Works by Couñago, Rafael M.

Results: 15

Front Cover: (S)‐ML‐SA1 Activates Autophagy via TRPML1‐TFEB Pathway (ChemBioChem 22/2024).

Published in:

ChemBioChem, 2024, v. 25, n. 22, p. 1, doi. 10.1002/cbic.202482201

By:

Cunha, Micael R.;
Do Amaral, Bruno S.;
Takarada, Jéssica E.;
Valderrama, Gabriel V.;
Batista, Andrea N. L.;
Batista, João M.;
Cass, Quezia B.;
Couñago, Rafael M.;
Massirer, Katlin B.

Publication type:

Article

(S)‐ML‐SA1 Activates Autophagy via TRPML1‐TFEB Pathway.

Published in:

ChemBioChem, 2024, v. 25, n. 22, p. 1, doi. 10.1002/cbic.202400506

By:

Cunha, Micael R.;
Do Amaral, Bruno S.;
Takarada, Jéssica E.;
Valderrama, Gabriel V.;
Batista, Andrea N. L.;
Batista, João M.;
Cass, Quezia B.;
Couñago, Rafael M.;
Massirer, Katlin B.

Publication type:

Article

SGC-CAMKK2-1: A Chemical Probe for CAMKK2.

Published in:

Cells (2073-4409), 2023, v. 12, n. 2, p. 287, doi. 10.3390/cells12020287

By:

Wells, Carrow;
Liang, Yi;
Pulliam, Thomas L.;
Lin, Chenchu;
Awad, Dominik;
Eduful, Benjamin;
O'Byrne, Sean;
Hossain, Mohammad Anwar;
Catta-Preta, Carolina Moura Costa;
Ramos, Priscila Zonzini;
Gileadi, Opher;
Gileadi, Carina;
Couñago, Rafael M.;
Stork, Brittany;
Langendorf, Christopher G.;
Nay, Kevin;
Oakhill, Jonathan S.;
Mukherjee, Debarati;
Racioppi, Luigi;
Means, Anthony R.

Publication type:

Article

Chemical Space Exploration of Oxetanes.

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 21, p. 8199, doi. 10.3390/ijms21218199

By:

Alves, Fernando Rodrigues de Sá;
Couñago, Rafael M.;
Laufer, Stefan

Publication type:

Article

An open source plant kinase chemogenomics set.

Published in:

Plant Direct, 2022, v. 6, n. 11, p. 1, doi. 10.1002/pld3.460

By:

Ercoli, Maria Florencia;
Ramos, Priscila Zonzini;
Jain, Rashmi;
Pilotte, Joseph;
Dong, Oliver Xiaoou;
Thompson, Ty;
Wells, Carrow I.;
Elkins, Jonathan M.;
Edwards, Aled M.;
Couñago, Rafael M.;
Drewry, David H.;
Ronald, Pamela C.

Publication type:

Article

Editorial: Exploring novel approaches to small molecule kinase inhibitors in cancer treatment.

Published in:

Frontiers in Chemistry, 2025, p. 1, doi. 10.3389/fchem.2025.1559849

By:

Carbone, Anna;
Couñago, Rafael M.;
Salas, Cristian O.;
Moltalbano, Alessandra

Publication type:

Article

Binding and structural analyses of potent inhibitors of the human Ca<sup>2+</sup>/calmodulin dependent protein kinase kinase 2 (CAMKK2) identified from a collection of commercially-available kinase inhibitors.

Published in:

Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-52795-1

By:

Profeta, Gerson S.;
dos Reis, Caio V.;
Santiago, André da S.;
Godoi, Paulo H. C.;
Fala, Angela M.;
Wells, Carrow I.;
Sartori, Roger;
Salmazo, Anita P. T.;
Ramos, Priscila Z.;
Massirer, Katlin B.;
Elkins, Jonathan M.;
Drewry, David H.;
Gileadi, Opher;
Couñago, Rafael M.

Publication type:

Article

Structural Analysis of Inhibitor Binding to CAMKK1 Identifies Features Necessary for Design of Specific Inhibitors.

Published in:

Scientific Reports, 2018, v. 8, n. 1, p. 1, doi. 10.1038/s41598-018-33043-4

By:

Santiago, André da Silva;
Couñago, Rafael M.;
Ramos, Priscila Zonzini;
Godoi, Paulo H. C.;
Massirer, Katlin B.;
Gileadi, Opher;
Elkins, Jonathan M.

Publication type:

Article

AdcA and AdcAII employ distinct zinc acquisition mechanisms and contribute additively to zinc homeostasis in S treptococcus pneumoniae.

Published in:

Molecular Microbiology, 2014, v. 91, n. 4, p. 834, doi. 10.1111/mmi.12504

By:

Plumptre, Charles D.;
Eijkelkamp, Bart A.;
Morey, Jacqueline R.;
Behr, Felix;
Couñago, Rafael M.;
Ogunniyi, Abiodun D.;
Kobe, Bostjan;
O'Mara, Megan L.;
Paton, James C.;
McDevitt, Christopher A.

Publication type:

Article

Dysregulation of transition metal ion homeostasis is the molecular basis for cadmium toxicity in Streptococcus pneumoniae.

Published in:

Nature Communications, 2015, v. 6, n. 3, p. 6418, doi. 10.1038/ncomms7418

By:

Begg, Stephanie L.;
Eijkelkamp, Bart A.;
Luo, Zhenyao;
Couñago, Rafael M.;
Morey, Jacqueline R.;
Maher, Megan J.;
Ong, Cheryl-lynn Y.;
McEwan, Alastair G.;
Kobe, Bostjan;
O'Mara, Megan L.;
Paton, James C.;
McDevitt, Christopher A.

Publication type:

Article

Evolution of the B3 DNA Binding Superfamily: New Insights into REM Family Gene Diversification.

Published in:

PLoS ONE, 2009, v. 4, n. 6, p. 1, doi. 10.1371/journal.pone.0005791

By:

Romanel, Elisson A. C.;
Schrago, Carlos G.;
Couñago, Rafael M.;
Russo, Claudia A. M.;
Alves-Ferreira, Márcio

Publication type:

Article

Imperfect coordination chemistry facilitates metal ion release in the Psa permease.

Published in:

Nature Chemical Biology, 2014, v. 10, n. 1, p. 35, doi. 10.1038/nchembio.1382

By:

Couñago, Rafael M;
Ween, Miranda P;
Begg, Stephanie L;
Bajaj, Megha;
Zuegg, Johannes;
O'Mara, Megan L;
Cooper, Matthew A;
McEwan, Alastair G;
Paton, James C;
Kobe, Bostjan;
McDevitt, Christopher A

Publication type:

Article

Strategic Fluorination to Achieve a Potent, Selective, Metabolically Stable, and Orally Bioavailable Inhibitor of CSNK2.

Published in:

Molecules, 2024, v. 29, n. 17, p. 4158, doi. 10.3390/molecules29174158

By:

Ong, Han Wee;
Yang, Xuan;
Smith, Jeffery L.;
Taft-Benz, Sharon;
Howell, Stefanie;
Dickmander, Rebekah J.;
Havener, Tammy M.;
Sanders, Marcia K.;
Brown, Jason W.;
Couñago, Rafael M.;
Chang, Edcon;
Krämer, Andreas;
Moorman, Nathaniel J.;
Heise, Mark;
Axtman, Alison D.;
Drewry, David H.;
Willson, Timothy M.

Publication type:

Article

In Depth Analysis of Kinase Cross Screening Data to Identify CAMKK2 Inhibitory Scaffolds.

Published in:

Molecules, 2020, v. 25, n. 2, p. 325, doi. 10.3390/molecules25020325

By:

O'Byrne, Sean N.;
Scott, John W.;
Pilotte, Joseph R.;
Santiago, André da S.;
Langendorf, Christopher G.;
Oakhill, Jonathan S.;
Eduful, Benjamin J.;
Couñago, Rafael M.;
Wells, Carrow I.;
Zuercher, William J.;
Willson, Timothy M.;
Drewry, David H.

Publication type:

Article

1,2,6-Thiadiazinones as Novel Narrow Spectrum Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) Inhibitors.

Published in:

Molecules, 2018, v. 23, n. 5, p. 1221, doi. 10.3390/molecules23051221

By:

Asquith, Christopher R. M.;
Godoi, Paulo H.;
Couñago, Rafael M.;
Laitinen, Tuomo;
Scott, John W.;
Langendorf, Christopher G.;
Oakhill, Jonathan S.;
Drewry, David H.;
Zuercher, William J.;
Koutentis, Panayiotis A.;
Willson, Timothy M.;
Kalogirou, Andreas S.;
Besson, Thierry

Publication type:

Article