Found: 8
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Anti-seizure effects of JNJ-54175446 in the intra-amygdala kainic acid model of drug-resistant temporal lobe epilepsy in mice.
- Published in:
- Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2023.1308478
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- Publication type:
- Article
Clinical pharmacokinetics, pharmacodynamics, safety, and tolerability of JNJ-54175446, a brain permeable P2X7 antagonist, in a randomised single-ascending dose study in healthy participants.
- Published in:
- 2018
- By:
- Publication type:
- journal article
Characterization of the central nervous system penetrant and selective purine P2X7 receptor antagonist JNJ-54175446 in patients with major depressive disorder.
- Published in:
- Translational Psychiatry, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41398-023-02557-5
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- Publication type:
- Article
<sup>18</sup>F-JNJ-64413739, a Novel PET Ligand for the P2X7 Ion Channel: Radiation Dosimetry, Kinetic Modeling, Test-Retest Variability, and Occupancy of the P2X7 Antagonist JNJ-54175446.
- Published in:
- Journal of Nuclear Medicine, 2019, v. 60, n. 5, p. 683, doi. 10.2967/jnumed.118.216747
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- Publication type:
- Article
The P2X7 receptor contributes to seizures and inflammation‐driven long‐lasting brain hyperexcitability following hypoxia in neonatal mice.
- Published in:
- British Journal of Pharmacology, 2023, v. 180, n. 13, p. 1710, doi. 10.1111/bph.16033
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- Publication type:
- Article
Increased uptake of the P2X7 receptor radiotracer <sup>18</sup>F‐JNJ‐64413739 in the brain and peripheral organs according to the severity of status epilepticus in male mice.
- Published in:
- Epilepsia (Series 4), 2023, v. 64, n. 2, p. 511, doi. 10.1111/epi.17484
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- Publication type:
- Article
Potent and selective pharmacodynamic synergy between the metabotropic glutamate receptor subtype 2--positive allosteric modulator JNJ-46356479 and levetiracetam in the mouse 6-Hz (44-mA) model.
- Published in:
- Epilepsia (Series 4), 2018, v. 59, n. 3, p. 724, doi. 10.1111/epi.14005
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- Publication type:
- Article
Efficacy of mGlu<sub>2</sub>-positive allosteric modulators alone and in combination with levetiracetam in the mouse 6 Hz model of psychomotor seizures.
- Published in:
- Epilepsia (Series 4), 2017, v. 58, n. 3, p. 484, doi. 10.1111/epi.13659
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- Publication type:
- Article