Works matching AU Chopra, Ian

Results: 47

Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections.

Published in:

Nature Reviews Microbiology, 2011, v. 9, n. 1, p. 62, doi. 10.1038/nrmicro2474

By:

Hurdle, Julian G.;
O'Neill, Alex J.;
Chopra, Ian;
Lee, Richard E.

Publication type:

Article

Structure-based discovery of antibacterial drugs.

Published in:

Nature Reviews Microbiology, 2010, v. 8, n. 7, p. 501, doi. 10.1038/nrmicro2349

By:

Simmons, Katie J.;
Chopra, Ian;
Fishwick, Colin W. G.

Publication type:

Article

A De Novo Designed Inhibitor of D-Ala–D-Ala Ligase from E. coli.

Published in:

Angewandte Chemie International Edition, 2005, v. 44, n. 39, p. 6403, doi. 10.1002/anie.200501662

By:

Gilbert E. Besong;
Julieanne M. Bostock;
Will Stubbings;
Ian Chopra;
David I. Roper;
Adrian J. Lloyd;
Colin W. G. Fishwick;
A. Peter Johnson

Publication type:

Article

Antibiotic resistance in Staphylococcus aureus: concerns, causes and cures.

Published in:

2003

By:

Chopra, Ian

Publication type:

journal article

The 2012 Garrod Lecture: Discovery of antibacterial drugs in the 21st century.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2013, v. 68, n. 3, p. 496, doi. 10.1093/jac/dks436

By:

Chopra, Ian

Publication type:

Article

The silver cation (Ag+): antistaphylococcal activity, mode of action and resistance studies.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2013, v. 68, n. 1, p. 131, doi. 10.1093/jac/dks372

By:

Randall, Christopher P.;
Oyama, Linda B.;
Bostock, Julieanne M.;
Chopra, Ian;
O'Neill, Alex J.

Publication type:

Article

Benzothioxalone derivatives as novel inhibitors of UDP-N-acetylglucosamine enolpyruvyl transferases (MurA and MurZ).

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2010, v. 65, n. 12, p. 2566, doi. 10.1093/jac/dkq349

By:

Miller, Keith;
Dunsmore, Colin J.;
Leeds, Jennifer A.;
Patching, Simon G.;
Sachdeva, Meena;
Blake, Katy L.;
Stubbings, William J.;
Simmons, Katie J.;
Henderson, Peter J. F.;
Angeles, Joe De Los;
Fishwick, Colin W. G.;
Chopra, Ian

Publication type:

Article

XF-70 and XF-73, novel antibacterial agents active against slow-growing and non-dividing cultures of Staphylococcus aureus including biofilms.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2010, v. 65, n. 1, p. 72, doi. 10.1093/jac/dkp409

By:

Ooi, Nicola;
Miller, Keith;
Randall, Christopher;
Rhys-Williams, William;
Love, William;
Chopra, Ian

Publication type:

Article

XF-73, a novel antistaphylococcal membrane-active agent with rapid bactericidal activity.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2009, v. 64, n. 4, p. 735, doi. 10.1093/jac/dkp299

By:

Ooi, Nicola;
Miller, Keith;
Hobbs, Joanne;
Rhys-Williams, William;
Love, William;
Chopra, Ian

Publication type:

Article

Analysis of mutational resistance to trimethoprim in Staphylococcus aureus by genetic and structural modelling techniques.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2009, v. 63, n. 6, p. 1112, doi. 10.1093/jac/dkp090

By:

Vickers, Anna A.;
Potter, Nicola J.;
Fishwick, Colin W. G.;
Chopra, Ian;
OÂNeill, Alex J.

Publication type:

Article

Evolution of extended-spectrum β-lactamases in a MutS-deficient Pseudomonas aeruginosa hypermutator.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2006, v. 58, n. 4, p. 905

By:

Ian Chopra

Publication type:

Article

In vivo transfer of high-level mupirocin resistance from Staphylococcus epidermidis to methicillin-resistant Staphylococcus aureus associated with failure of mupirocin prophylaxis.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2005, v. 56, n. 6, p. 1166, doi. 10.1093/jac/dki387

By:

Julian G. Hurdle;
Alex J. O'Neill;
Lona Mody;
Ian Chopra;
Suzanne F. Bradley

Publication type:

Article

Antistaphylococcal activity of the novel cephalosporin CB-181963 (CAB-175).

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2005, v. 55, n. 4, p. 579, doi. 10.1093/jac/dki003

By:

Keith Miller;
Christopher Storey;
William J. Stubbings;
Anthony M. Hoyle;
Joanne K. Hobbs;
Ian Chopra

Publication type:

Article

Comparison of assays for detection of agents causing membrane damage in Staphylococcus aureus.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2004, v. 54, n. 6, p. 1127, doi. 10.1093/jac/dkh476

By:

Alexander John O'Neill;
Keith Miller;
Brunello Oliva;
Ian Chopra

Publication type:

Article

Anti-staphylococcal activity of indolmycin, a potential topical agent for control of staphylococcal infections.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2004, v. 54, n. 2, p. 549

By:

Ian Chopra

Publication type:

Article

Mecillinam has potent in vitro activity against Chlamydophila pneumoniae ATCC VR1310.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2004, v. 53, n. 6, p. 1112, doi. 10.1093/jac/dkh233

By:

Julieanne M. Bostock;
Ian Geary;
Adrian Eley;
Ian Chopra

Publication type:

Article

Anti-staphylococcal activity and mode of action of clofazimine.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2004, v. 53, n. 3, p. 435, doi. 10.1093/jac/dkh114

By:

Brunello Oliva;
Alexander John ONeill;
Keith Miller;
William Stubbings;
Ian Chopra

Publication type:

Article

The isoleucyl-tRNA synthetase mutation V588F conferring mupirocin resistance in glycopeptide-intermediate Staphylococcus aureus is not associated with a significant fitness burden.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2004, v. 53, n. 1, p. 102

By:

Julian G. Hurdle;
Alex J. O'Neill;
Ian Chopra

Publication type:

Article

Insertional inactivation of mutS in Staphylococcus aureus reveals potential for elevated mutation frequencies, although the prevalence of mutators in clinical isolates is low.

Published in:

2002

By:

O’Neill, Alexander J.;
Chopra, Ian;
O'Neill, Alexander J

Publication type:

journal article

Response of Escherichia coli hypermutators to selection pressure with antimicrobial agents from different classes.

Published in:

2002

By:

Miller, Keith;
O'Neill, Alexander John;
Chopra, Ian

Publication type:

journal article

Mutation frequencies for resistance to fusidic acid and rifampicin in Staphylococcus aureus.

Published in:

2001

By:

O'Neill, Alex J.;
Cove, Jonathan H.;
Chopra, Ian;
O'Neill, A J;
Cove, J H;
Chopra, I

Publication type:

journal article

Inhibition of staphylococcal growth by fusidic acid prevents production of volatile metabolites.

Published in:

2000

By:

Caggiano, Nico;
Chopra, Ian;
Caggiano, N;
Chopra, I

Publication type:

Letter

Population Diversification in <i>Staphylococcus aureus</i> Biofilms May Promote Dissemination and Persistence.

Published in:

PLoS ONE, 2013, v. 8, n. 4, p. 1, doi. 10.1371/journal.pone.0062513

By:

Savage, Victoria J.;
Chopra, Ian;
O’Neill, Alex J.

Publication type:

Article

Increased Mutability of Staphylococci in Biofilms as a Consequence of Oxidative Stress.

Published in:

PLoS ONE, 2012, v. 7, n. 10, p. 1, doi. 10.1371/journal.pone.0047695

By:

Ryder, Victoria J.;
Chopra, Ian;
O'Neill, Alex J.

Publication type:

Article

6-Arylpyrido[2,3-d]pyrimidines as Novel ATP-Competitive Inhibitors of Bacterial D-Alanine:D-Alanine Ligase.

Published in:

PLoS ONE, 2012, v. 7, n. 8, p. 1, doi. 10.1371/journal.pone.0039922

By:

Škedelj, Veronika;
Arsovska, Emilija;
Tomašić, Tihomir;
Kroflič, Ana;
Hodnik, Vesna;
Hrast, Martina;
Bešter-Rogač, Marija;
Anderluh, Gregor;
Gobec, Stanislav;
Bostock, Julieanne;
Chopra, Ian;
O'Neill, Alex J.;
Randall, Christopher;
Zega, Anamarija;
Cascales, Eric

Publication type:

Article

The nature of Staphylococcus aureus MurA and MurZ and approaches for detection of peptidoglycan biosynthesis inhibitors.

Published in:

Molecular Microbiology, 2009, v. 72, n. 2, p. 335, doi. 10.1111/j.1365-2958.2009.06648.x

By:

Blake, Katy L.;
O'Neill, Alex J.;
Mengin-Lecreulx, Dominique;
Henderson, Peter J. F.;
Bostock, Julieanne M.;
Dunsmore, Colin J.;
Simmons, Katie J.;
Fishwick, Colin W. G.;
Leeds, Jennifer A.;
Chopra, Ian

Publication type:

Article

Molecular basis of fusB-mediated resistance to fusidic acid in Staphylococcus aureus.

Published in:

Molecular Microbiology, 2006, v. 59, n. 2, p. 664, doi. 10.1111/j.1365-2958.2005.04971.x

By:

O'Neill, Alexander John;
Chopra, Ian

Publication type:

Article

Characterization of Global Patterns and the Genetics of Fusidic Acid Resistance.

Published in:

Clinical Infectious Diseases, 2011, v. 52, n. Suppl 7, p. S487, doi. 10.1093/cid/cir164

By:

Farrell, David J.;
Castanheira, Mariana;
Chopra, Ian

Publication type:

Article

New approaches to the control of infections caused by antibiotic-resistant bacteria.

Published in:

1996

By:

Chopra, Ian;
Hodgson, John

Publication type:

Editorial

Bacterial resistance mechanisms as therapeutic targets.

Published in:

1994

By:

Coleman, Ken;
Athalye, Medha;
Clancey, Annette;
Davison, Mark;
Payne, David J.;
Perry, Caroline R.;
Chopra, Ian;
Coleman, K;
Athalye, M;
Clancey, A;
Davison, M;
Payne, D J;
Perry, C R;
Chopra, I

Publication type:

journal article

Mode of action of the cyclic depsipeptide antibiotic LL-AO341 beta 1 and partial characterization of a Staphylococcus aureus mutant resistant to the antibiotic.

Published in:

1993

By:

Oliva, Brunello;
Maiese, William M.;
Greenstein, Michael;
Borders, Donald B.;
Chopra, Ian;
Oliva, B;
Maiese, W M;
Greenstein, M;
Borders, D B;
Chopra, I

Publication type:

journal article

Efflux-based antibiotic resistance mechanisms: the evidence for increasing prevalence.

Published in:

1992

By:

CHOPRA, IAN;
Chopra, I

Publication type:

journal article

Uptake of minocycline by Escherichia coli.

Published in:

1992

By:

Chopra, Ian;
Hacker, Keith;
Chopra, I;
Hacker, K

Publication type:

journal article

Inhibition of K88ab-mediated haemagglutination by polymyxin B nonapeptide.

Published in:

1991

By:

Matranga, Anna M. C.;
Moore, Brian;
Bennett, Peter M.;
Chopra, Ian;
Matranga, A M;
Moore, B;
Bennett, P M;
Chopra, I

Publication type:

journal article

Uptake of tetracycline by Escherichia coli is not mediated by the sodium dependent glutamate transport system.

Published in:

1990

By:

CHOPRA, IAN;
ISMAIL, SAJIDA;
Chopra, I;
Ismail, S

Publication type:

Letter

Penetration of antibiotics to tbeir target sites.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 1990, v. 26, n. 5, p. 607

By:

CHOPRA, IAN

Publication type:

Article

Multiple isoelectric forms of bacterial penicillin-binding proteins: artefacts or genuine cellular components?

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 1988, v. 22, n. 2, p. 113

By:

Shohayed, Mohamed;
Chopra, Ian

Publication type:

Article

Inhibition of Providencia stuartii cell envelope enzymes by chlorhexidine.

Published in:

1987

By:

Chopra, Ian;
Johnson, Susan C.;
Bennett, Peter M.;
Chopra, I;
Johnson, S C;
Bennett, P M

Publication type:

journal article

Transport of tetracyclines into Escherichia coli requires a carboxamide group at the C2 position of the molecule.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 1986, v. 18, n. 6, p. 661

By:

Chopra, Ian

Publication type:

Article

Polymyxin B and polymyxin B nonapeptide alter cytoplasmic membrane permeability in Escherichia coli.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 1986, v. 18, n. 5, p. 557

By:

Dixon, Ronald A.;
Chopra, Ian

Publication type:

Article

Antibiotics and bacterial adhesion.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 1986, v. 18, n. 5, p. 553

By:

CHOPRA, IAN

Publication type:

Article

Inhibition of K88-mediated adhesion of Escherichia coli to mammalian receptors by antibiotics that affect bacterial protein synthesis.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 1986, v. 18, n. 4, p. 441

By:

Chopra, Ian;
Hacker, Keith

Publication type:

Article

Inhibition of β-lactamase synthesis in Staphylococcus aureus by minocycline.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 1985, v. 16, n. 1, p. 17

By:

Chopra, Ian;
Anderson, Maxine A.

Publication type:

Article

Biochemical characterisation of the chlamydial MurF ligase, and possible sequence of the chlamydial peptidoglycan pentapeptide stem.

Published in:

Archives of Microbiology, 2012, v. 194, n. 6, p. 505, doi. 10.1007/s00203-011-0784-8

By:

Patin, Delphine;
Bostock, Julieanne;
Chopra, Ian;
Mengin-Lecreulx, Dominique;
Blanot, Didier

Publication type:

Article

A De Novo Designed Inhibitor of D-Ala–D-Ala Ligase from E. coli.

Published in:

Angewandte Chemie, 2005, v. 117, n. 39, p. 6561, doi. 10.1002/ange.200501662

By:

Gilbert E. Besong;
Julieanne M. Bostock;
Will Stubbings;
Ian Chopra;
David I. Roper;
Adrian J. Lloyd;
Colin W. G. Fishwick;
A. Peter Johnson

Publication type:

Article

Outer membrane composition in Escherichia coli and the poor activity of hydrophobic antibiotics against enteric bacteria.

Published in:

1982

By:

SHALES, STUART;
CHOPRA, IAN;
Shales, S;
Chopra, I

Publication type:

Letter

Synthesis and Biological Evaluation of N-Acylhydrazones as Inhibitors of MurC and MurD Ligases.

Published in:

ChemMedChem, 2008, v. 3, n. 9, p. 1362, doi. 10.1002/cmdc.200800087

By:

Šink, Roman;
Kovač, Andreja;
Tomašić, Tihomir;
Rupnik, Veronika;
Boniface, Audrey;
Bostock, Julieanne;
Chopra, Ian;
Blanot, Didier;
Mašič, Lucija Peterlin;
Gobec, Stanislav;
Zega, Anamarija

Publication type:

Article