Works by Chee Onn Leong

Results: 48

Adeno-Associated Virus-Engineered Umbilical Cord-Derived Mesenchymal Stromal Cells Overexpressing Human sFlt-1 for Anti-Angiogenesis.

Published in:

Life (2075-1729), 2025, v. 15, n. 5, p. 728, doi. 10.3390/life15050728

By:

Choy, Ewa Yee-Wa;
Leong, Chee-Onn;
Cheong, Soon-Keng;
Then, Khong-Lek;
Then, Kong-Yong

Publication type:

Article

Potential role of heteroplasmic mitochondrial DNA mutations in modulating the subtype-specific adaptation of oral squamous cell carcinoma to cisplatin therapy.

Published in:

Discover Oncology, 2024, v. 15, n. 1, p. 1, doi. 10.1007/s12672-024-01445-8

By:

Aminuddin, Amnani;
Ng, Pei Yuen;
Leong, Chee Onn;
Makpol, Suzana;
Chua, Eng Wee

Publication type:

Article

Genetic Biomarkers as Predictors of Response to Tocilizumab in Rheumatoid Arthritis: A Systematic Review and Meta-Analysis.

Published in:

Genes, 2022, v. 13, n. 7, p. 1284, doi. 10.3390/genes13071284

By:

Janahiraman, Sivakami;
Too, Chun Lai;
Lee, Kai Wei;
Shahril, Nor Shuhaila;
Leong, Chee Onn

Publication type:

Article

Orofacial Pain of Muscular Origin Is Not Associated with Herpes Virus-6 Infection: A Pilot Study.

Published in:

Journal of Oral & Facial Pain & Headache, 2014, v. 28, n. 4, p. 346, doi. 10.11607/ofph.1095

By:

Yoshinobu Shoji;
Heng Lungh Choo;
Chee Onn Leong;
Aung Lwin Oo;
Townsend, Grant

Publication type:

Article

Author Correction: Mitochondrial DNA alterations may influence the cisplatin responsiveness of oral squamous cell carcinoma.

Published in:

2021

By:

Aminuddin, Amnani;
Ng, Pei Yuen;
Leong, Chee-Onn;
Chua, Eng Wee

Publication type:

Correction Notice

Sphingosine Kinase 1 Regulates the Survival of Breast Cancer Stem Cells and Non-stem Breast Cancer Cells by Suppression of STAT1.

Published in:

Cells (2073-4409), 2020, v. 9, n. 4, p. 886, doi. 10.3390/cells9040886

By:

Hii, Ling-Wei;
Chung, Felicia Fei-Lei;
Mai, Chun Wai;
Yee, Zong Yang;
Chan, Hong Hao;
Raja, Vijay Joseph;
Dephoure, Noah Elias;
Pyne, Nigel J.;
Pyne, Susan;
Leong, Chee-Onn

Publication type:

Article

Contrasting sirtuin and poly( ADP-ribose)polymerase activities of selected 2,4,6-trisubstituted benzimidazoles.

Published in:

Chemical Biology & Drug Design, 2018, v. 91, n. 1, p. 213, doi. 10.1111/cbdd.13072

By:

Yeong, Keng Yoon;
Tan, Soo Choon;
Mai, Chun‐Wai;
Leong, Chee‐Onn;
Chung, Felicia Fei‐Lei;
Lee, Yean Kee;
Chee, Chin Fei;
Abdul Rahman, Noorsaadah

Publication type:

Article

Toxicity of single-walled carbon nanotubes.

Published in:

Archives of Toxicology, 2016, v. 90, n. 1, p. 103, doi. 10.1007/s00204-014-1376-6

By:

Ong, Li-Chu;
Chung, Felicia;
Tan, Yuen-Fen;
Leong, Chee-Onn

Publication type:

Article

Rapid Changes In Mitochondrial DNA May Participate In The Development Of Cisplatin-Resistant Oral Squamous Cell Carcinomas.

Published in:

Malaysian Journal of Medicine & Health Sciences, 2022, v. 18, p. 20

By:

Aminuddin, Amnani;
Pei Yuen Ng;
Makpol, Suzana;
Chee-Onn Leong;
Eng Wee Chua

Publication type:

Article

The p63/p73 network mediates chemosensitivity to cisplatin in a biologically defined subset of primary breast cancers.

Published in:

Journal of Clinical Investigation, 2007, v. 117, n. 5, p. 1370, doi. 10.1172/JCI30866

By:

Chee-Onn Leong;
Vidnovic, Nick;
DeYoung, Maurice Phillip;
Sgroi, Dennis;
Ellisen, Leif W.

Publication type:

Article

N, N'‐Disubstituted Benzimidazolium Salts: Synthesis, Characterization, Micromolar Detection of Fe(III) ions in Aqueous system, Biological Evaluation and Molecular Docking Studies.

Published in:

ChemistrySelect, 2022, v. 7, n. 48, p. 1, doi. 10.1002/slct.202203239

By:

Sharma, Himshikha;
Chaudhary, Shweta;
Nirwan, Sonam;
Kakkar, Rita;
Liew, HuiShan;
Low, May‐Lee;
Mai, Chun‐Wai;
Hii, Ling‐Wei;
Leong, Chee‐Onn;
Daisy Milton, Marilyn

Publication type:

Article

Jerantinine A induces tumor-specific cell death through modulation of splicing factor 3b subunit 1 (SF3B1).

Published in:

Scientific Reports, 2017, p. 42504, doi. 10.1038/srep42504

By:

Chung, Felicia Fei-Lei;
Tan, Perry Faith Tze Ming;
Raja, Vijay Joseph;
Tan, Boon-Shing;
Lim, Kuan-Hon;
Kam, Toh-Seok;
Hii, Ling-Wei;
Tan, Si Hoey;
See, Sze-Jia;
Tan, Yuen-Fen;
Wong, Li-Zhe;
Yam, Wai Keat;
Mai, Chun Wai;
Bradshaw, Tracey D.;
Leong, Chee-Onn

Publication type:

Article

Advances in Nanomaterials Used in Co-Delivery of siRNA and Small Molecule Drugs for Cancer Treatment.

Published in:

Nanomaterials (2079-4991), 2021, v. 11, n. 10, p. 2467, doi. 10.3390/nano11102467

By:

Chung, Shei Li;
Yee, Maxine Swee-Li;
Hii, Ling-Wei;
Lim, Wei-Meng;
Ho, Mui Yen;
Khiew, Poi Sim;
Leong, Chee-Onn

Publication type:

Article

Impact of Microplastics and Nanoplastics on Human Health.

Published in:

Nanomaterials (2079-4991), 2021, v. 11, n. 2, p. 496, doi. 10.3390/nano11020496

By:

Yee, Maxine Swee-Li;
Hii, Ling-Wei;
Looi, Chin King;
Lim, Wei-Meng;
Wong, Shew-Fung;
Kok, Yih-Yih;
Tan, Boon-Keat;
Wong, Chiew-Yen;
Leong, Chee-Onn;
Liao, Vivian Hsiu-Chuan

Publication type:

Article

Cudraflavone C Induces Tumor-Specific Apoptosis in Colorectal Cancer Cells through Inhibition of the Phosphoinositide 3-Kinase (PI3K)-AKT Pathway.

Published in:

PLoS ONE, 2017, v. 12, n. 1, p. 1, doi. 10.1371/journal.pone.0170551

By:

Soo, Hsien-Chuen;
Chung, Felicia Fei-Lei;
Lim, Kuan-Hon;
Yap, Veronica Alicia;
Bradshaw, Tracey D.;
Hii, Ling-Wei;
Tan, Si-Hoey;
See, Sze-Jia;
Tan, Yuen-Fen;
Leong, Chee-Onn;
Mai, Chun-Wai

Publication type:

Article

An evaluation of tocotrienol ethosomes for transdermal delivery using Strat-M<sup>®</sup> membrane and excised human skin.

Published in:

Pharmaceutical Development & Technology, 2021, v. 26, n. 2, p. 243, doi. 10.1080/10837450.2020.1860087

By:

Nair, Rajesh Sreedharan;
Billa, Nashiru;
Leong, Chee-Onn;
Morris, Andrew P.

Publication type:

Article

4-chloro-1,2-phenylenediamine Induces Apoptosis in Mardin-Darby canine kidney cells via activation of caspases.

Published in:

Environmental Toxicology, 2014, v. 29, n. 6, p. 655, doi. 10.1002/tox.21792

By:

Onn, Leong Chee;
Ching, Chen Ssu;
Lian, Tiong Yee;
Foon, Loh Veng;
Chew Hee, Ng;
Moi, Chye Soi

Publication type:

Article

The Role of Ras-Associated Protein 1 (Rap1) in Cancer: Bad Actor or Good Player?

Published in:

Biomedicines, 2020, v. 8, n. 9, p. 334, doi. 10.3390/biomedicines8090334

By:

Looi, Chin-King;
Hii, Ling-Wei;
Ngai, Siew Ching;
Leong, Chee-Onn;
Mai, Chun-Wai

Publication type:

Article

Mitochondrial DNA alterations may influence the cisplatin responsiveness of oral squamous cell carcinoma.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-64664-3

By:

Aminuddin, Amnani;
Ng, Pei Yuen;
Leong, Chee-Onn;
Chua, Eng Wee

Publication type:

Article

Histone Deacetylase Inhibitors Restore Cancer Cell Sensitivity towards T Lymphocytes Mediated Cytotoxicity in Pancreatic Cancer.

Published in:

Cancers, 2022, v. 14, n. 15, p. 3709, doi. 10.3390/cancers14153709

By:

Looi, Chin-King;
Gan, Li-Lian;
Sim, Wynne;
Hii, Ling-Wei;
Chung, Felicia Fei-Lei;
Leong, Chee-Onn;
Lim, Wei-Meng;
Mai, Chun-Wai

Publication type:

Article

Current Status and Future Perspectives about Molecular Biomarkers of Nasopharyngeal Carcinoma.

Published in:

Cancers, 2021, v. 13, n. 14, p. 3490, doi. 10.3390/cancers13143490

By:

Siak, Pui Yan;
Khoo, Alan Soo-Beng;
Leong, Chee Onn;
Hoh, Boon-Peng;
Cheah, Shiau-Chuen

Publication type:

Article

Roles of Inflammasomes in Epstein–Barr Virus-Associated Nasopharyngeal Cancer.

Published in:

Cancers, 2021, v. 13, n. 8, p. 1786, doi. 10.3390/cancers13081786

By:

Looi, Chin King;
Hii, Ling-Wei;
Chung, Felicia Fei-Lei;
Mai, Chun-Wai;
Lim, Wei-Meng;
Leong, Chee-Onn;
Mosialos, George

Publication type:

Article

Molecular Mechanisms and Potential Therapeutic Reversal of Pancreatic Cancer-Induced Immune Evasion.

Published in:

Cancers, 2020, v. 12, n. 7, p. 1872, doi. 10.3390/cancers12071872

By:

Gan, Li-Lian;
Hii, Ling-Wei;
Wong, Shew-Fung;
Leong, Chee-Onn;
Mai, Chun-Wai

Publication type:

Article

Lutein improves cell viability and reduces Alu RNA accumulation in hydrogen peroxide challenged retinal pigment epithelial cells.

Published in:

Cutaneous & Ocular Toxicology, 2018, v. 37, n. 1, p. 52, doi. 10.1080/15569527.2017.1335748

By:

Chong, You Sheng;
Mai, Chun Wai;
Leong, Chee Onn;
Wong, Lai Chun

Publication type:

Article

The role of Epstein–Barr virus in nasopharyngeal carcinoma.

Published in:

Frontiers in Microbiology, 2023, v. 14, p. 1, doi. 10.3389/fmicb.2023.1116143

By:

Zhi Yi Su;
Pui Yan Siak;
Chee-Onn Leong;
Shiau-Chuen Cheah

Publication type:

Article

Nutlin-3 sensitizes nasopharyngeal carcinoma cells to cisplatin-induced cytotoxicity.

Published in:

Oncology Reports, 2015, v. 34, n. 4, p. 1692, doi. 10.3892/or.2015.4177

By:

YEE-LIN VOON;
AHMAD, MUNIRAH;
POOI-FONG WONG;
HUSAINI, ROSLINA;
WAYNE TIONG-WENG NG;
CHEE-ONN LEONG;
LANE, DAVID PHILIP;
ALAN SOO-BENG KHOO

Publication type:

Article

Histone deacetylase (HDAC) inhibitors and doxorubicin combinations target both breast cancer stem cells and non-stem breast cancer cells simultaneously.

Published in:

Breast Cancer Research & Treatment, 2020, v. 179, n. 3, p. 615, doi. 10.1007/s10549-019-05504-5

By:

Hii, Ling-Wei;
Chung, Felicia Fei-Lei;
Soo, Jaslyn Sian-Siu;
Tan, Boon Shing;
Mai, Chun-Wai;
Leong, Chee-Onn

Publication type:

Article

Rapamycin synergizes cisplatin sensitivity in basal-like breast cancer cells through up-regulation of p73.

Published in:

Breast Cancer Research & Treatment, 2011, v. 128, n. 2, p. 301, doi. 10.1007/s10549-010-1055-0

By:

Wong, Su;
Tiong, Kai;
Kong, Weng;
Yue, Yuen;
Chua, Choon;
Lim, Jae;
Lee, Chai;
Quah, Sean;
Fow, Cindy;
Chung, Cyril;
So, Irene;
Tan, Boon;
Choo, Heng;
Rosli, Rozita;
Cheong, Soon-Keng;
Leong, Chee-Onn

Publication type:

Article

Mechanisms of acquired resistance to 2-(4-Amino-3-methylphenyl)benzothiazole in breast cancer cell lines.

Published in:

Breast Cancer Research & Treatment, 2008, v. 110, n. 1, p. 57, doi. 10.1007/s10549-007-9690-9

By:

Tracey Bradshaw;
Erica Stone;
Valentina Trapani;
Chee-Onn Leong;
Charles Matthews;
Robert te Poele;
Malcolm Stevens

Publication type:

Article

Safety profile of sikamat virus and its oncolytic potential in leukemic cells and cancer stem cells.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-96061-z

By:

Siew, Zhen Yun;
Ong, Ghee Khang;
Wong, Siew Tung;
Leong, Pooi Pooi;
Tan, Boon Shing;
Leong, Chee-Onn;
Chupri, Juita Binti;
Fang, Chee-Mun;
Voon, Kenny

Publication type:

Article

Cytotoxic activity of phytochemicals from the stem bark of Calophyllum castaneum.

Published in:

Pakistan Journal of Pharmaceutical Sciences, 2019, v. 32, n. 5, p. 2183

By:

Chan Kiang Lim;
Shu Ying Gan;
Vivien Yi Mian Jong;
Chee Onn Leong;
Chun Wai Mai;
Chin Fei Chee

Publication type:

Article

Roles of receptor‐interacting protein kinase 1 in SH‐SY5Y cells with beta amyloid‐induced neurotoxicity.

Published in:

Journal of Cellular & Molecular Medicine, 2022, v. 26, n. 5, p. 1434, doi. 10.1111/jcmm.17095

By:

Chan, Hong‐Hao;
Leong, Chee‐Onn;
Lim, Chooi‐Ling;
Koh, Rhun‐Yian

Publication type:

Article

Inhibition of Janus Kinase 1 synergizes docetaxel sensitivity in prostate cancer cells.

Published in:

Journal of Cellular & Molecular Medicine, 2021, v. 25, n. 17, p. 8187, doi. 10.1111/jcmm.16684

By:

Nalairndran, Geetha;
Chung, Ivy;
Abdul Razack, Azad Hassan;
Chung, Felicia Fei‐Lei;
Hii, Ling‐Wei;
Lim, Wei‐Meng;
Looi, Chin King;
Mai, Chun‐Wai;
Leong, Chee‐Onn

Publication type:

Article

Phosphoinositide‐dependent Kinase‐1 (PDPK1) regulates serum/glucocorticoid‐regulated Kinase 3 (SGK3) for prostate cancer cell survival.

Published in:

Journal of Cellular & Molecular Medicine, 2020, v. 24, n. 20, p. 12188, doi. 10.1111/jcmm.15876

By:

Nalairndran, Geetha;
Hassan Abdul Razack, Azad;
Mai, Chun‐Wai;
Fei‐Lei Chung, Felicia;
Chan, Kok‐Keong;
Hii, Ling‐Wei;
Lim, Wei‐Meng;
Chung, Ivy;
Leong, Chee‐Onn

Publication type:

Article

An Evaluation of Curcumin-Encapsulated Chitosan Nanoparticles for Transdermal Delivery.

Published in:

AAPS PharmSciTech, 2019, v. 20, n. 2, p. 1, doi. 10.1208/s12249-018-1279-6

By:

Nair, Rajesh Sreedharan;
Morris, Andrew;
Billa, Nashiru;
Leong, Chee-Onn

Publication type:

Article

Association of BRCA1- and BRCA2-deficiency with mutation burden, expression of PD-L1/PD-1, immune infiltrates, and T cell-inflamed signature in breast cancer.

Published in:

PLoS ONE, 2019, v. 14, n. 4, p. 1, doi. 10.1371/journal.pone.0215381

By:

Wen, Wei Xiong;
Leong, Chee-Onn

Publication type:

Article

Functional Roles of JNK and p38 MAPK Signaling in Nasopharyngeal Carcinoma.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 3, p. 1108, doi. 10.3390/ijms23031108

By:

Pua, Lesley Jia Wei;
Mai, Chun-Wai;
Chung, Felicia Fei-Lei;
Khoo, Alan Soo-Beng;
Leong, Chee-Onn;
Lim, Wei-Meng;
Hii, Ling-Wei

Publication type:

Article

Triple-negative breast cancer is associated with EGFR, CK5/6 and c-KIT expression in Malaysian women.

Published in:

BMC Clinical Pathology, 2012, v. 12, n. 1, p. 1, doi. 10.1186/1472-6890-12-18

By:

Kanapathy Pillai, Shant Kishen;
Tay, Annie;
Nair, Suseela;
Chee-Onn Leong

Publication type:

Article

Novel antitumour indole alkaloid, Jerantinine A, evokes potent G2/M cell cycle arrest targeting microtubules.

Published in:

Investigational New Drugs, 2014, v. 32, n. 5, p. 838, doi. 10.1007/s10637-014-0126-1

By:

Raja, Vijay;
Lim, Kuan-Hon;
Leong, Chee-Onn;
Kam, Toh-Seok;
Bradshaw, Tracey

Publication type:

Article

Targeting the crosstalk of epigenetic modifications and immune evasion in nasopharyngeal cancer.

Published in:

Cell Biology & Toxicology, 2023, v. 39, n. 6, p. 2501, doi. 10.1007/s10565-023-09830-9

By:

Looi, Chin-King;
Foong, Lian-Chee;
Chung, Felicia Fei-Lei;
Khoo, Alan Soo-Beng;
Loo, Ee-Mun;
Leong, Chee-Onn;
Mai, Chun-Wai

Publication type:

Article

A hierarchical cluster analysis for clinical profiling of tofacitinib treatment response in patients with rheumatoid arthritis.

Published in:

Clinical Rheumatology, 2024, v. 43, n. 8, p. 2489, doi. 10.1007/s10067-024-07035-x

By:

Janahiraman, Sivakami;
Shahril, Nor Shuhaila;
Jayaraj, Vivek Jason;
Ch'ng, Suyin;
Eow, Liu Hong;
Mageswaren, Eashwary;
Lim, Ai Lee;
Chong, Hwee Cheng;
Ong, Ping Seung;
Ismail, Asmahan Mohamed;
Rahim, Siti Mariam Ab;
Ng, Chun Ruh;
Suahilai, Dayang Masyrinartie;
Ramlan, Azwarina Hanim;
Too, Chun Lai;
Leong, Chee Onn

Publication type:

Article

Effects of Amyloid Precursor Protein Overexpression on NF-κB, Rho-GTPase and Pro-Apoptosis Bcl-2 Pathways in Neuronal Cells.

Published in:

Reports of Biochemistry & Molecular Biology, 2021, v. 9, n. 4, p. 417

By:

Hong Hao Chan;
Yong Qi Leong;
Shee Man Voon;
Meng Liy Pan;
Chee Onn Leong;
Chooi Ling Lim;
Rhun Yian Koh

Publication type:

Article

Nasopharyngeal Carcinoma and Its Microenvironment: Past, Current, and Future Perspectives.

Published in:

Frontiers in Oncology, 2022, v. 12, p. 1, doi. 10.3389/fonc.2022.840467

By:

Su, Zhi Yi;
Siak, Pui Yan;
Leong, Chee-Onn;
Cheah, Shiau-Chuen

Publication type:

Article

Therapeutic challenges and current immunomodulatory strategies in targeting the immunosuppressive pancreatic tumor microenvironment.

Published in:

Journal of Experimental & Clinical Cancer Research (17569966), 2019, v. 38, n. 1, p. N.PAG, doi. 10.1186/s13046-019-1153-8

By:

Looi, Chin-King;
Chung, Felicia Fei-Lei;
Leong, Chee-Onn;
Wong, Shew-Fung;
Rosli, Rozita;
Mai, Chun-Wai

Publication type:

Article

Advancing Pharmacy Service using Big Data - Are We Fully Utilising the Big Data's Potential Yet?

Published in:

Journal of Pharmacy & Pharmaceutical Sciences, 2018, v. 21, p. 217, doi. 10.18433/jpps29869

By:

Hui-Qi See;
Jin-Ning Chan;
Shu-Jin Ling;
Shang-Cheng Gan;
Chee-Onn Leong;
Chun-Wai Mai

Publication type:

Article

The synergism of Clinacanthus nutans Lindau extracts with gemcitabine: downregulation of anti-apoptotic markers in squamous pancreatic ductal adenocarcinoma.

Published in:

BMC Complementary & Alternative Medicine, 2019, v. 19, n. 1, p. N.PAG, doi. 10.1186/s12906-019-2663-9

By:

Hii, Ling-Wei;
Lim, Swee-Hua Erin;
Leong, Chee-Onn;
Chin, Swee-Yee;
Tan, Ngai-Paing;
Lai, Kok-Song;
Mai, Chun-Wai

Publication type:

Article

A genotype imputation reference panel specific for native Southeast Asian populations.

Published in:

NPJ Genomic Medicine, 2024, v. 9, n. 1, p. 1, doi. 10.1038/s41525-024-00435-7

By:

Cengnata, Alvin;
Deng, Lian;
Yap, Wai-Sum;
Lim, Lay-Hong Renee;
Leong, Chee-Onn;
Xu, Shuhua;
Hoh, Boon-Peng

Publication type:

Article

p63 regulates an adhesion programme and cell survival in epithelial cells.

Published in:

Nature Cell Biology, 2006, v. 8, n. 6, p. 551, doi. 10.1038/ncb1420

By:

Carroll, Danielle K.;
Carroll, Jason S.;
Chee-Onn Leong;
Fang Cheng;
Brown, Myles;
Mills, Alea. A.;
Brugge, Joan S.;
Ellisen, Leif W.

Publication type:

Article