Works by Chenel, Marylore

Results: 38

Simultaneous central nervous system distribution and pharmacokinetic--pharmacodynamic modelling of the electroencephalogram effect of norfloxacin administered at a convulsant dose in rats.

Published in:

British Journal of Pharmacology, 2004, v. 142, n. 2, p. 323, doi. 10.1038/sj.bjp.0705748

By:

Chenel, Marylore;
Marchand, Sandrine;
Dupuis, Antoine;
Lamarche, Isabelle;
Paquereau, Joël;
Pariat, Claudine;
Couet, William

Publication type:

Article

How to Successfully Generate an Alternative Approach to a Thorough QT Study: GLPG1972 as an Example.

Published in:

Clinical Pharmacology & Therapeutics, 2023, v. 113, n. 2, p. 310, doi. 10.1002/cpt.2596

By:

Meyer, Claudia;
Dierick, Ines;
Gauderat, Glenn;
Langenhorst, Jurgen;
Sarr, Céline;
Leroux, Emilie;
Chenel, Marylore;
Fouliard, Sylvain;
Passier, Paul

Publication type:

Article

Impact of Hepatic CYP3A4 Ontogeny Functions on Drug–Drug Interaction Risk in Pediatric Physiologically‐Based Pharmacokinetic/Pharmacodynamic Modeling: Critical Literature Review and Ivabradine Case Study.

Published in:

Clinical Pharmacology & Therapeutics, 2021, v. 109, n. 6, p. 1618, doi. 10.1002/cpt.2134

By:

Lang, Jennifer;
Vincent, Ludwig;
Chenel, Marylore;
Ogungbenro, Kayode;
Galetin, Aleksandra

Publication type:

Article

Transforming Translation Through Quantitative Pharmacology for High‐Impact Decision Making in Drug Discovery and Development.

Published in:

Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 6, p. 1285, doi. 10.1002/cpt.1667

By:

Gupta, Neeraj;
Bottino, Dean;
Simonsson, Ulrika S.H.;
Musante, Cynthia J.;
Bueters, Tjerk;
Rieger, Theodore R.;
Macha, Sreeraj;
Chenel, Marylore;
Fancourt, Craig;
Kanodia, Jitendra;
Nayak, Satyaprakash

Publication type:

Article

Development of a Physiologically-Based Pharmacokinetic Model of the Rat Central Nervous System.

Published in:

Pharmaceutics, 2014, v. 6, n. 1, p. 97, doi. 10.3390/pharmaceutics6010097

By:

Badhan, Raj K. Singh;
Chenel, Marylore;
Penny, Jeffrey I.

Publication type:

Article

Model-based approaches for ivabradine development in paediatric population, part II: PK and PK/PD assessment.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2016, v. 43, n. 1, p. 29, doi. 10.1007/s10928-015-9452-y

By:

Peigné, Sophie;
Fouliard, Sylvain;
Chenel, Marylore;
Decourcelle, Sophie

Publication type:

Article

Model-based approaches for ivabradine development in paediatric population, part I: study preparation assessment.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2016, v. 43, n. 1, p. 13, doi. 10.1007/s10928-015-9451-z

By:

Peigné, Sophie;
Brendel, Karl;
Gesson, Charlotte;
Fouliard, Sylvain;
Chenel, Marylore;
Bouzom, François

Publication type:

Article

Pharmacogenetics and population pharmacokinetics: impact of the design on three tests using the SAEM algorithm.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2009, v. 36, n. 4, p. 317, doi. 10.1007/s10928-009-9124-x

By:

Julie Bertrand;
Emmanuelle Comets;
Céline Laffont;
Marylore Chenel;
France Mentré

Publication type:

Article

Drug–drug interaction predictions with PBPK models and optimal multiresponse sampling time designs: application to midazolam and a phase I compound. Part 1: comparison of uniresponse and multiresponse designs using PopDes.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2008, v. 35, n. 6, p. 635, doi. 10.1007/s10928-008-9104-6

By:

Marylore Chenel;
François Bouzom

Publication type:

Article

Drug–drug interaction predictions with PBPK models and optimal multiresponse sampling time designs: application to midazolam and a phase I compound. Part 2: clinical trial results.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2008, v. 35, n. 6, p. 661, doi. 10.1007/s10928-008-9105-5

By:

Marylore Chenel;
François Bouzom;
Fanny Cazade

Publication type:

Article

Simultaneous Ivabradine Parent-Metabolite PBPK/PD Modelling Using a Bayesian Estimation Method.

Published in:

AAPS Journal, 2020, v. 22, n. 6, p. N.PAG, doi. 10.1208/s12248-020-00502-8

By:

Lang, Jennifer;
Vincent, Ludwig;
Chenel, Marylore;
Ogungbenro, Kayode;
Galetin, Aleksandra

Publication type:

Article

Impact of Interleukin-6 on Drug-Metabolizing Enzymes and Transporters in Intestinal Cells.

Published in:

AAPS Journal, 2020, v. 22, n. 1, p. 1, doi. 10.1208/s12248-019-0395-x

By:

Simon, Florian;
Garcia, Jessica;
Guyot, Laetitia;
Guitton, Jérôme;
Vilchez, Gaelle;
Bardel, Claire;
Chenel, Marylore;
Tod, Michel;
Payen, Léa

Publication type:

Article

Application of Item Response Theory to Model Disease Progression and Agomelatine Effect in Patients with Major Depressive Disorder.

Published in:

AAPS Journal, 2020, v. 22, n. 1, p. 1, doi. 10.1208/s12248-019-0379-x

By:

Cerou, Marc;
Peigné, Sophie;
Comets, Emmanuelle;
Chenel, Marylore

Publication type:

Article

Correction to: Model-Based Adaptive Optimal Design (MBAOD) Improves Combination Dose Finding Designs: an Example in Oncology.

Published in:

AAPS Journal, 2018, v. 20, n. 3, p. 1, doi. 10.1208/s12248-018-0218-5

By:

Pierrillas, Philippe B.;
Fouliard, Sylvain;
Chenel, Marylore;
Hooker, Andrew C.;
Friberg, Lena E.;
Karlsson, Mats O.

Publication type:

Article

Model-Based Adaptive Optimal Design (MBAOD) Improves Combination Dose Finding Designs: an Example in Oncology.

Published in:

AAPS Journal, 2018, v. 20, n. 2, p. 1, doi. 10.1208/s12248-018-0206-9

By:

Pierrillas, Philippe B.;
Fouliard, Sylvain;
Chenel, Marylore;
Hooker, Andrew C.;
Friberg, Lena F.;
Karlsson, Mats O.

Publication type:

Article

Improvement of Parameter Estimations in Tumor Growth Inhibition Models on Xenografted Animals: Handling Sacrifice Censoring and Error Caused by Experimental Measurement on Larger Tumor Sizes.

Published in:

AAPS Journal, 2016, v. 18, n. 5, p. 1262, doi. 10.1208/s12248-016-9936-8

By:

Pierrillas, Philippe;
Tod, Michel;
Amiel, Magali;
Chenel, Marylore;
Henin, Emilie

Publication type:

Article

Improvement of Parameter Estimations in Tumor Growth Inhibition Models on Xenografted Animals: a Novel Method to Handle the Interval Censoring Caused by Measurement of Smaller Tumors.

Published in:

AAPS Journal, 2016, v. 18, n. 2, p. 404, doi. 10.1208/s12248-015-9862-1

By:

Pierrillas, Philippe;
Tod, Michel;
Amiel, Magali;
Chenel, Marylore;
Henin, Emilie

Publication type:

Article

Comparison of Nonlinear Mixed Effects Models and Noncompartmental Approaches in Detecting Pharmacogenetic Covariates.

Published in:

AAPS Journal, 2015, v. 17, n. 3, p. 597, doi. 10.1208/s12248-015-9726-8

By:

Tessier, Adrien;
Bertrand, Julie;
Chenel, Marylore;
Comets, Emmanuelle

Publication type:

Article

Development of a Complex Parent-Metabolite Joint Population Pharmacokinetic Model.

Published in:

AAPS Journal, 2011, v. 13, n. 3, p. 390, doi. 10.1208/s12248-011-9282-9

By:

Bertrand, Julie;
Laffont, Céline;
Mentré, France;
Chenel, Marylore;
Comets, Emmanuelle

Publication type:

Article

Modeling Approach to Predict the Impact of Inflammation on the Pharmacokinetics of CYP2C19 and CYP3A4 Substrates.

Published in:

Pharmaceutical Research, 2021, v. 38, n. 3, p. 415, doi. 10.1007/s11095-021-03019-7

By:

Simon, Florian;
Gautier-Veyret, Elodie;
Truffot, Aurélie;
Chenel, Marylore;
Payen, Léa;
Stanke-Labesque, Françoise;
Tod, Michel

Publication type:

Article

Application of Hematological Toxicity Modeling in Clinical Development of Abexinostat (S-78454, PCI-24781), A New Histone Deacetylase Inhibitor.

Published in:

Pharmaceutical Research, 2013, v. 30, n. 10, p. 2640, doi. 10.1007/s11095-013-1089-1

By:

Chalret du Rieu, Quentin;
Fouliard, Sylvain;
Jacquet-Bescond, Anne;
Robert, Renata;
Kloos, Ioana;
Depil, Stéphane;
Chatelut, Etienne;
Chenel, Marylore

Publication type:

Article

A Physiologically Based Pharmacokinetic Model for Strontium Exposure in Rat.

Published in:

Pharmaceutical Research, 2013, v. 30, n. 6, p. 1536, doi. 10.1007/s11095-013-0991-x

By:

Pertinez, Henry;
Chenel, Marylore;
Aarons, Leon

Publication type:

Article

Optimal Sampling Times for a Drug and its Metabolite using SIMCYP® Simulations as Prior Information.

Published in:

Clinical Pharmacokinetics, 2013, v. 52, n. 1, p. 43, doi. 10.1007/s40262-012-0022-9

By:

Dumont, Cyrielle;
Mentre, France;
Gaynor, Clare;
Brendel, Karl;
Gesson, Charlotte;
Chenel, Marylore

Publication type:

Article

Predictions of metabolic drug-drug interactions using physiologically based modelling: Two cytochrome P450 3A4 substrates coadministered with ketoconazole or verapamil.

Published in:

2010

By:

Perdaems N;
Blasco H;
Vinson C;
Chenel M;
Whalley S;
Cazade F;
Bouzom F;
Perdaems, Nathalie;
Blasco, Helene;
Vinson, Cedric;
Chenel, Marylore;
Whalley, Sarah;
Cazade, Fanny;
Bouzom, François

Publication type:

journal article

Predictions of Metabolic Drug-Drug Interactions Using Physiologically Based Modelling.

Published in:

Clinical Pharmacokinetics, 2010, v. 49, n. 4, p. 239, doi. 10.2165/11318130-000000000-00000

By:

Perdaems, Nathalie;
Blasco, Helene;
Vinson, Cedric;
Chenel, Marylore;
Whalley, Sarah;
Cazade, Fanny;
Bouzom, François

Publication type:

Article

Translational approach from preclinical to clinical: comparison of dose finding methods of a new Bcl2 inhibitor using PK-PD modeling and interspecies extrapolation.

Published in:

Investigational New Drugs, 2020, v. 38, n. 6, p. 1796, doi. 10.1007/s10637-020-00953-y

By:

Pierrillas, Philippe B.;
Henin, Emilie;
Ogier, Julien;
Amiel, Magali;
Kraus-Berthier, Laurence;
Chenel, Marylore;
Bouzom, François;
Tod, Michel

Publication type:

Article

Pharmacokinetic/Pharmacodynamic modeling of abexinostat-induced thrombocytopenia across different patient populations: application for the determination of the maximum tolerated doses in both lymphoma and solid tumour patients.

Published in:

Investigational New Drugs, 2014, v. 32, n. 5, p. 985, doi. 10.1007/s10637-014-0118-1

By:

Chalret du Rieu, Quentin;
Fouliard, Sylvain;
White-Koning, Mélanie;
Kloos, Ioana;
Chatelut, Etienne;
Chenel, Marylore

Publication type:

Article

Two-stage Adaptive Designs in Nonlinear Mixed Effects Models: Application to Pharmacokinetics in Children.

Published in:

Communications in Statistics: Simulation & Computation, 2016, v. 45, n. 5, p. 1511, doi. 10.1080/03610918.2014.930901

By:

Dumont, Cyrielle;
Chenel, Marylore;
Mentré, France

Publication type:

Article

Bioavailability of a novel sustained‐release pellet formulation of 5‐flucytosine in healthy‐fed participants for use in patients with cryptococcal meningitis.

Published in:

CTS: Clinical & Translational Science, 2024, v. 17, n. 9, p. 1, doi. 10.1111/cts.13908

By:

Ibnou Zekri Lassout, Nabila;
Goyal, Vishal;
Krantz, Edrich;
Simon, Francois;
Neven, Anouk;
Eriksson, Johanna;
Saayman, Amaria;
Satam, Vijay;
Ruffell, Carol;
Victor, Sarika;
Chenel, Marylore;
Celebic, Aljosa;
Caplain, Henri;
Gillon, Jean‐Yves;
Deshmukh, Abhijit;
Antarkar, Amit;
Sjögren, Eric;
Ribeiro, Isabela

Publication type:

Article

Bioavailability of three novel oral, sustained‐release pellets, relative to an immediate‐release tablet containing 500 mg flucytosine: A randomized, open‐label, crossover study in healthy volunteers.

Published in:

CTS: Clinical & Translational Science, 2024, v. 17, n. 3, p. 1, doi. 10.1111/cts.13756

By:

Goyal, Vishal;
Krantz, Edrich;
Simon, Francois;
Neven, Anouk;
Eriksson, Johanna;
Saayman, Amaria;
Ibnou Zekri Lassout, Nabila;
Louis, Mathieu;
Robinson, Stephen;
Deshmukh, Abhijit;
Antarkar, Amit;
Ruffell, Carol;
Victor, Sarika;
Chenel, Marylore;
Celebic, Aljosa;
Caplain, Henri;
Gillon, Jean‐Yves;
Ribeiro, Isabela

Publication type:

Article

Influence of Covariance Between Random Effects in Design for Nonlinear Mixed-Effect Models with an Illustration in Pediatric Pharmacokinetics.

Published in:

Journal of Biopharmaceutical Statistics, 2014, v. 24, n. 3, p. 471, doi. 10.1080/10543406.2014.888443

By:

Dumont, Cyrielle;
Chenel, Marylore;
Mentré, France

Publication type:

Article

Impact of interleukin‐6 on drug transporters and permeability in the hCMEC/D3 blood–brain barrier model.

Published in:

Fundamental & Clinical Pharmacology, 2021, v. 35, n. 2, p. 397, doi. 10.1111/fcp.12596

By:

Simon, Florian;
Guyot, Laetitia;
Garcia, Jessica;
Vilchez, Gaelle;
Bardel, Claire;
Chenel, Marylore;
Tod, Michel;
Payen, Léa

Publication type:

Article

Some Alternatives to Asymptotic Tests for the Analysis of Pharmacogenetic Data Using Nonlinear Mixed Effects Models.

Published in:

Biometrics, 2012, v. 68, n. 1, p. 146, doi. 10.1111/j.1541-0420.2011.01665.x

By:

Bertrand, Julie;
Comets, Emmanuelle;
Chenel, Marylore;
Mentré, France

Publication type:

Article

Getting Innovative Therapies Faster to Patients at the Right Dose: Impact of Quantitative Pharmacology Towards First Registration and Expanding Therapeutic Use.

Published in:

Clinical Pharmacology & Therapeutics, 2018, v. 103, n. 3, p. 378, doi. 10.1002/cpt.978

By:

Nayak, Satyaprakash;
Sander, Oliver;
Al‐huniti, Nidal;
De Alwis, Dinesh;
Chain, Anne;
Chenel, Marylore;
Sunkaraneni, Soujanya;
Agrawal, Shruti;
Gupta, Neeraj;
Visser, Sandra A. G.

Publication type:

Article

Harnessing Open‐Source Solutions: Insights From the First Open Systems Pharmacology (OSP) Community Conference.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2025, v. 14, n. 5, p. 822, doi. 10.1002/psp4.70028

By:

Dallmann, André;
Feick, Denise;
Balazki, Pavel;
Benamara, Salih;
Burghaus, Rolf;
Chenel, Marylore;
Choi, Siak‐Leng;
Cordes, Henrik;
Guimarães, Mariana;
Hamadeh, Abdullah;
Ince, Ibrahim;
Job, Kathleen M.;
Kanacher, Tobias;
Kovar, Andreas;
Kuepfer, Lars;
Lippert, Jörg;
Macente, Julia;
Nauwelaerts, Nina;
Niederalt, Christoph;
Peters, Sheila

Publication type:

Article

Model‐Informed Drug Development of a Sustained Release Formulation of Flucytosine in the Treatment of Cryptococcal Meningitis: A Case Study Using Physiologically Based Pharmacokinetic Modeling.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2025, v. 14, n. 4, p. 651, doi. 10.1002/psp4.13309

By:

Eriksson, Johanna;
Sjögren, Erik;
Gillon, Jean‐Yves;
Caplain, Henri;
Goyal, Vishal;
Satam, Vijay;
Robinson, Stephen;
Ribeiro, Isabela;
Chenel, Marylore

Publication type:

Article

Modeling restoration of gefitinib efficacy by co‐administration of MET inhibitors in an EGFR inhibitor‐resistant NSCLC xenograft model: A tumor‐in‐host DEB‐based approach.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2021, v. 10, n. 11, p. 1396, doi. 10.1002/psp4.12710

By:

Tosca, Elena M.;
Gauderat, Glenn;
Fouliard, Sylvain;
Burbridge, Mike;
Chenel, Marylore;
Magni, Paolo

Publication type:

Article

Model Description Language (MDL): A Standard for Modeling and Simulation.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2017, v. 6, n. 10, p. 647, doi. 10.1002/psp4.12222

By:

Smith, Mike K.;
Moodie, Stuart L.;
Bizzotto, Roberto;
Blaudez, Eric;
Borella, Elisa;
Carrara, Letizia;
Chan, Phylinda;
Chenel, Marylore;
Comets, Emmanuelle;
Gieschke, Ronald;
Harling, Kajsa;
Harnisch, Lutz;
Hartung, Niklas;
Hooker, Andrew C.;
Karlsson, Mats O.;
Kaye, Richard;
Kloft, Charlotte;
Kokash, Natallia;
Lavielle, Marc;
Lestini, Giulia

Publication type:

Article