Works by Cepinskas, Gediminas

Results: 46

Organ and cell-specific biomarkers of Long-COVID identified with targeted proteomics and machine learning.

Published in:

Molecular Medicine, 2023, v. 29, n. 1, p. 1, doi. 10.1186/s10020-023-00610-z

By:

Patel, Maitray A.;
Knauer, Michael J.;
Nicholson, Michael;
Daley, Mark;
Van Nynatten, Logan R.;
Cepinskas, Gediminas;
Fraser, Douglas D.

Publication type:

Article

Elevated vascular transformation blood biomarkers in Long-COVID indicate angiogenesis as a key pathophysiological mechanism.

Published in:

Molecular Medicine, 2022, v. 28, n. 1, p. 1, doi. 10.1186/s10020-022-00548-8

By:

Patel, Maitray A.;
Knauer, Michael J.;
Nicholson, Michael;
Daley, Mark;
Van Nynatten, Logan R.;
Martin, Claudio;
Patterson, Eric K.;
Cepinskas, Gediminas;
Seney, Shannon L.;
Dobretzberger, Verena;
Miholits, Markus;
Webb, Brian;
Fraser, Douglas D.

Publication type:

Article

Development and characterization of a fecal-induced peritonitis model of murine sepsis: results from a multi-laboratory study and iterative modification of experimental conditions.

Published in:

Intensive Care Medicine Experimental, 2023, v. 11, n. 1, p. 1, doi. 10.1186/s40635-023-00533-3

By:

Sharma, Neha;
Chwastek, Damian;
Dwivedi, Dhruva J.;
Schlechte, Jared;
Yu, Ian-Ling;
McDonald, Braedon;
Arora, Jaskirat;
Cani, Erblin;
Eng, Mikaela;
Engelberts, Doreen;
Kuhar, Eva;
Medeiros, Sarah K.;
Bourque, Stephane L.;
Cepinskas, Gediminas;
Gill, Sean E.;
Jahandideh, Forough;
Macala, Kimberly F.;
Panahi, Sareh;
Pape, Cynthia;
Sontag, David

Publication type:

Article

Carbon monoxide‐releasing molecule‐3 (CORM‐3) offers protection in an in vitro model of compartment syndrome.

Published in:

Microcirculation, 2019, v. 26, n. 7, p. N.PAG, doi. 10.1111/micc.12577

By:

Bihari, Aurelia;
Chung, Kyukwang (Akira);
Cepinskas, Gediminas;
Sanders, David;
Schemitsch, Emil;
Lawendy, Abdel‐Rahman

Publication type:

Article

Pretreatment of Human Cerebrovascular Endothelial Cells with CO-releasing Molecule-3 Interferes with JNK/ AP-1 Signaling and Suppresses LPS-induced Proadhesive Phenotype.

Published in:

Microcirculation, 2015, v. 22, n. 1, p. 28, doi. 10.1111/micc.12161

By:

Serizawa, Fukashi;
Patterson, Eric;
Potter, Richard F.;
Fraser, Douglas D.;
Cepinskas, Gediminas

Publication type:

Article

Diabetic Ketoacidosis Elicits Systemic Inflammation Associated with Cerebrovascular Endothelial Cell Dysfunction.

Published in:

Microcirculation, 2013, v. 20, n. 6, p. 534, doi. 10.1111/micc.12053

By:

Close, Taylor E.;
Cepinskas, Gediminas;
Omatsu, Tatsushi;
Rose, Keeley L.;
Summers, Kelly;
Patterson, Eric K.;
Fraser, Douglas D.

Publication type:

Article

Neutrophils Induce Sequential Focal Changes in Endothelial Adherens Junction Components: Role of Elastase.

Published in:

Microcirculation, 2003, v. 10, n. 2, p. 205, doi. 10.1038/sj.mn.7800185

By:

Ionescu, Carmen V;
Cepinskas, Gediminas;
Savickiene, Jurate;
Sandig, Martin;
Kvietys, Peter R

Publication type:

Article

Nitric Oxide Attenuates but Superoxide Enhances iNOS Expression in Endotoxin- and IFNγ-Stimulated Skeletal Muscle Endothelial Cells.

Published in:

Microcirculation, 2001, v. 8, n. 6, p. 415, doi. 10.1080/mic.8.6.415.425

By:

WU, FENG;
CEPINSKAS, GEDIMINAS;
WILSON, JOHN X;
TYML, KAREL

Publication type:

Article

Carbon Monoxide Liberated from CO-Releasing Molecule (CORM-2) Attenuates Ischemia/Reperfusion (I/R)-Induced Inflammation in the Small Intestine.

Published in:

Inflammation, 2010, v. 33, n. 2, p. 92, doi. 10.1007/s10753-009-9162-y

By:

Katada, Kazuhiro;
Bihari, Aurelia;
Mizuguchi, Shinjiro;
Yoshida, Norimasa;
Yoshikawa, Toshikazu;
Fraser, Douglas;
Potter, Richard;
Cepinskas, Gediminas

Publication type:

Article

Human severe sepsis cytokine mixture increases β2-integrin-dependent polymorphonuclear leukocyte adhesion to cerebral microvascular endothelial cells in vitro.

Published in:

Critical Care, 2015, v. 19, n. 1, p. 1, doi. 10.1186/s13054-015-0883-z

By:

Blom, Chris;
Deller, Brittany L.;
Fraser, Douglas D.;
Patterson, Eric K.;
Martin, Claudio M.;
Young, Bryan;
Liaw, Patricia C.;
Yazdan-Ashoori, Payam;
Ortiz, Angelica;
Webb, Brian;
Kilmer, Greg;
Carter, David E.;
Cepinskas, Gediminas

Publication type:

Article

A Proteinase 3 Contribution to Juvenile Idiopathic Arthritis-Associated Cartilage Damage.

Published in:

Pathophysiology, 2021, v. 28, n. 3, p. 320, doi. 10.3390/pathophysiology28030021

By:

Patterson, Eric K.;
Vanin Moreno, Nicolas;
Fraser, Douglas D.;
Cepinskas, Gediminas;
Iida, Takaya;
Berard, Roberta A.

Publication type:

Article

Critically Ill COVID-19 Patients Exhibit Anti-SARS-CoV-2 Serological Responses.

Published in:

Pathophysiology, 2021, v. 28, n. 2, p. 212, doi. 10.3390/pathophysiology28020014

By:

Fraser, Douglas D.;
Cepinskas, Gediminas;
Slessarev, Marat;
Martin, Claudio M.;
Daley, Mark;
Patel, Maitray A.;
Miller, Michael R.;
Patterson, Eric K.;
O'Gorman, David B.;
Gill, Sean E.;
Higgins, Ian;
John, Julius P. P.;
Melo, Christopher;
Nini, Lylia;
Wang, Xiaoqin;
Zeidler, Johannes;
Cruz-Aguado, Jorge A.

Publication type:

Article

Pediatric sepsis inflammatory blood biomarkers that correlate with clinical variables and severity of illness scores.

Published in:

Journal of Inflammation, 2024, v. 21, n. 1, p. 1, doi. 10.1186/s12950-024-00379-w

By:

Leonard, Sean;
Guertin, Hailey;
Odoardi, Natalya;
Miller, Michael R.;
Patel, Maitray A.;
Daley, Mark;
Cepinskas, Gediminas;
Fraser, Douglas D.

Publication type:

Article

The Effect of Tidal Volume on Systemic Inflammation in Acid-Induced Lung Injury.

Published in:

Respiration, 2011, v. 81, n. 4, p. 333, doi. 10.1159/000323609

By:

Walker, Melissa G.;
Yao, Li-Juan;
Patterson, Eric K.;
Joseph, Mariamma G.;
Cepinskas, Gediminas;
Veldhuizen, Ruud A.W.;
Lewis, James F.;
Yamashita, Cory M.

Publication type:

Article

Longitudinal analysis of mucosa‐associated invariant T cells in sepsis reveals their early numerical decline with prognostic implications and a progressive loss of antimicrobial functions.

Published in:

Immunology & Cell Biology, 2023, v. 101, n. 3, p. 249, doi. 10.1111/imcb.12619

By:

Choi, Joshua;
Schmerk, Crystal L;
Mele, Tina S;
Rudak, Patrick T;
Wardell, Christine M;
Deng, Gansen;
Pavri, Farzan R;
Kim, Kyoungok;
Cepinskas, Gediminas;
He, Wenqing;
Haeryfar, SM Mansour

Publication type:

Article

Neutrophil serine proteases in vitro: How much and why?

Published in:

Journal of Leukocyte Biology, 2022, v. 112, n. 4, p. 585, doi. 10.1002/JLB.3LT0722-360R

By:

Patterson, Eric K.;
Fraser, Douglas D.;
Cepinskas, Gediminas

Publication type:

Article

Anti-inflammatory Effects of Carbon Monoxide-Releasing Molecule on Trinitrobenzene Sulfonic Acid-Induced Colitis in Mice.

Published in:

Digestive Diseases & Sciences, 2014, v. 59, n. 6, p. 1142, doi. 10.1007/s10620-013-3014-1

By:

Fukuda, Wataru;
Takagi, Tomohisa;
Katada, Kazuhiro;
Mizushima, Katsura;
Okayama, Tetsuya;
Yoshida, Naohisa;
Kamada, Kazuhiro;
Uchiyama, Kazuhiko;
Ishikawa, Takeshi;
Handa, Osamu;
Konishi, Hideyuki;
Yagi, Nobuaki;
Ichikawa, Hiroshi;
Yoshikawa, Toshikazu;
Cepinskas, Gediminas;
Naito, Yuji;
Itoh, Yoshito

Publication type:

Article

PMN transendothelial migration decreases nuclear NFκB in IL-1 β-activated endothelial cells: role of PECAM-1.

Published in:

Journal of Cell Biology, 2003, v. 161, n. 3, p. 641, doi. 10.1083/jcb.200212048

By:

Cepinskas, Gediminas;
Savickiene, Jurate;
Ionescu, Carmen V.;
Kvietys, Peter R.

Publication type:

Article

Delayed preconditioning in cardiac myocytes with respect to development of a proinflammatory phenotype: role of SOD and NOS

Published in:

Cardiovascular Research, 2003, v. 59, n. 4, p. 901, doi. 10.1016/S0008-6363(03)00502-9

By:

Rui, Tao;
Cepinskas, Gediminas;
Feng, Qingping;
Kvietys, Peter R.

Publication type:

Article

A reduced proteomic signature in critically ill Covid-19 patients determined with plasma antibody micro-array and machine learning.

Published in:

Clinical Proteomics, 2024, v. 21, n. 1, p. 1, doi. 10.1186/s12014-024-09488-3

By:

Patel, Maitray A.;
Daley, Mark;
Van Nynatten, Logan R.;
Slessarev, Marat;
Cepinskas, Gediminas;
Fraser, Douglas D.

Publication type:

Article

Novel plasma protein biomarkers from critically ill sepsis patients.

Published in:

Clinical Proteomics, 2022, v. 19, n. 1, p. 1, doi. 10.1186/s12014-022-09389-3

By:

Van Nynatten, Logan R.;
Slessarev, Marat;
Martin, Claudio M.;
Leligdowicz, Aleks;
Miller, Michael R.;
Patel, Maitray A.;
Daley, Mark;
Patterson, Eric K.;
Cepinskas, Gediminas;
Fraser, Douglas D.

Publication type:

Article

Plasma proteome of Long-COVID patients indicates HIF-mediated vasculo-proliferative disease with impact on brain and heart function.

Published in:

Journal of Translational Medicine, 2023, v. 21, n. 1, p. 1, doi. 10.1186/s12967-023-04149-9

By:

Iosef, Cristiana;
Knauer, Michael J.;
Nicholson, Michael;
Van Nynatten, Logan R.;
Cepinskas, Gediminas;
Draghici, Sorin;
Han, Victor K. M.;
Fraser, Douglas D.

Publication type:

Article

Differential expression of plasma proteins and pathway enrichments in pediatric diabetic ketoacidosis.

Published in:

Molecular Medicine, 2025, v. 31, n. 1, p. 1, doi. 10.1186/s10020-024-01056-7

By:

Spagnolo, Paolo;
Cela, Enis;
Patel, Maitray A.;
Tweddell, David;
Daley, Mark;
Clarson, Cheril;
Stranges, Saverio;
Cepinskas, Gediminas;
Fraser, Douglas D.

Publication type:

Article

Metabolomic signature of pediatric diabetic ketoacidosis: key metabolites, pathways, and panels linked to clinical variables.

Published in:

Molecular Medicine, 2024, v. 30, n. 1, p. 1, doi. 10.1186/s10020-024-01046-9

By:

Spagnolo, Paolo;
Tweddell, David;
Cela, Enis;
Daley, Mark;
Clarson, Cheril;
Rupar, C. Anthony;
Stranges, Saverio;
Bravo, Michael;
Cepinskas, Gediminas;
Fraser, Douglas D.

Publication type:

Article

The plasma proteome differentiates the multisystem inflammatory syndrome in children (MIS-C) from children with SARS-CoV-2 negative sepsis.

Published in:

Molecular Medicine, 2024, v. 30, n. 1, p. 1, doi. 10.1186/s10020-024-00806-x

By:

Patel, Maitray A.;
Fraser, Douglas D.;
Daley, Mark;
Cepinskas, Gediminas;
Veraldi, Noemi;
Grazioli, Serge

Publication type:

Article

Application of Human Plasma/Serum to Cell Culture In Vitro: A Translational Research Approach to Better Define Disease Mechanisms.

Published in:

CTS: Clinical & Translational Science, 2025, v. 18, n. 3, p. 1, doi. 10.1111/cts.70161

By:

Cela, Enis;
Patterson, Eric K.;
Gill, Sean E.;
Cepinskas, Gediminas;
Fraser, Douglas D.

Publication type:

Article

Carbon monoxide releasing molecule-3 improves myocardial function in mice with sepsis by inhibiting NLRP3 inflammasome activation in cardiac fibroblasts.

Published in:

Basic Research in Cardiology, 2017, v. 112, n. 2, p. 1, doi. 10.1007/s00395-017-0603-8

By:

Zhang, Wenbo;
Tao, Aibin;
Lan, Ting;
Cepinskas, Gediminas;
Kao, Raymond;
Martin, Claudio;
Rui, Tao

Publication type:

Article

Functional mass spectrometry indicates anti-protease and complement activity increase with COVID-19 severity.

Published in:

Experimental Biology & Medicine, 2025, p. 1, doi. 10.3389/ebm.2025.10308

By:

Fraser, Douglas D.;
Roy, Swapan;
Kuruc, Matt;
Quintero, Maritza;
Van Nynatten, Logan R.;
Cepinskas, Gediminas;
Zheng, Haiyan;
Soherwardy, Amenah;
Roy, Devjit

Publication type:

Article

Proteinase 3 contributes to endothelial dysfunction in an experimental model of sepsis.

Published in:

Experimental Biology & Medicine, 2021, v. 246, n. 21, p. 2338, doi. 10.1177/15353702211029284

By:

Patterson, Eric K;
Gillio-Meina, Carolina;
Martin, Claudio M;
Fraser, Douglas D;
Van Nynatten, Logan R;
Slessarev, Marat;
Cepinskas, Gediminas

Publication type:

Article

Concussive injury elicits JNK‐mediated human astrocyte retraction (651.10).

Published in:

FASEB Journal, 2014, v. 28, p. N.PAG, doi. 10.1096/fasebj.28.1_supplement.651.10

By:

Augustine, Claudia;
Cepinskas, Gediminas;
Fraser, Douglas

Publication type:

Article

Modulating myeloperoxidase‐induced endothelial damage by a carbon monoxide‐releasing molecule, CORM‐3 (146.9).

Published in:

FASEB Journal, 2014, v. 28, p. N.PAG, doi. 10.1096/fasebj.28.1_supplement.146.9

By:

Patterson, Eric;
Capretta, Alfredo;
Fraser, Douglas;
Potter, Richard;
Cepinskas, Gediminas

Publication type:

Article

CORM‐3 derived CO suppresses NLRP3 inflammasome in cardiac fibroblasts and protects cardiomyocytes from apoptosis in mice with sepsis (1096.6).

Published in:

FASEB Journal, 2014, v. 28, p. N.PAG, doi. 10.1096/fasebj.28.1_supplement.1096.6

By:

Zhang, Wenbo;
Xu, Xuemei;
Mele, Tina;
Kao, Raymond;
Cepinskas, Gediminas;
Martin, Claudio;
Rui, Tao

Publication type:

Article

Cerebrovascular Endothelial Cell Activation in Paediatric Diabetic Ketoacidosis.

Published in:

FASEB Journal, 2013, v. 27, p. 870.8, doi. 10.1096/fasebj.27.1_supplement.870.8

By:

Omatsu, Tatsushi;
Cepinskas, Gediminas;
Fraser, Douglas D

Publication type:

Article

Severe sepsis cytomix elicits inflammation in cerebrovascular endothelial cells and polymorphonuclear (PMN) leukocytes in vitro.

Published in:

FASEB Journal, 2013, v. 27, p. 868.7, doi. 10.1096/fasebj.27.1_supplement.868.7

By:

Blom, Christopher;
Deller, Brittany;
Fraser, Douglas D;
Martin, Claudio;
Young, Bryan;
Cepinskas, Gediminas

Publication type:

Article

Concussive injury elicits human cerebrovascular endothelial cell activation in vitro.

Published in:

FASEB Journal, 2013, v. 27, p. 650.10, doi. 10.1096/fasebj.27.1_supplement.650.10

By:

Augustine, Claudia;
Cepinskas, Gediminas;
Fraser, Douglas

Publication type:

Article

Modulating Myeloperoxidase‐Induced Endothelial Permeability by a Carbon Monoxide‐Releasing Molecule, CORM‐3.

Published in:

FASEB Journal, 2013, v. 27, p. 646.12, doi. 10.1096/fasebj.27.1_supplement.646.12

By:

Patterson, Eric K;
Serizawa, Fukashi;
Capretta, Alfredo;
Fraser, Douglas D;
Potter, Richard F;
Cepinskas, Gediminas

Publication type:

Article

Carbon monoxide (CO)‐dependent modulation of polymorphonuclear leukocyte (PMN) adhesion to human cerebrovascular endothelial cells in an in vitro model of endotoxemia.

Published in:

FASEB Journal, 2013, v. 27, p. 57.10, doi. 10.1096/fasebj.27.1_supplement.57.10

By:

Serizawa, Fukashi;
Patterson, Eric;
Potter, Richard F;
Fraser, Duglas;
Cepinskas, Gediminas

Publication type:

Article

Role of iNOS-derived nitric oxide (NO) on hind limb ischemia/reperfusion (I/R)-induced remote injury to the gut.

Published in:

FASEB Journal, 2007, v. 21, n. 6, p. A1219, doi. 10.1096/fasebj.21.6.a1219-d

By:

Katada, Kazuhiro;
Bihari, Aurelia;
Harris, Kenneth A.;
Forbes, Tom L.;
Potter, Richard F.;
Cepinskas, Gediminas

Publication type:

Article

Carbon monoxide (CO)-releasing molecule (CORM)-liberated CO attenuates inflammatory response in the liver of thermally-injured mice.

Published in:

FASEB Journal, 2007, v. 21, n. 6, p. A768, doi. 10.1096/fasebj.21.6.a768-b

By:

Bing-Wei Sun;
Bihari, Aurelia;
Xi Chen;
Zhao-Yung Chen;
Ningzheng Tai;
Potter, Richard F.;
Cepinskas, Gediminas

Publication type:

Article

Anti-α4β1 integrin antibody induces receptor internalization and does not impair the function of circulating neutrophilic leukocytes.

Published in:

Inflammation Research, 2010, v. 59, n. 8, p. 647, doi. 10.1007/s00011-010-0177-5

By:

Fleming, Jennifer;
Bao, Feng;
Cepinskas, Gediminas;
Weaver, Lynne

Publication type:

Article

Inhibition of calpain reduces oxidative stress and attenuates endothelial dysfunction in diabetes.

Published in:

Cardiovascular Diabetology, 2014, v. 13, n. 1, p. 1, doi. 10.1186/1475-2840-13-88

By:

Bainian Chen;
Qing Zhao;
Ni, Rui;
Tang, Futian;
Shan, Limei;
Cepinskas, Inga;
Cepinskas, Gediminas;
Wang Wang;
Schiller, Peter W.;
Tianqing Peng

Publication type:

Article

Putative biomarkers of hepatic dysfunction in critically ill sepsis patients.

Published in:

Clinical & Experimental Medicine, 2025, v. 25, n. 1, p. 1, doi. 10.1007/s10238-024-01545-3

By:

Van Nynatten, Logan R.;
Patel, Maitray A.;
Daley, Mark;
Miller, Michael R.;
Cepinskas, Gediminas;
Slessarev, Marat;
Russell, James A.;
Fraser, Douglas D.

Publication type:

Article

National Preclinical Sepsis Platform: developing a framework for accelerating innovation in Canadian sepsis research.

Published in:

2021

By:

Mendelson, Asher A.;
Lansdell, Casey;
Fox-Robichaud, Alison E.;
Liaw, Patricia;
Arora, Jaskirat;
Cailhier, Jean-François;
Cepinskas, Gediminas;
Charbonney, Emmanuel;
dos Santos, Claudia;
Dwivedi, Dhruva;
Ellis, Christopher G.;
Fergusson, Dean;
Fiest, Kirsten;
Gill, Sean E.;
Hendrick, Kathryn;
Hunniford, Victoria T.;
Kowalewska, Paulina M.;
Krewulak, Karla;
Lehmann, Christian;
Macala, Kimberly

Publication type:

Letter

Transcriptional profiling of leukocytes in critically ill COVID19 patients: implications for interferon response and coagulation.

Published in:

Intensive Care Medicine Experimental, 2020, v. 8, n. 1, p. 1, doi. 10.1186/s40635-020-00361-9

By:

Gill, Sean E.;
dos Santos, Claudia C.;
O'Gorman, David B.;
Carter, David E.;
Patterson, Eric K.;
Slessarev, Marat;
Martin, Claudio;
Daley, Mark;
Miller, Michael R.;
Cepinskas, Gediminas;
Fraser, Douglas D.;
Lawson COVID19 Study Team;
Arntfield, Robert;
Ball, Ian;
Barkwell, Gordon;
Bentall, Tracey;
Bosma, Karen;
Cameron, Saoirse;
Campbell, Eileen;
Gillio-Meina, Carolina

Publication type:

Article

Carbon monoxide-releasing molecules protect against ischemia-reperfusion injury during kidney transplantation.

Published in:

Kidney International, 2011, v. 79, n. 10, p. 1080, doi. 10.1038/ki.2010.542

By:

Caumartin, Yves;
Stephen, Jancy;
Deng, Jian P.;
Dameng Lian;
Zhu Lan;
Weihua Liu;
Garcia, Bertha;
Jevnikar, Anthony M.;
Hao Wang;
Cepinskas, Gediminas;
Luke, Patrick P. W.

Publication type:

Article

COVID‐19 plasma proteome reveals novel temporal and cell‐specific signatures for disease severity and high‐precision disease management.

Published in:

Journal of Cellular & Molecular Medicine, 2023, v. 27, n. 1, p. 141, doi. 10.1111/jcmm.17622

By:

Iosef, Cristiana;
Martin, Claudio M.;
Slessarev, Marat;
Gillio‐Meina, Carolina;
Cepinskas, Gediminas;
Han, Victor K. M.;
Fraser, Douglas D.

Publication type:

Article