Works by Chen, Ye-Guang

Results: 58

The critical role of BMP signaling in gastric epithelial cell differentiation revealed by organoids.

Published in:

Cell Regeneration, 2025, v. 14, n. 1, p. 1, doi. 10.1186/s13619-025-00237-x

By:

Hong, Fan;
Wang, Xiaodan;
Zhong, Nanshan;
Zhang, Ze;
Lin, Shibo;
Zhang, Mengxian;
Li, Haonan;
Liu, Yuan;
Wang, Yalong;
Zhao, Lianzheng;
Yang, Xiao;
Zhou, Hongwen;
Liang, Hui;
Chen, Ye-Guang

Publication type:

Article

Transforming Growth Factor Beta Promotes Inflammation and Tumorigenesis in Smad4‐Deficient Intestinal Epithelium in a YAP‐Dependent Manner.

Published in:

Advanced Science, 2023, v. 10, n. 23, p. 1, doi. 10.1002/advs.202300708

By:

Liu, Liansheng;
Wang, Yalong;
Yu, Shicheng;
Liu, Huidong;
Li, Yehua;
Hua, Shan;
Chen, Ye‐Guang

Publication type:

Article

Internalization of the TGF-β type I receptor into caveolin-1 and EEA1 double-positive early endosomes.

Published in:

Cell Research, 2015, v. 25, n. 6, p. 738, doi. 10.1038/cr.2015.60

By:

He, Kangmin;
Yan, Xiaohua;
Li, Nan;
Dang, Song;
Xu, Li;
Zhao, Bing;
Li, Zijian;
Lv, Zhizhen;
Fang, Xiaohong;
Zhang, Youyi;
Chen, Ye-Guang

Publication type:

Article

Dapper1 promotes autophagy by enhancing the Beclin1-Vps34-Atg14L complex formation.

Published in:

Cell Research, 2014, v. 24, n. 8, p. 912, doi. 10.1038/cr.2014.84

By:

Ma, Benyu;
Cao, Weipeng;
Li, Wenxia;
Gao, Chan;
Qi, Zhen;
Zhao, Yan;
Du, Jun;
Xue, Hua;
Peng, Junya;
Wen, Jun;
Chen, Hua;
Ning, Yuanheng;
Huang, Lei;
Zhang, Hong;
Gao, Xiang;
Yu, Li;
Chen, Ye-Guang

Publication type:

Article

Structural insights into the TRIM family of ubiquitin E3 ligases.

Published in:

Cell Research, 2014, v. 24, n. 6, p. 762, doi. 10.1038/cr.2014.46

By:

Li, Yang;
Wu, Han;
Wu, Wei;
Zhuo, Wei;
Liu, Weixiao;
Zhang, Yixiao;
Cheng, Minzhang;
Chen, Ye-Guang;
Gao, Ning;
Yu, Hongtao;
Wang, Linfang;
Li, Wei;
Yang, Maojun

Publication type:

Article

Design of stapled α-helical peptides to specifically activate Wnt/β-catenin signaling.

Published in:

Cell Research, 2013, v. 23, n. 4, p. 581, doi. 10.1038/cr.2013.30

By:

Cui, Hong-Kui;
Zhao, Bing;
Li, Yehua;
Guo, Ye;
Hu, Hao;
Liu, Lei;
Chen, Ye-Guang

Publication type:

Article

PICK1 promotes caveolin-dependent degradation of TGF-β type I receptor.

Published in:

Cell Research, 2012, v. 22, n. 10, p. 1467, doi. 10.1038/cr.2012.92

By:

Zhao, Bing;
Wang, Qiang;
Du, Jun;
Luo, Shiwen;
Xia, Jun;
Chen, Ye-Guang

Publication type:

Article

Xbp1-mediated histone H4 deacetylation contributes to DNA double-strand break repair in yeast.

Published in:

Cell Research, 2011, v. 21, n. 11, p. 1619, doi. 10.1038/cr.2011.58

By:

Tao, Ran;
Chen, Hua;
Gao, Chan;
Xue, Peng;
Yang, Fuquan;
Han, Jing-Dong J;
Zhou, Bing;
Chen, Ye-Guang

Publication type:

Article

A stromal lineage maintains crypt structure and villus homeostasis in the intestinal stem cell niche.

Published in:

BMC Biology, 2023, v. 21, n. 1, p. 1, doi. 10.1186/s12915-023-01667-2

By:

Xiang, Jinnan;
Guo, Jigang;
Zhang, Shaoyang;
Wu, Hongguang;
Chen, Ye-Guang;
Wang, Junping;
Li, Baojie;
Liu, Huijuan

Publication type:

Article

Tankyrases maintain homeostasis of intestinal epithelium by preventing cell death.

Published in:

PLoS Genetics, 2018, v. 14, n. 9, p. 1, doi. 10.1371/journal.pgen.1007697

By:

Ye, Pan;
Chiang, Y. Jeffery;
Qi, Zhen;
Li, Yehua;
Wang, Shan;
Liu, Yuan;
Li, Xintong;
Chen, Ye-Guang

Publication type:

Article

Noncanonical TGF-β signaling leads to FBXO3-mediated degradation of ΔNp63α promoting breast cancer metastasis and poor clinical prognosis.

Published in:

PLoS Biology, 2021, v. 19, n. 2, p. 1, doi. 10.1371/journal.pbio.3001113

By:

Niu, Mengmeng;
He, Yajun;
Xu, Jing;
Ding, Liangping;
He, Tao;
Yi, Yong;
Fu, Mengyuan;
Guo, Rongtian;
Li, Fengtian;
Chen, Hu;
Chen, Ye-Guang;
Xiao, Zhi-Xiong Jim

Publication type:

Article

c-Abl promotes osteoblast expansion by differentially regulating canonical and non-canonical BMP pathways and p16<sup>INK4a</sup> expression.

Published in:

Nature Cell Biology, 2012, v. 14, n. 7, p. 727, doi. 10.1038/ncb2528

By:

Kua, Hui-Yi;
Liu, Huijuan;
Leong, Wai Fook;
Li, Lili;
Jia, Deyong;
Ma, Gang;
Hu, Yuanyu;
Wang, Xueying;
Chau, Jenny F. L.;
Chen, Ye-Guang;
Mishina, Yuji;
Boast, Sharon;
Yeh, James;
Xia, Li;
Chen, Guo-Qiang;
He, Lin;
Goff, Stephen P.;
Li, Baojie

Publication type:

Article

The nuclear import function of Smad2 is masked by SARA and unmasked by TGFb-dependent phosphorylation.

Published in:

Nature Cell Biology, 2000, v. 2, n. 8, p. 559, doi. 10.1038/35019649

By:

Xu, Lan;
Chen, Ye-Guang;
Massagué, Joan

Publication type:

Article

ARL13B promotes angiogenesis and glioma growth by activating VEGFA-VEGFR2 signaling.

Published in:

Neuro-Oncology, 2023, v. 25, n. 5, p. 871, doi. 10.1093/neuonc/noac245

By:

Chen, Limin;
Xie, Xinsheng;
Wang, Tiantian;
Xu, Linlin;
Zhai, Zhenyu;
Wu, Haibin;
Deng, Libin;
Lu, Quqin;
Chen, Zhengjun;
Yang, Xiao;
Lu, Hua;
Chen, Ye-Guang;
Luo, Shiwen

Publication type:

Article

Liquid–liquid phase separation drives the β‐catenin destruction complex formation.

Published in:

BioEssays, 2021, v. 43, n. 10, p. 1, doi. 10.1002/bies.202100138

By:

Shi, Qiaoni;
Kang, Kexin;
Chen, Ye‐Guang

Publication type:

Article

Recent advances in tissue stem cells.

Published in:

SCIENCE CHINA Life Sciences, 2021, v. 64, n. 12, p. 1998, doi. 10.1007/s11427-021-2007-8

By:

Fu, Xin;
He, Qiang;
Tao, Yu;
Wang, Mengdi;
Wang, Wei;
Wang, Yalong;
Yu, Qing Cissy;
Zhang, Fang;
Zhang, Xiaoyu;
Chen, Ye-Guang;
Gao, Dong;
Hu, Ping;
Hui, Lijian;
Wang, Xiaoqun;
Zeng, Yi Arial

Publication type:

Article

BMP suppresses Wnt signaling via the Bcl11b-regulated NuRD complex to maintain intestinal stem cells.

Published in:

EMBO Journal, 2024, v. 43, n. 23, p. 6032, doi. 10.1038/s44318-024-00276-1

By:

Li, Yehua;
Wang, Xiaodan;
Huang, Meimei;
Wang, Xu;
Li, Chunlin;
Li, Siqi;
Tang, Yuhui;
Yu, Shicheng;
Wang, Yalong;
Song, Wanglu;
Wu, Wei;
Liu, Yuan;
Chen, Ye-Guang

Publication type:

Article

Establishment of human distal lung organoids for SARS-CoV-2 infection.

Published in:

2021

By:

Wang, Ting;
Zhang, Ning;
Fan, Shipan;
Zhao, Lianzheng;
Song, Wanlu;
Gong, Yuhuan;
Shen, Quan;
Zhang, Cheng;
Ren, Peng;
Lin, Chutong;
Fu, Wei;
Gao, George F.;
Ma, Shaohua;
Bi, Yuhai;
Chen, Ye-Guang

Publication type:

Letter

Establishment of human distal lung organoids for SARS-CoV-2 infection.

Published in:

2021

By:

Wang, Ting;
Zhang, Ning;
Fan, Shipan;
Zhao, Lianzheng;
Song, Wanlu;
Gong, Yuhuan;
Shen, Quan;
Zhang, Cheng;
Ren, Peng;
Lin, Chutong;
Fu, Wei;
Gao, George F.;
Ma, Shaohua;
Bi, Yuhai;
Chen, Ye-Guang

Publication type:

Letter

A PROTAC peptide induces durable β-catenin degradation and suppresses Wnt-dependent intestinal cancer.

Published in:

Cell Discovery, 2020, v. 6, n. 1, p. 1, doi. 10.1038/s41421-020-0171-1

By:

Liao, Hongwei;
Li, Xiang;
Zhao, Lianzheng;
Wang, Yalong;
Wang, Xiaodan;
Wu, Ye;
Zhou, Xin;
Fu, Wei;
Liu, Lei;
Hu, Hong-Gang;
Chen, Ye-Guang

Publication type:

Article

Retraction: Noncanonical TGF-β signaling leads to FBXO3-mediated degradation of ΔNp63α promoting breast cancer metastasis and poor clinical prognosis.

Published in:

2024

By:

Niu, Mengmeng;
He, Yajun;
Xu, Jing;
Ding, Liangping;
He, Tao;
Yi, Yong;
Fu, Mengyuan;
Guo, Rongtian;
Li, Fengtian;
Chen, Hu;
Chen, Ye-Guang;
Jim Xiao, Zhi-Xiong

Publication type:

Correction Notice

Fine-tune of intrinsic ERK activity by extrinsic BMP signaling in mouse embryonic stem cells.

Published in:

Protein & Cell, 2012, v. 3, n. 6, p. 401, doi. 10.1007/s13238-012-2925-5

By:

Li, Zhongwei;
Chen, Ye-Guang

Publication type:

Article

Visualization of the post-Golgi vesicle-mediated transportation of TGF- β receptor II by quasi-TIRFM.

Published in:

Journal of Biophotonics, 2014, v. 7, n. 10, p. 788, doi. 10.1002/jbio.201300020

By:

Luo, Wangxi;
Xia, Tie;
Xu, Li;
Chen, Ye-Guang;
Fang, Xiaohong

Publication type:

Article

Identification of novel rare mutations of DACT1 in human neural tube defects.

Published in:

Human Mutation, 2012, v. 33, n. 10, p. 1450, doi. 10.1002/humu.22121

By:

Shi, Yan;
Ding, Yi;
Lei, Yun-Ping;
Yang, Xue-Yan;
Xie, Guo-Ming;
Wen, Jun;
Cai, Chun-Quan;
Li, Hong;
Chen, Ying;
Zhang, Ting;
Wu, Bai-Lin;
Jin, Li;
Chen, Ye-Guang;
Wang, Hong-Yan

Publication type:

Article

PRMT5 Maintains Homeostasis of the Intestinal Epithelium by Modulating Cell Proliferation and Survival.

Published in:

Advanced Science, 2025, v. 12, n. 12, p. 1, doi. 10.1002/advs.202415559

By:

Li, Leilei;
Zhang, Zhe;
Wang, Xu;
Zhao, Haiyong;
Liu, Liansheng;
Xiao, Yanhui;
Hua, Shan;
Chen, Ye‐Guang

Publication type:

Article

A resident stromal cell population actively restrains innate immune response in the propagation phase of colitis pathogenesis in mice.

Published in:

Science Translational Medicine, 2021, v. 13, n. 603, p. 1, doi. 10.1126/scitranslmed.abb5071

By:

Gao, Liang;
Yu, Qian;
Zhang, Huasheng;
Wang, Zhengting;
Zhang, Tianyu;
Xiang, Jinnan;
Yu, Shuxiang;
Zhang, Shaoyang;
Wu, Hongguang;
Xu, Yizhou;
Wang, Zhuo;
Shen, Lu;
Shu, Gang;
Chen, Ye-Guang;
Liu, Huijuan;
Shen, Lei;
Li, Baojie

Publication type:

Article

ALK-mediated Tyr95 phosphorylation of Smad4 impairs its transcription activity and the tumor suppressive activity of TGF-β.

Published in:

SCIENCE CHINA Life Sciences, 2019, v. 62, n. 3, p. 431, doi. 10.1007/s11427-019-9506-x

By:

Shi, Qiaoni;
Chen, Ye-Guang

Publication type:

Article

BMP signaling in homeostasis, transformation and inflammatory response of intestinal epithelium.

Published in:

SCIENCE CHINA Life Sciences, 2018, v. 61, n. 7, p. 800, doi. 10.1007/s11427-018-9310-7

By:

Wang, Shan;
Chen, Ye-Guang

Publication type:

Article

Interplay between TGF-β signaling and receptor tyrosine kinases in tumor development.

Published in:

SCIENCE CHINA Life Sciences, 2017, v. 60, n. 10, p. 1133, doi. 10.1007/s11427-017-9173-5

By:

Shi, Qiaoni;
Chen, Ye-Guang

Publication type:

Article

Regulation of intestinal stem cell fate specification.

Published in:

SCIENCE CHINA Life Sciences, 2015, v. 58, n. 6, p. 570, doi. 10.1007/s11427-015-4859-7

By:

Qi, Zhen;
Chen, Ye-Guang

Publication type:

Article

Regulation of embryonic stem cell self-renewal and differentiation by TGF-β family signaling.

Published in:

SCIENCE CHINA Life Sciences, 2010, v. 53, n. 4, p. 497, doi. 10.1007/s11427-010-0096-2

By:

Fei, Teng;
Chen, Ye-Guang

Publication type:

Article

BMP restricts stemness of intestinal Lgr5<sup>+</sup> stem cells by directly suppressing their signature genes.

Published in:

Nature Communications, 2017, v. 8, n. 1, p. 13824, doi. 10.1038/ncomms13824

By:

Qi, Zhen;
Li, Yehua;
Zhao, Bing;
Xu, Chi;
Liu, Yuan;
Li, Haonan;
Zhang, Bingjie;
Wang, Xinquan;
Yang, Xiao;
Xie, Wei;
Li, Baojie;
Han, Jing-Dong Jackie;
Chen, Ye-Guang

Publication type:

Article

The non-muscle-myosin-II heavy chain Myh9 mediates colitis-induced epithelium injury by restricting Lgr5+ stem cells.

Published in:

Nature Communications, 2015, v. 6, n. 5, p. 7166, doi. 10.1038/ncomms8166

By:

Zhao, Bing;
Qi, Zhen;
Li, Yehua;
Wang, Chongkai;
Fu, Wei;
Chen, Ye-Guang

Publication type:

Article

Araf kinase antagonizes Nodal-Smad2 activity in mesendoderm development by directly phosphorylating the Smad2 linker region.

Published in:

Nature Communications, 2013, v. 4, n. 4, p. 1728, doi. 10.1038/ncomms2762

By:

Liu, Xingfeng;
Xiong, Cong;
Jia, Shunji;
Zhang, Yu;
Chen, Ye-Guang;
Wang, Qiang;
Meng, Anming

Publication type:

Article

Activin Signaling and Its Role in Regulation of Cell Proliferation, Apoptosis, and Carcinogenesis.

Published in:

Experimental Biology & Medicine, 2006, v. 231, n. 5, p. 534, doi. 10.1177/153537020623100507

By:

Chen, Ye-Guang;
Wang, Qiang;
Lin, Shi-Lung;
Chang, C. Donald;
Chung, Jody;
Ying, Shao-Yao

Publication type:

Article

Tuft cells promote human intestinal epithelium regeneration as reserve stem cells after irradiation.

Published in:

Cell Regeneration, 2024, v. 13, n. 1, p. 1, doi. 10.1186/s13619-024-00214-w

By:

Li, Yehua;
Zhang, Mengxian;
Ma, Xianrun;
Chen, Ye-Guang

Publication type:

Article

Identification of feature genes in intestinal epithelial cell types.

Published in:

Cell Regeneration, 2024, v. 13, n. 1, p. 1, doi. 10.1186/s13619-024-00208-8

By:

Lou, Ruoyu;
Song, Wanlu;
Yu, Shicheng;
Wang, Xiaodan;
Liu, Yuan;
Chen, Ye-Guang;
Wang, Yalong

Publication type:

Article

METTL3 restricts RIPK1-dependent cell death via the ATF3-cFLIP axis in the intestinal epithelium.

Published in:

Cell Regeneration, 2024, v. 13, n. 1, p. 1, doi. 10.1186/s13619-024-00197-8

By:

Huang, Meimei;
Wang, Xiaodan;
Zhang, Mengxian;
Liu, Yuan;
Chen, Ye-Guang

Publication type:

Article

New progress in roles of TGF-β signaling crosstalks in cellular functions, immunity and diseases.

Published in:

Cell Regeneration, 2024, v. 13, n. 1, p. 1, doi. 10.1186/s13619-024-00194-x

By:

Gu, Shuchen;
Derynck, Rik;
Chen, Ye-Guang;
Feng, Xin-Hua

Publication type:

Article

Unveiling new horizons in heart research: the promise of multi-chamber cardiac organoids.

Published in:

Cell Regeneration, 2024, v. 13, n. 1, p. 1, doi. 10.1186/s13619-024-00193-y

By:

Hou, Junjie;
Chen, Ye-Guang;
Xiong, Jing-Wei

Publication type:

Article

Correction: The cyclooxygenase-expressing mesenchyme resists intestinal epithelial injury by paracrine signaling.

Published in:

2023

By:

Wei, Siting;
Li, Meng;
Song, Wanlu;
Liu, Jiaye;
Yu, Shicheng;
Wang, Yalong;
Zhang, Mengxian;
Du, Huijun;
Liu, Yuan;
Liu, Huidong;
Fu, Wei;
Li, Baojie;
Chen, Ye-Guang

Publication type:

Correction Notice

The cyclooxygenase-expressing mesenchyme resists intestinal epithelial injury by paracrine signaling.

Published in:

Cell Regeneration, 2023, v. 12, n. 1, p. 1, doi. 10.1186/s13619-023-00174-7

By:

Wei, Siting;
Li, Meng;
Song, Wanlu;
Liu, Jiaye;
Yu, Shicheng;
Wang, Yalong;
Zhang, Mengxian;
Du, Huijun;
Liu, Yuan;
Liu, Huidong;
Fu, Wei;
Li, Baojie;
Chen, Ye-Guang

Publication type:

Article

Cross-species single-cell transcriptomic analysis of animal gastric antrum reveals intense porcine mucosal immunity.

Published in:

Cell Regeneration, 2023, v. 12, n. 1, p. 1, doi. 10.1186/s13619-023-00171-w

By:

Wang, Xiaodan;
Hong, Fan;
Li, Haonan;
Wang, Yalong;
Zhang, Mengxian;
Lin, Shibo;
Liang, Hui;
Zhou, Hongwen;
Liu, Yuan;
Chen, Ye-Guang

Publication type:

Article

Development of a 32-gene signature using machine learning for accurate prediction of inflammatory bowel disease.

Published in:

Cell Regeneration, 2023, v. 12, n. 1, p. 1, doi. 10.1186/s13619-022-00143-6

By:

Yu, Shicheng;
Zhang, Mengxian;
Ye, Zhaofeng;
Wang, Yalong;
Wang, Xu;
Chen, Ye-Guang

Publication type:

Article

Intestinal cellular heterogeneity and disease development revealed by single-cell technology.

Published in:

Cell Regeneration, 2022, v. 11, n. 1, p. 1, doi. 10.1186/s13619-022-00127-6

By:

Wang, Yalong;
Song, Wanlu;
Yu, Shicheng;
Liu, Yuan;
Chen, Ye-Guang

Publication type:

Article

DDB1 maintains intestinal homeostasis by preventing cell cycle arrest.

Published in:

2022

By:

Zhao, Lianzheng;
Liao, Hongwei;
Wang, Xiaodan;
Chen, Ye-Guang

Publication type:

Letter

Cross-species single-cell transcriptomic analysis reveals divergence of cell composition and functions in mammalian ileum epithelium.

Published in:

Cell Regeneration, 2022, v. 11, n. 1, p. 1, doi. 10.1186/s13619-022-00118-7

By:

Li, Haonan;
Wang, Xiaodan;
Wang, Yalong;
Zhang, Mengxian;
Hong, Fan;
Wang, Hong;
Cui, Along;
Zhao, Jianguo;
Ji, Weizhi;
Chen, Ye-Guang

Publication type:

Article

Gut stem cell aging is driven by mTORC1 via a p38 MAPK-p53 pathway.

Published in:

Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-019-13911-x

By:

He, Dan;
Wu, Hongguang;
Xiang, Jinnan;
Ruan, Xinsen;
Peng, Peike;
Ruan, Yuanyuan;
Chen, Ye-Guang;
Wang, Yibin;
Yu, Qiang;
Zhang, Hongbing;
Habib, Samy L.;
De Pinho, Ronald A.;
Liu, Huijuan;
Li, Baojie

Publication type:

Article

Four Amino Acids within a Tandem QxVx Repeat in a Predicted Extended α-Helix of the Smad-Binding Domain of Sip1 Are Necessary for Binding to Activated Smad Proteins.

Published in:

PLoS ONE, 2013, v. 8, n. 10, p. 1, doi. 10.1371/journal.pone.0076733

By:

Conidi, Andrea;
van den Berghe, Veronique;
Leslie, Kris;
Stryjewska, Agata;
Xue, Hua;
Chen, Ye-Guang;
Seuntjens, Eve;
Huylebroeck, Danny

Publication type:

Article

2D- and 3D-Based Intestinal Stem Cell Cultures for Personalized Medicine.

Published in:

Cells (2073-4409), 2018, v. 7, n. 12, p. 225, doi. 10.3390/cells7120225

By:

Liu, Yuan;
Chen, Ye-Guang

Publication type:

Article