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Mechanisms of cardiac arrhythmias and sudden death in transgenic rabbits with long QT syndrome.
Published in:
2008
By:
- Brunner, Michael;
- Xuwen Peng;
- Gong Xin Liu;
- Xiao-Qin Ren;
- Ziv, Ohad;
- Choi, Bum-Rak;
- Mathur, Rajesh;
- Hajjiri, Mohammed;
- Odening, Katja E.;
- Steinberg, Eric;
- Folco, Eduardo J.;
- Pringa, Ekatherini;
- Centracchio, Jason;
- Macharzina, Roland R.;
- Donahay, Tammy;
- Schofield, Lorraine;
- Rana, Naveed;
- Kirk, Malcolm;
- Mitchell, Gary F.;
- Poppas, Athena
Publication type:
journal article
Origin of complex behaviour of spatially discordant alternans in a transgenic rabbit model of type 2 long QT syndrome.
Published in:
Journal of Physiology, 2009, v. 587, n. 19, p. 4661, doi. 10.1113/jphysiol.2009.175018
By:
- Ziv, Ohad;
- Morales, Eduardo;
- Song, Yoon-kyu;
- Peng, Xuwen;
- Odening, Katja E.;
- Buxton, Alfred E.;
- Karma, Alain;
- Koren, Gideon;
- Choi, Bum-Rak
Publication type:
Article
Dispersion of repolarization and refractoriness are determinants of arrhythmia phenotype in transgenic mice with long QT.
Published in:
Journal of Physiology, 2006, v. 578, n. 1, p. 115, doi. 10.1113/jphysiol.2006.122622
By:
- London, Barry;
- Baker, Linda C.;
- Petkova-Kirova, Polina;
- Nerbonne, Jeanne M.;
- Choi, Bum-Rak;
- Salama, Guy
Publication type:
Article
Cytosolic Ca2+ triggers early afterdepolarizations and torsade de pointes in rabbit hearts with type 2 long QT syndrome.
Published in:
Journal of Physiology, 2002, v. 543, n. 2, p. 615, doi. 10.1113/jphysiol.2002.024570
By:
- Choi, Bum-Rak;
- Burton, Francis;
- Salama, Guy
Publication type:
Article
Simultaneous maps of optical action potentials and calcium transients in guinea-pig hearts: mechanisms underlying concordant alternans.
Published in:
Journal of Physiology, 2000, v. 529, n. 1, p. 171, doi. 10.1111/j.1469-7793.2000.00171.x
By:
- Choi, Bum-Rak;
- Salama, Guy
Publication type:
Article
Human Atrial Cardiac Microtissues for Chamber-Specific Arrhythmic Risk Assessment.
Published in:
Cellular & Molecular Bioengineering, 2021, v. 14, n. 5, p. 441, doi. 10.1007/s12195-021-00703-x
By:
- Soepriatna, Arvin H.;
- Kim, Tae Yun;
- Daley, Mark C.;
- Song, Elena;
- Choi, Bum-Rak;
- Coulombe, Kareen L. K.
Publication type:
Article
Correction: Spatially Discordant Alternans and Arrhythmias in Tachypacing-Induced Cardiac Myopathy in Transgenic LQT1 Rabbits: The Importance of IKs and Ca2+ Cycling.
Published in:
PLoS ONE, 2015, v. 10, n. 7, p. 1, doi. 10.1371/journal.pone.0132198
By:
- Lau, Emily;
- Kossidas, Konstantinos;
- Kim, Tae Yun;
- Kunitomo, Yukiko;
- Ziv, Ohad;
- Song, Zhen;
- Taylor, Chantel;
- Schofield, Lorraine;
- Yammine, Joe;
- Liu, Gongxin;
- Peng, Xuwen;
- Qu, Zhilin;
- Koren, Gideon;
- Choi, Bum-Rak
Publication type:
Article
Spatially Discordant Alternans and Arrhythmias in Tachypacing-Induced Cardiac Myopathy in Transgenic LQT1 Rabbits: The Importance of IKs and Ca2+ Cycling.
Published in:
PLoS ONE, 2015, v. 10, n. 5, p. 1, doi. 10.1371/journal.pone.0122754
By:
- Lau, Emily;
- Kossidas, Konstantinos;
- Kim, Tae Yun;
- Kunitomo, Yukiko;
- Ziv, Ohad;
- Zhen, Song;
- Taylor, Chantel;
- Schofield, Lorraine;
- Yammine, Joe;
- Liu, Gongxin;
- Peng, Xuwen;
- Qu, Zhilin;
- Koren, Gideon;
- Choi, Bum-Rak
Publication type:
Article
Dual-Dye Optical Mapping after Myocardial Infarction: Does the Site of Ventricular Stimulation Alter the Properties of Electrical Propagation?
Published in:
Journal of Cardiovascular Electrophysiology, 2008, v. 19, n. 2, p. 197, doi. 10.1111/j.1540-8167.2007.00998.x
By:
- SABA, SAMIR;
- MATHIER, MICHAEL A.;
- MEHDI, HAIDER;
- LIU, TONG;
- CHOI, BUM‐RAK;
- LONDON, BARRY;
- SALAMA, GUY
Publication type:
Article
Sex Modulates the Arrhythmogenic Substrate in Prepubertal Rabbit Hearts with Long QT 2.
Published in:
Journal of Cardiovascular Electrophysiology, 2005, v. 16, n. 5, p. 516, doi. 10.1046/j.1540-8167.2005.40622.x
By:
- LIU, TONG;
- CHOI, BUM‐RAK;
- DRICI, MILOU‐DANIEL;
- SALAMA, GUY
Publication type:
Article
Adaptation of Cardiac Action Potential Durations to Stimulation History with Random Diastolic Intervals.
Published in:
Journal of Cardiovascular Electrophysiology, 2004, v. 15, n. 10, p. 1188, doi. 10.1046/j.1540-8167.2004.04070.x
By:
- CHOI, BUM‐RAK;
- LIU, TONG;
- SALAMA, GUY
Publication type:
Article
Fiber Orientation and Cell-Cell Coupling Influence Ventricular Fibrillation Dynamics.
Published in:
Journal of Cardiovascular Electrophysiology, 2003, v. 14, n. 8, p. 851, doi. 10.1046/j.1540-8167.2003.02522.x
By:
- Choi, Bum‐Rak;
- Liu, Tong;
- Lavasani, Mitra;
- Salama, Guy
Publication type:
Article
Short-Long Heart Rate Variation Increases Dispersion of Action Potential Duration in Long QT Type 2 Transgenic Rabbit Model.
Published in:
Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-51230-9
By:
- Kim, Tae Yun;
- Jeng, Paul;
- Hwang, JungMin;
- Pfeiffer, Zachary;
- Patel, Divyang;
- Cooper, Leroy L;
- Kossidas, Konstantinos;
- Centracchio, Jason;
- Peng, Xuwen;
- Koren, Gideon;
- Qu, Zhilin;
- Choi, Bum-Rak
Publication type:
Article
One Billion hiPSC-Cardiomyocytes: Upscaling Engineered Cardiac Tissues to Create High Cell Density Therapies for Clinical Translation in Heart Regeneration.
Published in:
Bioengineering (Basel), 2023, v. 10, n. 5, p. 587, doi. 10.3390/bioengineering10050587
By:
- Dwyer, Kiera D.;
- Kant, Rajeev J.;
- Soepriatna, Arvin H.;
- Roser, Stephanie M.;
- Daley, Mark C.;
- Sabe, Sharif A.;
- Xu, Cynthia M.;
- Choi, Bum-Rak;
- Sellke, Frank W.;
- Coulombe, Kareen L. K.
Publication type:
Article
A predictive in vitro risk assessment platform for pro-arrhythmic toxicity using human 3D cardiac microtissues.
Published in:
Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-89478-9
By:
- Kofron, Celinda M.;
- Kim, Tae Yun;
- Munarin, Fabiola;
- Soepriatna, Arvin H.;
- Kant, Rajeev J.;
- Mende, Ulrike;
- Choi, Bum-Rak;
- Coulombe, Kareen L. K.
Publication type:
Article
Associations of Prolonged QTc in Sickle Cell Disease.
Published in:
PLoS ONE, 2016, v. 11, n. 10, p. 1, doi. 10.1371/journal.pone.0164526
By:
- Indik, Julia H.;
- Nair, Vineet;
- Rafikov, Ruslan;
- Nyotowidjojo, Iwan S.;
- Bisla, Jaskanwal;
- Kansal, Mayank;
- Parikh, Devang S.;
- Robinson, Melissa;
- Desai, Anand;
- Oberoi, Megha;
- Gupta, Akash;
- Abbasi, Taimur;
- Khalpey, Zain;
- Patel, Amit R.;
- Lang, Roberto M.;
- Dudley, Samuel C.;
- Choi, Bum-Rak;
- Garcia, Joe G. N.;
- Machado, Roberto F.;
- Desai, Ankit A.
Publication type:
Article
Beyond Pharmaceuticals: Fit-for-Purpose New Approach Methodologies for Environmental Cardiotoxicity Testing.
Published in:
Altex, 2023, v. 40, n. 1, p. 103, doi. 10.14573/altex.2109131
By:
- Daley, Mark C.;
- Mende, Ulrike;
- Choi, Bum-Rak;
- McMullen, Patrick D.;
- Coulombe, Kareen L. K.
Publication type:
Article
PKA phosphorylation underlies functional recruitment of sarcolemmal SK2 channels in ventricular myocytes from hypertrophic hearts.
Published in:
Journal of Physiology, 2020, v. 598, n. 14, p. 2847, doi. 10.1113/JP277618
By:
- Hamilton, Shanna;
- Polina, Iuliia;
- Terentyeva, Radmila;
- Bronk, Peter;
- Kim, Tae Yun;
- Roder, Karim;
- Clements, Richard T.;
- Koren, Gideon;
- Choi, Bum‐Rak;
- Terentyev, Dmitry
Publication type:
Article
Mechanisms linking T‐wave alternans to spontaneous initiation of ventricular arrhythmias in rabbit models of long QT syndrome.
Published in:
Journal of Physiology, 2018, v. 596, n. 8, p. 1341, doi. 10.1113/JP275492
By:
- Liu, Weiqing;
- Kim, Tae Yun;
- Huang, Xiaodong;
- Liu, Michael B.;
- Koren, Gideon;
- Choi, Bum‐Rak;
- Qu, Zhilin
Publication type:
Article
Differential conditions for early after-depolarizations and triggered activity in cardiomyocytes derived from transgenic LQT1 and LQT2 rabbits.
Published in:
Journal of Physiology, 2012, v. 590, n. 5, p. 1171, doi. 10.1113/jphysiol.2011.218164
By:
- Liu, Gong-Xin;
- Choi, Bum-Rak;
- Ziv, Ohad;
- Li, Weiyan;
- de Lange, Enno;
- Qu, Zhilin;
- Koren, Gideon
Publication type:
Article
Pharmacological Modulation of Mitochondrial Ca2+ Content Regulates Sarcoplasmic Reticulum Ca2+ Release via Oxidation of the Ryanodine Receptor by Mitochondria-Derived Reactive Oxygen Species.
Published in:
Frontiers in Physiology, 2018, p. N.PAG, doi. 10.3389/fphys.2018.01831
By:
- Hamilton, Shanna;
- Terentyeva, Radmila;
- Kim, Tae Yun;
- Bronk, Peter;
- Clements, Richard T.;
- O-Uchi, Jin;
- Csordás, György;
- Choi, Bum-Rak;
- Terentyev, Dmitry
Publication type:
Article
Action potential metrics and automated data analysis pipeline for cardiotoxicity testing using optically mapped hiPSC-derived 3D cardiac microtissues.
Published in:
PLoS ONE, 2023, v. 17, n. 2, p. 1, doi. 10.1371/journal.pone.0280406
By:
- Soepriatna, Arvin H.;
- Navarrete-Welton, Allison;
- Kim, Tae Yun;
- Daley, Mark C.;
- Bronk, Peter;
- Kofron, Celinda M.;
- Mende, Ulrike;
- Coulombe, Kareen L. K.;
- Choi, Bum-Rak
Publication type:
Article
In vitro to in vivo extrapolation from 3D hiPSC-derived cardiac microtissues and physiologically based pharmacokinetic modeling to inform next-generation arrhythmia risk assessment.
Published in:
Toxicological Sciences, 2024, v. 201, n. 1, p. 145, doi. 10.1093/toxsci/kfae079
By:
- Daley, Mark C;
- Moreau, Marjory;
- Bronk, Peter;
- Fisher, Jeffrey;
- Kofron, Celinda M;
- Mende, Ulrike;
- McMullen, Patrick;
- Choi, Bum-Rak;
- Coulombe, Kareen
Publication type:
Article
ML-GAP: machine learning-enhanced genomic analysis pipeline using autoencoders and data augmentation.
Published in:
Frontiers in Genetics, 2024, p. 1, doi. 10.3389/fgene.2024.1442759
By:
- Agraz, Melih;
- Goksuluk, Dincer;
- Peng Zhang;
- Choi, Bum-Rak;
- Clements, Richard T.;
- Choudhary, Gaurav;
- Karniadakis, George Em
Publication type:
Article
Human Cardiac Fibroblast Number and Activation State Modulate Electromechanical Function of hiPSC-Cardiomyocytes in Engineered Myocardium.
Published in:
Stem Cells International, 2020, p. 1, doi. 10.1155/2020/9363809
By:
- Rupert, Cassady E.;
- Kim, Tae Yun;
- Choi, Bum-Rak;
- Coulombe, Kareen L. K.
Publication type:
Article
Directed fusion of cardiac spheroids into larger heterocellular microtissues enables investigation of cardiac action potential propagation via cardiac fibroblasts.
Published in:
PLoS ONE, 2018, v. 13, n. 5, p. 1, doi. 10.1371/journal.pone.0196714
By:
- Kim, Tae Yun;
- Kofron, Celinda M.;
- King, Michelle E.;
- Markes, Alexander R.;
- Okundaye, Amenawon O.;
- Qu, Zhilin;
- Mende, Ulrike;
- Choi, Bum-Rak
Publication type:
Article

Found: 26

Mechanisms of cardiac arrhythmias and sudden death in transgenic rabbits with long QT syndrome.

Origin of complex behaviour of spatially discordant alternans in a transgenic rabbit model of type 2 long QT syndrome.

Dispersion of repolarization and refractoriness are determinants of arrhythmia phenotype in transgenic mice with long QT.

Cytosolic Ca<sup>2+</sup> triggers early afterdepolarizations and torsade de pointes in rabbit hearts with type 2 long QT syndrome.

Simultaneous maps of optical action potentials and calcium transients in guinea-pig hearts: mechanisms underlying concordant alternans.

Human Atrial Cardiac Microtissues for Chamber-Specific Arrhythmic Risk Assessment.

Correction: Spatially Discordant Alternans and Arrhythmias in Tachypacing-Induced Cardiac Myopathy in Transgenic LQT1 Rabbits: The Importance of I<sub>Ks</sub> and Ca<sup>2+</sup> Cycling.

Spatially Discordant Alternans and Arrhythmias in Tachypacing-Induced Cardiac Myopathy in Transgenic LQT1 Rabbits: The Importance of I<sub>Ks</sub> and Ca<sup>2+</sup> Cycling.

Dual-Dye Optical Mapping after Myocardial Infarction: Does the Site of Ventricular Stimulation Alter the Properties of Electrical Propagation?

Sex Modulates the Arrhythmogenic Substrate in Prepubertal Rabbit Hearts with Long QT 2.

Adaptation of Cardiac Action Potential Durations to Stimulation History with Random Diastolic Intervals.

Fiber Orientation and Cell-Cell Coupling Influence Ventricular Fibrillation Dynamics.

Short-Long Heart Rate Variation Increases Dispersion of Action Potential Duration in Long QT Type 2 Transgenic Rabbit Model.

One Billion hiPSC-Cardiomyocytes: Upscaling Engineered Cardiac Tissues to Create High Cell Density Therapies for Clinical Translation in Heart Regeneration.

A predictive in vitro risk assessment platform for pro-arrhythmic toxicity using human 3D cardiac microtissues.

Associations of Prolonged QTc in Sickle Cell Disease.

Beyond Pharmaceuticals: Fit-for-Purpose New Approach Methodologies for Environmental Cardiotoxicity Testing.

PKA phosphorylation underlies functional recruitment of sarcolemmal SK2 channels in ventricular myocytes from hypertrophic hearts.

Mechanisms linking T‐wave alternans to spontaneous initiation of ventricular arrhythmias in rabbit models of long QT syndrome.

Differential conditions for early after-depolarizations and triggered activity in cardiomyocytes derived from transgenic LQT1 and LQT2 rabbits.

Pharmacological Modulation of Mitochondrial Ca<sup>2+</sup> Content Regulates Sarcoplasmic Reticulum Ca<sup>2+</sup> Release via Oxidation of the Ryanodine Receptor by Mitochondria-Derived Reactive Oxygen Species.

Action potential metrics and automated data analysis pipeline for cardiotoxicity testing using optically mapped hiPSC-derived 3D cardiac microtissues.

In vitro to in vivo extrapolation from 3D hiPSC-derived cardiac microtissues and physiologically based pharmacokinetic modeling to inform next-generation arrhythmia risk assessment.

ML-GAP: machine learning-enhanced genomic analysis pipeline using autoencoders and data augmentation.

Human Cardiac Fibroblast Number and Activation State Modulate Electromechanical Function of hiPSC-Cardiomyocytes in Engineered Myocardium.

Directed fusion of cardiac spheroids into larger heterocellular microtissues enables investigation of cardiac action potential propagation via cardiac fibroblasts.