Works by Clarke, Alan R.

Results: 69

Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at...

Published in:

Nature, 1992, v. 360, n. 6401, p. 225, doi. 10.1038/360225a0

By:

Mombaerts, Peter;
Clarke, Alan R.

Publication type:

Article

Requirement for a functional Rb-1 gene in murine development.

Published in:

Nature, 1992, v. 359, n. 6393, p. 328, doi. 10.1038/359328a0

By:

Clarke, Alan R.;
Maandag, Els Robanus

Publication type:

Article

Microtubule Stress Modifies Intra-Nuclear Location of Msh2 in Mouse Embryonic Fibroblasts.

Published in:

Cell Cycle, 2004, v. 3, n. 5, p. 662, doi. 10.4161/cc.3.5.855

By:

Marquez, Nuria;
Chappell, Sally C.;
Sansom, Owen J.;
Clarke, Alan R.;
Teesdale-Spittle, Paul;
Errington, Rachel J.;
Smith, Paul J.

Publication type:

Article

What are the best routes to effectively model human colorectal cancer?

Published in:

Molecular Oncology, 2013, v. 7, n. 2, p. 178, doi. 10.1016/j.molonc.2013.02.006

By:

Young, Madeleine;
Ordonez, Liliana;
Clarke, Alan R.

Publication type:

Article

Author Correction: Spatiotemporal regulation of liver development by the Wnt/β-catenin pathway.

Published in:

2020

By:

Burke, Zoë D.;
Reed, Karen R.;
Yeh, Sheng-Wen;
Meniel, Valerie;
Sansom, Owen J.;
Clarke, Alan R.;
Tosh, David

Publication type:

Correction Notice

Author Correction: Spatiotemporal regulation of liver development by the Wnt/β-catenin pathway.

Published in:

2020

By:

Burke, Zoë D.;
Reed, Karen R.;
Yeh, Sheng-Wen;
Meniel, Valerie;
Sansom, Owen J.;
Clarke, Alan R.;
Tosh, David

Publication type:

Correction Notice

Hepatic progenitor cells of biliary origin with liver repopulation capacity.

Published in:

Nature Cell Biology, 2015, v. 17, n. 8, p. 971, doi. 10.1038/ncb3203

By:

Lu, Wei-Yu;
Bird, Thomas G.;
Boulter, Luke;
Tsuchiya, Atsunori;
Cole, Alicia M.;
Hay, Trevor;
Guest, Rachel V.;
Wojtacha, Davina;
Man, Tak Yung;
Mackinnon, Alison;
Ridgway, Rachel A.;
Kendall, Timothy;
Williams, Michael J.;
Jamieson, Thomas;
Raven, Alex;
Hay, David C.;
Iredale, John P.;
Clarke, Alan R.;
Sansom, Owen J.;
Forbes, Stuart J.

Publication type:

Article

p21 loss blocks senescence following Apc loss and provokes tumourigenesis in the renal but not the intestinal epithelium.

Published in:

EMBO Molecular Medicine, 2010, v. 2, n. 11, p. 472, doi. 10.1002/emmm.201000101

By:

Cole, Alicia M.;
Ridgway, Rachel A.;
Derkits, Sahra E.;
Parry, Lee;
Barker, Nick;
Clevers, Hans;
Clarke, Alan R.;
Sansom, Owen J.

Publication type:

Article

Mbd2 enables tumourigenesis within the intestine while preventing tumour‐promoting inflammation.

Published in:

Journal of Pathology, 2018, v. 245, n. 3, p. 270, doi. 10.1002/path.5074

By:

May, Stephanie;
Owen, Heather;
Phesse, Toby J.;
Greenow, Kirsty R.;
Jones, Gareth‐Rhys;
Blackwood, Adam;
Cook, Peter C.;
Towers, Christopher;
Gallimore, Awen M.;
Williams, Geraint T.;
Stürzl, Michael;
Britzen‐Laurent, Nathalie;
Sansom, Owen J.;
MacDonald, Andrew S.;
Bird, Adrian P.;
Clarke, Alan R.;
Parry, Lee

Publication type:

Article

PTEN loss and activation of K‐RAS and β‐catenin cooperate to accelerate prostate tumourigenesis.

Published in:

Journal of Pathology, 2017, v. 243, p. 442, doi. 10.1002/path.4977

By:

Jefferies, Matthew T.;
Cox, Adam C.;
Shorning, Boris Y.;
Meniel, Valerie;
Griffiths, David;
Kynaston, Howard G.;
Smalley, Matthew J.;
Clarke, Alan R.

Publication type:

Article

PTEN loss and activation of K-RAS and β-catenin cooperate to accelerate prostate tumourigenesis.

Published in:

Journal of Pathology, 2017, v. 243, n. 4, p. 442, doi. 10.1002/path.4977

By:

Jefferies, Matthew T;
Cox, Adam C;
Shorning, Boris Y;
Meniel, Valerie;
Griffiths, David;
Kynaston, Howard G;
Smalley, Matthew J;
Clarke, Alan R

Publication type:

Article

PTEN loss and KRAS activation leads to the formation of serrated adenomas and metastatic carcinoma in the mouse intestine.

Published in:

Journal of Pathology, 2014, v. 233, n. 1, p. 27, doi. 10.1002/path.4312

By:

Davies, Emma J;
Marsh Durban, Victoria;
Meniel, Valerie;
Williams, Geraint T;
Clarke, Alan R

Publication type:

Article

PTEN loss and KRAS activation cooperate in murine biliary tract malignancies.

Published in:

Journal of Pathology, 2013, v. 230, n. 2, p. 165, doi. 10.1002/path.4189

By:

Marsh, Victoria;
Davies, Emma J;
Williams, Geraint T;
Clarke, Alan R

Publication type:

Article

WT1 and kidney failure.

Published in:

Journal of Pathology, 2003, v. 200, n. 5, p. 667

By:

Aswin L Menke;
Annemieke IJpenberg;
Stewart Fleming;
Allyson Ross;
Claire N Medine;
Charles E Patek;
Lee Spraggon;
Jeremy Hughes;
Alan R Clarke;
Nicholas D Hastie

Publication type:

Article

Apoptosis induced by γ-irradiation, but not CD4 ligation, of peripheral T lymphocytes in vivo is p53-dependent.

Published in:

Journal of Pathology, 1997, v. 181, n. 2, p. 166, doi. 10.1002/(SICI)1096-9896(199702)181:2<166::AID-PATH740>3.0.CO;2-D

By:

Malcomson, Roger D. G.;
Clarke, Alan R.;
Peter, Audrey;
Coutts, Shelagh B.;
Howie, Sarah E. M.;
Harrison, David J.

Publication type:

Article

Animal models amd the molecular pathology of Cancer.

Published in:

Journal of Pathology, 1997, v. 181, n. 2, p. 130, doi. 10.1002/(SICI)1096-9896(199702)181:2<130::AID-PATH754>3.0.CO;2-F

By:

Lovejoy, Elizabeth A.;
Clarke, Alan R.;
Harrison, David J.

Publication type:

Article

Epigenetic silencing of serine protease HTRA1 drives polyploidy.

Published in:

2016

By:

Schmidt, Nina;
Irle, Inga;
Ripkens, Kamilla;
Lux, Vanda;
Nelles, Jasmin;
Johannes, Christian;
Parry, Lee;
Greenow, Kirsty;
Amir, Sarah;
Campioni, Mara;
Baldi, Alfonso;
Chio Oka;
Masashi Kawaichi;
Clarke, Alan R.;
Ehrmann, Michael;
Oka, Chio;
Kawaichi, Masashi

Publication type:

journal article

Crypt stem cells as the cells-of-origin of intestinal cancer.

Published in:

Nature, 2009, v. 457, n. 7229, p. 608, doi. 10.1038/nature07602

By:

Barker, Nick;
Ridgway, Rachel A.;
van Es, Johan H.;
van de Wetering, Marc;
Begthel, Harry;
van den Born, Maaike;
Danenberg, Esther;
Clarke, Alan R.;
Sansom, Owen J.;
Clevers, Hans

Publication type:

Article

Inactivation of Apc perturbs mammary development, but only directly results in acanthoma in the context of Tcf-1 deficiency.

Published in:

Oncogene, 2002, v. 21, n. 42, p. 6446, doi. 10.1038/sj.onc.1205892

By:

Gallagher, Ronald C.J.;
Hay, Trevor;
Meniel, Valerie;
Naughton, Catherine;
Anderson, Thomas J.;
Shibata, Hiroyuki;
Ito, Masaki;
Clevers, Hans;
Noda, Tetsuo;
Sansom, Owen J.;
Mason, John O.;
Clarke, Alan R.

Publication type:

Article

Heterozygosity for p53 promotes microsatellite instability and tumorigenesis on a Msh2 deficient background.

Published in:

Oncogene, 2002, v. 21, n. 41, p. 6299, doi. 10.1038/sj.onc.1205727

By:

Toft, Neil J.;
Curtis, Lucy J.;
Sansom, Owen J.;
Leitch, Andrea L.;
Wyllie, Andrew H.;
te Riele, Hein;
Arends, Mark J.;
Clarke, Alan R.

Publication type:

Article

The ability to engage enterocyte apoptosis does not predict long-term crypt survival in p53 and Msh2 deficient mice.

Published in:

Oncogene, 2002, v. 21, n. 38, p. 5934, doi. 10.1038/sj.onc.1205760

By:

Sansom, Owen J.;
Clarke, Alan R.

Publication type:

Article

Carcinogen-induced pancreatic lesions in the mouse: effect of Smad4 and Apc genotypes.

Published in:

Oncogene, 2002, v. 21, n. 30, p. 4696, doi. 10.1038/sj.onc.1205673

By:

Cullingworth, Jan;
Hooper, Martin L.;
Harrison, David J.;
Mason, John O.;
Sirard, Christian;
Patek, Charles E.;
Clarke, Alan R.

Publication type:

Article

Msh-2 suppresses in vivo mutation in a gene dose and lesion dependent manner.

Published in:

Oncogene, 2001, v. 20, n. 27, p. 3580, doi. 10.1038/sj.onc.1204449

By:

Sansom, Owen J;
Toft, Neil J;
Winton, Douglas J;
Clarke, Alan R

Publication type:

Article

A role for mismatch repair in control of DNA ploidy following DNA damage.

Published in:

Oncogene, 2001, v. 20, n. 15, p. 1923, doi. 10.1038/sj.onc.1204276

By:

Strathdee, Gordon;
Sansom, Owen J;
Sim, Alyson;
Clarke, Alan R;
Brown, Robert

Publication type:

Article

A novel role for IRF-1 as a suppressor of apoptosis.

Published in:

Oncogene, 2000, v. 19, n. 54, p. 6386, doi. 10.1038/sj.onc.1204016

By:

Chapman, Rachel S;
Duff, Eleanor K;
Lourenco, Paula C;
Tonner, Elizabeth;
Flint, David J;
Clarke, Alan R;
Watson, Christine J

Publication type:

Article

Dysregulated expression of β-catenin marks early neoplastic change in Apc mutant mice, but not all lesions arising in Msh2 deficient mice.

Published in:

Oncogene, 1999, v. 18, n. 51, p. 7219, doi. 10.1038/sj.onc.1203181

By:

Kongkanuntn, Rungtiva;
Bubb, Vivien J;
Sansom, Owen J;
Wyllie, Andrew H;
Harrison, David J;
Clarke, Alan R

Publication type:

Article

Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation.

Published in:

Nature Genetics, 2008, v. 40, n. 12, p. 1436, doi. 10.1038/ng.256

By:

Marsh, Victoria;
Winton, Douglas J.;
Williams, Geraint T.;
Dubois, Nicole;
.Trumpp, Andreas;
Sansom, Owen J.;
Clarke, Alan R.

Publication type:

Article

Deficiency of Mbd2 suppresses intestinal tumorigenesis.

Published in:

Nature Genetics, 2003, v. 34, n. 2, p. 145, doi. 10.1038/ng1155

By:

Sansom, Owen J;
Berger, Jennifer;
Bishop, Stefan M;
Hendrich, Brian;
Bird, Adrian;
Clarke, Alan R

Publication type:

Article

APC2 is critical for ovarian WNT signalling control, fertility and tumour suppression.

Published in:

2019

By:

Mohamed, Noha-Ehssan;
Hay, Trevor;
Reed, Karen R.;
Smalley, Matthew J.;
Clarke, Alan R.

Publication type:

journal article

Apoptosis and carcinogenesis.

Published in:

British Medical Bulletin, 1997, v. 53, n. 3, p. 554, doi. 10.1093/oxfordjournals.bmb.a011630

By:

Lyons, Scott K;
Clarke, Alan R

Publication type:

Article

Absence of p53 in Clara cells favours multinucleation and loss of cell cycle arrest.

Published in:

BMC Cell Biology, 2002, v. 3, p. 27, doi. 10.1186/1471-2121-3-27

By:

Armit, Christopher J.;
O'Dea, Shirley;
Clarke, Alan R.;
Harrison, David J.

Publication type:

Article

A limited role for p53 in modulating the immediate phenotype of Apc loss in the intestine.

Published in:

BMC Cancer, 2008, v. 8, p. 1, doi. 10.1186/1471-2407-8-162

By:

Reed, Karen R.;
Meniel, Valerie S.;
Marsh, Victoria;
Cole, Alicia;
Sansom, Owen J.;
Clarke, Alan R.

Publication type:

Article

Caspase-dependent proteolytic cleavage of STAT3α in ES cells, in mammary glands undergoing forced involution and in breast cancer cell lines.

Published in:

BMC Cancer, 2007, v. 7, p. 29, doi. 10.1186/1471-2407-7-29

By:

Matthews, James R.;
Watson, Susan M.R.;
Tevendale, Maxine C.L.;
Watson, Christine J.;
Clarke, Alan R.

Publication type:

Article

PPARδ status and mismatch repair mediated neoplasia in the mouse intestine.

Published in:

BMC Cancer, 2006, v. 6, p. 113, doi. 10.1186/1471-2407-6-113

By:

Reed, Karen R;
Sansom, Owen J;
Hayes, Anthony J;
Gescher, Andreas J;
Peters, Jeffrey M;
Clarke, Alan R

Publication type:

Article

Origin and maintenance of the intestinal cancer stem cell.

Published in:

Molecular Carcinogenesis, 2011, v. 50, n. 4, p. 254, doi. 10.1002/mc.20631

By:

Davies, Emma J.;
Marsh, Victoria;
Clarke, Alan R.

Publication type:

Article

Cre‐loxP mediated control of PrP to study transmissible spongiform encephalopathy diseases.

Published in:

Genesis: The Journal of Genetics & Development, 2004, v. 40, n. 1, p. 1, doi. 10.1002/gene.20046

By:

Nadia L. Tuzi;
Alan R. Clarke;
Barry Bradford;
Lorraine Aitchison;
Val Thomson;
Jean C. Manson

Publication type:

Article

Ablation of ß1 integrin in mammary epithelium reveals a key role for integrin in glandular morphogenesis and differentiation.

Published in:

Journal of Cell Biology, 2005, v. 171, n. 4, p. 717, doi. 10.1083/jcb.200503144

By:

Naylor, Matthew J.;
Na Li;
Cheung, Julia;
Lowe, Emma T.;
Lambert, Elise;
Marlow, Rebecca;
Wang, Pengbo;
Schatzmann, Franziska;
Wintermantel, Timothy;
Schüetz, Günther;
Clarke, Alan R.;
Mueller, Ulrich;
Hynes, Nancy E.;
Streuli, Charles H.

Publication type:

Article

OncomiRdbB: a comprehensive database of microRNAs and their targets in breast cancer.

Published in:

BMC Bioinformatics, 2014, v. 15, n. 1, p. 2, doi. 10.1186/1471-2105-15-15

By:

Khurana, Rimpi;
Verma, Vinod Kumar;
Rawoof, Abdul;
Tiwari, Shrish;
Nair, Rekha A.;
Mahidhara, Ganesh;
Idris, Mohammed M.;
Clarke, Alan R.;
Kumar, Lekha Dinesh

Publication type:

Article

Spatiotemporal regulation of liver development by the Wnt/β-catenin pathway.

Published in:

Scientific Reports, 2018, v. 8, n. 1, p. 1, doi. 10.1038/s41598-018-20888-y

By:

Burke, Zoë D.;
Reed, Karen R.;
Yeh, Sheng-Wen;
Meniel, Valerie;
Sansom, Owen J.;
Clarke, Alan R.;
Tosh, David

Publication type:

Article

p53, mutation frequency and apoptosis in the murine small intestine.

Published in:

Oncogene, 1997, v. 14, n. 17, p. 2015, doi. 10.1038/sj.onc.1201040

By:

Clarke, Alan R;
Howard, Louise A;
Harrison, David J;
Winton, Douglas J

Publication type:

Article

Myc deletion rescues Apc deficiency in the small intestine.

Published in:

Nature, 2007, v. 446, n. 7136, p. 676, doi. 10.1038/nature05674

By:

Sansom, Owen J.;
Meniel, Valerie S.;
Muncan, Vanesa;
Phesse, Toby J.;
Wilkins, Julie A.;
Reed, Karen R.;
Vass, J. Keith;
Athineos, Dimitris;
Clevers, Hans;
Clarke, Alan R.

Publication type:

Article

Lkb1 and Pten Synergise to Suppress mTOR-Mediated Tumorigenesis and Epithelial-Mesenchymal Transition in the Mouse Bladder.

Published in:

PLoS ONE, 2011, v. 6, n. 1, p. 1, doi. 10.1371/journal.pone.0016209

By:

Shorning, Boris Y.;
Griffiths, David;
Clarke, Alan R.

Publication type:

Article

Lkb1 Deficiency Alters Goblet and Paneth Cell Differentiation in the Small Intestine.

Published in:

PLoS ONE, 2009, v. 4, n. 1, p. 1, doi. 10.1371/journal.pone.0004264

By:

Shorning, Boris Y.;
Zabkiewicz, Joanna;
McCarthy, Afshan;
Pearson, Helen B.;
Winton, Douglas J.;
Sansom, Owen J.;
Ashworth, Alan;
Clarke, Alan R.

Publication type:

Article

Brg1 Loss Attenuates Aberrant Wnt-Signalling and Prevents Wnt-Dependent Tumourigenesis in the Murine Small Intestine.

Published in:

PLoS Genetics, 2014, v. 10, n. 7, p. 1, doi. 10.1371/journal.pgen.1004453

By:

Holik, Aliaksei Z.;
Young, Madeleine;
Krzystyniak, Joanna;
Williams, Geraint T.;
Metzger, Daniel;
Shorning, Boris Y.;
Clarke, Alan R.

Publication type:

Article

<i>Cited1</i> Deficiency Suppresses Intestinal Tumorigenesis.

Published in:

PLoS Genetics, 2013, v. 9, n. 8, p. 1, doi. 10.1371/journal.pgen.1003638

By:

Méniel, Valérie;
Song, Fei;
Phesse, Toby;
Young, Madeleine;
Poetz, Oliver;
Parry, Lee;
Jenkins, John R.;
Williams, Geraint T.;
Dunwoodie, Sally L.;
Watson, Alastair;
Clarke, Alan R.

Publication type:

Article

Apc deficiency predisposes to renal carcinoma in the mouse.

Published in:

Oncogene, 2005, v. 24, n. 55, p. 8205, doi. 10.1038/sj.onc.1208956

By:

Sansom, Owen J.;
Griffiths, David F. R.;
Reed, Karen R.;
Winton, Douglas J.;
Clarke, Alan R.

Publication type:

Article

Brca2 deficiency in the murine small intestine sensitizes to p53-dependent apoptosis and leads to the spontaneous deletion of stem cells.

Published in:

Oncogene, 2005, v. 24, n. 23, p. 3842, doi. 10.1038/sj.onc.1208533

By:

Hay, Trevor;
Patrick, Teresa;
Winton, Douglas;
Sansom, Owen J.;
Clarke, Alan R.

Publication type:

Article

p53 mediates a default programme of mammary gland involution in the absence of STAT3.

Published in:

Oncogene, 2005, v. 24, n. 19, p. 3083, doi. 10.1038/sj.onc.1208512

By:

Matthews, James R;
Clarke, Alan R

Publication type:

Article

PPARdstatus and Apc-mediated tumourigenesis in the mouse intestine.

Published in:

Oncogene, 2004, v. 23, n. 55, p. 8992, doi. 10.1038/sj.onc.1208143

By:

Reed, Karen R.;
Sansom, Owen J.;
Hayes, Anthony J.;
Gescher, Andreas J.;
Winton, Douglas J.;
Peters, Jeffrey M.;
Clarke, Alan R.

Publication type:

Article

MBD4 deficiency does not increase mutation or accelerate tumorigenesis in mice lacking MMR.

Published in:

Oncogene, 2004, v. 23, n. 33, p. 5693, doi. 10.1038/sj.onc.1207767

By:

Sansom, Owen J;
Bishop, Stefan M;
Bird, Adrian;
Clarke, Alan R

Publication type:

Article