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The P522R protective variant of PLCG2 promotes the expression of antigen presentation genes by human microglia in an Alzheimer's disease mouse model.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 10, p. 1765, doi. 10.1002/alz.12577
By:
- Claes, Christel;
- England, Whitney E.;
- Danhash, Emma P.;
- Kiani Shabestari, Sepideh;
- Jairaman, Amit;
- Chadarevian, Jean Paul;
- Hasselmann, Jonathan;
- Tsai, Andy P.;
- Coburn, Morgan A.;
- Sanchez, Jessica;
- Lim, Tau En;
- Hidalgo, Jorge L. S.;
- Tu, Christina;
- Cahalan, Michael D.;
- Lamb, Bruce T.;
- Landreth, Gary E.;
- Spitale, Robert C.;
- Blurton‐Jones, Mathew;
- Davtyan, Hayk
Publication type:
Article
The first MultiTEP‐based conjugated vaccine targeting pyroglutamated pE3‐Aβ is immunogenic and effective in a 5xFAD animal model.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, p. 1, doi. 10.1002/alz.054681
By:
- Zagorski, Karen;
- King, Olga;
- Hovakimyan, Armine;
- Antonyan, Tatevik;
- Petrushina, Irina;
- Chadarevian, Jean Paul;
- Danhash, Emma;
- Cribbs, David H.;
- Davtyan, Hayk;
- Blurton‐Jones, Mathew;
- Agadjanyan, Michael G;
- Ghochikyan, Anahit
Publication type:
Article
Examining the effects of the microglial PLCG2 P522R mutation by transplantation of human stem cell‐derived microglia in chimeric AD mice: Molecular and cell biology/stem cells, iPS cells.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.041539
By:
- Claes, Christel;
- Danhash, Emma;
- Hasselmann, Jonathan;
- Chadarevian, Jean Paul;
- Shabestari, Sepideh Kiani;
- Lim, Tau En;
- Tu, Christina;
- Silva, Jorge;
- Coburn, Morgan A.;
- Jairaman, Amit;
- Cahalan, Michael;
- Blurton‐Jones, Mathew;
- Davtyan, Hayk
Publication type:
Article
mRNA Vaccine for Alzheimer's Disease: Pilot Study.
Published in:
Vaccines, 2024, v. 12, n. 6, p. 659, doi. 10.3390/vaccines12060659
By:
- Hovakimyan, Armine;
- Chilingaryan, Garri;
- King, Olga;
- Capocchi, Joia Kai;
- Chadarevian, Jean Paul;
- Davtyan, Hayk;
- Kniazev, Roman;
- Agadjanyan, Michael G.;
- Ghochikyan, Anahit
Publication type:
Article
TREM2 regulates purinergic receptor-mediated calcium signaling and motility in human iPSC-derived microglia.
Published in:
eLife, 2022, p. 1, doi. 10.7554/eLife.73021
By:
- Jairaman, Amit;
- McQuade, Amanda;
- Granzotto, Alberto;
- You Jung Kang;
- Chadarevian, Jean Paul;
- Gandhi, Sunil;
- Parker, Ian;
- Smith, Ian;
- Hansang Cho;
- Sensi, Stefano L.;
- Othy, Shivashankar;
- Blurton-Jones, Mathew;
- Cahalan, Michael D.
Publication type:
Article
A MultiTEP platform-based epitope vaccine targeting the phosphatase activating domain (PAD) of tau: therapeutic efficacy in PS19 mice.
Published in:
Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-51809-2
By:
- Hovakimyan, Armine;
- Antonyan, Tatevik;
- Shabestari, Sepideh Kiani;
- Svystun, Olga;
- Chailyan, Gor;
- Coburn, Morgan A.;
- Carlen-Jones, William;
- Petrushina, Irina;
- Chadarevian, Jean Paul;
- Zagorski, Karen;
- Petrovsky, Nikolai;
- Cribbs, David H.;
- Agadjanyan, Michael G.;
- Ghochikyan, Anahit;
- Davtyan, Hayk
Publication type:
Article
Controlled Release of Stem Cell Secretome Attenuates Inflammatory Response against Implanted Biomaterials.
Published in:
Advanced Healthcare Materials, 2020, v. 9, n. 12, p. 1, doi. 10.1002/adhm.201901874
By:
- Mohammadi, Mohammadreza;
- Luong, Jennifer Cam;
- Rodriguez, Samuel Mathew;
- Cao, Rui;
- Wheeler, Ashlyn Elizabeth;
- Lau, Hien;
- Li, Shiri;
- Shabestari, Sepideh Kiani;
- Chadarevian, Jean Paul;
- Alexander, Michael;
- Vos, Paul;
- Zhao, Weian;
- Lakey, Jonathan Robert Tod
Publication type:
Article
The CD22-IGF2R interaction is a therapeutic target for microglial lysosome dysfunction in Niemann-Pick type C.
Published in:
Science Translational Medicine, 2021, v. 13, n. 622, p. 1, doi. 10.1126/scitranslmed.abg2919
By:
- Pluvinage, John V.;
- Sun, Jerry;
- Claes, Christel;
- Flynn, Ryan A.;
- Haney, Michael S.;
- Iram, Tal;
- Meng, Xiangling;
- Lindemann, Rachel;
- Riley, Nicholas M.;
- Danhash, Emma;
- Chadarevian, Jean Paul;
- Tapp, Emma;
- Gate, David;
- Kondapavulur, Sravani;
- Cobos, Inma;
- Chetty, Sundari;
- Pașca, Anca M.;
- Pașca, Sergiu P.;
- Berry-Kravis, Elizabeth;
- Bertozzi, Carolyn R.
Publication type:
Article
Novel Vaccine against Pathological Pyroglutamate-Modified Amyloid Beta for Prevention of Alzheimer's Disease.
Published in:
International Journal of Molecular Sciences, 2023, v. 24, n. 12, p. 9797, doi. 10.3390/ijms24129797
By:
- Zagorski, Karen;
- King, Olga;
- Hovakimyan, Armine;
- Petrushina, Irina;
- Antonyan, Tatevik;
- Chailyan, Gor;
- Ghazaryan, Manush;
- Hyrc, Krzysztof L.;
- Chadarevian, Jean Paul;
- Davtyan, Hayk;
- Blurton-Jones, Mathew;
- Cribbs, David H.;
- Agadjanyan, Michael G.;
- Ghochikyan, Anahit
Publication type:
Article
Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease.
Published in:
Nature Communications, 2020, v. 11, n. 1, p. N.PAG, doi. 10.1038/s41467-020-19227-5
By:
- McQuade, Amanda;
- Kang, You Jung;
- Hasselmann, Jonathan;
- Jairaman, Amit;
- Sotelo, Alexandra;
- Coburn, Morgan;
- Shabestari, Sepideh Kiani;
- Chadarevian, Jean Paul;
- Fote, Gianna;
- Tu, Christina H.;
- Danhash, Emma;
- Silva, Jorge;
- Martinez, Eric;
- Cotman, Carl;
- Prieto, G. Aleph;
- Thompson, Leslie M.;
- Steffan, Joan S.;
- Smith, Ian;
- Davtyan, Hayk;
- Cahalan, Michael
Publication type:
Article
Plaque-associated human microglia accumulate lipid droplets in a chimeric model of Alzheimer's disease.
Published in:
Molecular Neurodegeneration, 2021, v. 16, n. 1, p. 1, doi. 10.1186/s13024-021-00473-0
By:
- Claes, Christel;
- Danhash, Emma Pascal;
- Hasselmann, Jonathan;
- Chadarevian, Jean Paul;
- Shabestari, Sepideh Kiani;
- England, Whitney E.;
- Lim, Tau En;
- Hidalgo, Jorge Luis Silva;
- Spitale, Robert C.;
- Davtyan, Hayk;
- Blurton-Jones, Mathew
Publication type:
Article

Found: 11