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Development and application of a PBPK modeling strategy to support antimalarial drug development.
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- CPT: Pharmacometrics & Systems Pharmacology, 2023, v. 12, n. 9, p. 1335, doi. 10.1002/psp4.13013
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- Article
Intestinal Lymph Flow, and Lipid and Drug Transport Scale Allometrically From Pre-clinical Species to Humans.
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- Frontiers in Physiology, 2020, v. 11, p. 1, doi. 10.3389/fphys.2020.00458
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- Article
Therapeutic efficacy of antimalarial drugs targeting DosRS signaling in Mycobacterium abscessus.
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- Science Translational Medicine, 2022, v. 14, n. 633, p. 1, doi. 10.1126/scitranslmed.abj3860
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- Article
Computational Prediction of CNS Drug Exposure Based on a Novel In Vivo Dataset.
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- Pharmaceutical Research, 2012, v. 29, n. 11, p. 3131, doi. 10.1007/s11095-012-0806-5
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- Article
An evaluation of the relative roles of the unstirred water layer and receptor sink in limiting the in-vitro intestinal permeability of drug compounds of varying lipophilicity.
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- Journal of Pharmacy & Pharmacology, 2008, v. 60, n. 10, p. 1311, doi. 10.1211/jpp.60.10.0007
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- Article
Pharmacokinetics and brain uptake of AM-36, a novel neuroprotective agent, following intravenous administration to rats.
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- Journal of Pharmacy & Pharmacology, 2008, v. 60, n. 2, p. 171, doi. 10.1211/jpp.60.2.0005
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- Article
Methods to assess drug permeability across the blood–brain barrier.
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- Journal of Pharmacy & Pharmacology, 2006, v. 58, n. 3, p. 281
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- Article
Assessing the utility of an anti-malarial pharmacokinetic-pharmacodynamic model for aiding drug clinical development.
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- Malaria Journal, 2012, v. 11, n. 1, p. 303, doi. 10.1186/1475-2875-11-303
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- Article
Efficacy, metabolism and pharmacokinetics of Ro 15-5458, a forgotten schistosomicidal 9-acridanone hydrazone.
- Published in:
- 2020
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- Publication type:
- journal article
The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson's disease.
- Published in:
- Acta Neuropathologica Communications, 2017, v. 5, p. 1, doi. 10.1186/s40478-017-0456-2
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- Article
The PICTURE study: diagnostic accuracy of multiparametric MRI in men requiring a repeat prostate biopsy.
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- British Journal of Cancer, 2017, v. 116, n. 9, p. 1159, doi. 10.1038/bjc.2017.57
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- Article
The PICTURE study: diagnostic accuracy of multiparametric MRI in men requiring a repeat prostate biopsy.
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- 2017
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- Publication type:
- journal article
Immunohistochemical biomarker validation in highly selective needle biopsy microarrays derived from mpMRI‐characterized prostates.
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- Prostate, 2018, v. 78, n. 16, p. 1229, doi. 10.1002/pros.23698
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- Article
Brain uptake of diazepam and phenytoin in a genetic animal model of absence epilepsy.
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- Clinical & Experimental Pharmacology & Physiology, 2010, v. 37, n. 5/6, p. 647, doi. 10.1111/j.1440-1681.2010.05362.x
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- Publication type:
- Article
Robot-assisted radical prostatectomy vs laparoscopic and open retropubic radical prostatectomy: functional outcomes 18 months after diagnosis from a national cohort study in England.
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- 2018
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- Publication type:
- journal article
Drug delivery: A key factor in realising the full therapeutic potential of drugs.
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- Drug Development Research, 1999, v. 46, n. 3/4, p. 316, doi. 10.1002/(SICI)1098-2299(199903/04)46:3/4<316::AID-DDR18>3.0.CO;2-E
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- Article
In vitro assessment of the pharmacodynamic properties and the partitioning of OZ277/RBx-11160 in cultures of Plasmodium falciparum.
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- Journal of Antimicrobial Chemotherapy (JAC), 2006, v. 58, n. 1, p. 52, doi. 10.1093/jac/dkl209
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- Article
Ivacaftor Is Associated with Reduced Lung Infection by Key Cystic Fibrosis Pathogens. A Cohort Study Using National Registry Data.
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- 2019
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- Publication type:
- journal article
Using Human Plasma as an Assay Medium in Caco-2 Studies Improves Mass Balance for Lipophilic Compounds.
- Published in:
- Pharmaceutical Research, 2018, v. 35, n. 11, p. 1, doi. 10.1007/s11095-018-2493-3
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- Publication type:
- Article
Clinimetric analysis of outcome measures for airway clearance in people with cystic fibrosis: a systematic review.
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- Therapeutic Advances in Respiratory Disease, 2022, p. 1, doi. 10.1177/17534666221122572
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- Publication type:
- Article
First-in-man safety and pharmacokinetics of synthetic ozonide OZ439 demonstrates an improved exposure profile relative to other peroxide antimalarials.
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- British Journal of Clinical Pharmacology, 2013, v. 75, n. 2, p. 535, doi. 10.1111/j.1365-2125.2012.04368.x
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- Article
Hospital Volume Does Not Influence the Safety of Percutaneous Nephrolithotomy in England: A Population-Based Cohort Study.
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- Journal of Endourology, 2015, v. 29, n. 8, p. 899, doi. 10.1089/end.2015.0007
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- Article
A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance.
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- Nature Communications, 2017, v. 8, n. 5, p. 15159, doi. 10.1038/ncomms15159
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- Article
Sansanmycin natural product analogues as potent and selective anti-mycobacterials that inhibit lipid I biosynthesis.
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- Nature Communications, 2017, v. 8, n. 3, p. 14414, doi. 10.1038/ncomms14414
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- Publication type:
- Article
Pyrazoleamide compounds are potent antimalarials that target Na<sup>+</sup> homeostasis in intraerythrocytic Plasmodium falciparum.
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- Nature Communications, 2014, v. 5, n. 11, p. 5521, doi. 10.1038/ncomms6521
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- Article
Defining Normal Parameters for the Male Nipple-Areola Complex: A Prospective Observational Study and Recommendations for Placement on the Chest Wall.
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- 2018
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- Publication type:
- journal article
O3-05-04: The 8-hydroxyquinoline analog PBT2 rapidly restores cognition and reduces soluble Abeta in Alzheimer transgenic mice
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- 2008
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- Publication type:
- Abstract
Correction to: The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson's disease.
- Published in:
- 2021
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- Publication type:
- Correction Notice
Added value of diffusion‐weighted images and dynamic contrast enhancement in multiparametric magnetic resonance imaging for the detection of clinically significant prostate cancer in the PICTURE trial.
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- BJU International, 2020, v. 125, n. 3, p. 391, doi. 10.1111/bju.14953
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- Publication type:
- Article
National cohort study comparing severe medium‐term urinary complications after robot‐assisted vs laparoscopic vs retropubic open radical prostatectomy.
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- BJU International, 2018, v. 121, n. 3, p. 445, doi. 10.1111/bju.14054
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- Publication type:
- Article
Quantifying severe urinary complications after radical prostatectomy: the development and validation of a surgical performance indicator using hospital administrative data.
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- BJU International, 2017, v. 120, n. 2, p. 219, doi. 10.1111/bju.13770
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- Article
Transperineal template prostate-mapping biopsies: an evaluation of different protocols in the detection of clinically significant prostate cancer.
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- BJU International, 2016, v. 118, n. 3, p. 384, doi. 10.1111/bju.13306
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- Article
Development of Diaminoquinazoline Histone Lysine Methyltransferase Inhibitors as Potent Blood-Stage Antimalarial Compounds.
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- ChemMedChem, 2014, v. 9, n. 10, p. 2360, doi. 10.1002/cmdc.201402098
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- Article
Structure-Activity Relationship Studies of Pyrrolone Antimalarial Agents.
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- ChemMedChem, 2013, v. 8, n. 9, p. 1537, doi. 10.1002/cmdc.201300177
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- Article
Selecting an anti-malarial clinical candidate from two potent dihydroisoquinolones.
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- Malaria Journal, 2021, v. 20, n. 1, p. 1, doi. 10.1186/s12936-021-03617-1
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- Article
An in vitro toolbox to accelerate anti-malarial drug discovery and development.
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- Malaria Journal, 2020, v. 19, n. 1, p. 1, doi. 10.1186/s12936-019-3075-5
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- Article
Identification of an antimalarial synthetic trioxolane drug development candidate.
- Published in:
- Nature, 2004, v. 430, n. 7002, p. 900, doi. 10.1038/nature02779
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- Article
In vitro and in vivo characterization of the antimalarial lead compound SSJ-I83 in Plasmodium models.
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- Drug Design, Development & Therapy, 2013, v. 7, p. 1377, doi. 10.2147/DDDT.S51298
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- Publication type:
- Article
Nitroheterocyclic drugs cure experimental Trypanosoma cruzi infections more effectively in the chronic stage than in the acute stage.
- Published in:
- Scientific Reports, 2016, p. 35351, doi. 10.1038/srep35351
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- Publication type:
- Article
Increased In Vivo Exposure of N-(4-Hydroxyphenyl) Retinamide (4-HPR) to Achieve Plasma Concentrations Effective against Dengue Virus.
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- Pharmaceutics, 2023, v. 15, n. 7, p. 1974, doi. 10.3390/pharmaceutics15071974
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- Publication type:
- Article
System-wide biochemical analysis reveals ozonide antimalarials initially act by disrupting Plasmodium falciparum haemoglobin digestion.
- Published in:
- PLoS Pathogens, 2020, v. 16, n. 6, p. 1, doi. 10.1371/journal.ppat.1008485
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- Publication type:
- Article