Works by Cinar, Resat

Results: 33

An overview of cannabinoid receptor 1 (CB1) and therapeutic approaches-11.

Published in:

2012

By:

Çinar, Özge Gündüz;
Çinar, Resat

Publication type:

Journal Article

Kannabinoid Tip 1 Reseptör (CB1) ve Terapötik Yaklaşimlara Genel Bakiş-II.

Published in:

Journal of Marmara University Institute of Health Sciences, 2012, v. 2, n. 1, p. 1

By:

Çinar, Özge Gündüz;
Çinar, Reşat

Publication type:

Article

Peripheral Hybrid CB1R and iNOS Antagonist MRI-1867 Displays Anti-Fibrotic Efficacy in Bleomycin-Induced Skin Fibrosis.

Published in:

Frontiers in Endocrinology, 2021, v. 12, p. 1, doi. 10.3389/fendo.2021.744857

By:

Zawatsky, Charles N.;
Park, Joshua K.;
Abdalla, Jasmina;
Kunos, George;
Iyer, Malliga R.;
Cinar, Resat

Publication type:

Article

Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes.

Published in:

Nature Medicine, 2013, v. 19, n. 9, p. 1132, doi. 10.1038/nm.3265

By:

Jourdan, Tony;
Godlewski, Grzegorz;
Cinar, Resat;
Bertola, Adeline;
Szanda, Gergő;
Liu, Jie;
Tam, Joseph;
Han, Tiffany;
Mukhopadhyay, Bani;
Skarulis, Monica C;
Ju, Cynthia;
Aouadi, Myriam;
Czech, Michael P;
Kunos, George

Publication type:

Article

Chronic Alcohol Intake Compromises Lung Immunity by Altering Immunometabolism in Humans and Mouse Models.

Published in:

American Journal of Respiratory Cell & Molecular Biology, 2024, v. 71, n. 5, p. 559, doi. 10.1165/rcmb.2024-0086OC

By:

Pommerolle, Lenny;
Arif, Muhammad;
Behee, Madeline;
Appolonia, Corynn N.;
Basu, Abhishek;
Wolf, Kaelin M.;
Zawatsky, Charles N.;
Johnson, Natalie;
Rivellini, Olivia;
Park, Joshua K.;
Cinar, Resat

Publication type:

Article

Bleomycin Induces Drug Efflux in Lungs: A Pitfall for Pharmacological Studies of Pulmonary Fibrosis.

Published in:

American Journal of Respiratory Cell & Molecular Biology, 2020, v. 62, n. 2, p. 178, doi. 10.1165/rcmb.2018-0147OC

By:

Park, Joshua K.;
Coffey, Nathan J.;
Bodine, Steven P.;
Zawatsky, Charles N.;
Jay, Lindsey;
Gahl, William A.;
Kunos, George;
Gochuico, Bernadette R.;
Malicdan, May Christine V.;
Cinar, Resat

Publication type:

Article

Synthesis of 13C6‐labeled, dual‐target inhibitor of cannabinoid‐1 receptor (CB1R) and inducible nitric oxide synthase (iNOS).

Published in:

Journal of Labelled Compounds & Radiopharmaceuticals, 2018, v. 61, n. 10, p. 773, doi. 10.1002/jlcr.3639

By:

Iyer, Malliga R.;
Cinar, Resat;
Coffey, Nathan J.;
Kunos, George

Publication type:

Article

Cover Image.

Published in:

Journal of Labelled Compounds & Radiopharmaceuticals, 2018, v. 61, n. 10, p. i, doi. 10.1002/jlcr.3676

By:

Iyer, Malliga R.;
Cinar, Resat;
Coffey, Nathan J.;
Kunos, George

Publication type:

Article

Synthesis of S-2-(( S)-3-(4-chlorophenyl)- N'-((4-chlorophenyl)sulfonyl)-4-phenyl-4,5-dihydro-1 H-pyrazole-1-carboximidamido)-3-(methyl- d3)butanamide-d5, octadeuterated JD5037.

Published in:

Journal of Labelled Compounds & Radiopharmaceuticals, 2017, v. 60, n. 10, p. 460, doi. 10.1002/jlcr.3521

By:

Iyer, Malliga R.;
Cinar, Resat;
Coffey, Nathan J.;
Chorvat, Robert J.;
Kunos, George

Publication type:

Article

Ligand-specific regulation of the endogenous mu-opioid receptor by chronic treatment with mu-opioid Peptide agonists.

Published in:

2013

By:

Murányi, Marianna;
Cinar, Resat;
Kékesi, Orsolya;
Birkás, Erika;
Fábián, Gabriella;
Bozó, Beáta;
Zentai, András;
Tóth, Géza;
Kicsi, Emese Gabriella;
Mácsai, Mónika;
Dochnal, Roberta;
Szabó, Gyula;
Szücs, Mária

Publication type:

Journal Article

Ligand-Specific Regulation of the Endogenous Mu-Opioid Receptor by Chronic Treatment with Mu-Opioid Peptide Agonists.

Published in:

BioMed Research International, 2013, v. 2013, p. 1, doi. 10.1155/2013/501086

By:

Murányi, Marianna;
Cinar, Resat;
Kékesi, Orsolya;
Birkás, Erika;
Fábián, Gabriella;
Bozó, Beáta;
Zentai, András;
Tóth, Géza;
Kicsi, Emese Gabriella;
Mácsai, Mónika;
Dochnal, Roberta;
Szabó, Gyula;
Szücs, Maria

Publication type:

Article

Deficiency in endocannabinoid synthase DAGLB contributes to early onset Parkinsonism and murine nigral dopaminergic neuron dysfunction.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-31168-9

By:

Liu, Zhenhua;
Yang, Nannan;
Dong, Jie;
Tian, Wotu;
Chang, Lisa;
Ma, Jinghong;
Guo, Jifeng;
Tan, Jieqiong;
Dong, Ao;
He, Kaikai;
Zhou, Jingheng;
Cinar, Resat;
Wu, Junbing;
Salinas, Armando G.;
Sun, Lixin;
Kumar, Mantosh;
Sullivan, Breanna T.;
Oldham, Braden B.;
Pitz, Vanessa;
Makarious, Mary B.

Publication type:

Article

Cannabinoid 1 Receptor Promotes Cardiac Dysfunction, Oxidative Stress, Inflammation, and Fibrosis in Diabetic Cardiomyopathy.

Published in:

FASEB Journal, 2013, v. 27, p. 1128.10, doi. 10.1096/fasebj.27.1_supplement.1128.10

By:

PACHER, PAL;
Rajesh, Mohanraj;
Batkai, Sandor;
Mukhopadhyay, Partha;
Lee, Wen‐Shin;
Horvath, Bela;
Cinar, Resat;
Liaudet, Lucas;
Mackie, Ken;
Haskó, György

Publication type:

Article

CB1R and iNOS are distinct players promoting pulmonary fibrosis in Hermansky–Pudlak syndrome.

Published in:

Clinical & Translational Medicine, 2021, v. 11, n. 7, p. 1, doi. 10.1002/ctm2.471

By:

Cinar, Resat;
Park, Joshua K.;
Zawatsky, Charles N.;
Coffey, Nathan J.;
Bodine, Steven P.;
Abdalla, Jasmina;
Yokoyama, Tadafumi;
Jourdan, Tony;
Jay, Lindsey;
Zuo, Mei Xing G.;
O'Brien, Kevin J.;
Huang, Junfeng;
Mackie, Ken;
Alimardanov, Asaf;
Iyer, Malliga R.;
Gahl, William A.;
Kunos, George;
Gochuico, Bernadette R.;
Malicdan, May Christine V.

Publication type:

Article

Dual inhibition of cannabinoid CB1 receptor and inducible NOS attenuates obesity-induced chronic kidney disease.

Published in:

2020

By:

Udi, Shiran;
Hinden, Liad;
Ahmad, Majdoleen;
Drori, Adi;
Iyer, Malliga R.;
Cinar, Resat;
Herman‐Edelstein, Michal;
Tam, Joseph;
Herman-Edelstein, Michal

Publication type:

journal article

β-Caryophyllene protects against alcoholic steatohepatitis by attenuating inflammation and metabolic dysregulation in mice.

Published in:

2018

By:

Varga, Zoltan V.;
Matyas, Csaba;
Erdelyi, Katalin;
Cinar, Resat;
Nieri, Daniela;
Chicca, Andrea;
Nemeth, Balazs Tamas;
Paloczi, Janos;
Lajtos, Tamas;
Corey, Lukas;
Hasko, Gyorgy;
Gao, Bin;
Kunos, George;
Gertsch, Jürg;
Pacher, Pal

Publication type:

journal article

The novel, orally available and peripherally restricted selective cannabinoid CB2 receptor agonist LEI-101 prevents cisplatin-induced nephrotoxicity.

Published in:

2016

By:

Mukhopadhyay, Partha;
Baggelaar, Marc;
Erdelyi, Katalin;
Cao, Zongxian;
Cinar, Resat;
Fezza, Filomena;
Ignatowska ‐ Janlowska, Bogna;
Wilkerson, Jenny;
Gils, Noortje;
Hansen, Thomas;
Ruben, Marc;
Soethoudt, Marjolein;
Heitman, Laura;
Kunos, George;
Maccarrone, Mauro;
Lichtman, Aron;
Pacher, Pál;
Van der Stelt, Mario;
Ignatowska-Janlowska, Bogna;
van Gils, Noortje

Publication type:

journal article

Network analyses identify liver-specific targets for treating liver diseases.

Published in:

Molecular Systems Biology, 2017, v. 13, n. 8, p. n/a, doi. 10.15252/msb.20177703

By:

Lee, Sunjae;
Zhang, Cheng;
Liu, Zhengtao;
Klevstig, Martina;
Mukhopadhyay, Bani;
Bergentall, Mattias;
Cinar, Resat;
Ståhlman, Marcus;
Sikanic, Natasha;
Park, Joshua K;
Deshmukh, Sumit;
Harzandi, Azadeh M;
Kuijpers, Tim;
Grøtli, Morten;
Elsässer, Simon J;
Piening, Brian D;
Snyder, Michael;
Smith, Ulf;
Nielsen, Jens;
Bäckhed, Fredrik

Publication type:

Article

Progressive pulmonary fibrosis in a murine model of Hermansky-Pudlak syndrome.

Published in:

2022

By:

Abudi-Sinreich, Shachar;
Bodine, Steven P.;
Yokoyama, Tadafumi;
Tolman, Nathanial J.;
Tyrlik, Michal;
Testa, Lauren C.;
Han, Chen G.;
Dorward, Heidi M.;
Wincovitch, Stephen M.;
Anikster, Yair;
Gahl, William A.;
Cinar, Resat;
Gochuico, Bernadette R.;
Malicdan, May Christine V.

Publication type:

journal article

Cholesterol as a modulator of cannabinoid receptor CB2 signaling.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-83245-6

By:

Yeliseev, Alexei;
Iyer, Malliga R.;
Joseph, Thomas T.;
Coffey, Nathan J.;
Cinar, Resat;
Zoubak, Lioudmila;
Kunos, George;
Gawrisch, Klaus

Publication type:

Article

Endocannabinoid System and Cannabinoid 1 Receptors in Patients With Pharmacoresistant Temporal Lobe Epilepsy and Comorbid Mood Disorders.

Published in:

Frontiers in Behavioral Neuroscience, 2020, v. 14, p. 1, doi. 10.3389/fnbeh.2020.00052

By:

Rocha, Luisa;
Cinar, Resat;
Guevara-Guzmán, Rosalinda;
Alonso-Vanegas, Mario;
San-Juan, Daniel;
Martínez-Juárez, Iris;
Castañeda-Cabral, José Luis;
Carmona-Cruz, Francia

Publication type:

Article

Evaluation of the Therapeutic Potential of Sulfonyl Urea Derivatives as Soluble Epoxide Hydrolase (sEH) Inhibitors.

Published in:

Molecules, 2024, v. 29, n. 13, p. 1, doi. 10.3390/molecules29133036

By:

Kundu, Biswajit;
Dvorácskó, Szabolcs;
Basu, Abhishek;
Pommerolle, Lenny;
Kyu Ah Kim;
Wood, Casey M.;
Gibbs, Eve;
Behee, Madeline;
Tarasova, Nadya I.;
Cinar, Resat;
Iyer, Malliga R.

Publication type:

Article

Effects of a Peripherally Restricted Hybrid Inhibitor of CB1 Receptors and iNOS on Alcohol Drinking Behavior and Alcohol-Induced Endotoxemia.

Published in:

Molecules, 2021, v. 26, n. 16, p. 5089, doi. 10.3390/molecules26165089

By:

Santos-Molina, Luis;
Herrerias, Alexa;
Zawatsky, Charles N.;
Gunduz-Cinar, Ozge;
Cinar, Resat;
Iyer, Malliga R.;
Wood, Casey M.;
Lin, Yuhong;
Gao, Bin;
Kunos, George;
Godlewski, Grzegorz

Publication type:

Article

An Integrative Multiomics Framework for Identification of Therapeutic Targets in Pulmonary Fibrosis.

Published in:

Advanced Science, 2023, v. 10, n. 16, p. 1, doi. 10.1002/advs.202207454

By:

Arif, Muhammad;
Basu, Abhishek;
Wolf, Kaelin M.;
Park, Joshua K.;
Pommerolle, Lenny;
Behee, Madeline;
Gochuico, Bernadette R.;
Cinar, Resat

Publication type:

Article

Anandamide Is a Potential Blood Biomarker of Hermansky-Pudlak Syndrome Pulmonary Fibrosis.

Published in:

American Journal of Respiratory & Critical Care Medicine, 2025, v. 211, n. 4, p. 650, doi. 10.1164/rccm.202406-1143RL

By:

Cinar, Resat;
Basu, Abhishek;
Arif, Muhammad;
Park, Joshua K.;
Zawatsky, Charles N.;
Zuo, Ben Long G.;
Zuo, Mei Xing G.;
O'Brien, Kevin J.;
Behan, Molly;
Introne, Wendy;
Iyer, Malliga R.;
Gahl, William A.;
Malicdan, May Christine V.;
Gochuico, Bernadette R.

Publication type:

Article

Dual inhibition of CB1 receptors and iNOS, as a potential novel approach to the pharmacological management of acute and long COVID‐19.

Published in:

British Journal of Pharmacology, 2022, v. 179, n. 10, p. 2121, doi. 10.1111/bph.15461

By:

Cinar, Resat;
Iyer, Malliga R.;
Kunos, George

Publication type:

Article

Simultaneous Inhibition of Peripheral CB1R and iNOS Mitigates Obesity-Related Dyslipidemia Through Distinct Mechanisms.

Published in:

2020

By:

Roger, Célia;
Buch, Chloé;
Muller, Tania;
Leemput, Julia;
Demizieux, Laurent;
Passilly-Degrace, Patricia;
Cinar, Resat;
Iyer, Malliga R.;
Kunos, George;
Vergès, Bruno;
Degrace, Pascal;
Jourdan, Tony

Publication type:

journal article

Developmental Role of Macrophage Cannabinoid-1 Receptor Signaling in Type 2 Diabetes.

Published in:

2017

By:

Jourdan, Tony;
Szanda, Gergő;
Cinar, Resat;
Godlewski, Grzegorz;
Holovac, David J.;
Park, Joshua K.;
Nicoloro, Sarah;
Yuefei Shen;
Jie Liu;
Rosenberg, Avi Z.;
Ziyi Liu;
Czech, Michael P.;
Kunos, George;
Shen, Yuefei;
Liu, Jie;
Liu, Ziyi

Publication type:

journal article

Cannabinoid 1 Receptor Promotes Cardiac Dysfunction, Oxidative Stress, Inflammation, and Fibrosis in Diabetic Cardiomyopathy.

Published in:

Diabetes, 2012, v. 61, n. 3, p. 716, doi. 10.2337/db11-0477

By:

Rajesh, Mohanraj;
Bátkai, Sándor;
Kechrid, Malek;
Mukhopadhyay, Partha;
Wen-Shin Lee;
Horvéth, Béla;
Holovac, Eileen;
Cinar, Resat;
Liaudet, Lucas;
Mackie, Ken;
Haskó, György;
Pacher, Pál

Publication type:

Article

The endocannabinoid system promotes hepatocyte progenitor cell proliferation and maturation by modulating cellular energetics.

Published in:

Cell Death Discovery, 2023, v. 9, n. 1, p. 1, doi. 10.1038/s41420-023-01400-6

By:

Mukhopadhyay, Bani;
Holovac, Kellie;
Schuebel, Kornel;
Mukhopadhyay, Partha;
Cinar, Resat;
Iyer, Sindhu;
Marietta, Cheryl;
Goldman, David;
Kunos, George

Publication type:

Article

Cannabinoid‐1 receptor deletion in podocytes mitigates both glomerular and tubular dysfunction in a mouse model of diabetic nephropathy.

Published in:

Diabetes, Obesity & Metabolism, 2018, v. 20, n. 3, p. 698, doi. 10.1111/dom.13150

By:

Jourdan, Tony;
Park, Joshua K.;
Varga, Zoltán V.;
Pálóczi, János;
Coffey, Nathan J.;
Rosenberg, Avi Z.;
Godlewski, Grzegorz;
Cinar, Resat;
Mackie, Ken;
Pacher, Pal;
Kunos, George

Publication type:

Article

Chronic and Binge Alcohol Ingestion Increases Truncated Oxidized Phosphatidylcholines in Mice Lungs Due to Increased Oxidative Stress.

Published in:

Frontiers in Physiology, 2022, v. 13, p. 1, doi. 10.3389/fphys.2022.860449

By:

Appolonia, Corynn N.;
Wolf, Kaelin M.;
Zawatsky, Charles N.;
Cinar, Resat

Publication type:

Article

The effects of acute alcohol administration on circulating endocannabinoid levels in humans.

Published in:

2022

By:

Sloan, Matthew E.;
Grant, Caroline W.;
Stangl, Bethany L.;
Klepp, Timothy D.;
Brewton, Honoree W.;
Cinar, Resat;
Kunos, George;
Ramchandani, Vijay A.

Publication type:

journal article

Works by Cinar, Resat

An overview of cannabinoid receptor 1 (CB1) and therapeutic approaches-11.

Kannabinoid Tip 1 Reseptör (CB<sub>1</sub>) ve Terapötik Yaklaşimlara Genel Bakiş-II.

Peripheral Hybrid CB<sub>1</sub>R and iNOS Antagonist MRI-1867 Displays Anti-Fibrotic Efficacy in Bleomycin-Induced Skin Fibrosis.

Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes.

Chronic Alcohol Intake Compromises Lung Immunity by Altering Immunometabolism in Humans and Mouse Models.

Bleomycin Induces Drug Efflux in Lungs: A Pitfall for Pharmacological Studies of Pulmonary Fibrosis.

Synthesis of <sup>13</sup>C<sub>6</sub>‐labeled, dual‐target inhibitor of cannabinoid‐1 receptor (CB<sub>1</sub>R) and inducible nitric oxide synthase (iNOS).

Cover Image.

Synthesis of S-2-(( S)-3-(4-chlorophenyl)- N'-((4-chlorophenyl)sulfonyl)-4-phenyl-4,5-dihydro-1 H-pyrazole-1-carboximidamido)-3-(methyl- d<sub>3</sub>)butanamide-d<sub>5</sub>, octadeuterated JD5037.

Ligand-specific regulation of the endogenous mu-opioid receptor by chronic treatment with mu-opioid Peptide agonists.

Ligand-Specific Regulation of the Endogenous Mu-Opioid Receptor by Chronic Treatment with Mu-Opioid Peptide Agonists.

Deficiency in endocannabinoid synthase DAGLB contributes to early onset Parkinsonism and murine nigral dopaminergic neuron dysfunction.

Cannabinoid 1 Receptor Promotes Cardiac Dysfunction, Oxidative Stress, Inflammation, and Fibrosis in Diabetic Cardiomyopathy.

CB<sub>1</sub>R and iNOS are distinct players promoting pulmonary fibrosis in Hermansky–Pudlak syndrome.

Dual inhibition of cannabinoid CB<sub>1</sub> receptor and inducible NOS attenuates obesity-induced chronic kidney disease.

β-Caryophyllene protects against alcoholic steatohepatitis by attenuating inflammation and metabolic dysregulation in mice.

The novel, orally available and peripherally restricted selective cannabinoid CB2 receptor agonist LEI-101 prevents cisplatin-induced nephrotoxicity.

Network analyses identify liver-specific targets for treating liver diseases.

Progressive pulmonary fibrosis in a murine model of Hermansky-Pudlak syndrome.

Cholesterol as a modulator of cannabinoid receptor CB2 signaling.

Endocannabinoid System and Cannabinoid 1 Receptors in Patients With Pharmacoresistant Temporal Lobe Epilepsy and Comorbid Mood Disorders.

Evaluation of the Therapeutic Potential of Sulfonyl Urea Derivatives as Soluble Epoxide Hydrolase (sEH) Inhibitors.

Effects of a Peripherally Restricted Hybrid Inhibitor of CB1 Receptors and iNOS on Alcohol Drinking Behavior and Alcohol-Induced Endotoxemia.

An Integrative Multiomics Framework for Identification of Therapeutic Targets in Pulmonary Fibrosis.

Anandamide Is a Potential Blood Biomarker of Hermansky-Pudlak Syndrome Pulmonary Fibrosis.

Dual inhibition of CB<sub>1</sub> receptors and iNOS, as a potential novel approach to the pharmacological management of acute and long COVID‐19.

Simultaneous Inhibition of Peripheral CB1R and iNOS Mitigates Obesity-Related Dyslipidemia Through Distinct Mechanisms.

Developmental Role of Macrophage Cannabinoid-1 Receptor Signaling in Type 2 Diabetes.

Cannabinoid 1 Receptor Promotes Cardiac Dysfunction, Oxidative Stress, Inflammation, and Fibrosis in Diabetic Cardiomyopathy.

The endocannabinoid system promotes hepatocyte progenitor cell proliferation and maturation by modulating cellular energetics.

Cannabinoid‐1 receptor deletion in podocytes mitigates both glomerular and tubular dysfunction in a mouse model of diabetic nephropathy.

Chronic and Binge Alcohol Ingestion Increases Truncated Oxidized Phosphatidylcholines in Mice Lungs Due to Increased Oxidative Stress.

The effects of acute alcohol administration on circulating endocannabinoid levels in humans.