Works matching AU Chabes, Andrei

Results: 42

Highly mutagenic and severely imbalanced dNTP pools can escape detection by the S-phase checkpoint.

Published in:

Nucleic Acids Research, 2010, v. 38, n. 12, p. 3975, doi. 10.1093/nar/gkq128

By:

Kumar, Dinesh;
Viberg, Jörgen;
Nilsson, Anna Karin;
Chabes, Andrei

Publication type:

Article

Elevated dNTP levels suppress hyper-recombination in Saccharomyces cerevisiae S-phase checkpoint mutants.

Published in:

Nucleic Acids Research, 2010, v. 38, n. 4, p. 1195, doi. 10.1093/nar/gkp1064

By:

Fasullo, Michael;
Tsaponina, Olga;
Sun, Mingzeng;
Chabes, Andrei

Publication type:

Article

Evidence for lesion bypass by yeast replicative DNA polymerases during DNA damage.

Published in:

Nucleic Acids Research, 2008, v. 36, n. 17, p. 5660, doi. 10.1093/nar/gkn555

By:

Sabouri, Nasim;
Viberg, Jörgen;
Goyal, Dinesh Kumar;
Johansson, Erik;
Chabes, Andrei

Publication type:

Article

DNA Building Blocks at the Foundation of Better Survival.

Published in:

Cell Cycle, 2003, v. 2, n. 3, p. 172, doi. 10.4161/cc.2.3.354

By:

Chabes, Andrei;
Thelander, Lars

Publication type:

Article

dNTP pools determine fork progression and origin usage under replication stress.

Published in:

EMBO Journal, 2012, v. 31, n. 4, p. 883, doi. 10.1038/emboj.2011.470

By:

Poli, Jérôme;
Tsaponina, Olga;
Crabbé, Laure;
Keszthelyi, Andrea;
Pantesco, Véronique;
Chabes, Andrei;
Lengronne, Armelle;
Pasero, Philippe

Publication type:

Article

Endogenous DNA replication stress results in expansion of dNTP pools and a mutator phenotype.

Published in:

EMBO Journal, 2012, v. 31, n. 4, p. 895, doi. 10.1038/emboj.2011.485

By:

Davidson, Marta B;
Katou, Yuki;
Keszthelyi, Andrea;
Sing, Tina L;
Xia, Tian;
Ou, Jiongwen;
Vaisica, Jessica A;
Thevakumaran, Neroshan;
Marjavaara, Lisette;
Myers, Chad L;
Chabes, Andrei;
Shirahige, Katsuhiko;
Brown, Grant W

Publication type:

Article

Evidence that processing of ribonucleotides in DNA by topoisomerase 1 is leading-strand specific.

Published in:

Nature Structural & Molecular Biology, 2015, v. 22, n. 4, p. 291, doi. 10.1038/nsmb.2989

By:

Williams, Jessica S;
Clausen, Anders R;
Lujan, Scott A;
Marjavaara, Lisette;
Clark, Alan B;
Burgers, Peter M;
Chabes, Andrei;
Kunkel, Thomas A

Publication type:

Article

NME6: ribonucleotide salvage sustains mitochondrial transcription.

Published in:

2023

By:

Wanrooij, Paulina H;
Chabes, Andrei

Publication type:

Editorial

Mrc1 and Rad9 cooperate to regulate initiation and elongation of DNA replication in response to DNA damage.

Published in:

EMBO Journal, 2018, v. 37, n. 21, p. N.PAG, doi. 10.15252/embj.201899319

By:

Bacal, Julien;
Moriel‐Carretero, María;
Pardo, Benjamin;
Barthe, Antoine;
Sharma, Sushma;
Chabes, Andrei;
Lengronne, Armelle;
Pasero, Philippe

Publication type:

Article

Rtt105 functions as a chaperone for replication protein A to preserve genome stability.

Published in:

EMBO Journal, 2018, v. 37, n. 17, p. 1, doi. 10.15252/embj.201899154

By:

Li, Shuqi;
Xu, Zhiyun;
Xu, Jiawei;
Zuo, Linyu;
Yu, Chuanhe;
Zheng, Pu;
Gan, Haiyun;
Wang, Xuezheng;
Li, Longtu;
Sharma, Sushma;
Chabes, Andrei;
Li, Di;
Wang, Sheng;
Zheng, Sihao;
Li, Jinbao;
Chen, Xuefeng;
Sun, Yujie;
Xu, Dongyi;
Han, Junhong;
Chan, Kuiming

Publication type:

Article

Replication-IDentifier links epigenetic and metabolic pathways to the replication stress response.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-56561-y

By:

van der Horst, Sophie C.;
Kollenstart, Leonie;
Batté, Amandine;
Keizer, Sander;
Vreeken, Kees;
Pandey, Praveen;
Chabes, Andrei;
van Attikum, Haico

Publication type:

Article

Developmental signals control chromosome segregation fidelity during pluripotency and neurogenesis by modulating replicative stress.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-51821-9

By:

de Jaime-Soguero, Anchel;
Hattemer, Janina;
Bufe, Anja;
Haas, Alexander;
van den Berg, Jeroen;
van Batenburg, Vincent;
Das, Biswajit;
di Marco, Barbara;
Androulaki, Stefania;
Böhly, Nicolas;
Landry, Jonathan J. M.;
Schoell, Brigitte;
Rosa, Viviane S.;
Villacorta, Laura;
Baskan, Yagmur;
Trapp, Marleen;
Benes, Vladimir;
Chabes, Andrei;
Shahbazi, Marta;
Jauch, Anna

Publication type:

Article

Telomere Length Homeostasis Responds to Changes in Intracellular dNTP Pools.

Published in:

Genetics, 2013, v. 193, n. 4, p. 1095, doi. 10.1534/genetics.112.149120

By:

Gupta, Amitabha;
Sharma, Sushma;
Reichenbach, Patrick;
Marjavaara, Lisette;
Nilsson, Anna Karin;
Lingner, Joachim;
Chabes, Andrei;
Rothstein, Rodney;
Chang, Michael

Publication type:

Article

Phosphines are ribonucleotide reductase reductants that act via C-terminal cysteines similar to thioredoxins and glutaredoxins.

Published in:

Scientific Reports, 2014, p. 1, doi. 10.1038/srep05539

By:

Domkin, Vladimir;
Chabes, Andrei

Publication type:

Article

A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme.

Published in:

Nature Communications, 2019, v. 10, n. 1, p. 1, doi. 10.1038/s41467-018-08145-2

By:

Xing, Xuanxuan;
Kane, Daniel P.;
Bulock, Chelsea R.;
Moore, Elizabeth A.;
Sharma, Sushma;
Chabes, Andrei;
Shcherbakova, Polina V.

Publication type:

Article

A geographically matched control population efficiently limits the number of candidate disease-causing variants in an unbiased whole-genome analysis.

Published in:

PLoS ONE, 2019, v. 14, n. 3, p. 1, doi. 10.1371/journal.pone.0213350

By:

Rentoft, Matilda;
Svensson, Daniel;
Sjödin, Andreas;
Olason, Pall I.;
Sjöström, Olle;
Nylander, Carin;
Osterman, Pia;
Sjögren, Rickard;
Netotea, Sergiu;
Wibom, Carl;
Cederquist, Kristina;
Chabes, Andrei;
Trygg, Johan;
Melin, Beatrice S.;
Johansson, Erik

Publication type:

Article

Acute Smc5/6 depletion reveals its primary role in rDNA replication by restraining recombination at fork pausing sites.

Published in:

PLoS Genetics, 2018, v. 14, n. 1, p. 1, doi. 10.1371/journal.pgen.1007129

By:

Peng, Xiao P.;
Lim, Shelly;
Li, Shibai;
Marjavaara, Lisette;
Chabes, Andrei;
Zhao, Xiaolan

Publication type:

Article

Rnr1, but not Rnr3, facilitates the sustained telomerase-dependent elongation of telomeres.

Published in:

PLoS Genetics, 2017, v. 13, n. 10, p. 1, doi. 10.1371/journal.pgen.1007082

By:

Maicher, André;
Gazy, Inbal;
Sharma, Sushma;
Marjavaara, Lisette;
Grinberg, Gilad;
Shemesh, Keren;
Chabes, Andrei;
Kupiec, Martin

Publication type:

Article

Chl1 helicase controls replication fork progression by regulating dNTP pools.

Published in:

Life Science Alliance, 2022, v. 5, n. 4, p. 1, doi. 10.26508/lsa.202101153

By:

Batté, Amandine;
van der Horst, Sophie C.;
Tittel-Elmer, Mireille;
Su Ming Sun;
Sushma Sharma;
van Leeuwen, Jolanda;
Chabes, Andrei;
van Attikum, Haico

Publication type:

Article

Upregulation of dNTP Levels After Telomerase Inactivation Influences Telomerase-Independent Telomere Maintenance Pathway Choice in Saccharomyces cerevisiae.

Published in:

G3: Genes | Genomes | Genetics, 2018, v. 8, n. 8, p. 2551, doi. 10.1534/g3.118.200280

By:

van Mourik, Paula M.;
de Jong, Jannie;
Sharma, Sushma;
Alan Kavšek;
Chabes, Andrei;
Chang, Michael

Publication type:

Article

The ribonucleotide reductase inhibitor Sml1 is a new target of the Mec1/Rad53 kinase cascade during growth and in response to DNA damage.

Published in:

EMBO Journal, 2001, v. 20, n. 13, p. 3544, doi. 10.1093/emboj/20.13.3544

By:

Zhao, Xiaolan;
Chabes, Andrei;
Domkin, Vladimir;
Thelander, Lars;
Rothstein, Rodney

Publication type:

Article

Isocratic HPLC analysis for the simultaneous determination of dNTPs, rNTPs and ADP in biological samples.

Published in:

Nucleic Acids Research, 2022, v. 50, n. 3, p. e18, doi. 10.1093/nar/gkab1117

By:

Ranjbarian, Farahnaz;
Sharma, Sushma;
Falappa, Giulia;
Taruschio, Walter;
Chabes, Andrei;
Hofer, Anders

Publication type:

Article

Inactivation of folylpolyglutamate synthetase Met7 results in genome instability driven by an increased dUTP/dTTP ratio.

Published in:

Nucleic Acids Research, 2020, v. 48, n. 1, p. 264, doi. 10.1093/nar/gkz1006

By:

Schmidt, Tobias T;
Sharma, Sushma;
Reyes, Gloria X;
Kolodziejczak, Anna;
Wagner, Tina;
Luke, Brian;
Hofer, Anders;
Chabes, Andrei;
Hombauer, Hans

Publication type:

Article

The absence of the catalytic domains of Saccharomyces cerevisiae DNA polymerase ϵ strongly reduces DNA replication fidelity.

Published in:

Nucleic Acids Research, 2019, v. 47, n. 8, p. 3986, doi. 10.1093/nar/gkz048

By:

Garbacz, Marta A;
Cox, Phillip B;
Sharma, Sushma;
Lujan, Scott A;
Chabes, Andrei;
Kunkel, Thomas A

Publication type:

Article

A genetic screen pinpoints ribonucleotide reductase residues that sustain dNTP homeostasis and specifies a highly mutagenic type of dNTP imbalance.

Published in:

Nucleic Acids Research, 2019, v. 47, n. 1, p. 237, doi. 10.1093/nar/gky1154

By:

Schmidt, Tobias T;
Sharma, Sushma;
Reyes, Gloria X;
Gries, Kerstin;
Gross, Maike;
Zhao, Boyu;
Yuan, Jui-Hung;
Wade, Rebecca;
Chabes, Andrei;
Hombauer, Hans

Publication type:

Article

Simultaneous determination of ribonucleoside and deoxyribonucleoside triphosphates in biological samples by hydrophilic interaction liquid chromatography coupled with tandem mass spectrometry.

Published in:

Nucleic Acids Research, 2018, v. 46, n. 11, p. 1, doi. 10.1093/nar/gky203

By:

Kong, Ziqing;
Jia, Shaodong;
Chabes, Anna Lena;
Appelblad, Patrik;
Lundmark, Richard;
Moritz, Thomas;
Chabes, Andrei

Publication type:

Article

Yeast DNA polymerase ζ maintains consistent activity and mutagenicity across a wide range of physiological dNTP concentrations.

Published in:

Nucleic Acids Research, 2017, v. 45, n. 3, p. 1200, doi. 10.1093/nar/gkw1149

By:

Kochenova, Olga V.;
Bezalel-Buch, Rachel;
Tran, Phong;
Makarova, Alena V.;
Chabes, Andrei;
Burgers, Peter M. J.;
Shcherbakova, Polina V.

Publication type:

Article

The mutation spectrum in genomic late replication domains shapes mammalian GC content.

Published in:

Nucleic Acids Research, 2016, v. 44, n. 9, p. 4222, doi. 10.1093/nar/gkw268

By:

Kenigsberg, Ephraim;
Yishai Yehuda;
Marjavaara, Lisette;
Keszthelyi, Andrea;
Chabes, Andrei;
Tanay, Amos;
Simon, Itamar

Publication type:

Article

Genome-wide analysis of the specificity and mechanisms of replication infidelity driven by imbalanced dNTP pools.

Published in:

Nucleic Acids Research, 2016, v. 44, n. 4, p. 1669, doi. 10.1093/nar/gkv1298

By:

Watt, Danielle L.;
Buckland, Robert J.;
Lujan, Scott A.;
Kunkel, Thomas A.;
Chabes, Andrei

Publication type:

Article

Telomere length kinetics assay (TELKA) sorts the telomere length maintenance (tlm) mutants into functional groups.

Published in:

Nucleic Acids Research, 2014, v. 42, n. 10, p. 6314, doi. 10.1093/nar/gku267

By:

Rubinstein, Linda;
Ungar, Lior;
Harari, Yaniv;
Babin, Vera;
Ben-Aroya, Shay;
Merenyi, Gabor;
Marjavaara, Lisette;
Chabes, Andrei;
Kupiec, Martin

Publication type:

Article

Pre-activation of the genome integrity checkpoint increases DNA damage tolerance.

Published in:

Nucleic Acids Research, 2013, v. 41, n. 22, p. 10371, doi. 10.1093/nar/gkt820

By:

Tsaponina, Olga;
Chabes, Andrei

Publication type:

Article

Mechanisms of mutagenesis in vivo due to imbalanced dNTP pools.

Published in:

Nucleic Acids Research, 2011, v. 39, n. 4, p. 1360, doi. 10.1093/nar/gkq829

By:

Kumar, Dinesh;
Abdulovic, Amy L.;
Viberg, Jörgen;
Nilsson, Anna Karin;
Kunkel, Thomas A.;
Chabes, Andrei

Publication type:

Article

Ribonucleotides in mitochondrial DNA.

Published in:

FEBS Letters, 2019, v. 593, n. 13, p. 1554, doi. 10.1002/1873-3468.13440

By:

Wanrooij, Paulina H.;
Chabes, Andrei

Publication type:

Article

Corrigendum: Phosphines are ribonucleotide reductase reductants that act via C-terminal cysteines similar to thioredoxins and glutaredoxins.

Published in:

Scientific Reports, 2017, p. 45880, doi. 10.1038/srep45880

By:

Domkin, Vladimir;
Chabes, Andrei

Publication type:

Article

Increased and Imbalanced dNTP Pools Symmetrically Promote Both Leading and Lagging Strand Replication Infidelity.

Published in:

PLoS Genetics, 2014, v. 10, n. 12, p. 1, doi. 10.1371/journal.pgen.1004846

By:

Buckland, Robert J.;
Watt, Danielle L.;
Chittoor, Balasubramanyam;
Nilsson, Anna Karin;
Kunkel, Thomas A.;
Chabes, Andrei

Publication type:

Article

H2B Mono-ubiquitylation Facilitates Fork Stalling and Recovery during Replication Stress by Coordinating Rad53 Activation and Chromatin Assembly.

Published in:

PLoS Genetics, 2014, v. 10, n. 10, p. 1, doi. 10.1371/journal.pgen.1004667

By:

Lin, Chia-Yeh;
Wu, Meng-Ying;
Gay, Sophie;
Marjavaara, Lisette;
Lai, Mong Sing;
Hsiao, Wei-Chun;
Hung, Shih-Hsun;
Tseng, Hsin-Yi;
Wright, Duncan Edward;
Wang, Chen-Yi;
Hsu, Guoo-Shyng W.;
Devys, Didier;
Chabes, Andrei;
Kao, Cheng-Fu

Publication type:

Article

Altered dNTP pools accelerate tumor formation in mice.

Published in:

Nucleic Acids Research, 2024, v. 52, n. 20, p. 12475, doi. 10.1093/nar/gkae843

By:

Tran, Phong;
Mishra, Pradeep;
Williams, Leonard G;
Moskalenko, Roman;
Sharma, Sushma;
Nilsson, Anna Karin;
Watt, Danielle L;
Andersson, Pernilla;
Bergh, Anders;
Pursell, Zachary F;
Chabes, Andrei

Publication type:

Article

Genome instability due to ribonucleotide incorporation into DNA.

Published in:

Nature Chemical Biology, 2010, v. 6, n. 10, p. 774, doi. 10.1038/nchembio.424

By:

McElhinny, Stephanie A. Nick;
Kumar, Dinesh;
Clark, Alan B.;
Watt, Danielle L.;
Watts, Brian E.;
Lundström, Else-Britt;
Johansson, Erik;
Chabes, Andrei;
Kunkel, Thomas A.

Publication type:

Article

Molecular Basis of the Essential S Phase Function of the Rad53 Checkpoint Kinase.

Published in:

Molecular & Cellular Biology, 2013, v. 33, n. 16, p. 3202, doi. 10.1128/MCB.00474-13

By:

Hoch, Nicolas C.;
Chen, Eric S.-W.;
Buckland, Robert;
Shun-Chung Wang;
Fazio, Alessandro;
Hammet, Andrew;
Pellicioli, Achille;
Chabes, Andrei;
Ming-Daw Tsai;
Heierhorst, Jörg

Publication type:

Article

Molecular Basis of the Essential S Phase Function of the Rad53 Checkpoint Kinase.

Published in:

Molecular & Cellular Biology, 2013, v. 33, n. 15, p. 3202, doi. 10.1128/MCB.00474-13

By:

Hoch, Nicolas C.;
Chen, Eric S.-W.;
Buckland, Robert;
Shun-Chung Wang;
Fazio, Alessandro;
Hammet, Andrew;
Pellicioli, Achille;
Chabes, Andrei;
Ming-Daw Tsai;
Heierhorst, Jörg

Publication type:

Article

Replication Fork Collapse and Genome Instability in a Deoxycytidylate Deaminase Mutant.

Published in:

Molecular & Cellular Biology, 2012, v. 32, n. 21, p. 4445, doi. 10.1128/MCB.01062-12

By:

Sanchez, Arancha;
Sharma, Sushma;
Rozenzhak, Sophie;
Roguev, Assen;
Krogan, Nevan J.;
Chabes, Andrei;
Russell, Paul

Publication type:

Article

Ixr1 Is Required for the Expression of the Ribonucleotide Reductase Rnr1 and Maintenance of dNTP Pools.

Published in:

PLoS Genetics, 2011, v. 7, n. 5, p. 1, doi. 10.1371/journal.pgen.1002061

By:

Tsaponina, Olga;
Barsoum, Emad;
Aström, Stefan U.;
Chabes, Andrei

Publication type:

Article