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Activation of group II metabotropic glutamate (mGlu2/3) receptors regulates excitatory synaptic plasticity in the nucleus accumbens: Implications for the treatment of schizophrenia.
- Published in:
- FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.R6041
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- Article
Profiling beneficial and potential adverse effects of MeCP2 overexpression in a hypomorphic Rett syndrome mouse model.
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- Genes, Brain & Behavior, 2022, v. 21, n. 1, p. 1, doi. 10.1111/gbb.12752
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- Article
Input-specific regulation of glutamatergic synaptic transmission in the medial prefrontal cortex by mGlu<sub>2</sub>/mGlu<sub>4</sub> receptor heterodimers.
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- Science Signaling, 2021, v. 14, n. 677, p. 1, doi. 10.1126/scisignal.abd2319
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- Article
Phenotypic profiling of mGlu<sub>7</sub> knockout mice reveals new implications for neurodevelopmental disorders.
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- Genes, Brain & Behavior, 2020, v. 19, n. 7, p. 1, doi. 10.1111/gbb.12654
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- Article
Biased M<sub>1</sub> receptor–positive allosteric modulators reveal role of phospholipase D in M<sub>1</sub>-dependent rodent cortical plasticity.
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- Science Signaling, 2019, v. 12, n. 610, p. 1, doi. 10.1126/scisignal.aax2057
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- Article
Roles of the M<sub>4</sub> acetylcholine receptor in the basal ganglia and the treatment of movement disorders.
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- 2019
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- journal article
P4‐681: OPTIMIZATION OF NOVEL M1 PAMS FOR CLINICAL DEVELOPMENT WITH ENHANCED EFFICACY WHILE AVOIDING ADVERSE EFFECT LIABILITY FOR THE TREATMENT OF ALZHEIMER'S DISEASE.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P1592, doi. 10.1016/j.jalz.2019.09.046
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- Article
3293 Region Specific Dysregulation of Dopaminergic Signaling in Mice Displaying Excessive Over-Grooming.
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- 2019
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- Abstract
Contextual Fear Extinction Induces Hippocampal Metaplasticity Mediated by Metabotropic Glutamate Receptor 5.
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- Cerebral Cortex, 2018, v. 28, n. 12, p. 4291, doi. 10.1093/cercor/bhx282
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- Article
Mutual activation of glutamatergic mGlu<sub>4</sub> and muscarinic M<sub>4</sub> receptors reverses schizophrenia-related changes in rodents.
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- Psychopharmacology, 2018, v. 235, n. 10, p. 2897, doi. 10.1007/s00213-018-4980-y
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- Article
mGlu<sub>7</sub> potentiation rescues cognitive, social, and respiratory phenotypes in a mouse model of Rett syndrome.
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- Science Translational Medicine, 2017, v. 9, n. 403, p. 1, doi. 10.1126/scitranslmed.aai7459
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- Article
Targeting metabotropic glutamate receptors for novel treatments of schizophrenia.
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- Molecular Brain, 2017, v. 10, p. 1, doi. 10.1186/s13041-017-0293-z
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- Article
SELECTIVE POTENTIATION OF MUSCARINIC ACETYLCHOLINE RECEPTOR SUBTYPE 1 DEMONSTRATES EFFICACY AND SAFETY IN PRECLINICAL MODELS OF ALZHEIMER'S DISEASE.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P181, doi. 10.1016/j.jalz.2016.06.314
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- Article
mGlu<sub>5</sub> positive allosteric modulation normalizes synaptic plasticity defects and motor phenotypes in a mouse model of Rett syndrome.
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- Human Molecular Genetics, 2016, v. 25, n. 10, p. 1990, doi. 10.1093/hmg/ddw074
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- Article
Neurobiological Insights from mGlu Receptor Allosteric Modulation.
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- International Journal of Neuropsychopharmacology, 2016, v. 19, n. 5, p. 1, doi. 10.1093/ijnp/pyv133
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- Article
M<sub>1</sub> and M<sub>3</sub> muscarinic receptors may play a role in the neurotoxicity of anhydroecgonine methyl ester, a cocaine pyrolysis product.
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- Scientific Reports, 2015, v. 5, n. 1, p. 17555, doi. 10.1038/srep17555
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- Article
Tackling reproducibility in academic preclinical drug discovery.
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- 2015
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- journal article
Activation of Metabotropic Glutamate Receptor 7 Is Required for Induction of Long-Term Potentiation at SCCA1 Synapses in the Hippocampus.
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- Journal of Neuroscience, 2015, v. 35, n. 19, p. 7600, doi. 10.1523/JNEUROSCI.4543-14.2015
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- Article
Relationship between In Vivo Receptor Occupancy and Efficacy of Metabotropic Glutamate Receptor Subtype 5 Allosteric Modulators with Different In Vitro Binding Profiles.
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- Neuropsychopharmacology, 2015, v. 40, n. 3, p. 755, doi. 10.1038/npp.2014.245
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- Article
Anticholinergic drugs rescue synaptic plasticity in DYT1 dystonia: Role of M<sub>1</sub> muscarinic receptors.
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- Movement Disorders, 2014, v. 29, n. 13, p. 1655, doi. 10.1002/mds.26009
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- Article
Anticholinergic drugs rescue synaptic plasticity in DYT1 dystonia: role of M1 muscarinic receptors.
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- 2014
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- journal article
Modulation of neuronal microcircuit activities within the medial prefrontal cortex by mGluR5 positive allosteric modulator.
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- Journal of Psychopharmacology, 2014, v. 28, n. 10, p. 935, doi. 10.1177/0269881114542856
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- Article
Opportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders.
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- Nature Reviews Drug Discovery, 2014, v. 13, n. 9, p. 692, doi. 10.1038/nrd4308
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- Article
Discovery, Synthesis and Characterization of a Highly Muscarinic Acetylcholine Receptor (mAChR)-Selective M<sub>5</sub>-Orthosteric Antagonist, VU0488130 (ML381): A Novel Molecular Probe.
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- ChemMedChem, 2014, v. 9, n. 8, p. 1677, doi. 10.1002/cmdc.201402051
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- Article
Antipsychotic Drug-Like Effects of the Selective M<sub>4</sub> Muscarinic Acetylcholine Receptor Positive Allosteric Modulator VU0152100.
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- Neuropsychopharmacology, 2014, v. 39, n. 7, p. 1578, doi. 10.1038/npp.2014.2
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- Article
M<sub>5</sub> Receptor Activation Produces Opposing Physiological Outcomes in Dopamine Neurons Depending on the Receptor's Location.
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- Journal of Neuroscience, 2014, v. 34, n. 9, p. 3253, doi. 10.1523/JNEUROSCI.4896-13.2014
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- Article
Selective Actions of Novel Allosteric Modulators Reveal Functional Heteromers of Metabotropic Glutamate Receptors in the CNS.
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- Journal of Neuroscience, 2014, v. 34, n. 1, p. 79, doi. 10.1523/JNEUROSCI.1129-13.2014
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- Article
Activation of M<sub>1</sub> and M<sub>4</sub> muscarinic receptors as potential treatments for Alzheimer's disease and schizophrenia.
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- Neuropsychiatric Disease & Treatment, 2014, v. 10, p. 183, doi. 10.2147/NDT.S55104
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- Article
Bringing together the academic drug discovery community.
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- Nature Reviews Drug Discovery, 2013, v. 12, n. 11, p. 811, doi. 10.1038/nrd4155
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- Article
Discovery of 2-(2-Benzoxazoyl amino)-4-Aryl-5-Cyanopyrimidine as Negative Allosteric Modulators (NAMs) of Metabotropic Glutamate Receptor 5 (mGlu<sub>5</sub>): From an Artificial Neural Network Virtual Screen to an In Vivo Tool Compound.
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- ChemMedChem, 2012, v. 7, n. 3, p. 406, doi. 10.1002/cmdc.201100510
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- Article
Neurotherapeutics.
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- Neuropsychopharmacology, 2012, v. 37, n. 1, p. 1, doi. 10.1038/npp.2011.233
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- Article
Impact of isoflurane anesthesia on D2 receptor occupancy by [<sup>18</sup>F]fallypride measured by microPET with a modified Logan plot.
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- Synapse, 2011, v. 65, n. 11, p. 1173, doi. 10.1002/syn.20955
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- Article
Advancing drug discovery for schizophrenia.
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- Annals of the New York Academy of Sciences, 2011, v. 1236, n. 1, p. 30, doi. 10.1111/j.1749-6632.2011.06216.x
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- Article
The mGluR2 Positive Allosteric Modulator BINA Decreases Cocaine Self-Administration and Cue-Induced Cocaine-Seeking and Counteracts Cocaine-Induced Enhancement of Brain Reward Function in Rats.
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- Neuropsychopharmacology, 2010, v. 35, n. 10, p. 2021, doi. 10.1038/npp.2010.82
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- Article
A Selective Allosteric Potentiator of the M<sub>1</sub> Muscarinic Acetylcholine Receptor Increases Activity of Medial Prefrontal Cortical Neurons and Restores Impairments in Reversal Learning.
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- Journal of Neuroscience, 2009, v. 29, n. 45, p. 14271, doi. 10.1523/JNEUROSCI.3930-09.2009
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- Article
Synthesis and Structure-Activity Relationships of Allosteric Potentiators of the M<sub>4</sub> Muscarinic Acetylcholine Receptor.
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- ChemMedChem, 2009, v. 4, n. 10, p. 1600, doi. 10.1002/cmdc.200900231
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- Article
mGluR5 Positive Allosteric Modulators Facilitate both Hippocampal LTP and LTD and Enhance Spatial Learning.
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- Neuropsychopharmacology, 2009, v. 34, n. 9, p. 2057, doi. 10.1038/npp.2009.30
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- Article
Discovery of a highly M5-preferring muscarinic acetylcholine receptor allosteric potentiator
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- 2009
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- Abstract
Towards the treatment of Alzheimer's disease: Discovery and development of novel subtype-specific M1 allosteric agonists
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- 2009
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- Abstract
Acute administration of a novel M1 receptor allosteric potentiator (BQCA) restores reversal learning in a transgenic mouse model of Alzheimer's disease (Tg2576)
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- 2009
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- Abstract
Synthesis, SAR and Unanticipated Pharmacological Profiles of Analogues of the mGluR5 Ago-potentiator ADX-47273.
- Published in:
- ChemMedChem, 2009, v. 4, n. 4, p. 505, doi. 10.1002/cmdc.200800357
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- Article
Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders.
- Published in:
- 2009
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- Publication type:
- journal article
Promise of mGluR2/3 activators in psychiatry.
- Published in:
- Neuropsychopharmacology, 2009, v. 34, n. 1, p. 248, doi. 10.1038/npp.2008.156
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- Article
Novel Selective Allosteric Activator of theM<sub>1</sub> Muscarinic Acetylcholine Receptor Regulates Amyloid Processing and Produces Antipsychotic-Like Activity in Rats.
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- Journal of Neuroscience, 2008, v. 28, n. 41, p. 10422, doi. 10.1523/JNEUROSCI.1850-08.2008
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- Article
Opportunities and Challenges of Psychiatric Drug Discovery: Roles for Scientists in Academic, Industry, and Government Settings.
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- Neuropsychopharmacology, 2008, v. 33, n. 10, p. 2048, doi. 10.1038/sj.npp.1301638
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- Article
Opportunities and Challenges of Psychiatric Drug Discovery: Roles for Scientists in Academic, Industry, and Government Settings.
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- 2008
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- Correction notice
An allosteric potentiator of M<sub>4</sub> mAChR modulates hippocampal synaptic transmission.
- Published in:
- Nature Chemical Biology, 2008, v. 4, n. 1, p. 42, doi. 10.1038/nchembio.2007.55
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- Article
D1- and D2-like dopamine receptors regulate signaling properties of group I metabotropic glutamate receptors in the rat globus pallidus.
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- European Journal of Neuroscience, 2007, v. 26, n. 4, p. 852, doi. 10.1111/j.1460-9568.2007.05710.x
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- Article
Design, Synthesis, and In Vivo Efficacy of Glycine Transporter-1 (GlyT1) Inhibitors Derived from a Series of [4-Phenyl-1-(propylsulfonyl)piperidin-4-yl]methyl Benzamides.
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- ChemMedChem, 2006, v. 1, n. 8, p. 807, doi. 10.1002/cmdc.200600097
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- Article
METABOTROPIC GLUTAMATE RECEPTORS IN THE BASAL GANGLIA MOTOR CIRCUIT.
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- Nature Reviews Neuroscience, 2005, v. 6, n. 10, p. 787, doi. 10.1038/nrn1763
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- Article