Found: 11

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  • p53 rapidly restructures 3D chromatin organization to trigger a transcriptional response.

    Published in:
    Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-46666-1
    By:
    • Serra, François;
    • Nieto-Aliseda, Andrea;
    • Fanlo-Escudero, Lucía;
    • Rovirosa, Llorenç;
    • Cabrera-Pasadas, Mónica;
    • Lazarenkov, Aleksey;
    • Urmeneta, Blanca;
    • Alcalde-Merino, Alvaro;
    • Nola, Emanuele M.;
    • Okorokov, Andrei L.;
    • Fraser, Peter;
    • Graupera, Mariona;
    • Castillo, Sandra D.;
    • Sardina, Jose L.;
    • Valencia, Alfonso;
    • Javierre, Biola M.
    Publication type:
    Article

  • PI3K-C2β limits mTORC1 signaling and angiogenic growth.

    Published in:
    Science Signaling, 2023, v. 16, n. 813, p. 1, doi. 10.1126/scisignal.adg1913
    By:
    • Kobialka, Piotr;
    • Llena, Judith;
    • Deleyto-Seldas, Nerea;
    • Munar-Gelabert, Margalida;
    • Dengra, Jose A.;
    • Villacampa, Pilar;
    • Albinyà-Pedrós, Alba;
    • Muixi, Laia;
    • Andrade, Jorge;
    • van Splunder, Hielke;
    • Angulo-Urarte, Ana;
    • Potente, Michael;
    • Grego-Bessa, Joaquim;
    • Castillo, Sandra D.;
    • Vanhaesebroeck, Bart;
    • Efeyan, Alejo;
    • Graupera, Mariona
    Publication type:
    Article

  • The onset of PI3K‐related vascular malformations occurs during angiogenesis and is prevented by the AKT inhibitor miransertib.

    Published in:
    EMBO Molecular Medicine, 2022, v. 14, n. 7, p. 1, doi. 10.15252/emmm.202115619
    By:
    • Kobialka, Piotr;
    • Sabata, Helena;
    • Vilalta, Odena;
    • Gouveia, Leonor;
    • Angulo‐Urarte, Ana;
    • Muixí, Laia;
    • Zanoncello, Jasmina;
    • Muñoz‐Aznar, Oscar;
    • Olaciregui, Nagore G;
    • Fanlo, Lucia;
    • Esteve‐Codina, Anna;
    • Lavarino, Cinzia;
    • Javierre, Biola M;
    • Celis, Veronica;
    • Rovira, Carlota;
    • López‐Fernández, Susana;
    • Baselga, Eulàlia;
    • Mora, Jaume;
    • Castillo, Sandra D;
    • Graupera, Mariona
    Publication type:
    Article

  • Blockade of VEGF-C signaling inhibits lymphatic malformations driven by oncogenic PIK3CA mutation.

    Published in:
    Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-16496-y
    By:
    • Martinez-Corral, Ines;
    • Zhang, Yan;
    • Petkova, Milena;
    • Ortsäter, Henrik;
    • Sjöberg, Sofie;
    • Castillo, Sandra D.;
    • Brouillard, Pascal;
    • Libbrecht, Louis;
    • Saur, Dieter;
    • Graupera, Mariona;
    • Alitalo, Kari;
    • Boon, Laurence;
    • Vikkula, Miikka;
    • Mäkinen, Taija
    Publication type:
    Article

  • Endothelial cell rearrangements during vascular patterning require PI3-kinase-mediated inhibition of actomyosin contractility.

    Published in:
    Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-07172-3
    By:
    • Angulo-Urarte, Ana;
    • Casado, Pedro;
    • Castillo, Sandra D.;
    • Kobialka, Piotr;
    • Kotini, Maria Paraskevi;
    • Figueiredo, Ana M.;
    • Castel, Pau;
    • Rajeeve, Vinothini;
    • Milà-Guasch, Maria;
    • Millan, Jaime;
    • Wiesner, Cora;
    • Serra, Helena;
    • Muixi, Laia;
    • Casanovas, Oriol;
    • Viñals, Francesc;
    • Affolter, Markus;
    • Gerhardt, Holger;
    • Huveneers, Stephan;
    • Belting, Heinz-Georg;
    • Cutillas, Pedro R.
    Publication type:
    Article

  • Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling.

    Published in:
    Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-02002-4
    By:
    • Berenjeno, Inma M.;
    • Piñeiro, Roberto;
    • Castillo, Sandra D.;
    • Pearce, Wayne;
    • McGranahan, Nicholas;
    • Dewhurst, Sally M.;
    • Meniel, Valerie;
    • Birkbak, Nicolai J.;
    • Lau, Evelyn;
    • Sansregret, Laurent;
    • Morelli, Daniele;
    • Kanu, Nnennaya;
    • Srinivas, Shankar;
    • Graupera, Mariona;
    • Parker, Victoria E. R.;
    • Montgomery, Karen G.;
    • Moniz, Larissa S.;
    • Scudamore, Cheryl L.;
    • Phillips, Wayne A.;
    • Semple, Robert K.
    Publication type:
    Article

  • Phosphoinositide 3-kinase: a new kid on the block in vascular anomalies.

    Published in:
    Journal of Pathology, 2016, v. 240, n. 4, p. 387, doi. 10.1002/path.4802
    By:
    • Castillo, Sandra D;
    • Vanhaesebroeck, Bart;
    • Sebire, Neil J
    Publication type:
    Article

  • Somatic activating mutations in Pik3ca cause sporadic venous malformations in mice and humans.

    Published in:
    Science Translational Medicine, 2016, v. 8, n. 332, p. 1, doi. 10.1126/scitranslmed.aad9982
    By:
    • Castillo, Sandra D.;
    • Tzouanacou, Elena;
    • May Zaw-Thin;
    • Berenjeno, Inma M.;
    • Parker, Victoria E. R.;
    • Chivite, Iñigo;
    • Milà-Guasch, Maria;
    • Pearce, Wayne;
    • Solomon, Isabelle;
    • Angulo-Urarte, Ana;
    • Figueiredo, Ana M.;
    • Dewhurst, Robert E.;
    • Knox, Rachel G.;
    • Clark, Graeme R.;
    • Scudamore, Cheryl L.;
    • Badar, Adam;
    • Kalber, Tammy L.;
    • Foster, Julie;
    • Stuckey, Daniel J.;
    • David, Anna L.
    Publication type:
    Article

  • Determining the profiles and parameters for gene amplification testing of growth factor receptors in lung cancer.

    Published in:
    International Journal of Cancer, 2013, v. 133, n. 4, p. 898, doi. 10.1002/ijc.28090
    By:
    • Pros, Eva;
    • Lantuejoul, Sylvie;
    • Sanchez‐Verde, Lydia;
    • Castillo, Sandra D;
    • Bonastre, Ester;
    • Suarez‐Gauthier, Ana;
    • Conde, Esther;
    • Cigudosa, Juan C;
    • Lopez‐Rios, Fernando;
    • Torres‐Lanzas, Juan;
    • Castellví, Josep;
    • Cajal, Santiago Ramon y;
    • Brambilla, Elisabeth;
    • Sanchez‐Cespedes, Montse
    Publication type:
    Article

  • Gene amplification of the transcription factor DP1 and CTNND1 in human lung cancer.

    Published in:
    Journal of Pathology, 2010, v. 222, n. 1, p. 89, doi. 10.1002/path.2732
    By:
    • Castillo, Sandra D.;
    • Angulo, Barbara;
    • Suarez-Gauthier, Ana;
    • Melchor, Lorenzo;
    • Medina, Pedro P.;
    • Sanchez-Verde, Lydia;
    • Torres-Lanzas, Juan;
    • Pita, Guillermo;
    • Benitez, Javier;
    • Sanchez-Cespedes, Montse
    Publication type:
    Article

  • The SRY-HMG box gene, SOX4, is a target of gene amplification at chromosome 6p in lung cancer†.

    Published in:
    Human Molecular Genetics, 2009, v. 18, n. 7, p. 1343, doi. 10.1093/hmg/ddp034
    By:
    • Medina, Pedro P.;
    • Castillo, Sandra D.;
    • Blanco, Sandra;
    • Sanz-Garcia, Marta;
    • Largo, Cristina;
    • Alvarez, Sara;
    • Yokota, Jun;
    • Gonzalez-Neira, Ana;
    • Benitez, Javier;
    • Clevers, Hans C.;
    • Cigudosa, Juan C.;
    • Lazo, Pedro A.;
    • Sanchez-Cespedes, Montse
    Publication type:
    Article