Works by Cosenza, Lucia Carmela

Results: 29

A β-Thalassemia Cell Biobank: Updates, Further Validation in Genetic and Therapeutic Research and Opportunities During (and After) the COVID-19 Pandemic.

Published in:

Journal of Clinical Medicine, 2025, v. 14, n. 1, p. 289, doi. 10.3390/jcm14010289

By:

Gambari, Roberto;
Gamberini, Maria Rita;
Cosenza, Lucia Carmela;
Zuccato, Cristina;
Finotti, Alessia

Publication type:

Article

Increased Expression of α-Hemoglobin Stabilizing Protein (AHSP) mRNA in Erythroid Precursor Cells Isolated from β-Thalassemia Patients Treated with Sirolimus (Rapamycin).

Published in:

Journal of Clinical Medicine, 2024, v. 13, n. 9, p. 2479, doi. 10.3390/jcm13092479

By:

Zurlo, Matteo;
Zuccato, Cristina;
Cosenza, Lucia Carmela;
Gamberini, Maria Rita;
Finotti, Alessia;
Gambari, Roberto

Publication type:

Article

Effects of Sirolimus Treatment on Fetal Hemoglobin Production and Response to SARS-CoV-2 Vaccination: A Case Report Study.

Published in:

2023

By:

Gamberini, Maria Rita;
Zuccato, Cristina;
Zurlo, Matteo;
Cosenza, Lucia Carmela;
Finotti, Alessia;
Gambari, Roberto

Publication type:

Case Study

Teaching during COVID-19 pandemic in practical laboratory classes of applied biochemistry and pharmacology: A validated fast and simple protocol for detection of SARS-CoV-2 Spike sequences.

Published in:

PLoS ONE, 2022, v. 17, n. 4, p. 1, doi. 10.1371/journal.pone.0266419

By:

Gasparello, Jessica;
Papi, Chiara;
Zurlo, Matteo;
Cosenza, Lucia Carmela;
Breveglieri, Giulia;
Zuccato, Cristina;
Gambari, Roberto;
Finotti, Alessia

Publication type:

Article

The Cystic Fibrosis Transmembrane Conductance Regulator Gene (CFTR) Is under Post-Transcriptional Control of microRNAs: Analysis of the Effects of agomiRNAs Mimicking miR-145-5p, miR-101-3p, and miR-335-5p.

Published in:

Non-Coding RNA, 2023, v. 9, n. 2, p. 29, doi. 10.3390/ncrna9020029

By:

Papi, Chiara;
Gasparello, Jessica;
Zurlo, Matteo;
Cosenza, Lucia Carmela;
Gambari, Roberto;
Finotti, Alessia

Publication type:

Article

5613398 A DRUG REPOSITIONING PROJECT FOR Β-THALASSEMIA: SIROLIMUS AND CINCHONA ALKALOIDS.

Published in:

2023

By:

Michele Lipucci Di Paola, M.L.P.;
Cristina Zuccato, C.Z.;
Lucia Carmela Cosenza, L.C.C.;
Matteo Zurlo, M.Z.;
Monica Borgatti, M.B.;
Ilaria Lampronti, I.L.;
Chris Sotirelis, C.T.S.;
Marco Prosdocimi, M.P.;
Roberto Gambari, R.G.;
Alessia Finotti, A.F.

Publication type:

Abstract

5613417 CO-TREATMENT OF ERYTHROID CELLS ISOLATED FROM Β039-THALASSEMIA PATIENTS WITH CRISPR-CAS9 GENE EDITING AND FETAL HEMOGLOBIN INDUCTION.

Published in:

2023

By:

Lipucci di Paola, M.L.P.;
Lucia Carmela Cosenza, L.C.C.;
Cristina Zuccato, C.Z.;
Matteo Zurlo, M.Z.;
Roberto Gambari, R.G.;
Alessia Finotti, A.F.

Publication type:

Abstract

5613423 TREATMENT OF ERYTHROID PRECURSOR CELLS FROM β-THALASSEMIC PATIENTS WITH ISOXAZOLE DERIVATIVES: POTENT INDUCTION OF FETAL HEMOGLOBIN.

Published in:

2023

By:

Cristina Zuccato, C.Z.;
Lucia Carmela Cosenza, L.C.C.;
Gianni Sacchetti, G.S.;
Riccardo Rondanin, R.R.;
Daniele Simoni, D.S.;
Marco Prosdocimi, M.P.;
Lipucci di Paola, M.L.P.;
Alessia Finotti, A.F.;
Roberto Gambari, R.G.;
Ilaria Lampronti, I.L.

Publication type:

Abstract

Targeting miR-155-5p and miR-221-3p by peptide nucleic acids induces caspase-3 activation and apoptosis in temozolomide-resistant T98G glioma cells.

Published in:

International Journal of Oncology, 2019, v. 55, n. 1, p. 59, doi. 10.3892/ijo.2019.4810

By:

Milani, Roberta;
Brognara, Eleonora;
Fabbri, Enrica;
Manicardi, Alex;
Corradini, Roberto;
Finotti, Alessia;
Gasparello, Jessica;
Borgatti, Monica;
Cosenza, Lucia Carmela;
Lampronti, Ilaria;
Dechecchi, Maria Cristina;
Cabrini, Giulio;
Gambari, Roberto

Publication type:

Article

Production and Characterization of K562 Cellular Clones Hyper-Expressing the Gene Encoding α-Globin: Preliminary Analysis of Biomarkers Associated with Autophagy.

Published in:

Genes, 2023, v. 14, n. 3, p. 556, doi. 10.3390/genes14030556

By:

Zurlo, Matteo;
Gasparello, Jessica;
Cosenza, Lucia Carmela;
Breveglieri, Giulia;
Papi, Chiara;
Zuccato, Cristina;
Gambari, Roberto;
Finotti, Alessia

Publication type:

Article

Co-Treatment of Erythroid Cells from β-Thalassemia Patients with CRISPR-Cas9-Based β 0 39-Globin Gene Editing and Induction of Fetal Hemoglobin.

Published in:

Genes, 2022, v. 13, n. 10, p. N.PAG, doi. 10.3390/genes13101727

By:

Cosenza, Lucia Carmela;
Zuccato, Cristina;
Zurlo, Matteo;
Gambari, Roberto;
Finotti, Alessia

Publication type:

Article

Postnatal and non-invasive prenatal detection of β-thalassemia mutations based on Taqman genotyping assays.

Published in:

PLoS ONE, 2017, v. 12, n. 2, p. 1, doi. 10.1371/journal.pone.0172756

By:

Breveglieri, Giulia;
Travan, Anna;
D’Aversa, Elisabetta;
Cosenza, Lucia Carmela;
Pellegatti, Patrizia;
Guerra, Giovanni;
Gambari, Roberto;
Borgatti, Monica

Publication type:

Article

Changes in hemoglobin profile reflect autologous blood transfusion misuse in sports.

Published in:

2018

By:

Lamberti, Nicola;
Finotti, Alessia;
Gasparello, Jessica;
Lampronti, Ilaria;
Zambon, Christel;
Cosenza, Lucia Carmela;
Fabbri, Enrica;
Bianchi, Nicoletta;
Dalla Corte, Francesca;
Govoni, Maurizio;
Reverberi, Roberto;
Gambari, Roberto;
Manfredini, Fabio

Publication type:

journal article

Decrease in α-Globin and Increase in the Autophagy-Activating Kinase ULK1 mRNA in Erythroid Precursors from β-Thalassemia Patients Treated with Sirolimus.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 20, p. 15049, doi. 10.3390/ijms242015049

By:

Zurlo, Matteo;
Zuccato, Cristina;
Cosenza, Lucia Carmela;
Gasparello, Jessica;
Gamberini, Maria Rita;
Stievano, Alice;
Fortini, Monica;
Prosdocimi, Marco;
Finotti, Alessia;
Gambari, Roberto

Publication type:

Article

The rs368698783 (G>A) Polymorphism Affecting LYAR Binding to the Aγ-Globin Gene Is Associated with High Fetal Hemoglobin (HbF) in β-Thalassemia Erythroid Precursor Cells Treated with HbF Inducers.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 1, p. 776, doi. 10.3390/ijms24010776

By:

Zuccato, Cristina;
Cosenza, Lucia Carmela;
Zurlo, Matteo;
Breveglieri, Giulia;
Bianchi, Nicoletta;
Lampronti, Ilaria;
Gasparello, Jessica;
Scapoli, Chiara;
Borgatti, Monica;
Finotti, Alessia;
Gambari, Roberto

Publication type:

Article

New TMA (4,6,4′-Trimethyl angelicin) Analogues as Anti-Inflammatory Agents in the Treatment of Cystic Fibrosis Lung Disease.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 22, p. 14483, doi. 10.3390/ijms232214483

By:

Tupini, Chiara;
Chilin, Adriana;
Rossi, Alice;
De Fino, Ida;
Bragonzi, Alessandra;
D'Aversa, Elisabetta;
Cosenza, Lucia Carmela;
Vaccarin, Christian;
Sacchetti, Gianni;
Borgatti, Monica;
Tamanini, Anna;
Dechecchi, Maria Cristina;
Sanvito, Francesca;
Gambari, Roberto;
Cabrini, Giulio;
Lampronti, Ilaria

Publication type:

Article

Treatment of Erythroid Precursor Cells from β-Thalassemia Patients with Cinchona Alkaloids: Induction of Fetal Hemoglobin Production.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 24, p. 13433, doi. 10.3390/ijms222413433

By:

Zuccato, Cristina;
Cosenza, Lucia Carmela;
Zurlo, Matteo;
Lampronti, Ilaria;
Borgatti, Monica;
Scapoli, Chiara;
Gambari, Roberto;
Finotti, Alessia

Publication type:

Article

Discovery of Novel Fetal Hemoglobin Inducers through Small Chemical Library Screening.

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 19, p. 7426, doi. 10.3390/ijms21197426

By:

Breveglieri, Giulia;
Pacifico, Salvatore;
Zuccato, Cristina;
Cosenza, Lucia Carmela;
Sultan, Shaiq;
D'Aversa, Elisabetta;
Gambari, Roberto;
Preti, Delia;
Trapella, Claudio;
Guerrini, Remo;
Borgatti, Monica

Publication type:

Article

A validated cellular biobank for β-thalassemia.

Published in:

2016

By:

Cosenza, Lucia Carmela;
Breda, Laura;
Breveglieri, Giulia;
Zuccato, Cristina;
Finotti, Alessia;
Lampronti, Ilaria;
Borgatti, Monica;
Chiavilli, Francesco;
Gamberini, Maria Rita;
Satta, Stefania;
Manunza, Laura;
De Martis, Franca Rosa;
Moi, Paolo;
Rivella, Stefano;
Gambari, Roberto;
Bianchi, Nicoletta

Publication type:

journal article

Y-chromosome identification in circulating cell-free fetal DNA using surface plasmon resonance.

Published in:

2016

By:

Breveglieri, Giulia;
Bassi, Elisabetta;
Carlassara, Silvia;
Cosenza, Lucia Carmela;
Pellegatti, Patrizia;
Guerra, Giovanni;
Finotti, Alessia;
Gambari, Roberto;
Borgatti, Monica

Publication type:

journal article

The Long Scientific Journey of Sirolimus (Rapamycin): From the Soil of Easter Island (Rapa Nui) to Applied Research and Clinical Trials on β-Thalassemia and Other Hemoglobinopathies.

Published in:

Biology (2079-7737), 2023, v. 12, n. 9, p. 1202, doi. 10.3390/biology12091202

By:

Gambari, Roberto;
Zuccato, Cristina;
Cosenza, Lucia Carmela;
Zurlo, Matteo;
Gasparello, Jessica;
Finotti, Alessia;
Gamberini, Maria Rita;
Prosdocimi, Marco

Publication type:

Article

Altered erythroid-related miRNA levels as a possible novel biomarker for detection of autologous blood transfusion misuse in sport.

Published in:

2019

By:

Gasparello, Jessica;
Lamberti, Nicola;
Papi, Chiara;
Lampronti, Ilaria;
Cosenza, Lucia Carmela;
Fabbri, Enrica;
Bianchi, Nicoletta;
Zambon, Christel;
Dalla Corte, Francesca;
Govoni, Maurizio;
Reverberi, Roberto;
Manfredini, Fabio;
Gambari, Roberto;
Finotti, Alessia

Publication type:

journal article

Expression of γ-globin genes in β-thalassemia patients treated with sirolimus: results from a pilot clinical trial (Sirthalaclin).

Published in:

Therapeutic Advances in Hematology, 2022, v. 13, p. 1, doi. 10.1177/20406207221100648

By:

Zuccato, Cristina;
Cosenza, Lucia Carmela;
Zurlo, Matteo;
Gasparello, Jessica;
Papi, Chiara;
D'Aversa, Elisabetta;
Breveglieri, Giulia;
Lampronti, Ilaria;
Finotti, Alessia;
Borgatti, Monica;
Scapoli, Chiara;
Stievano, Alice;
Fortini, Monica;
Ramazzotti, Eric;
Marchetti, Nicola;
Prosdocimi, Marco;
Gamberini, Maria Rita;
Gambari, Roberto

Publication type:

Article

Effects of Mithramycin on BCL11A Gene Expression and on the Interaction of the BCL11A Transcriptional Complex to γ-Globin Gene Promoter Sequences.

Published in:

Genes, 2023, v. 14, n. 10, p. 1927, doi. 10.3390/genes14101927

By:

Finotti, Alessia;
Gasparello, Jessica;
Zuccato, Cristina;
Cosenza, Lucia Carmela;
Fabbri, Enrica;
Bianchi, Nicoletta;
Gambari, Roberto

Publication type:

Article

Surface plasmon resonance based analysis of the binding of LYAR protein to the rs368698783 (G>A) polymorphic Aγ-globin gene sequences mutated in β-thalassemia.

Published in:

Analytical & Bioanalytical Chemistry, 2019, v. 411, n. 29, p. 7699, doi. 10.1007/s00216-019-01987-9

By:

Gemmo, Chiara;
Breveglieri, Giulia;
Marzaro, Giovanni;
Lampronti, Ilaria;
Cosenza, Lucia Carmela;
Gasparello, Jessica;
Zuccato, Cristina;
Fabbri, Enrica;
Borgatti, Monica;
Chilin, Adriana;
Finotti, Alessia;
Gambari, Roberto

Publication type:

Article

Development and characterization of cellular biosensors for HTS of erythroid differentiation inducers targeting the transcriptional activity of γ-globin and β-globin gene promoters.

Published in:

Analytical & Bioanalytical Chemistry, 2019, v. 411, n. 29, p. 7669, doi. 10.1007/s00216-019-01959-z

By:

Breveglieri, Giulia;
Salvatori, Francesca;
Finotti, Alessia;
Cosenza, Lucia Carmela;
Zuccato, Cristina;
Bianchi, Nicoletta;
Breda, Laura;
Rivella, Stefano;
Bresciani, Alberto;
Bisbocci, Monica;
Borgatti, Monica;
Gambari, Roberto

Publication type:

Article

New Synthetic Isoxazole Derivatives Acting as Potent Inducers of Fetal Hemoglobin in Erythroid Precursor Cells Isolated from β-Thalassemic Patients.

Published in:

Molecules, 2024, v. 29, n. 1, p. 8, doi. 10.3390/molecules29010008

By:

Zuccato, Cristina;
Cosenza, Lucia Carmela;
Tupini, Chiara;
Finotti, Alessia;
Sacchetti, Gianni;
Simoni, Daniele;
Gambari, Roberto;
Lampronti, Ilaria

Publication type:

Article

Effects of Sirolimus treatment on patients with β‐Thalassemia: Lymphocyte immunophenotype and biological activity of memory CD4+ and CD8+ T cells.

Published in:

Journal of Cellular & Molecular Medicine, 2023, v. 27, n. 3, p. 353, doi. 10.1111/jcmm.17655

By:

Zurlo, Matteo;
Nicoli, Francesco;
Proietto, Davide;
Dallan, Beatrice;
Zuccato, Cristina;
Cosenza, Lucia Carmela;
Gasparello, Jessica;
Papi, Chiara;
d'Aversa, Elisabetta;
Borgatti, Monica;
Scapoli, Chiara;
Finotti, Alessia;
Gambari, Roberto

Publication type:

Article

An Aγ-globin G->A gene polymorphism associated with β039 thalassemia globin gene and high fetal hemoglobin production.

Published in:

BMC Medical Genetics, 2017, v. 18, p. 1, doi. 10.1186/s12881-017-0450-3

By:

Breveglieri, Giulia;
Bianchi, Nicoletta;
Cosenza, Lucia Carmela;
Gamberini, Maria Rita;
Chiavilli, Francesco;
Zuccato, Cristina;
Montagner, Giulia;
Borgatti, Monica;
Lampronti, Ilaria;
Finotti, Alessia;
Gambari, Roberto

Publication type:

Article

Works by Cosenza, Lucia Carmela

A β-Thalassemia Cell Biobank: Updates, Further Validation in Genetic and Therapeutic Research and Opportunities During (and After) the COVID-19 Pandemic.

Increased Expression of α-Hemoglobin Stabilizing Protein (AHSP) mRNA in Erythroid Precursor Cells Isolated from β-Thalassemia Patients Treated with Sirolimus (Rapamycin).

Effects of Sirolimus Treatment on Fetal Hemoglobin Production and Response to SARS-CoV-2 Vaccination: A Case Report Study.

Teaching during COVID-19 pandemic in practical laboratory classes of applied biochemistry and pharmacology: A validated fast and simple protocol for detection of SARS-CoV-2 Spike sequences.

The Cystic Fibrosis Transmembrane Conductance Regulator Gene (CFTR) Is under Post-Transcriptional Control of microRNAs: Analysis of the Effects of agomiRNAs Mimicking miR-145-5p, miR-101-3p, and miR-335-5p.

5613398 A DRUG REPOSITIONING PROJECT FOR Β-THALASSEMIA: SIROLIMUS AND CINCHONA ALKALOIDS.

5613417 CO-TREATMENT OF ERYTHROID CELLS ISOLATED FROM Β039-THALASSEMIA PATIENTS WITH CRISPR-CAS9 GENE EDITING AND FETAL HEMOGLOBIN INDUCTION.

5613423 TREATMENT OF ERYTHROID PRECURSOR CELLS FROM β-THALASSEMIC PATIENTS WITH ISOXAZOLE DERIVATIVES: POTENT INDUCTION OF FETAL HEMOGLOBIN.

Targeting miR-155-5p and miR-221-3p by peptide nucleic acids induces caspase-3 activation and apoptosis in temozolomide-resistant T98G glioma cells.

Production and Characterization of K562 Cellular Clones Hyper-Expressing the Gene Encoding α-Globin: Preliminary Analysis of Biomarkers Associated with Autophagy.

Co-Treatment of Erythroid Cells from β-Thalassemia Patients with CRISPR-Cas9-Based β 0 39-Globin Gene Editing and Induction of Fetal Hemoglobin.

Postnatal and non-invasive prenatal detection of β-thalassemia mutations based on Taqman genotyping assays.

Changes in hemoglobin profile reflect autologous blood transfusion misuse in sports.

Decrease in α-Globin and Increase in the Autophagy-Activating Kinase ULK1 mRNA in Erythroid Precursors from β-Thalassemia Patients Treated with Sirolimus.

The rs368698783 (G>A) Polymorphism Affecting LYAR Binding to the Aγ-Globin Gene Is Associated with High Fetal Hemoglobin (HbF) in β-Thalassemia Erythroid Precursor Cells Treated with HbF Inducers.

New TMA (4,6,4′-Trimethyl angelicin) Analogues as Anti-Inflammatory Agents in the Treatment of Cystic Fibrosis Lung Disease.

Treatment of Erythroid Precursor Cells from β-Thalassemia Patients with Cinchona Alkaloids: Induction of Fetal Hemoglobin Production.

Discovery of Novel Fetal Hemoglobin Inducers through Small Chemical Library Screening.

A validated cellular biobank for β-thalassemia.

Y-chromosome identification in circulating cell-free fetal DNA using surface plasmon resonance.

The Long Scientific Journey of Sirolimus (Rapamycin): From the Soil of Easter Island (Rapa Nui) to Applied Research and Clinical Trials on β-Thalassemia and Other Hemoglobinopathies.

Altered erythroid-related miRNA levels as a possible novel biomarker for detection of autologous blood transfusion misuse in sport.

Expression of γ-globin genes in β-thalassemia patients treated with sirolimus: results from a pilot clinical trial (Sirthalaclin).

Effects of Mithramycin on BCL11A Gene Expression and on the Interaction of the BCL11A Transcriptional Complex to γ-Globin Gene Promoter Sequences.

Surface plasmon resonance based analysis of the binding of LYAR protein to the rs368698783 (G>A) polymorphic Aγ-globin gene sequences mutated in β-thalassemia.

Development and characterization of cellular biosensors for HTS of erythroid differentiation inducers targeting the transcriptional activity of γ-globin and β-globin gene promoters.

New Synthetic Isoxazole Derivatives Acting as Potent Inducers of Fetal Hemoglobin in Erythroid Precursor Cells Isolated from β-Thalassemic Patients.

Effects of Sirolimus treatment on patients with β‐Thalassemia: Lymphocyte immunophenotype and biological activity of memory CD4<sup>+</sup> and CD8<sup>+</sup> T cells.

An Aγ-globin G->A gene polymorphism associated with β<sup>0</sup>39 thalassemia globin gene and high fetal hemoglobin production.