B.;
Wai-Hong Tham;
Cowman, Alan F.;
McFadden, Geoffrey I.;
Waller, Ross F.

Publication type:

Article

A 4-cyano-3-methylisoquinoline inhibitor of Plasmodium falciparum growth targets the sodium efflux pump PfATP4.

Published in:

Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-46500-5

By:

Gilson, Paul R.;
Kumarasingha, Rasika;
Thompson, Jennifer;
Zhang, Xinxin;
Penington, Jocelyn Sietsma;
Kalhor, Robabeh;
Bullen, Hayley E.;
Lehane, Adele M.;
Dans, Madeline G.;
de Koning-Ward, Tania F.;
Holien, Jessica K.;
Soares da Costa, Tatiana P.;
Hulett, Mark D.;
Buskes, Melissa J.;
Crabb, Brendan S.;
Kirk, Kiaran;
Papenfuss, Anthony T.;
Cowman, Alan F.;
Abbott, Belinda M.

Publication type:

Article

Guided STED nanoscopy enables super-resolution imaging of blood stage malaria parasites.

Published in:

Scientific Reports, 2019, v. 9, n. 1, p. 1, doi. 10.1038/s41598-019-40718-z

By:

Schloetel, Jan-Gero;
Heine, Jörn;
Cowman, Alan F.;
Pasternak, Michał

Publication type:

Article

Association of antibodies to Plasmodium falciparum reticulocyte binding protein homolog 5 with protection from clinical malaria.

Published in:

Frontiers in Microbiology, 2014, v. 5, p. 1, doi. 10.3389/fmicb.2014.00314

By:

Chiu, ChrisY. H.;
Healer, Julie;
Thompson, Jennifer K.;
Lin Chen;
Aiki Kaul;
Savergave, Laxman;
Raghuwanshi, Arjun;
LiWai Suen, Connie S. N.;
Siba, Peter M.;
Schofield, Louis;
Mueller, Ivo;
Cowman, Alan F.;
Hansen, Diana S.

Publication type:

Article

An alteration in concatameric structure is associated with efficient segregation of plasmids in transfected Plasmodium falciparum parasites.

Published in:

Nucleic Acids Research, 2001, v. 29, n. 3, p. 716, doi. 10.1093/nar/29.3.716

By:

O’Donnell, Rebecca A.;
Preiser, Peter R.;
Williamson, Donald H.;
Moore, Peter W.;
Cowman, Alan F.;
Crabb, Brendan S.

Publication type:

Article

Association between Naturally Acquired Antibodies to Erythrocyte-Binding Antigens of Plasmodium falciparum and Protection from Malaria and High-Density Parasitemia.

Published in:

Clinical Infectious Diseases, 2010, v. 51, n. 8, p. e50, doi. 10.1086/656413

By:

Richards, Jack S.;
Stanisic, Danielle I.;
Fowkes, Freya J. I.;
Tavul, Livingstone;
Dabod, Elijah;
Thompson, Jennifer K.;
Kumar, Sanjeev;
Chitnis, Chetan E.;
Narum, David L.;
Michon, Pascal;
Siba, Peter M.;
Cowman, Alan F.;
Mueller, Ivo;
Beeson, James G.

Publication type:

Article

Plasmodium falciparum erythrocyte invasion through glycophorin C and selection for Gerbich negativity in human populations.

Published in:

Nature Medicine, 2003, v. 9, n. 1, p. 87, doi. 10.1038/nm807

By:

Maier, Alexander G.;
Duraisingh, Manoj T.;
Reeder, John C.;
Patel, Sheral S.;
Kazura, James W.;
Zimmerman, Peter A.;
Cowman, Alan F.

Publication type:

Article

Functional conservation of the malaria vaccine antigen MSP-1<sub>19</sub>across distantly related Plasmodium species.

Published in:

Nature Medicine, 2000, v. 6, n. 1, p. 91, doi. 10.1038/71595

By:

O'Donnell, Rebecca A.;
Saul, Allan;
Cowman, Alan F.;
Crabb, Brendan S.

Publication type:

Article

Monitoring for Plasmodium falciparum drug resistance to artemisinin and artesunate in Binh Phuoc Province, Vietnam: 1998-2009.

Published in:

Malaria Journal, 2010, v. 9, p. 181, doi. 10.1186/1475-2875-9-181

By:

Thanh, Ngo V.;
Toan, Tran Q.;
Cowman, Alan F.;
Casey, Gerard J.;
Phuc, Bui Q.;
Tien, Nong T.;
Hung, Nguyen M.;
Biggs, Beverley-Ann

Publication type:

Article