Works by Chen, Horng H.

Results: 45

Natriuretic peptide levels and predicting risk of developing new diabetes mellitus and metabolic syndrome.

Published in:

Diabetes, Obesity & Metabolism, 2025, v. 27, n. 2, p. 777, doi. 10.1111/dom.16073

By:

Singh, Jasraj;
Adel, Fadi W.;
Scott, Christopher G.;
Chen, Horng H.

Publication type:

Article

Intact acute cardiorenal and humoral responsiveness following chronic subcutaneous administration of the cardiac peptide BNP in experimental heart failure

Published in:

European Journal of Heart Failure, 2006, v. 8, n. 7, p. 681, doi. 10.1016/j.ejheart.2005.12.005

By:

Chen, Horng H.;
Schirger, John A.;
Cataliotti, Alessandro;
Burnett, John C.

Publication type:

Article

Leukemia inhibitory factor is augmented in the heart in experimental heart failure

Published in:

2003

By:

Jougasaki, Michihisa;
Leskinen, Hanna;
Larsen, Amy M.;
Cataliotti, Alessandro;
Chen, Horng H.;
Burnett Jr., John C.;
Burnett, John C Jr

Publication type:

journal article

The modulating actions of sulfonylurea on atrial natriuretic peptide release in experimental acute heart failure.

Published in:

2000

By:

Chen, Horng H.;
Oh, Karen Y.;
Terzic, Andre;
Burnett, John C.;
Chen, H H;
Oh, K Y;
Terzic, A;
Burnett, J C Jr

Publication type:

journal article

Insulin Therapy is Associated With Increased Myocardial Interstitial Fibrosis and Cardiomyocyte Apoptosis in a Rodent Model of Experimental Diabetes.

Published in:

Frontiers in Physiology, 2022, v. 13, p. 1, doi. 10.3389/fphys.2022.890907

By:

Adel, Fadi W.;
Zheng, Ye;
Wan, Siu-Hin;
Greason, Christie;
Pan, Shuchong;
Ameenuddin, Syed;
Chen, Horng H.

Publication type:

Article

The Importance of Natriuretic Peptides in Cardiometabolic Diseases.

Published in:

Journal of the Endocrine Society, 2020, v. 4, n. 6, p. 1, doi. 10.1210/jendso/bvaa052

By:

Vinnakota, Shravya;
Chen, Horng H

Publication type:

Article

Suppression of Tumorigenicity 2 in Heart Failure With Preserved Ejection Fraction.

Published in:

2017

By:

AbouEzzeddine, Omar F.;
McKie, Paul M.;
Dunlay, Shannon M.;
Stevens, Susanna R.;
Felker, G. Michael;
Borlaug, Barry A.;
Chen, Horng H.;
Tracy, Russell P.;
Braunwald, Eugene;
Redfield, Margaret M.

Publication type:

journal article

M-atrial natriuretic peptide and nitroglycerin in a canine model of experimental acute hypertensive heart failure: differential actions of 2 cGMP activating therapeutics.

Published in:

2014

By:

McKie, Paul M;
Cataliotti, Alessandro;
Ichiki, Tomoko;
Sangaralingham, S Jeson;
Chen, Horng H;
Burnett, John C;
Burnett, John C Jr

Publication type:

journal article

Natriuretic peptide pathways in heart failure: further therapeutic possibilities.

Published in:

Cardiovascular Research, 2022, v. 118, n. 18, p. 3416, doi. 10.1093/cvr/cvac125

By:

Sangaralingham, S Jeson;
Kuhn, Michaela;
Cannone, Valentina;
Chen, Horng H;
Burnett, John C

Publication type:

Article

Evidence for Angiotensin II as a Naturally Existing Suppressor for the Guanylyl Cyclase A Receptor and Cyclic GMP Generation.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 10, p. 8547, doi. 10.3390/ijms24108547

By:

Ma, Xiao;
Iyer, Seethalakshmi R.;
Ma, Xiaoyu;
Reginauld, Shawn H.;
Chen, Yang;
Pan, Shuchong;
Zheng, Ye;
Moroni, Dante G.;
Yu, Yue;
Zhang, Lianwen;
Cannone, Valentina;
Chen, Horng H.;
Ferrario, Carlos M.;
Sangaralingham, S. Jeson;
Burnett Jr., John C.

Publication type:

Article

Effect of cardiac resynchronization therapy on broad neurohormone biomarkers in heart failure.

Published in:

Journal of Interventional Cardiac Electrophysiology, 2011, v. 30, n. 3, p. 241, doi. 10.1007/s10840-011-9551-7

By:

Ying-xue Dong;
Burnett Jr., John C.;
Chen, Horng H.;
Sandberg, Sharon;
Yan-zhong Yang;
Yanhua Zhang;
Peng-Sheng Chen;
Yong-Mei Cha

Publication type:

Article

Biomarker-based risk prediction in the community.

Published in:

European Journal of Heart Failure. Supplements, 2016, v. 18, n. 11, p. 1342, doi. 10.1002/ejhf.663

By:

Abou Ezzeddine, Omar F.;
Mckie, Paul M.;
Scott, Christopher G.;
Rodeheffer, Richard J.;
Chen, Horng H.;
Felker, G. Michael;
Jaffe, Allan S.;
Burnett, John C.;
Redfield, Margaret M.

Publication type:

Article

Cenderitide, a novel dual GC-A and GC-B receptor activator, is a potent chronic cardiorenal fibroinhibiting peptide which suppresses aldosterone and reduces proteinuria in models of ardiorenal fibrosis.

Published in:

2011

By:

Martin, Fernando L.;
McKie, Paul M.;
Sangaralingham, Jeson S.;
Ichiki, Tomoko;
Harders, Gerald E.;
Chen, Horng H.;
Burnett, Jr, John C.

Publication type:

Abstract

Treatment with CBA-NP a novel chimeric natriuretic peptide attenuates cardiorenal fibrosis and improves diastolic dysfunction in diabetic rat model.

Published in:

2011

By:

Ameenuddin, Syed;
Oehler, Elise A.;
Burnett, Jr, John C.;
Chen, Horng H.

Publication type:

Abstract

Cenderitide (CD-NP), a novel peptide designed to activate both guanylyl cyclase B and A, activates the second messenger cGMP, suppresses aldosterone, and preserves GFR without reducing blood pressure in a proof-of-concept study in patients with chronic heart failure

Published in:

2011

By:

Costello-Boerrigter, Lisa C.;
Schirger, John A.;
Miller, Wayne L.;
Boerrigter, Guido;
Chen, Horng H.;
Kempf, Ruth;
Lee, Candace Y.;
Burnett, Jr, John C.

Publication type:

Abstract

Incidence of Preclinical Heart Failure in a Community Population.

Published in:

2022

By:

Young, Kathleen A.;
Scott, Christopher G.;
Rodeheffer, Richard J.;
Chen, Horng H.

Publication type:

journal article

Cardiorenal Effects of Long-Term Phosphodiesterase V Inhibition in Pre-Heart Failure.

Published in:

2022

By:

Hubers, Scott A.;
Siu-Hin Wan;
Adel, Fadi W.;
Benike, Sherry L.;
Burnett Jr, John C.;
Scott, Christopher;
Chen, Horng H.;
Wan, Siu-Hin;
Burnett, John C Jr

Publication type:

journal article

M-atrial natriuretic peptide and nitroglycerin in experimental acute hypertensive heart failure: differential actions of two cGMP activating therapeutics.

Published in:

2013

By:

McKie, Paul M.;
Cataliotti, Alessandro;
Ichiki, Tomoko;
Jeson Sangaralingham, S.;
Horng H Chen;
Burnett Jr, John C.

Publication type:

Abstract

Chronic natriuretic peptide protein therapeutics.

Published in:

2013

By:

Chen, Horng H.;
Cataliotti, Alessandro;
Burnett Jr, John C.

Publication type:

Abstract

Dopamine vs nesiritide for acute heart failure with renal dysfunction--reply.

Published in:

2014

By:

Chen, Horng H;
Redfield, Margaret M

Publication type:

commentary

Dopamine vs Nesiritide for Acute Heart Failure With Renal Dysfunction.

Published in:

2014

By:

Chen, Horng H.;
Redfield, Margaret M.

Publication type:

Letter to the Editor

Low-dose dopamine or low-dose nesiritide in acute heart failure with renal dysfunction: the ROSE acute heart failure randomized trial.

Published in:

2013

By:

Chen, Horng H;
Anstrom, Kevin J;
Givertz, Michael M;
Stevenson, Lynne W;
Semigran, Marc J;
Goldsmith, Steven R;
Bart, Bradley A;
Bull, David A;
Stehlik, Josef;
LeWinter, Martin M;
Konstam, Marvin A;
Huggins, Gordon S;
Rouleau, Jean L;
O'Meara, Eileen;
Tang, W H Wilson;
Starling, Randall C;
Butler, Javed;
Deswal, Anita;
Felker, G Michael;
O'Connor, Christopher M

Publication type:

journal article

Low-Dose Dopamine or Low-Dose Nesiritide in Acute Heart Failure With Renal Dysfunction.

Published in:

JAMA: Journal of the American Medical Association, 2013, v. 310, n. 23, p. 2533, doi. 10.1001/jama.2013.282190

By:

Horng H. Chen;
Anstrom, Kevin J.;
Givertz, Michael M.;
Stevenson, Lynne W.;
Semigran, Marc J.;
Goldsmith, Steven R.;
Bart, Bradley A.;
Bull, David A.;
Stehlik, Josef;
LeWinter, Martin M.;
Konstam, Marvin A.;
Huggins, Gordon S.;
Rouleau, Jean L.;
O'Meara, Eileen;
Wilson Tang, W. H.;
Starling, Randall C.;
Butler, Javed;
Deswal, Anita;
Felker, G. Michael;
O'Connor, Christopher M.

Publication type:

Article

Effect of phosphodiesterase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction: a randomized clinical trial.

Published in:

2013

By:

Redfield, Margaret M;
Chen, Horng H;
Borlaug, Barry A;
Semigran, Marc J;
Lee, Kerry L;
Lewis, Gregory;
LeWinter, Martin M;
Rouleau, Jean L;
Bull, David A;
Mann, Douglas L;
Deswal, Anita;
Stevenson, Lynne W;
Givertz, Michael M;
Ofili, Elizabeth O;
O'Connor, Christopher M;
Felker, G Michael;
Goldsmith, Steven R;
Bart, Bradley A;
McNulty, Steven E;
Ibarra, Jenny C

Publication type:

journal article

Effect of Phosphodiesterase-5 Inhibition on Exercise Capacity and Clinical Status in Heart Failure With Preserved Ejection Fraction.

Published in:

JAMA: Journal of the American Medical Association, 2013, v. 309, n. 12, p. 1268, doi. 10.1001/jama.2013.2024

By:

Redfield, Margaret M.;
Chen, Horng H.;
Borlaug, Barry A.;
Semigran, Marc J.;
Lee, Kerry L.;
Lewis, Gregory;
LeWinter, Martin M.;
Bouleau, Jean L.;
Bull, David A.;
Mann, Douglas L.;
Deswal, Anita;
Stevenson, Lynne W.;
Givertz, Michael M.;
Ofili, Elizabeth O.;
O'Connor, Christopher M.;
Felker, G. Michael;
Goldsmith, Steven B.;
Bart, Bradley A.;
McNulty, Steven E.;
Ibarra, Jenny C.

Publication type:

Article

Renal actions of synthetic Dendroaspis natriuretic peptide.

Published in:

Kidney International, 1999, v. 56, n. 2, p. 502, doi. 10.1046/j.1523-1755.1999.00573.x

By:

Lisy, Ondrej;
Jougasaki, Michihisa;
Heublein, Denise M.;
Schirger, John A.;
Chen, Horng H.;
Wennberg, Paul W.;
Burnett, John C.

Publication type:

Article

The ASCEND-HF trial: an acute study of clinical effectiveness of nesiritide and decompensated heart failure.

Published in:

Expert Review of Cardiovascular Therapy, 2012, v. 10, n. 5, p. 557, doi. 10.1586/ERC.12.31

By:

Dandamudi, Sanjay;
Chen, Horng H.

Publication type:

Article

Implications of peripheral oedema in heart failure with preserved ejection fraction: a heart failure network analysis.

Published in:

ESC Heart Failure, 2021, v. 8, n. 1, p. 662, doi. 10.1002/ehf2.13159

By:

Fudim, Marat;
Ashur, Nicolas;
Jones, Aaron D.;
Ambrosy, Andrew P.;
Bart, Bradley A.;
Butler, Javed;
Chen, Horng H.;
Greene, Stephen J.;
Reddy, Yogesh;
Redfield, Margaret M.;
Sharma, Abhinav;
Hernandez, Adrian F.;
Felker, Gary Michael;
Borlaug, Barry A.;
Mentz, Robert J.

Publication type:

Article

Effect of Inorganic Nitrite vs Placebo on Exercise Capacity Among Patients With Heart Failure With Preserved Ejection Fraction: The INDIE-HFpEF Randomized Clinical Trial.

Published in:

2018

By:

Borlaug, Barry A.;
Anstrom, Kevin J.;
Lewis, Gregory D.;
Shah, Sanjiv J.;
Levine, James A.;
Koepp, Gabe A.;
Givertz, Michael M.;
Felker, G. Michael;
LeWinter, Martin M.;
Mann, Douglas L.;
Margulies, Kenneth B.;
Smith, Andrew L.;
Tang, W. H. Wilson;
Whellan, David J.;
Chen, Horng H.;
Davila-Roman, Victor G.;
McNulty, Steven;
Desvigne-Nickens, Patrice;
Hernandez, Adrian F.;
Braunwald, Eugene

Publication type:

journal article

Acute oral pegylated human BNP activates cGMP and decreases mean arterial pressure in normal dogs

Published in:

2005

By:

Cataliotti, Alessandro;
Schirger, John A.;
Martin, Fernando L.;
Chen, Horng H.;
James, Kenneth D.;
Miller, Mark A.;
Malkar, Navdeep B.;
Ekwuribe, Nnoch N.;
Burnett, John C.

Publication type:

Abstract

BNP enhances renal actions of lasix and suppresses lasix-induced aldosterone activation in experimental heart failure

Published in:

2003

By:

Cataliotti, Alessandro;
Boerrigter, Guido;
Costello-Boerrigter, Lisa C.;
Tsuruda, Toshihiro;
Schirger, John A.;
Chen, Horng H.;
Malatino, Lorenzo S.;
Burnett Jr, John C.

Publication type:

Abstract

Cell Surface Protein Disulfide Isomerase Regulates Natriuretic Peptide Generation of Cyclic Guanosine Monophosphate.

Published in:

PLoS ONE, 2014, v. 9, n. 11, p. 1, doi. 10.1371/journal.pone.0112986

By:

Pan, Shuchong;
Chen, Horng H.;
Correia, Cristina;
Dai, Haiming;
Witt, Tyra A.;
Kleppe, Laurel S.;
JrBurnett, John C.;
Simari, Robert D.

Publication type:

Article

Cenderitide-Eluting Film for Potential Cardiac Patch Applications.

Published in:

PLoS ONE, 2013, v. 8, n. 7, p. 1, doi. 10.1371/journal.pone.0068346

By:

Ng, Xu Wen;
Huang, Yingying;
Chen, Horng H.;
Burnett Jr, John C.;
Boey, Freddy Y. C.;
Venkatraman, Subbu S.

Publication type:

Article

In-Vivo Evaluation of an In Situ Polymer Precipitation Delivery System for a Novel Natriuretic Peptide.

Published in:

PLoS ONE, 2013, v. 8, n. 2, p. 1, doi. 10.1371/journal.pone.0052484

By:

Lim, Soo Ghim;
Venkatraman, Subbu S.;
Burnett Jr, John C.;
Chen, Horng H.

Publication type:

Article

CD-NP: A Novel Engineered Dual Guanylyl Cyclase Activator with Anti-Fibrotic Actions in the Heart.

Published in:

PLoS ONE, 2012, v. 7, n. 12, p. 1, doi. 10.1371/journal.pone.0052422

By:

Martin, Fernando L.;
Sangaralingham, S. Jeson;
Huntley, Brenda K.;
McKie, Paul M.;
Ichiki, Tomoko;
Chen, Horng H.;
Korinek, Josef;
Harders, Gerald E.;
Burnett Jr., John C.

Publication type:

Article

Pharmacodynamics of a Novel Designer Natriuretic Peptide, CD-NP, in a First-in-Human Clinical Trial in Healthy Subjects.

Published in:

Journal of Clinical Pharmacology, 2009, v. 49, n. 6, p. 668, doi. 10.1177/0091270009336233

By:

Lee, Candace Y. W.;
Chen, Horng H.;
Lisy, Ondrej;
Swan, Suzanne;
Cannon, Courtney;
Lieu, Hsiao D.;
Burnett Jr., John C.

Publication type:

Article

A Human Study to Evaluate Safety, Tolerability, and Cyclic GMP Activating Properties of Cenderitide in Subjects With Stable Chronic Heart Failure.

Published in:

Clinical Pharmacology & Therapeutics, 2018, v. 104, n. 3, p. 546, doi. 10.1002/cpt.974

By:

Kawakami, Rika;
Lee, Candace Y. W.;
Schirger, John A.;
Chen, Horng H.;
Benike, Sherry L.;
Martin, Fernando L.;
Sangaralingham, S. Jeson;
Ichiki, Tomoko;
Burnett, Jr., John C.;
Cannone, Valentina;
Scott, Christopher;
Bailey, Kent R.

Publication type:

Article

Assessing intrinsic renal sodium avidity in acute heart failure: implications in predicting and guiding decongestion.

Published in:

European Journal of Heart Failure, 2022, v. 24, n. 10, p. 1978, doi. 10.1002/ejhf.2662

By:

Martens, Pieter;
Chen, Horng H.;
Verbrugge, Frederik H.;
Testani, Jeffrey T.;
Mullens, Wilfried;
Tang, W.H. Wilson

Publication type:

Article

Biomarker-based risk prediction in the community.

Published in:

2016

By:

AbouEzzeddine, Omar F.;
McKie, Paul M.;
Scott, Christopher G.;
Rodeheffer, Richard J.;
Chen, Horng H.;
Michael Felker, G.;
Jaffe, Allan S.;
Burnett, John C.;
Redfield, Margaret M.

Publication type:

journal article

Chronic subcutaneous brain natriuretic peptide therapy in asymptomatic systolic heart failure.

Published in:

2016

By:

McKie, Paul M.;
Schirger, John A.;
Benike, Sherry L.;
Harstad, Lynn K.;
Slusser, Joshua P.;
Hodge, David O.;
Redfield, Margaret M.;
Burnett, John C.;
Chen, Horng H.

Publication type:

journal article

Effects of phosphodiesterase V inhibition alone and in combination with BNP on cardiovascular and renal response to volume load in human preclinical diastolic dysfunction.

Published in:

Physiological Reports, 2021, v. 9, n. 16, p. 1, doi. 10.14814/phy2.14974

By:

Wan, Siu‐Hin;
McKie, Paul M.;
Slusser, Joshua P.;
Burnett, John C.;
Hodge, David O.;
Chen, Horng H.

Publication type:

Article

Pharmacodynamics of a Novel Designer Natriuretic Peptide, CD-NP, in a First-in-Human Clinical Trial in Healthy Subjects.

Published in:

Journal of Clinical Pharmacology, 2010, v. 50, n. 6, p. 668, doi. 10.1177/0091270009336233

By:

Lee, Candace Y. W.;
Chen, Horng H.;
Lisy, Ondrej;
Swan, Suzanne;
Cannon, Courtney;
Lieu, Hsiao D.;
Burnett Jr., John C.

Publication type:

Article

Cardiac resynchronization therapy improves myocardial conduction.

Published in:

Pacing & Clinical Electrophysiology, 2019, v. 42, n. 2, p. 238, doi. 10.1111/pace.13581

By:

Yang, Mei;
Li, Xuping;
Yang, Dachun;
Li, Yigang;
Zhou, Shenghua;
Liang, Jinjun;
Wu, Gang;
Del‐Carpio Munoz, Freddy;
Chen, Horng H.;
Friedman, Paul A.;
Cha, Yong‐Mei

Publication type:

Article

B-type natriuretic peptide and extracellular matrix protein interactions in human cardiac fibroblasts.

Published in:

Journal of Cellular Physiology, 2010, v. 225, n. 1, p. 251, doi. 10.1002/jcp.22253

By:

HUNTLEY, BRENDA K.;
ICHIKI, TOMOKO;
SANGARALINGHAM, S. JESON;
CHEN, HORNG H.;
BURNETT JR., JOHN C.

Publication type:

Article

The role of multimodality imaging in diabetic cardiomyopathy: a brief review.

Published in:

2025

By:

Adel, Fadi W.;
Chen, Horng H.

Publication type:

Literature Review