Works matching AU Cherepanov, Peter

Results: 48

The structural biology of HIV-1: mechanistic and therapeutic insights.

Published in:

Nature Reviews Microbiology, 2012, v. 10, n. 4, p. 279, doi. 10.1038/nrmicro2747

By:

Engelman, Alan;
Cherepanov, Peter

Publication type:

Article

SARS-CoV-2 antibody responses associate with sex, age and disease severity in previously uninfected people admitted to hospital with COVID-19: An ISARIC4C prospective study.

Published in:

Frontiers in Immunology, 2023, v. 14, p. 1, doi. 10.3389/fimmu.2023.1146702

By:

Parker, Eleanor;
Thomas, Jordan;
Roper, Kelly J.;
Ijaz, Samreen;
Edwards, Tansy;
Marchesin, Federica;
Katsanovskaja, Ksenia;
Lett, Lauren;
Jones, Christopher;
Hardwick, Hayley E.;
Davis, Chris;
Vink, Elen;
McDonald, Sarah E.;
Moore, Shona C.;
Dicks, Steve;
Jegatheesan, Keerthana;
Cook, Nicola J.;
Hope, Joshua;
Cherepanov, Peter;
McClure, Myra O.

Publication type:

Article

Structures of TGF-β with betaglycan and signaling receptors reveal mechanisms of complex assembly and signaling.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-56796-9

By:

Wieteska, Łukasz;
Taylor, Alexander B.;
Punch, Emma;
Coleman, Jonathan A.;
Conway, Isabella O.;
Lin, Yeu-Farn;
Byeon, Chang-Hyeock;
Hinck, Cynthia S.;
Krzysiak, Troy;
Ishima, Rieko;
López-Casillas, Fernando;
Cherepanov, Peter;
Bernard, Daniel J.;
Hill, Caroline S.;
Hinck, Andrew P.

Publication type:

Article

Reduced neutralisation of the Delta (B.1.617.2) SARS-CoV-2 variant of concern following vaccination.

Published in:

PLoS Pathogens, 2021, v. 17, n. 12, p. 1, doi. 10.1371/journal.ppat.1010022

By:

Davis, Chris;
Logan, Nicola;
Tyson, Grace;
Orton, Richard;
Harvey, William T.;
Perkins, Jonathan S.;
Mollett, Guy;
Blacow, Rachel M.;
Peacock, Thomas P.;
Barclay, Wendy S.;
Cherepanov, Peter;
Palmarini, Massimo;
Murcia, Pablo R.;
Patel, Arvind H.;
Robertson, David L.;
Haughney, John;
Thomson, Emma C.;
Willett, Brian J.

Publication type:

Article

LcrV is a channel size-determining component of the Yop effector translocon of Yersinia.

Published in:

Molecular Microbiology, 2001, v. 39, n. 3, p. 620, doi. 10.1046/j.1365-2958.2001.02259.x

By:

Holmström, Anna;
Olsson, Jan;
Cherepanov, Peter;
Maier, Elke;
Nordfelth, Roland;
Pettersson, Jonas;
Benz, Roland;
Wolf-Watz, Hans;
Forsberg, Åke

Publication type:

Article

HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor.

Published in:

Nucleic Acids Research, 2012, v. 40, n. 22, p. 11518, doi. 10.1093/nar/gks913

By:

Wang, Hao;
Jurado, Kellie A.;
Wu, Xiaolin;
Shun, Ming-Chieh;
Li, Xiang;
Ferris, Andrea L.;
Smith, Steven J.;
Patel, Pratiq A.;
Fuchs, James R.;
Cherepanov, Peter;
Kvaratskhelia, Mamuka;
Hughes, Stephen H.;
Engelman, Alan

Publication type:

Article

Functional and structural characterization of the integrase from the prototype foamy virus.

Published in:

Nucleic Acids Research, 2009, v. 37, n. 1, p. 243, doi. 10.1093/nar/gkn938

By:

Valkov, Eugene;
Gupta, Saumya Shree;
Hare, Stephen;
Helander, Anna;
Roversi, Pietro;
McClure, Myra;
Cherepanov, Peter

Publication type:

Article

LEDGF/p75 interacts with divergent lentiviral integrases and modulates their enzymatic activity in vitro.

Published in:

Nucleic Acids Research, 2007, v. 35, n. 1, p. 113, doi. 10.1093/nar/gkl885

By:

Cherepanov, Peter

Publication type:

Article

A tripartite DNA-binding element, comprised of the nuclear localization signal and two AT-hook motifs, mediates the association of LEDGF/p75 with chromatin in vivo.

Published in:

Nucleic Acids Research, 2006, v. 34, n. 5, p. 1653, doi. 10.1093/nar/gkl052

By:

Turlure, Fanny;
Maertens, Goedele;
Rahman, Shaila;
Cherepanov, Peter;
Engelman, Alan

Publication type:

Article

Multivalent interactions essential for lentiviral integrase function.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-29928-8

By:

Ballandras-Colas, Allison;
Chivukula, Vidya;
Gruszka, Dominika T.;
Shan, Zelin;
Singh, Parmit K.;
Pye, Valerie E.;
McLean, Rebecca K.;
Bedwell, Gregory J.;
Li, Wen;
Nans, Andrea;
Cook, Nicola J.;
Fadel, Hind J.;
Poeschla, Eric M.;
Griffiths, David J.;
Vargas, Javier;
Taylor, Ian A.;
Lyumkis, Dmitry;
Yardimci, Hasan;
Engelman, Alan N.;
Cherepanov, Peter

Publication type:

Article

Publisher Correction: Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures.

Published in:

2021

By:

Barski, Michal S.;
Vanzo, Teresa;
Zhao, Xue Zhi;
Smith, Steven J.;
Ballandras-Colas, Allison;
Cronin, Nora B.;
Pye, Valerie E.;
Hughes, Stephen H.;
Burke Jr., Terrence R.;
Cherepanov, Peter;
Maertens, Goedele N.

Publication type:

Correction Notice

Characterization of humoral and SARS-CoV-2 specific T cell responses in people living with HIV.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-26137-7

By:

Alrubayyi, Aljawharah;
Gea-Mallorquí, Ester;
Touizer, Emma;
Hameiri-Bowen, Dan;
Kopycinski, Jakub;
Charlton, Bethany;
Fisher-Pearson, Natasha;
Muir, Luke;
Rosa, Annachiara;
Roustan, Chloe;
Earl, Christopher;
Cherepanov, Peter;
Pellegrino, Pierre;
Waters, Laura;
Burns, Fiona;
Kinloch, Sabine;
Dong, Tao;
Dorrell, Lucy;
Rowland-Jones, Sarah;
McCoy, Laura E.

Publication type:

Article

Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-25284-1

By:

Barski, Michal S.;
Vanzo, Teresa;
Zhao, Xue Zhi;
Smith, Steven J.;
Ballandras-Colas, Allison;
Cronin, Nora B.;
Pye, Valerie E.;
Hughes, Stephen H.;
Burke Jr., Terrence R.;
Cherepanov, Peter;
Maertens, Goedele N.

Publication type:

Article

The Yersinia YopE and YopH type III effector proteins enhance bacterial proliferation following contact with eukaryotic cells.

Published in:

BMC Microbiology, 2001, v. 1, p. 22, doi. 10.1186/1471-2180-1-22

By:

Bartra, Sara;
Cherepanov, Peter;
Forsberg, Åke;
Schesser, Kurt

Publication type:

Article

ATG9B is a tissue-specific homotrimeric lipid scramblase that can compensate for ATG9A.

Published in:

Autophagy, 2024, v. 20, n. 3, p. 557, doi. 10.1080/15548627.2023.2275905

By:

Chiduza, George N.;
Garza-Garcia, Acely;
Almacellas, Eugenia;
De Tito, Stefano;
Pye, Valerie E;
van Vliet, Alexander R.;
Cherepanov, Peter;
Tooze, Sharon A.

Publication type:

Article

Activity of recombinant HIV‐1 integrase onmini‐HIV DNA.

Published in:

Nucleic Acids Research, 1999, v. 27, n. 10, p. 2202, doi. 10.1093/nar/27.10.2202

By:

Cherepanov, Peter;
Surratt, David;
Toelen, Jaan;
Pluymers, Wim;
Griffith, Jack;
De Clercq, Erik;
Debyser, Zeger

Publication type:

Article

Structural Basis for Functional Tetramerization of Lentiviral Integrase.

Published in:

PLoS Pathogens, 2009, v. 5, n. 7, p. 1, doi. 10.1371/journal.ppat.1000515

By:

Hare, Stephen;
Di Nunzio, Francesca;
Labeja, Alfred;
Jimin Wang;
Engelman, Alan;
Cherepanov, Peter

Publication type:

Article

The SET Complex Acts as a Barrier to Autointegration of HIV-1.

Published in:

PLoS Pathogens, 2009, v. 5, n. 3, p. 1, doi. 10.1371/journal.ppat.1000327

By:

Nan Yan;
Cherepanov, Peter;
Daigle, Janet E.;
Engelman, Alan;
Lieberman, Judy

Publication type:

Article

A Novel Co-Crystal Structure Affords the Design of Gain-of-Function Lentiviral Integrase Mutants in the Presence of Modified PSIP1/LEDGF/p75.

Published in:

PLoS Pathogens, 2009, v. 5, n. 1, p. 1, doi. 10.1371/journal.ppat.1000259

By:

Hare, Stephen;
Ming-Chieh Shun;
Gupta, Saumya Shree;
Valkov, Eugene;
Engelman, Alan;
Cherepanov, Peter

Publication type:

Article

The Lentiviral Integrase Binding Protein LEDGF/p75 and HIV-1 Replication.

Published in:

PLoS Pathogens, 2008, v. 4, n. 3, p. 1, doi. 10.1371/journal.ppat.1000046

By:

Engelman, Alan;
Cherepanov, Peter

Publication type:

Article

Expression of HIV-1 integrase in CEM cells inhibits HIV-1 replication.

Published in:

Journal of Gene Medicine, 2004, v. 6, n. 3, p. 268, doi. 10.1002/jgm.520

By:

Johan van Griensven;
Xiaojing Zhan;
Bénédicte Van Maele;
Wim Pluymers;
Martine Michiels;
Erik De Clercq;
Peter Cherepanov;
Zeger Debyser

Publication type:

Article

Cdt1 stabilizes an open MCM ring for helicase loading.

Published in:

Nature Communications, 2017, v. 8, n. 6, p. 15720, doi. 10.1038/ncomms15720

By:

Frigola, Jordi;
He, Jun;
Kinkelin, Kerstin;
Pye, Valerie E.;
Renault, Ludovic;
Douglas, Max E.;
Remus, Dirk;
Cherepanov, Peter;
Costa, Alessandro;
Diffley, John F. X.

Publication type:

Article

Timed chromatin invasion during mitosis governs prototype foamy virus integration site selection and infectivity Open Access.

Published in:

Nucleic Acids Research, 2025, v. 53, n. 10, p. 1, doi. 10.1093/nar/gkaf449

By:

Lagadec, Floriane;
Singh, Parmit K;
Calmels, Christina;
Lapaillerie, Delphine;
Lindemann, Dirk;
Parissi, Vincent;
Cherepanov, Peter;
Engelman, Alan N;
Lesbats, Paul

Publication type:

Article

B-to-A transition in target DNA during retroviral integration.

Published in:

Nucleic Acids Research, 2022, v. 50, n. 15, p. 8898, doi. 10.1093/nar/gkac644

By:

Jóźwik, Ilona K;
Li, Wen;
Zhang, Da-Wei;
Wong, Doris;
Grawenhoff, Julia;
Ballandras-Colas, Allison;
Aiyer, Sriram;
Cherepanov, Peter;
Engelman, Alan N;
Lyumkis, Dmitry

Publication type:

Article

Differential role for phosphorylation in alternative polyadenylation function versus nuclear import of SR-like protein CPSF6.

Published in:

Nucleic Acids Research, 2019, v. 47, n. 9, p. 4663, doi. 10.1093/nar/gkz206

By:

Jang, Sooin;
Cook, Nicola J;
Pye, Valerie E;
Bedwell, Gregory J;
Dudek, Amanda M;
Singh, Parmit K;
Cherepanov, Peter;
Engelman, Alan N

Publication type:

Article

Integrase residues that determine nucleotide preferences at sites of HIV-1 integration: implications for the mechanism of target DNA binding.

Published in:

Nucleic Acids Research, 2014, v. 42, n. 8, p. 5164, doi. 10.1093/nar/gku136

By:

Serrao, Erik;
Krishnan, Lavanya;
Shun, Ming-Chieh;
Li, Xiang;
Cherepanov, Peter;
Engelman, Alan;
Maertens, Goedele N.

Publication type:

Article

Severe Acute Respiratory Syndrome Coronavirus 2 Serosurveillance in a Patient Population Reveals Differences in Virus Exposure and Antibody-Mediated Immunity According to Host Demography and Healthcare Setting.

Published in:

2021

By:

Hughes, Ellen C;
Amat, Julien A R;
Haney, Joanne;
Parr, Yasmin A;
Logan, Nicola;
Palmateer, Norah;
Nickbakhsh, Sema;
Ho, Antonia;
Cherepanov, Peter;
Rosa, Annachiara;
McAuley, Andrew;
Broos, Alice;
Herbert, Imogen;
Arthur, Ursula;
Szemiel, Agnieszka M;
Roustan, Chloe;
Dickson, Elizabeth;
Gunson, Rory N;
Viana, Mafalda;
Willett, Brian J

Publication type:

journal article

3?-Processing and strand transfer catalysed by retroviral integrase in crystallo.

Published in:

EMBO Journal, 2012, v. 31, n. 13, p. 3020, doi. 10.1038/emboj.2012.118

By:

Hare, Stephen;
Maertens, Goedele N;
Cherepanov, Peter

Publication type:

Article

Crystal structure of human CDC7 kinase in complex with its activator DBF4.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 11, p. 1101, doi. 10.1038/nsmb.2404

By:

Hughes, Siobhan;
Elustondo, Frédéric;
Di Fonzo, Andrea;
Leroux, Frédéric G;
Wong, Ai C;
Snijders, Ambrosius P;
Matthews, Stephen J;
Cherepanov, Peter

Publication type:

Article

Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75.

Published in:

Nature Structural & Molecular Biology, 2005, v. 12, n. 6, p. 526, doi. 10.1038/nsmb937

By:

Cherepanov, Peter;
Sun, Zhen-Yu J;
Rahman, Shaila;
Maertens, Goedele;
Wagner, Gerhard;
Engelman, Alan

Publication type:

Article

Cryo-EM structure of the deltaretroviral intasome in complex with the PP2A regulatory subunit B56γ.

Published in:

Nature Communications, 2020, v. 11, n. 1, p. N.PAG, doi. 10.1038/s41467-020-18874-y

By:

Barski, Michał S.;
Minnell, Jordan J.;
Hodakova, Zuzana;
Pye, Valerie E.;
Nans, Andrea;
Cherepanov, Peter;
Maertens, Goedele N.

Publication type:

Article

Key determinants of target DNA recognition by retroviral intasomes.

Published in:

Retrovirology, 2015, v. 12, n. 1, p. 1, doi. 10.1186/s12977-015-0167-3

By:

Serrao, Erik;
Ballandras-Colas, Allison;
Cherepanov, Peter;
Maertens, Goedele N.;
Engelman, Alan N.

Publication type:

Article

HIV-1 exploits importin 7 to maximize nuclear import of its DNA genome.

Published in:

Retrovirology, 2009, v. 6, p. 1, doi. 10.1186/1742-4690-6-11

By:

Zaitseva, Lyubov;
Cherepanov, Peter;
Leyens, Lada;
Wilson, Sam J.;
Rasaiyaah, Jane;
Fassati, Ariberto

Publication type:

Article

Centralspindlin links the mitotic spindle to the plasma membrane during cytokinesis.

Published in:

Nature, 2012, v. 492, n. 7428, p. 276, doi. 10.1038/nature11773

By:

Lekomtsev, Sergey;
Su, Kuan-Chung;
Pye, Valerie E.;
Blight, Ken;
Sundaramoorthy, Sriramkumar;
Takaki, Tohru;
Collinson, Lucy M.;
Cherepanov, Peter;
Divecha, Nullin;
Petronczki, Mark

Publication type:

Article

The mechanism of retroviral integration from X-ray structures of its key intermediates.

Published in:

Nature, 2010, v. 468, n. 7321, p. 326, doi. 10.1038/nature09517

By:

Maertens, Goedele N.;
Hare, Stephen;
Cherepanov, Peter

Publication type:

Article

Retroviral intasome assembly and inhibition of DNA strand transfer.

Published in:

Nature, 2010, v. 464, n. 7286, p. 232, doi. 10.1038/nature08784

By:

Hare, Stephen;
Gupta, Saumya Shree;
Valkov, Eugene;
Engelman, Alan;
Cherepanov, Peter

Publication type:

Article

Simple, sensitive, specific self-sampling assay secures SARS-CoV-2 antibody signals in sero-prevalence and post-vaccine studies.

Published in:

Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-05640-x

By:

Khan, Maryam;
Rosadas, Carolina;
Katsanovskaja, Ksenia;
Weber, Isaac D.;
Shute, Justin;
Ijaz, Samreen;
Marchesin, Federica;
McClure, Eleanor;
Elias, Salem;
Flower, Barnaby;
Gao, He;
Quinlan, Rachael;
Short, Charlotte;
Rosa, Annachiara;
Roustan, Chloe;
Moshe, Maya;
Taylor, Graham P.;
Elliott, Paul;
Cooke, Graham S.;
Cherepanov, Peter

Publication type:

Article

SARS-CoV-2 S2–targeted vaccination elicits broadly neutralizing antibodies.

Published in:

Science Translational Medicine, 2022, v. 14, n. 655, p. 1, doi. 10.1126/scitranslmed.abn3715

By:

Ng, Kevin W.;
Faulkner, Nikhil;
Finsterbusch, Katja;
Wu, Mary;
Harvey, Ruth;
Hussain, Saira;
Greco, Maria;
Liu, Yafei;
Kjaer, Svend;
Swanton, Charles;
Gandhi, Sonia;
Beale, Rupert;
Gamblin, Steve J.;
Cherepanov, Peter;
McCauley, John;
Daniels, Rodney;
Howell, Michael;
Arase, Hisashi;
Wack, Andreas;
Bauer, David L.V.

Publication type:

Article

The Interaction Between Lentiviral Integrase and LEDGF: Structural and Functional Insights.

Published in:

Viruses (1999-4915), 2009, v. 1, n. 3, p. 780, doi. 10.3390/v1030780

By:

Hare, Stephen;
Cherepanov, Peter

Publication type:

Article

Structural characterisation of the Chaetomium thermophilum Chl1 helicase.

Published in:

PLoS ONE, 2021, v. 16, n. 5, p. 1, doi. 10.1371/journal.pone.0251261

By:

Hodáková, Zuzana;
Nans, Andrea;
Kunzelmann, Simone;
Mehmood, Shahid;
Taylor, Ian;
Uhlmann, Frank;
Cherepanov, Peter;
Singleton, Martin R.

Publication type:

Article

Structural basis for retroviral integration into nucleosomes.

Published in:

Nature, 2015, v. 523, n. 7560, p. 366, doi. 10.1038/nature14495

By:

Maskell, Daniel P.;
Renault, Ludovic;
Serrao, Erik;
Lesbats, Paul;
Matadeen, Rishi;
Hare, Stephen;
Lindemann, Dirk;
Engelman, Alan N.;
Costa, Alessandro;
Cherepanov, Peter

Publication type:

Article

Integrase illuminated.

Published in:

EMBO Reports, 2010, v. 11, n. 5, p. 328, doi. 10.1038/embor.2010.58

By:

Cherepanov, Peter

Publication type:

Article

Retroviral integration into nucleosomes through DNA looping and sliding along the histone octamer.

Published in:

Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-12007-w

By:

Wilson, Marcus D.;
Renault, Ludovic;
Maskell, Daniel P.;
Ghoneim, Mohamed;
Pye, Valerie E.;
Nans, Andrea;
Rueda, David S.;
Cherepanov, Peter;
Costa, Alessandro

Publication type:

Article

Author Correction: Scalable and robust SARS-CoV-2 testing in an academic center.

Published in:

2020

By:

Aitken, Jim;
Ambrose, Karen;
Barrell, Sam;
Beale, Rupert;
Bineva-Todd, Ganka;
Biswas, Dhruva;
Byrne, Richard;
Caidan, Simon;
Cherepanov, Peter;
Churchward, Laura;
Clark, Graham;
Crawford, Margaret;
Cubitt, Laura;
Dearing, Vicky;
Earl, Christopher;
Edwards, Amelia;
Ekin, Chris;
Fidanis, Efthymios;
Gaiba, Alessandra;
Gamblin, Steve

Publication type:

Correction Notice

Scalable and robust SARS-CoV-2 testing in an academic center.

Published in:

2020

By:

Aitken, Jim;
Ambrose, Karen;
Barrell, Sam;
Beale, Rupert;
Bineva-Todd, Ganka;
Biswas, Dhruva;
Byrne, Richard;
Caidan, Simon;
Cherepanov, Peter;
Churchward, Laura;
Clark, Graham;
Crawford, Margaret;
Cubitt, Laura;
Dearing, Vicky;
Earl, Christopher;
Edwards, Amelia;
Ekin, Chris;
Fidanis, Efthymios;
Gaiba, Alessandra;
Gamblin, Steve

Publication type:

Letter

Close‐up: HIV/SIV intasome structures shed new light on integrase inhibitor binding and viral escape mechanisms.

Published in:

FEBS Journal, 2021, v. 288, n. 2, p. 427, doi. 10.1111/febs.15438

By:

Engelman, Alan N.;
Cherepanov, Peter

Publication type:

Article

Correction: Interactions of Prototype Foamy Virus Capsids with Host Cell Polo-Like Kinases Are Important for Efficient Viral DNA Integration.

Published in:

2016

By:

Zurnic, Irena;
Hütter, Sylvia;
Rzeha, Ute;
Helbig, Roger;
Stanke, Nicole;
Reh, Juliane;
Müllers, Erik;
Hamann, Martin V.;
Kern, Tobias;
Gerresheim, Gesche K.;
Lindel, Fabian;
Serrao, Erik;
Lesbats, Paul;
Engelman, Alan N.;
Cherepanov, Peter;
Lindemann, Dirk

Publication type:

Correction Notice

Interactions of Prototype Foamy Virus Capsids with Host Cell Polo-Like Kinases Are Important for Efficient Viral DNA Integration.

Published in:

PLoS Pathogens, 2016, v. 12, n. 8, p. 1, doi. 10.1371/journal.ppat.1005860

By:

Zurnic, Irena;
Hütter, Sylvia;
Rzeha, Ute;
Stanke, Nicole;
Reh, Juliane;
Müllers, Erik;
Hamann, Martin V.;
Kern, Tobias;
Gerresheim, Gesche K.;
Lindel, Fabian;
Serrao, Erik;
Lesbats, Paul;
Engelman, Alan N.;
Cherepanov, Peter;
Lindemann, Dirk

Publication type:

Article