Works by Chakravarthy, Manu

Results: 24

A novel, multitargeted endogenous metabolic modulator composition impacts metabolism, inflammation, and fibrosis in nonalcoholic steatohepatitis-relevant primary human cell models.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-88913-1

By:

Daou, Nadine;
Viader, Andreu;
Cokol, Murat;
Nitzel, Arianna;
Chakravarthy, Manu V.;
Afeyan, Raffi;
Tramontin, Tony;
Marukian, Svetlana;
Hamill, Michael J.

Publication type:

Article

The ABCs of β-cell dysfunction in type 2 diabetes.

Published in:

Nature Medicine, 2007, v. 13, n. 3, p. 241, doi. 10.1038/nm0307-241

By:

Chakravarthy, Manu V.;
Semenkovich, Clay F.

Publication type:

Article

752-P: LIVRQNac (AXA1125) Enhances Insulin Sensitivity in Primary Human Hepatocytes and in Subjects with NAFLD and T2D.

Published in:

Diabetes, 2021, v. 70, p. N.PAG, doi. 10.2337/db21-752-P

By:

BAUM, SETH;
HARRISON, STEPHEN A.;
GUNN, NADEGE T.;
YOUNES, ZIAD;
KOHLI, ANITA;
PATIL, RASHMEE;
FRIAS, JUAN P.;
HAMILL, MICHAEL;
DAOU, NADINE;
ZHAO, JEFF;
CHAKRAVARTHY, MANU;
KOZIEL, MARGARET

Publication type:

Article

Effects of 13-Hour Hyperglucagonemia on Energy Expenditure and Hepatic Glucose Production in Humans.

Published in:

2017

By:

Chakravarthy, Manu;
Parsons, Stephanie;
Lassman, Michael E.;
Butterfield, Kristin;
Lee, Anita Y.H.;
Ying Chen;
Previs, Stephen;
Spond, Jeffrey;
Shan Yang;
Bock, Christopher;
Fanchao Yi;
Moon, Jon;
Wohlers-Kariesch, Erica;
Smith, Steven R.;
Meyer, Christian;
Chen, Ying;
Yang, Shan;
Yi, Fanchao

Publication type:

journal article

Decreased complexity of glucose dynamics preceding the onset of diabetes in mice and rats.

Published in:

PLoS ONE, 2017, v. 12, n. 9, p. 1, doi. 10.1371/journal.pone.0182810

By:

Zhang, Xiaohua Douglas;
Pechter, David;
Yang, Liming;
Ping, Xiaoli;
Yao, Zuliang;
Zhang, Rumin;
Shen, Xiaolan;
Li, Nina Xiaoyan;
Connick, Jonathan;
Nawrocki, Andrea R.;
Chakravarthy, Manu;
Li, Cai

Publication type:

Article

Quantification, Variability, and Reproducibility of Basal Skeletal Muscle Glucose Uptake in Healthy Humans Using <sup>18</sup>F-FDG PET/CT.

Published in:

Journal of Nuclear Medicine, 2015, v. 56, n. 10, p. 1520, doi. 10.2967/jnumed.115.159715

By:

Gheysens, Olivier;
Postnov, Andrey;
Deroose, Christophe M.;
Vandermeulen, Corinne;
de Hoon, Jan;
Declercq, Ruben;
Dennie, Justin;
Mixson, Lori;
De Lepeleire, Inge;
Van Laere, Koen;
Klimas, Michael;
Chakravarthy, Manu V.

Publication type:

Article

Cessation of daily exercise dramatically alters precursors of hepatic steatosis in Otsuka Long-Evans Tokushima Fatty (OLETF) rats.

Published in:

Journal of Physiology, 2008, v. 586, n. 17, p. 4241, doi. 10.1113/jphysiol.2008.156745

By:

Rector, R. Scott;
Thyfault, John P.;
Laye, Matthew J.;
Morris, R. Tyler;
Borengasser, Sarah J.;
Uptergrove, Grace M.;
Chakravarthy, Manu V.;
Booth, Frank W.;
Ibdah, Jamal A.

Publication type:

Article

Exercise and gene expression: physiological regulation of the human genome through physical activity.

Published in:

Journal of Physiology, 2002, v. 543, n. 2, p. 399, doi. 10.1113/jphysiol.2002.019265

By:

Booth, Frank W.;
Chakravarthy, Manu V.;
Spangenburg, Espen E.

Publication type:

Article

Harnessing Muscle–Liver Crosstalk to Treat Nonalcoholic Steatohepatitis.

Published in:

Frontiers in Endocrinology, 2020, v. 11, p. N.PAG, doi. 10.3389/fendo.2020.592373

By:

Chakravarthy, Manu V.;
Siddiqui, Mohammad S.;
Forsgren, Mikael F.;
Sanyal, Arun J.

Publication type:

Article

Cover Image.

Published in:

2020

By:

Chakravarthy, Manu V.;
Neuschwander‐Tetri, Brent A.

Publication type:

Cover Art

The metabolic basis of nonalcoholic steatohepatitis.

Published in:

Endocrinology, Diabetes & Metabolism, 2020, v. 3, n. 4, p. 1, doi. 10.1002/edm2.112

By:

Chakravarthy, Manu V.;
Neuschwander‐Tetri, Brent A.

Publication type:

Article

Thorough QTc Evaluation and the Safety of Supratherapeutic Doses of Odanacatib in Healthy Subjects.

Published in:

Clinical Pharmacology in Drug Development, 2019, v. 8, n. 7, p. 861, doi. 10.1002/cpdd.698

By:

McCrea, Jacqueline;
Mostoller, Kate;
Mahon, Chantal;
Liu, Chengcheng;
Liu, Fang;
Zajic, Stefan;
Panebianco, Deborah;
Chakravarthy, Manu;
Brandquist, Christine;
Gutierrez, Maria;
Stoch, S. Aubrey

Publication type:

Article

The Molecular Responses of Skeletal Muscle Satellite Cells to Continuous Expression of IGF-1: Implications for the Rescue of Induced Muscular Atrophy in Aged Rats.

Published in:

International Journal of Sport Nutrition & Exercise Metabolism, 2001, v. 11, n. 4, p. S44, doi. 10.1123/ijsnem.11.s1.s44

By:

Chakravarthy, Manu V.;
Booth, Frank W.;
Spangenburg, Espen E.

Publication type:

Article

Correction to: Effect of CYP3A Inhibition and Induction on the Pharmacokinetics of Suvorexant: Two Phase I, Open-Label, Fixed-Sequence Trials in Healthy Subjects.

Published in:

2019

By:

Wrishko, Rebecca E.;
McCrea, Jacqueline B.;
Yee, Ka Lai;
Liu, Wen;
Panebianco, Deborah;
Mangin, Eric;
Chakravarthy, Manu;
Martinez-Cantarin, Maria P.;
Kraft, Walter K.

Publication type:

Correction Notice

Effect of CYP3A Inhibition and Induction on the Pharmacokinetics of Suvorexant: Two Phase I, Open-Label, Fixed-Sequence Trials in Healthy Subjects.

Published in:

Clinical Drug Investigation, 2019, v. 39, n. 5, p. 441, doi. 10.1007/s40261-019-00764-x

By:

Wrishko, Rebecca E.;
McCrea, Jacqueline B.;
Yee, Ka Lai;
Liu, Wen;
Panebianco, Deborah;
Mangin, Eric;
Chakravarthy, Manu;
Martinez-Cantarin, Maria P.;
Kraft, Walter K.

Publication type:

Article

Editorial: Mitochondrial Biology and Its Role in Metabolic Diseases.

Published in:

Frontiers in Endocrinology, 2022, v. 13, p. 1, doi. 10.3389/fendo.2022.944728

By:

Schneider, Jochen G.;
Tozzo, Effie;
Chakravarthy, Manu V.

Publication type:

Article

Increased Bile Acid Synthesis and Impaired Bile Acid Transport in Human Obesity.

Published in:

2016

By:

Haeusler, Rebecca A;
Camastra, Stefania;
Nannipieri, Monica;
Astiarraga, Brenno;
Castro-Perez, Jose;
Xie, Dan;
Wang, Liangsu;
Chakravarthy, Manu;
Ferrannini, Ele

Publication type:

journal article

Editorial: Mitochondrial Biology and Its Role in Metabolic Diseases.

Published in:

Frontiers in Endocrinology, 2022, v. 13, p. 1, doi. 10.3389/fendo.2022.944728

By:

Schneider, Jochen G.;
Tozzo, Effie;
Chakravarthy, Manu V.

Publication type:

Article

Correlations Between MRI Biomarkers PDFF and cT1 With Histopathological Features of Non-Alcoholic Steatohepatitis.

Published in:

Frontiers in Endocrinology, 2021, v. 11, p. N.PAG, doi. 10.3389/fendo.2020.575843

By:

Dennis, Andrea;
Kelly, Matt D.;
Fernandes, Carolina;
Mouchti, Sofia;
Fallowfield, Jonathan A.;
Hirschfield, Gideon;
Pavlides, Michael;
Harrison, Stephen;
Chakravarthy, Manu V.;
Banerjee, Rajarshi;
Sanyal, Arun

Publication type:

Article

Increased Bile Acid Synthesis and Deconjugation After Biliopancreatic Diversion.

Published in:

2015

By:

Ferrannini, Ele;
Camastra, Stefania;
Astiarraga, Brenno;
Nannipieri, Monica;
Castro-Perez, Jose;
Dan Xie;
Liangsu Wang;
Chakravarthy, Manu;
Haeusler, Rebecca A.;
Xie, Dan;
Wang, Liangsu

Publication type:

journal article

Decreased fetal size is associated with beta-cell hyperfunction in early life and failure with age.

Published in:

2008

By:

Chakravarthy MV;
Zhu Y;
Wice MB;
Coleman T;
Pappan KL;
Marshall CA;
McDaniel ML;
Semenkovich CF;
Chakravarthy, Manu V;
Zhu, Yimin;
Wice, Mitchell B;
Coleman, Trey;
Pappan, Kirk L;
Marshall, Connie A;
McDaniel, Michael L;
Semenkovich, Clay F

Publication type:

journal article

Decreased Fetal Size Is Associated With β-Cell Hyperfunction in Early Life and Failure With Age.

Published in:

Diabetes, 2008, v. 57, n. 10, p. 2698, doi. 10.2337/db08-0404

By:

Chakravarthy, Manu V.;
Yimin Zhu;
Wice, Mitchell B.;
Coleman, Trey;
Pappan, Kirk L.;
Marshall, Connie A.;
McDaniel, Michael L.;
Semenkovich, Clay F.

Publication type:

Article

An Intrauterine Body Size Sensor Regulates Pancreatic Beta Cell Proliferation and Function.

Published in:

Diabetes, 2007, v. 56, p. A440

By:

Chakravarthy, Manu V.;
Zhu, Yimin;
Pappan, Kirk L.;
Marshall, Connie A.;
Mcdaniel, Michael L.;
Semenkovich, Clay F.

Publication type:

Article

Brain fatty acid synthase activates PPARalpha to maintain energy homeostasis.

Published in:

2007

By:

Chakravarthy, Manu V.;
Zhu, Yimin;
López, Miguel;
Li Yin;
Wozniak, David F.;
Coleman, Trey;
Zhiyuan Hu;
Wolfgang, Michael;
Vidal-Puig, Antonio;
Lane, M. Daniel;
Semenkovich, Clay F.;
López, Miguel;
Yin, Li;
Hu, Zhiyuan

Publication type:

journal article