Works by Coskun, Tamer

Results: 64
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    Glucose‐dependent insulinotropic polypeptide counteracts diet‐induced obesity along with reduced feeding, elevated plasma leptin and activation of leptin‐responsive and proopiomelanocortin neurons in the arcuate nucleus.

    Published in:
    Diabetes, Obesity & Metabolism, 2023, v. 25, n. 6, p. 1534, doi. 10.1111/dom.15001
    By:
    • Han, Wanxin;
    • Wang, Lei;
    • Ohbayashi, Kento;
    • Takeuchi, Masakazu;
    • O'Farrell, Libbey;
    • Coskun, Tamer;
    • Rakhat, Yermek;
    • Yabe, Daisuke;
    • Iwasaki, Yusaku;
    • Seino, Yutaka;
    • Yada, Toshihiko
    Publication type:
    Article
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    The effect of mirabegron on energy expenditure and brown adipose tissue in healthy lean South Asian and Europid men.

    Published in:
    Diabetes, Obesity & Metabolism, 2020, v. 22, n. 11, p. 2032, doi. 10.1111/dom.14120
    By:
    • Nahon, Kimberly J.;
    • Janssen, Laura G. M.;
    • Sardjoe Mishre, Aashley S. D.;
    • Bilsen, Manu P.;
    • van der Eijk, Jari A.;
    • Botani, Kani;
    • Overduin, Lisanne A.;
    • Ruiz, Jonatan R.;
    • Burakiewicz, Jedrzej;
    • Dzyubachyk, Oleh;
    • Webb, Andrew G.;
    • Kan, Hermien E.;
    • Berbée, Jimmy F. P.;
    • van Klinken, Jan-Bert;
    • van Dijk, Ko Willems;
    • van Weeghel, Michel;
    • Vaz, Frédéric M.;
    • Coskun, Tamer;
    • Jazet, Ingrid M.;
    • Kooijman, Sander
    Publication type:
    Article
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    The novel dual glucose‐dependent insulinotropic polypeptide and glucagon‐like peptide‐1 (GLP‐1) receptor agonist tirzepatide transiently delays gastric emptying similarly to selective long‐acting GLP‐1 receptor agonists

    Published in:
    Diabetes, Obesity & Metabolism, 2020, v. 22, n. 10, p. 1886, doi. 10.1111/dom.14110
    By:
    • Urva, Shweta;
    • Coskun, Tamer;
    • Loghin, Corina;
    • Cui, Xuewei;
    • Beebe, Emily;
    • O'Farrell, Libbey;
    • Briere, Daniel A.;
    • Benson, Charles;
    • Nauck, Michael A.;
    • Haupt, Axel
    Publication type:
    Article
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    High Fat Diet Increases Circulating Endocannabinoids Accompanied by Increased Synthesis Enzymes in Adipose Tissue.

    Published in:
    Frontiers in Physiology, 2019, p. N.PAG, doi. 10.3389/fphys.2018.01913
    By:
    • Kuipers, Eline N.;
    • Kantae, Vasudev;
    • Maarse, Boukje C. Eveleens;
    • van den Berg, Susan M.;
    • van Eenige, Robin;
    • Nahon, Kimberly J.;
    • Reifel-Miller, Anne;
    • Coskun, Tamer;
    • de Winther, Menno P. J.;
    • Lutgens, Esther;
    • Kooijman, Sander;
    • Harms, Amy C.;
    • Hankemeier, Thomas;
    • van der Stelt, Mario;
    • Rensen, Patrick C. N.;
    • Boon, Mariëtte R.
    Publication type:
    Article
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    Rational Design of a Fibroblast Growth Factor 21-Based Clinical Candidate, LY2405319.

    Published in:
    PLoS ONE, 2013, v. 8, n. 3, p. 1, doi. 10.1371/journal.pone.0058575
    By:
    • Kharitonenkov, Alexei;
    • Beals, John M.;
    • Micanovic, Radmila;
    • Strifler, Beth A.;
    • Rathnachalam, Radhakrishnan;
    • Wroblewski, Victor J.;
    • Li, Shun;
    • Koester, Anja;
    • Ford, Amy M.;
    • Coskun, Tamer;
    • Dunbar, James D.;
    • Cheng, Christine C.;
    • Frye, Christopher C.;
    • Bumol, Thomas F.;
    • Moller, David E.
    Publication type:
    Article
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    FGF21 Requires βklotho to Act In Vivo.

    Published in:
    PLoS ONE, 2012, v. 7, n. 11, p. 1, doi. 10.1371/journal.pone.0049977
    By:
    • Adams, Andrew C.;
    • Cheng, Christine C.;
    • Coskun, Tamer;
    • Kharitonenkov, Alexei
    Publication type:
    Article
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    Fundamentals of FGF19 & FGF21 Action In Vitro and In Vivo.

    Published in:
    PLoS ONE, 2012, v. 7, n. 5, p. 1, doi. 10.1371/journal.pone.0038438
    By:
    • Adams, Andrew C.;
    • Coskun, Tamer;
    • Irizarry Rovira, Armando R.;
    • Schneider, Michael A.;
    • Raches, David W.;
    • Micanovic, Radmila;
    • Bina, Holly A.;
    • Dunbar, James D.;
    • Kharitonenkov, Alexei
    Publication type:
    Article
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    The pharmacological basis for nonpeptide agonism of the GLP-1 receptor by orforglipron.

    Published in:
    Science Translational Medicine, 2024, v. 16, n. 778, p. 1, doi. 10.1126/scitranslmed.adp5765
    By:
    • Sloop, Kyle W.;
    • Cox, Amy L.;
    • Wainscott, David B.;
    • White, Alex;
    • Droz, Brian A.;
    • Stutsman, Cynthia;
    • Showalter, Aaron D.;
    • Suter, Todd M.;
    • Dunbar, James D.;
    • Snider, Brandy M.;
    • O'Farrell, Libbey S.;
    • Hewitt, Natalie;
    • Ruble, J. Craig;
    • Padgett, Leah R.;
    • Woerly, Eric M.;
    • Peterson, Jeffrey A.;
    • Coskun, Tamer;
    • Liu, Zhaomin;
    • Coutant, David E.;
    • Ai, Minrong
    Publication type:
    Article
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    FGF-21/FGF-21 receptor interaction and activation is determined by βKlotho.

    Published in:
    Journal of Cellular Physiology, 2008, v. 215, n. 1, p. 1, doi. 10.1002/jcp.21357
    By:
    • Kharitonenkov, Alexei;
    • Dunbar, James D.;
    • Bina, Holly A.;
    • Bright, Stuart;
    • Moyers, Julie S.;
    • Chen Zhang;
    • Liyun Ding;
    • Micanovic, Radmila;
    • Mehrbod, Sean F.;
    • Knierman, Michel D.;
    • Hale, John E.;
    • Coskun, Tamer;
    • Shanafelt, Armen B.
    Publication type:
    Article
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    Brainstem BDNF neurons are downstream of GFRAL/GLP1R signalling.

    Published in:
    Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-54367-y
    By:
    • Feetham, Claire H.;
    • Collabolletta, Valeria;
    • Worth, Amy A.;
    • Shoop, Rosemary;
    • Groom, Sam;
    • Harding, Court;
    • Boutagouga Boudjadja, Mehdi;
    • Coskun, Tamer;
    • Emmerson, Paul J.;
    • D'Agostino, Giuseppe;
    • Luckman, Simon M.
    Publication type:
    Article
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    The GPR120 agonist TUG-891 promotes metabolic health by stimulating mitochondrial respiration in brown fat.

    Published in:
    EMBO Molecular Medicine, 2018, v. 10, n. 3, p. 1, doi. 10.15252/emmm.201708047
    By:
    • Schilperoort, Maaike;
    • Dam, Andrea D;
    • Hoeke, Geerte;
    • Shabalina, Irina G;
    • Okolo, Anthony;
    • Hanyaloglu, Aylin C;
    • Dib, Lea H;
    • Mol, Isabel M;
    • Caengprasath, Natarin;
    • Chan, Yi‐Wah;
    • Damak, Sami;
    • Miller, Anne Reifel;
    • Coskun, Tamer;
    • Shimpukade, Bharat;
    • Ulven, Trond;
    • Kooijman, Sander;
    • Rensen, Patrick CN;
    • Christian, Mark
    Publication type:
    Article
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    Development of a long‐acting relaxin analogue, LY3540378, for treatment of chronic heart failure.

    Published in:
    British Journal of Pharmacology, 2023, v. 180, n. 15, p. 1965, doi. 10.1111/bph.16055
    By:
    • Verdino, Petra;
    • Lee, Stacey L.;
    • Cooper, Fariba N.;
    • Cottle, Steven R.;
    • Grealish, Patrick F.;
    • Hu, Charlie C.;
    • Meyer, Catalina M.;
    • Lin, Joanne;
    • Copeland, Victoria;
    • Porter, Gina;
    • Schroeder, Richard L.;
    • Thompson, Tyran D.;
    • Porras, Leah L.;
    • Dey, Asim;
    • Zhang, Hong Y.;
    • Beebe, Emily C.;
    • Matkovich, Scot J.;
    • Coskun, Tamer;
    • Balciunas, Aldona M.;
    • Ferrante, Andrea
    Publication type:
    Article
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    GIPR Agonism Enhances TZD-Induced Insulin Sensitivity in Obese IR Mice.

    Published in:
    Diabetes, 2024, v. 73, n. 2, p. 292, doi. 10.2337/db23-0172
    By:
    • Furber, Ellen C.;
    • Hyatt, Karissa;
    • Collins, Kyla;
    • Yu, Xinxin;
    • Droz, Brian A.;
    • Holland, Adrienne;
    • Friedrich, Jessica L.;
    • Wojnicki, Samantha;
    • Konkol, Debra L.;
    • O’Farrell, Libbey S.;
    • Baker, Hana E.;
    • Coskun, Tamer;
    • Scherer, Philipp E.;
    • Kusminski, Christine M.;
    • Christe, Michael E.;
    • Sloop, Kyle W.;
    • Samms, Ricardo J.
    Publication type:
    Article