Works matching AU Conklin, Bruce R.

Results: 56

Evaluation of CRISPR/Cas9 exon‐skipping vector for choroideremia using human induced pluripotent stem cell‐derived RPE.

Published in:

Journal of Gene Medicine, 2023, v. 25, n. 2, p. 1, doi. 10.1002/jgm.3464

By:

Iwagawa, Toshiro;
Masumoto, Hiroki;
Tabuchi, Hitoshi;
Tani, Kenzaburo;
Conklin, Bruce R.;
Watanabe, Sumiko

Publication type:

Article

GO-Elite: a flexible solution for pathway and ontology over-representation.

Published in:

Bioinformatics, 2012, v. 28, n. 16, p. 2209, doi. 10.1093/bioinformatics/bts366

By:

Zambon, Alexander C.;
Gaj, Stan;
Ho, Isaac;
Hanspers, Kristina;
Vranizan, Karen;
Evelo, Chris T.;
Conklin, Bruce R.;
Pico, Alexander R.;
Salomonis, Nathan

Publication type:

Article

A public gene trap resource for mouse functional genomics.

Published in:

2004

By:

Skarnes, William C.;
von Melchner, Harald;
Wurst, Wolfgang;
Hicks, Geoff;
Nord, Alex S.;
Cox, Tony;
Young, Stephen G.;
Ruiz, Patricia;
Soriano, Phil;
Tessier-Lavigne, Marc;
Conklin, Bruce R.;
Stanford, William L.;
Rossant, Janet

Publication type:

Letter

GenMAPP, a new tool for viewing and analyzing microarray data on biological pathways.

Published in:

Nature Genetics, 2002, v. 31, n. 1, p. 19, doi. 10.1038/ng0502-19

By:

Dahlquist, Kam D.;
Salomonis, Nathan;
Vranizan, Karen;
Lawlor, Steven C.;
Conklin, Bruce R.

Publication type:

Article

AKAP13 Rho-GEF and PKD-Binding Domain Deficient Mice Develop Normally but Have an Abnormal Response to β-Adrenergic-Induced Cardiac Hypertrophy.

Published in:

PLoS ONE, 2013, v. 8, n. 4, p. 1, doi. 10.1371/journal.pone.0062705

By:

Spindler, Matthew J.;
Burmeister, Brian T.;
Huang, Yu;
Hsiao, Edward C.;
Salomonis, Nathan;
Scott, Mark J.;
Srivastava, Deepak;
Carnegie, Graeme K.;
Conklin, Bruce R.

Publication type:

Article

Structure of a Novel Winged-Helix Like Domain from Human NFRKB Protein.

Published in:

PLoS ONE, 2012, v. 7, n. 9, p. 1, doi. 10.1371/journal.pone.0043761

By:

Kumar, Abhinav;
Möcklinghoff, Sabine;
Yumoto, Fumiaki;
Jaroszewski, Lukasz;
Farr, Carol L.;
Grzechnik, Anna;
Nguyen, Phuong;
Weichenberger, Christian X.;
Hsiu-Ju Chiu;
Klock, Heath E.;
Elsliger, Marc-André;
Deacon, Ashley M.;
Godzik, Adam;
Lesley, Scott A.;
Conklin, Bruce R.;
Fletterick, Robert J.;
Wilson, Ian A.;
Vertessy, Beata G.

Publication type:

Article

Mining Biological Pathways Using WikiPathways Web Services.

Published in:

PLoS ONE, 2009, v. 4, n. 7, p. 1, doi. 10.1371/journal.pone.0006447

By:

Kelder, Thomas;
Pico, Alexander R.;
Hanspers, Kristina;
van Iersel, Martijn P.;
Evelo, Chris;
Conklin, Bruce R.

Publication type:

Article

Lentiviral Vectors and Protocols for Creation of Stable hESC Lines for Fluorescent Tracking and Drug Resistance Selection of Cardiomyocytes.

Published in:

PLoS ONE, 2009, v. 4, n. 4, p. 1, doi. 10.1371/journal.pone.0005046

By:

Kita-Matsuo, Hiroko;
Barcova, Maria;
Prigozhina, Natalie;
Salomonis, Nathan;
Wei, Karen;
Jacot, Jeffrey G.;
Nelson, Brandon;
Spiering, Sean;
Haverslag, René;
Changsung Kim;
Talantova, Maria;
Bajpai, Ruchi;
Calzolari, Diego;
Terskikh, Alexey;
McCulloch, Andrew D.;
Price, Jeffrey H.;
Conklin, Bruce R.;
Chen, H. S. Vincent;
Mercola, Mark

Publication type:

Article

Marking Embryonic Stem Cells with a 2A Self-Cleaving Peptide: A NKX2-5 Emerald GFP BAC Reporter.

Published in:

PLoS ONE, 2008, v. 3, n. 7, p. 1, doi. 10.1371/journal.pone.0002532

By:

Hsiao, Edward C.;
Yoshinaga, Yuko;
Nguyen, Trieu D.;
Musone, Stacy L.;
Kim, Judy E.;
Swinton, Paul;
Espineda, Isidro;
Manalac, Carlota;
deJong, Pieter J.;
Conklin, Bruce R.

Publication type:

Article

Engineered G protein coupled receptors reveal independent regulation of internalization, desensitization and acute signaling.

Published in:

BMC Biology, 2005, v. 3, p. 3, doi. 10.1186/1741-7007-3-3

By:

Scearce-Levie, Kimberly;
Lieberman, Michael D.;
Elliott, Heather H.;
Conklin, Bruce R.

Publication type:

Article

Cardiac Microtissues: Maladaptive Contractility of 3D Human Cardiac Microtissues to Mechanical Nonuniformity (Adv. Healthcare Mater. 8/2020).

Published in:

Advanced Healthcare Materials, 2020, v. 9, n. 8, p. 1, doi. 10.1002/adhm.202070024

By:

Wang, Chenyan;
Koo, Sangmo;
Park, Minok;
Vangelatos, Zacharias;
Hoang, Plansky;
Conklin, Bruce R.;
Grigoropoulos, Costas P.;
Healy, Kevin E.;
Ma, Zhen

Publication type:

Article

Maladaptive Contractility of 3D Human Cardiac Microtissues to Mechanical Nonuniformity.

Published in:

Advanced Healthcare Materials, 2020, v. 9, n. 8, p. 1, doi. 10.1002/adhm.201901373

By:

Wang, Chenyan;
Koo, Sangmo;
Park, Minok;
Vangelatos, Zacharias;
Hoang, Plansky;
Conklin, Bruce R.;
Grigoropoulos, Costas P.;
Healy, Kevin E.;
Ma, Zhen

Publication type:

Article

SARS-CoV-2 infection of human iPSC–derived cardiac cells reflects cytopathic features in hearts of patients with COVID-19.

Published in:

Science Translational Medicine, 2021, v. 13, n. 590, p. 1, doi. 10.1126/scitranslmed.abf7872

By:

Perez-Bermejo, Juan A.;
Kang, Serah;
Rockwood, Sarah J.;
Simoneau, Camille R.;
Joy, David A.;
Silva, Ana C.;
Ramadoss, Gokul N.;
Flanigan, Will R.;
Fozouni, Parinaz;
Li, Huihui;
Chen, Pei-Yi;
Nakamura, Ken;
Whitman, Jeffrey D.;
Hanson, Paul J.;
McManus, Bruce M.;
Ott, Melanie;
Conklin, Bruce R.;
McDevitt, Todd C.

Publication type:

Article

Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans.

Published in:

Journal of Clinical Investigation, 2004, v. 114, n. 8, p. 1158, doi. 10.1172/JCI200421927

By:

Srinivasan, Supriya;
Lubrano-Berthelier, Cecile;
Govaerts, Cedric;
Picard, Franck;
Santiago, Pamela;
Conklin, Bruce R.;
Vaisse, Christian

Publication type:

Article

Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans.

Published in:

2004

By:

Srinivasan, Supriya;
Lubrano-Berthelier, Cecile;
Govaerts, Cedric;
Picard, Franck;
Santiago, Pamela;
Conklin, Bruce R;
Vaisse, Christian

Publication type:

journal article

Substitution of three amino acids switches receptor specificity of Gq alpha to that of Gi alpha.

Published in:

Nature, 1993, v. 363, n. 6426, p. 274, doi. 10.1038/363274a0

By:

Conklin, Bruce R.;
Farfel, Zvi

Publication type:

Article

Miniaturized iPS-Cell-Derived Cardiac Muscles for Physiologically Relevant Drug Response Analyses.

Published in:

Scientific Reports, 2016, p. 24726, doi. 10.1038/srep24726

By:

Huebsch, Nathaniel;
Loskill, Peter;
Deveshwar, Nikhil;
Spencer, C. Ian;
Judge, Luke M.;
Mandegar, Mohammad A.;
B. Fox, Cade;
Mohamed, Tamer M.A.;
Ma, Zhen;
Mathur, Anurag;
Sheehan, Alice M.;
Truong, Annie;
Saxton, Mike;
Yoo, Jennie;
Srivastava, Deepak;
Desai, Tejal A.;
So, Po-Lin;
Healy, Kevin E.;
Conklin, Bruce R.

Publication type:

Article

Systematic quantification of HDR and NHEJ reveals effects of locus, nuclease, and cell type on genome-editing.

Published in:

Scientific Reports, 2016, p. 23549, doi. 10.1038/srep23549

By:

Miyaoka, Yuichiro;
Berman, Jennifer R.;
Cooper, Samantha B.;
Mayerl, Steven J.;
Chan, Amanda H.;
Zhang, Bin;
Karlin-Neumann, George A.;
Conklin, Bruce R.

Publication type:

Article

Generating trunk neural crest from human pluripotent stem cells.

Published in:

Scientific Reports, 2016, p. 19727, doi. 10.1038/srep19727

By:

Huang, Miller;
Miller, Matthew L.;
McHenry, Lauren K.;
Zheng, Tina;
Zhen, Qiqi;
Ilkhanizadeh, Shirin;
Conklin, Bruce R.;
Bronner, Marianne E.;
Weiss, William A.

Publication type:

Article

Human iPSC-based Cardiac Microphysiological System For Drug Screening Applications.

Published in:

Scientific Reports, 2015, p. 8883, doi. 10.1038/srep08883

By:

Mathur, Anurag;
Loskill, Peter;
Shao, Kaifeng;
Huebsch, Nathaniel;
Hong, SoonGweon;
Marcus, Sivan G.;
Marks, Natalie;
Mandegar, Mohammad;
Conklin, Bruce R.;
Lee, Luke P.;
Healy, Kevin E.

Publication type:

Article

Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory.

Published in:

Nature Neuroscience, 2015, v. 18, n. 3, p. 423, doi. 10.1038/nn.3930

By:

Orr, Anna G;
Hsiao, Edward C;
Wang, Max M;
Ho, Kaitlyn;
Kim, Daniel H;
Wang, Xin;
Guo, Weikun;
Kang, Jing;
Yu, Gui-Qiu;
Adame, Anthony;
Devidze, Nino;
Dubal, Dena B;
Masliah, Eliezer;
Conklin, Bruce R;
Mucke, Lennart

Publication type:

Article

Conditional expression and signaling of a specifically designed Gi-coupled receptor in transgenic mice.

Published in:

Nature Biotechnology, 1999, v. 17, n. 2, p. 165, doi. 10.1038/6165

By:

Redfern, Charles H.;
Coward, Peter;
Degtyarev, Michael Y.;
Lee, Elena K.;
Kwa, Andrew T.;
Hennighausen, Lothar;
Bujard, Hermann;
Fishman, Glenn I.;
Conklin, Bruce R.

Publication type:

Article

Induced pluripotent stem cells from patients with human fibrodysplasia ossificans progressiva show increased mineralization and cartilage formation.

Published in:

2013

By:

Yoshihisa Matsumoto;
Yohei Hayashi;
Schlieve, Christopher R.;
Makoto Ikeya;
Kim, Hannah;
Nguyen, Trieu D.;
Sami, Salma;
Shiro Baba;
Barruet, Emilie;
Akira Nasu;
Isao Asaka;
Takanobu Otsuka;
Shinya Yamanaka;
Conklin, Bruce R.;
Junya Toguchida;
Hsiao, Edward C.;
Matsumoto, Yoshihisa;
Hayashi, Yohei;
Ikeya, Makoto;
Baba, Shiro

Publication type:

journal article

Finding the Right Questions: Exploratory Pathway Analysis to Enhance Biological Discovery in Large Datasets.

Published in:

PLoS Biology, 2010, v. 8, n. 8, p. 1, doi. 10.1371/journal.pbio.1000472

By:

Kelder, Thomas;
Conklin, Bruce R.;
Evelo, Chris T.;
Pico, Alexander R.

Publication type:

Article

Obtaining Consent for Future Research with Induced Pluripotent Cells: Opportunities and Challenges.

Published in:

PLoS Biology, 2009, v. 7, n. 2, p. e1000042, doi. 10.1371/journal.pbio.1000042

By:

Aalto-Setälä, Katriina;
Conklin, Bruce R.;
Lo, Bernard

Publication type:

Article

WikiPathways: Pathway Editing for the People.

Published in:

PLoS Biology, 2008, v. 6, n. 7, p. e184, doi. 10.1371/journal.pbio.0060184

By:

Pico, Alexander R.;
Kelder, Thomas;
Van Iersel, Martijn P.;
Hanspers, Kristina;
Conklin, Bruce R.;
Evelo, Chris

Publication type:

Article

Marriage of the flytrap and the serpent.

Published in:

Nature, 1994, v. 367, n. 6458, p. 22, doi. 10.1038/367022a0

By:

Conklin, Bruce R.;
Bourne, Henry R.

Publication type:

Article

Rapid, precise quantification of large DNA excisions and inversions by ddPCR.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41598-020-71742-z

By:

Watry, Hannah L.;
Feliciano, Carissa M.;
Gjoni, Ketrin;
Takahashi, Gou;
Miyaoka, Yuichiro;
Conklin, Bruce R.;
Judge, Luke M.

Publication type:

Article

Timed inhibition of CDC7 increases CRISPR-Cas9 mediated templated repair.

Published in:

Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-15845-1

By:

Wienert, Beeke;
Nguyen, David N.;
Guenther, Alexis;
Feng, Sharon J.;
Locke, Melissa N.;
Wyman, Stacia K.;
Shin, Jiyung;
Kazane, Katelynn R.;
Gregory, Georgia L.;
Carter, Matthew A. M.;
Wright, Francis;
Conklin, Bruce R.;
Marson, Alex;
Richardson, Chris D.;
Corn, Jacob E.

Publication type:

Article

Loss of Gi G-Protein-Coupled Receptor Signaling in Osteoblasts Accelerates Bone Fracture Healing.

Published in:

Journal of Bone & Mineral Research, 2015, v. 30, n. 10, p. 1896, doi. 10.1002/jbmr.2540

By:

Wang, Liping;
Hsiao, Edward C;
Lieu, Shirley;
Scott, Mark;
O'Carroll, Dylan;
Urrutia, Ashley;
Conklin, Bruce R;
Colnot, Celine;
Nissenson, Robert A

Publication type:

Article

Blockade of receptor-activated G.

Published in:

Journal of Bone & Mineral Research, 2011, v. 26, n. 4, p. 822, doi. 10.1002/jbmr.273

By:

Millard, Susan M.;
Louie, Alyssa M.;
Wattanachanya, Lalita;
Wronski, Thomas J.;
Conklin, Bruce R.;
Nissenson, Robert A.

Publication type:

Article

Gs G Protein--Coupled Receptor Signaling in Osteoblasts Elicits Age-Dependent Effects on Bone Formation.

Published in:

Journal of Bone & Mineral Research, 2010, v. 25, n. 3, p. 584, doi. 10.1002/jbmr.3

By:

Hsiao, Edward C.;
Boudignon, Benjamin M.;
Halloran, Bernard P.;
Nissenson, Robert A.;
Conklin, Bruce R.

Publication type:

Article

Alternative Splicing in the Differentiation of Human Embryonic Stem Cells into Cardiac Precursors.

Published in:

PLoS Computational Biology, 2009, v. 5, n. 11, p. 1, doi. 10.1371/journal.pcbi.1000553

By:

Salomonis, Nathan;
Nelson, Brandon;
Vranizan, Karen;
Pico, Alexander R.;
Hanspers, Kristina;
Kuchinsky, Allan;
Ta, Linda;
Mercola, Mark;
Conklin, Bruce R.

Publication type:

Article

AlleleAnalyzer: a tool for personalized and allele-specific sgRNA design.

Published in:

Genome Biology, 2019, v. 20, n. 1, p. N.PAG, doi. 10.1186/s13059-019-1783-3

By:

Keough, Kathleen C.;
Lyalina, Svetlana;
Olvera, Michael P.;
Whalen, Sean;
Conklin, Bruce R.;
Pollard, Katherine S.

Publication type:

Article

Isolation of single-base genome-edited human iPS cells without antibiotic selection.

Published in:

Nature Methods, 2014, v. 11, n. 3, p. 291, doi. 10.1038/nmeth.2840

By:

Miyaoka, Yuichiro;
Chan, Amanda H;
Judge, Luke M;
Yoo, Jennie;
Huang, Miller;
Nguyen, Trieu D;
Lizarraga, Paweena P;
So, Po-Lin;
Conklin, Bruce R

Publication type:

Article

Sculpting genomes with a hammer and chisel.

Published in:

Nature Methods, 2013, v. 10, n. 9, p. 839, doi. 10.1038/nmeth.2608

By:

Conklin, Bruce R.

Publication type:

Article

Engineering GPCR signaling pathways with RASSLs.

Published in:

Nature Methods, 2008, v. 5, n. 8, p. 673, doi. 10.1038/nmeth.1232

By:

Conklin, Bruce R.;
Hsiao, Edward C.;
Claeysen, Sylvie;
Dumuis, Aline;
Srinivasan, Supriya;
Forsayeth, John R;
Guettier, Jean-Marc;
Chang, W. C.;
Pei, Ying;
McCarthy, Ken D.;
Nissenson, Robert A;
Wess, Jürgen;
Bockaert, Joël;
Roth, Bryan L.

Publication type:

Article

Ligand-binding domains of nuclear receptors facilitate tight control of split CRISPR activity.

Published in:

Nature Communications, 2016, v. 7, n. 7, p. 12009, doi. 10.1038/ncomms12009

By:

Nguyen, Duy P.;
Miyaoka, Yuichiro;
Gilbert, Luke A.;
Mayerl, Steven J.;
Lee, Brian H.;
Weissman, Jonathan S.;
Conklin, Bruce R.;
Wells, James A.

Publication type:

Article

Self-organizing human cardiac microchambers mediated by geometric confinement.

Published in:

Nature Communications, 2015, v. 6, n. 7, p. 7413, doi. 10.1038/ncomms8413

By:

Ma, Zhen;
Wang, Jason;
Loskill, Peter;
Huebsch, Nathaniel;
Koo, Sangmo;
Svedlund, Felicia L.;
Marks, Natalie C.;
Hua, Ethan W.;
Grigoropoulos, Costas P.;
Conklin, Bruce R.;
Healy, Kevin E.

Publication type:

Article

Journal club.

Published in:

Nature, 2009, v. 461, n. 7264, p. 573, doi. 10.1038/461573e

By:

Conklin, Bruce R.

Publication type:

Article

Consent: criteria should be drawn up for tissue donors.

Published in:

2009

By:

Lo, Bernard;
Conklin, Bruce R.

Publication type:

Letter

Human induced pluripotent stem cell-based microphysiological tissue models of myocardium and liver for drug development.

Published in:

Stem Cell Research & Therapy, 2013, v. 4, p. 1, doi. 10.1186/scrt375

By:

Mathur, Anurag;
Loskill, Peter;
SoonGweon Hong;
Jae Young Lee;
Marcus, Sivan G.;
Dumont, Laure;
Conklin, Bruce R.;
Willenbring, Holger;
Lee, Luke P.;
Healy, Kevin E.

Publication type:

Article

Constitutive Gs activation using a single-construct tetracycline-inducible expression system in embryonic stem cells and mice.

Published in:

Stem Cell Research & Therapy, 2011, v. 2, n. 2, p. 1, doi. 10.1186/scrt52

By:

Hsiao, Edward C.;
Nguyen, Trieu D.;
Ng, Jennifer K;
Scott, Mark J.;
Wei Chun Chang;
Zahed, Hengameh;
Conklin, Bruce R.

Publication type:

Article

Stem cell pluripotency.

Published in:

Cell Cycle, 2010, v. 9, n. 16, p. 3133, doi. 10.4161/cc.9.16.12888

By:

Salomonis, Nathan;
Conklin, Bruce R.

Publication type:

Article

AKAP10 (I646V) functional polymorphism predicts heart rate and heart rate variability in apparently healthy, middle-aged European-Americans.

Published in:

Psychophysiology, 2009, v. 46, n. 3, p. 466, doi. 10.1111/j.1469-8986.2009.00802.x

By:

Neumann, Serina A.;
Tingley, Whittemore G.;
Conklin, Bruce R.;
Shrader, Catherine J.;
Peet, Eloise;
Muldoon, Matthew F.;
Jennings, J. Richard;
Ferrell, Robert E.;
Manuck, Stephen B.

Publication type:

Article

The BridgeDb framework: standardized access to gene, protein and metabolite identifier mapping services.

Published in:

BMC Bioinformatics, 2010, v. 11, p. 1, doi. 10.1186/1471-2105-11-5

By:

Iersel, Martijn P van;
Pico, Alexander R;
Kelder, Thomas;
Jianjiong Gao;
Ho, Isaac;
Hanspers, Kristina;
Conklin, Bruce R;
Evelo, Chris T

Publication type:

Article

Presenting and exploring biological pathways with PathVisio.

Published in:

2008

By:

van Iersel, Martijn P.;
Kelder, Thomas;
Pico, Alexander R.;
Hanspers, Kristina;
Coort, Susan;
Conklin, Bruce R.;
Evelo, Chris

Publication type:

Product Review

GenMAPP 2: new features and resources for pathway analysis.

Published in:

BMC Bioinformatics, 2007, v. 8, p. 217, doi. 10.1186/1471-2105-8-217

By:

Salomonis, Nathan;
Hanspers, Kristina;
Zambon, Alexander C;
Vranizan, Karen;
Lawlor, Steven C;
Dahlquist, Kam D;
Doniger, Scott W;
Stuart, Josh;
Conklin, Bruce R;
Pico, Alexander R

Publication type:

Article

Engineering the Melanocortin-4 Receptor to Control Gs Signaling in Vivo.

Published in:

Annals of the New York Academy of Sciences, 2003, v. 994, n. 1, p. 225, doi. 10.1111/j.1749-6632.2003.tb03184.x

By:

SRINIVASAN, SUPRIYA;
VAISSE, CHRISTIAN;
CONKLIN, BRUCE R.

Publication type:

Article

CRISPR off-target detection with DISCOVER-seq.

Published in:

Nature Protocols, 2020, v. 15, n. 5, p. 1775, doi. 10.1038/s41596-020-0309-5

By:

Wienert, Beeke;
Wyman, Stacia K.;
Yeh, Charles D.;
Conklin, Bruce R.;
Corn, Jacob E.

Publication type:

Article