Works by Challis, Gregory L.

Results: 36

Genome mining based on transcriptional regulatory networks uncovers a novel locus involved in desferrioxamine biosynthesis.

Published in:

PLoS Biology, 2025, v. 23, n. 6, p. 1, doi. 10.1371/journal.pbio.3003183

By:

Augustijn, Hannah E.;
Reitz, Zachary L.;
Zhang, Le;
Boot, Jeanine A.;
Elsayed, Somayah S.;
Challis, Gregory L.;
Medema, Marnix H.;
van Wezel, Gilles P.

Publication type:

Article

A Sweet Origin for the Key Congocidine Precursor 4-Acetamidopyrrole-2-carboxylate.

Published in:

Angewandte Chemie, 2012, v. 124, n. 30, p. 7572, doi. 10.1002/ange.201201445

By:

Lautru, Sylvie;
Song, Lijiang;
Demange, Luc;
Lombès, Thomas;
Galons, Hervé;
Challis, Gregory L.;
Pernodet, Jean-Luc

Publication type:

Article

Cloning and expression of Burkholderia polyyne biosynthetic gene clusters in Paraburkholderia hosts provides a strategy for biopesticide development.

Published in:

Microbial Biotechnology, 2022, v. 15, n. 10, p. 2547, doi. 10.1111/1751-7915.14106

By:

Petrova, Yoana D.;
Zhao, Jinlian;
Webster, Gordon;
Mullins, Alex J.;
Williams, Katherine;
Alswat, Amal S.;
Challis, Gregory L.;
Bailey, Andy M.;
Mahenthiralingam, Eshwar

Publication type:

Article

The dynamic architecture of the metabolic switch in Streptomyces coelicolor.

Published in:

BMC Genomics, 2010, v. 11, p. 1, doi. 10.1186/1471-2164-11-10

By:

Nieselt, Kay;
Battke, Florian;
Herbig, Alexander;
Bruheim, Per;
Wentzel, Alexander;
Jakobsen, Øyvind M.;
Sletta, Håvard;
Alam, Mohammad T;
Merlo, Maria E.;
Moore, Jonathan;
Omara, Walid A.M.;
Morrissey, Edward R.;
Juarez-Hermosillo, Miguel A.;
Rodríguez-García, Antonio;
Nentwich, Merle;
Thomas, Louise;
Iqbal, Mudassar;
Legaie, Roxane;
Gaze, William H.;
Challis, Gregory L.

Publication type:

Article

Docking domain-mediated subunit interactions in natural product megasynth(et)ases.

Published in:

Journal of Industrial Microbiology & Biotechnology, 2021, v. 48, n. 3/4, p. 1, doi. 10.1093/jimb/kuab018

By:

Smith, Helen G.;
Beech, Matthew J.;
Lewandowski, Józef R.;
Challis, Gregory L.;
Jenner, Matthew

Publication type:

Article

Docking domain-mediated subunit interactions in natural product megasynth(et)ases.

Published in:

Journal of Industrial Microbiology & Biotechnology, 2021, p. 1, doi. 10.1093/jimb/kuab018

By:

Smith, Helen G;
Beech, Matthew J;
Lewandowski, Józef R;
Challis, Gregory L;
Jenner, Matthew

Publication type:

Article

The Insect Pathogen Serratia marcescensDb10 Uses a Hybrid Non-Ribosomal Peptide Synthetase-Polyketide Synthase to Produce the Antibiotic Althiomycin.

Published in:

PLoS ONE, 2012, v. 7, n. 9, p. 1, doi. 10.1371/journal.pone.0044673

By:

Gerc, Amy J.;
Song, Lijiang;
Challis, Gregory L.;
Stanley-Wall, Nicola R.;
Coulthurst, Sarah J.;
Cornelis, Pierre

Publication type:

Article

Heterologous reconstitution of the biosynthesis pathway for 4-demethyl-premithramycinone, the aglycon of antitumor polyketide mithramycin.

Published in:

Microbial Cell Factories, 2020, v. 19, n. 1, p. 1, doi. 10.1186/s12934-020-01368-3

By:

Zabala, Daniel;
Song, Lijiang;
Dashti, Yousef;
Challis, Gregory L.;
Salas, José A.;
Méndez, Carmen

Publication type:

Article

A novel streptococcal integrative conjugative element involved in iron acquisition.

Published in:

Molecular Microbiology, 2008, v. 70, n. 5, p. 1274, doi. 10.1111/j.1365-2958.2008.06481.x

By:

Heather, Zoe;
Holden, Matthew T. G.;
Steward, Karen F.;
Parkhill, Julian;
Song, Lijiang;
Challis, Gregory L.;
Robinson, Carl;
Davis-Poynter, Nicholas;
Waller, Andrew S.

Publication type:

Article

Strategies for the Discovery of New Natural Products by Genome Mining.

Published in:

ChemBioChem, 2009, v. 10, n. 4, p. 625, doi. 10.1002/cbic.200800389

By:

Zerikly, Malek;
Challis, Gregory L.

Publication type:

Article

A Widely Distributed Bacterial Pathway for Siderophore Biosynthesis Independent of Nonribosomal Peptide Synthetases.

Published in:

ChemBioChem, 2007, v. 8, n. 13, p. 1477, doi. 10.1002/cbic.200790044

By:

Challis, Gregory L.

Publication type:

Article

Evidence for the Unusual Condensation of a Diketide with a Pentulose in the Methylenomycin Biosynthetic Pathway of Streptomyces coelicolor A3(2).

Published in:

ChemBioChem, 2005, v. 6, n. 12, p. 2166, doi. 10.1002/cbic.200500243

By:

Christophe Corre;
Gregory L. Challis

Publication type:

Article

A Widely Distributed Bacterial Pathway for Siderophore Biosynthesis Independent of Nonribosomal Peptide Synthetases.

Published in:

ChemBioChem, 2005, v. 6, n. 4, p. 601, doi. 10.1002/cbic.200400283

By:

Gregory L. Challis

Publication type:

Article

Structures of a non-ribosomal peptide synthetase condensation domain suggest the basis of substrate selectivity.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-22623-0

By:

Izoré, Thierry;
Candace Ho, Y. T.;
Kaczmarski, Joe A.;
Gavriilidou, Athina;
Chow, Ka Ho;
Steer, David L.;
Goode, Robert J. A.;
Schittenhelm, Ralf B.;
Tailhades, Julien;
Tosin, Manuela;
Challis, Gregory L.;
Krenske, Elizabeth H.;
Ziemert, Nadine;
Jackson, Colin J.;
Cryle, Max J.

Publication type:

Article

Cytochrome P450-mediated hydroxylation is required for polyketide macrolactonization in stambomycin biosynthesis.

Published in:

Journal of Antibiotics, 2014, v. 67, n. 1, p. 71, doi. 10.1038/ja.2013.119

By:

Song, Lijiang;
Laureti, Luisa;
Corre, Christophe;
Leblond, Pierre;
Aigle, Bertrand;
Challis, Gregory L

Publication type:

Article

Genomics‐Driven Discovery of a Novel Glutarimide Antibiotic from Burkholderia gladioli Reveals an Unusual Polyketide Synthase Chain Release Mechanism.

Published in:

Angewandte Chemie, 2020, v. 132, n. 51, p. 23345, doi. 10.1002/ange.202009007

By:

Nakou, Ioanna T.;
Jenner, Matthew;
Dashti, Yousef;
Romero‐Canelón, Isolda;
Masschelein, Joleen;
Mahenthiralingam, Eshwar;
Challis, Gregory L.

Publication type:

Article

Discovery and Biosynthesis of Bolagladins: Unusual Lipodepsipeptides from Burkholderia gladioli Clinical Isolates.

Published in:

Angewandte Chemie, 2020, v. 132, n. 48, p. 21737, doi. 10.1002/ange.202009110

By:

Dashti, Yousef;
Nakou, Ioanna T.;
Mullins, Alex J.;
Webster, Gordon;
Jian, Xinyun;
Mahenthiralingam, Eshwar;
Challis, Gregory L.

Publication type:

Article

Parallelized gene cluster editing illuminates mechanisms of epoxyketone proteasome inhibitor biosynthesis.

Published in:

Nucleic Acids Research, 2023, v. 51, n. 3, p. 1488, doi. 10.1093/nar/gkad009

By:

Huang, Chuan;
Zabala, Daniel;
de los Santos, Emmanuel L C;
Song, Lijiang;
Corre, Christophe;
Alkhalaf, Lona M;
Challis, Gregory L

Publication type:

Article

A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units.

Published in:

Nature Communications, 2016, v. 7, n. 12, p. 13609, doi. 10.1038/ncomms13609

By:

Ray, Lauren;
Valentic, Timothy R.;
Miyazawa, Takeshi;
Withall, David M.;
Song, Lijiang;
Milligan, Jacob C.;
Osada, Hiroyuki;
Takahashi, Shunji;
Tsai, Shiou-Chuan;
Challis, Gregory L.

Publication type:

Article

Cytochrome P450-catalyzed L-tryptophan nitration in thaxtomin phytotoxin biosynthesis.

Published in:

Nature Chemical Biology, 2012, v. 8, n. 10, p. 814, doi. 10.1038/nchembio.1048

By:

Barry, Sarah M;
Kers, Johan A;
Johnson, Evan G;
Song, Lijiang;
Aston, Philip R;
Patel, Bhumit;
Krasnoff, Stuart B;
Crane, Brian R;
Gibson, Donna M;
Loria, Rosemary;
Challis, Gregory L

Publication type:

Article

Erratum: A new family of ATP-dependent oligomerization-macrocyclization biocatalysts.

Published in:

2009

By:

Kadi, Nadia;
Oves-Costales, Daniel;
Barona-Gomez, Francisco;
Challis, Gregory L

Publication type:

Correction Notice

AcsD catalyzes enantioselective citrate desymmetrization in siderophore biosynthesis.

Published in:

Nature Chemical Biology, 2009, v. 5, n. 3, p. 174, doi. 10.1038/nchembio.145

By:

Schmelz, Stefan;
Kadi, Nadia;
McMahon, Stephen A;
Song, Lijiang;
Oves-Costales, Daniel;
Oke, Muse;
Liu, Huanting;
Johnson, Kenneth A;
Carter, Lester G;
Botting, Catherine H;
White, Malcolm F;
Challis, Gregory L;
Naismith, James H

Publication type:

Article

A new family of ATP-dependent oligomerization-macrocyclization biocatalysts.

Published in:

Nature Chemical Biology, 2007, v. 3, n. 10, p. 652, doi. 10.1038/nchembio.2007.23

By:

Kadi, Nadia;
Oves-Costales, Daniel;
Barona-Gomez, Francisco;
Challis, Gregory L.

Publication type:

Article

Engineering Escherichia coli to produce nonribosomal peptide antibiotics.

Published in:

Nature Chemical Biology, 2006, v. 2, n. 8, p. 398, doi. 10.1038/nchembio0806-398

By:

Challis, Gregory L.

Publication type:

Article

Discovery of a new peptide natural product by Streptomyces coelicolor genome mining.

Published in:

Nature Chemical Biology, 2005, v. 1, n. 5, p. 265, doi. 10.1038/nchembio731

By:

Lautru, Sylvie;
Deeth, Robert J.;
Bailey, Lianne M.;
Challis, Gregory L.

Publication type:

Article

Discovery of microbial natural products by activation of silent biosynthetic gene clusters.

Published in:

Nature Reviews Microbiology, 2015, v. 13, n. 8, p. 509, doi. 10.1038/nrmicro3496

By:

Rutledge, Peter J.;
Challis, Gregory L.

Publication type:

Article

Bovistol B, bovistol D and strossmayerin: Sesquiterpene metabolites from the culture filtrate of the basidiomycete Coprinopsis strossmayeri.

Published in:

PLoS ONE, 2020, v. 15, n. 4, p. 1, doi. 10.1371/journal.pone.0229925

By:

Banks, Alice M.;
Song, Lijiang;
Challis, Gregory L.;
Bailey, Andy M.;
Foster, Gary D.

Publication type:

Article

Genomics‐Driven Discovery of a Novel Glutarimide Antibiotic from Burkholderia gladioli Reveals an Unusual Polyketide Synthase Chain Release Mechanism.

Published in:

Angewandte Chemie International Edition, 2020, v. 59, n. 51, p. 23145, doi. 10.1002/anie.202009007

By:

Nakou, Ioanna T.;
Jenner, Matthew;
Dashti, Yousef;
Romero‐Canelón, Isolda;
Masschelein, Joleen;
Mahenthiralingam, Eshwar;
Challis, Gregory L.

Publication type:

Article

Discovery and Biosynthesis of Bolagladins: Unusual Lipodepsipeptides from Burkholderia gladioli Clinical Isolates.

Published in:

Angewandte Chemie International Edition, 2020, v. 59, n. 48, p. 21553, doi. 10.1002/anie.202009110

By:

Dashti, Yousef;
Nakou, Ioanna T.;
Mullins, Alex J.;
Webster, Gordon;
Jian, Xinyun;
Mahenthiralingam, Eshwar;
Challis, Gregory L.

Publication type:

Article

Cover Feature: Expanding the Substrate Scope of Nitrating Cytochrome P450 TxtE by Active Site Engineering of a Reductase Fusion (ChemBioChem 13/2021).

Published in:

ChemBioChem, 2021, v. 22, n. 13, p. 2183, doi. 10.1002/cbic.202100230

By:

Saroay, Rakesh;
Roiban, Gheorghe‐Doru;
Alkhalaf, Lona M.;
Challis, Gregory L.

Publication type:

Article

Expanding the Substrate Scope of Nitrating Cytochrome P450 TxtE by Active Site Engineering of a Reductase Fusion.

Published in:

ChemBioChem, 2021, v. 22, n. 13, p. 2262, doi. 10.1002/cbic.202100145

By:

Saroay, Rakesh;
Roiban, Gheorghe‐Doru;
Alkhalaf, Lona M.;
Challis, Gregory L.

Publication type:

Article

Discovery of Unusual Biaryl Polyketides by Activation of a Silent Streptomyces venezuelae Biosynthetic Gene Cluster.

Published in:

ChemBioChem, 2016, v. 17, n. 22, p. 2189, doi. 10.1002/cbic.201600396

By:

Thanapipatsiri, Anyarat;
Gomez‐Escribano, Juan Pablo;
Song, Lijiang;
Bibb, Maureen J.;
Al‐Bassam, Mahmoud;
Chandra, Govind;
Thamchaipenet, Arinthip;
Challis, Gregory L.;
Bibb, Mervyn J.

Publication type:

Article

Mechanisms for incorporation of glycerol-derived precursors into polyketide metabolites.

Published in:

Journal of Industrial Microbiology & Biotechnology, 2006, v. 33, n. 2, p. 105, doi. 10.1007/s10295-005-0026-7

By:

Walton, Laura J.;
Corre, Christophe;
Challis, Gregory L.

Publication type:

Article

Regio- and stereodivergent antibiotic oxidative carbocyclizations catalysed by Rieske oxygenase-like enzymes.

Published in:

Nature Chemistry, 2011, v. 3, n. 5, p. 388, doi. 10.1038/nchem.1024

By:

Sydor, Paulina K.;
Barry, Sarah M.;
Odulate, Olanipekun M.;
Barona-Gomez, Francisco;
Haynes, Stuart W.;
Corre, Christophe;
Song, Lijiang;
Challis, Gregory L.

Publication type:

Article

A Sweet Origin for the Key Congocidine Precursor 4-Acetamidopyrrole-2-carboxylate.

Published in:

Angewandte Chemie International Edition, 2012, v. 51, n. 30, p. 7454, doi. 10.1002/anie.201201445

By:

Lautru, Sylvie;
Song, Lijiang;
Demange, Luc;
Lombès, Thomas;
Galons, Hervé;
Challis, Gregory L.;
Pernodet, Jean-Luc

Publication type:

Article

The Complete Genome Sequence and Comparative Genome Analysis of the High Pathogenicity Yersinia enterocolitica Strain 8081.

Published in:

PLoS Genetics, 2006, v. 3, n. 6, p. 2039, doi. 10.1371/journal.pgen.0020206

By:

Thomson, Nicholas R.;
Howard, Sarah;
Wren, Brendan W.;
Holden, Matthew T. G.;
Crossman, Lisa;
Challis, Gregory L.;
Churcher, Carol;
Mungall, Karen;
Brooks, Karen;
Chillingworth, Tracey;
Feltwell, Theresa;
Abdellah, Zahra;
Hauser, Heidi;
Jagels, Kay;
Maddison, Mark;
Moule, Sharon;
Sanders, Mandy;
Whitehead, Sally;
Quail, Michael A.;
Dougan, Gordon

Publication type:

Article