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The molecular functions of RIT1 and its contribution to human disease.
Published in:
Biochemical Journal, 2020, v. 477, n. 15, p. 2755, doi. 10.1042/BCJ20200442
By:
- Van, Richard;
- Cuevas-Navarro, Antonio;
- Castel, Pau;
- McCormick, Frank
Publication type:
Article
The tumor suppressor PTEN and the PDK1 kinase regulate formation of the columnar neural epithelium.
Published in:
eLife, 2016, p. 1, doi. 10.7554/eLife.12034
By:
- Grego-Bessa, Joaquim;
- Bloomekatz, Joshua;
- Castel, Pau;
- Omelchenko, Tatiana;
- Baselga, José;
- Anderson, Kathryn V.
Publication type:
Article
Antagonism of EGFR and HER3 Enhances the Response to Inhibitors of the PI3K-Akt Pathway in Triple-Negative Breast Cancer.
Published in:
Science Signaling, 2014, v. 7, n. 318, p. 1, doi. 10.1126/scisignal.2005125
By:
- Tao, Jessica J.;
- Castel, Pau;
- Radosevic-Robin, Nina;
- Elkabets, Moshe;
- Auricchio, Neil;
- Aceto, Nicola;
- Weitsman, Gregory;
- Barber, Paul;
- Vojnovic, Borivoj;
- Ellis, Haley;
- Morse, Natasha;
- Viola-Villegas, Nerissa Therese;
- Bosch, Ana;
- Juric, Dejan;
- Hazra, Saswati;
- Singh, Sharat;
- Kim, Phillip;
- Bergamaschi, Anna;
- Maheswaran, Shyamala;
- Ng, Tony
Publication type:
Article
The 8th International RASopathies Symposium: Expanding research and care practice through global collaboration and advocacy.
Published in:
American Journal of Medical Genetics. Part A, 2024, v. 194, n. 4, p. 1, doi. 10.1002/ajmg.a.63477
By:
- Pierpont, Elizabeth I.;
- Bennett, Anton M.;
- Schoyer, Lisa;
- Stronach, Beth;
- Anschutz, April;
- Borrie, Sarah C.;
- Briggs, Benjamin;
- Burkitt‐Wright, Emma;
- Castel, Pau;
- Cirstea, Ion C.;
- Draaisma, Fieke;
- Ellis, Michelle;
- Fear, Vanessa S.;
- Frone, Megan N.;
- Flex, Elisabetta;
- Gelb, Bruce D.;
- Green, Tamar;
- Gripp, Karen W.;
- Khoshkhoo, Sattar;
- Kieran, Mark W.
Publication type:
Article
The seventh international RASopathies symposium: Pathways to a cure—expanding knowledge, enhancing research, and therapeutic discovery.
Published in:
American Journal of Medical Genetics. Part A, 2022, v. 188, n. 6, p. 1915, doi. 10.1002/ajmg.a.62716
By:
- Kontaridis, Maria I.;
- Roberts, Amy E.;
- Schill, Lisa;
- Schoyer, Lisa;
- Stronach, Beth;
- Andelfinger, Gregor;
- Aoki, Yoko;
- Axelrad, Marni E.;
- Bakker, Annette;
- Bennett, Anton M.;
- Broniscer, Alberto;
- Castel, Pau;
- Chang, Caitlin A.;
- Cyganek, Lukas;
- Das, Tirtha K.;
- den Hertog, Jeroen;
- Galperin, Emilia;
- Garg, Shruti;
- Gelb, Bruce D.;
- Gordon, Kristiana
Publication type:
Article
The sixth international RASopathies symposium: Precision medicine—From promise to practice.
Published in:
American Journal of Medical Genetics. Part A, 2020, v. 182, n. 3, p. 597, doi. 10.1002/ajmg.a.61434
By:
- Gripp, Karen W.;
- Schill, Lisa;
- Schoyer, Lisa;
- Stronach, Beth;
- Bennett, Anton M.;
- Blaser, Susan;
- Brown, Amanda;
- Burdine, Rebecca;
- Burkitt‐Wright, Emma;
- Castel, Pau;
- Darilek, Sandra;
- Dias, Alwyn;
- Dyer, Tuesdi;
- Ellis, Michelle;
- Erickson, Gregg;
- Gelb, Bruce D.;
- Green, Tamar;
- Gross, Andrea;
- Ho, Alan;
- Holder, James Lloyd
Publication type:
Article
Endothelial cell rearrangements during vascular patterning require PI3-kinase-mediated inhibition of actomyosin contractility.
Published in:
Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-07172-3
By:
- Angulo-Urarte, Ana;
- Casado, Pedro;
- Castillo, Sandra D.;
- Kobialka, Piotr;
- Kotini, Maria Paraskevi;
- Figueiredo, Ana M.;
- Castel, Pau;
- Rajeeve, Vinothini;
- Milà-Guasch, Maria;
- Millan, Jaime;
- Wiesner, Cora;
- Serra, Helena;
- Muixi, Laia;
- Casanovas, Oriol;
- Viñals, Francesc;
- Affolter, Markus;
- Gerhardt, Holger;
- Huveneers, Stephan;
- Belting, Heinz-Georg;
- Cutillas, Pedro R.
Publication type:
Article
The hVps34- SGK3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC1 and tumour growth.
Published in:
EMBO Journal, 2016, v. 35, n. 20, p. 2263, doi. 10.15252/embj.201670010
By:
- Bago, Ruzica;
- Sommer, Eeva;
- Castel, Pau;
- Crafter, Claire;
- Bailey, Fiona P;
- Shpiro, Natalia;
- Baselga, José;
- Cross, Darren;
- Eyers, Patrick A;
- Alessi, Dario R
Publication type:
Article
The hVps34- SGK3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC1 and tumour growth.
Published in:
EMBO Journal, 2016, v. 35, n. 17, p. 1902, doi. 10.15252/embj.201693929
By:
- Bago, Ruzica;
- Sommer, Eeva;
- Castel, Pau;
- Crafter, Claire;
- Bailey, Fiona P;
- Shpiro, Natalia;
- Baselga, José;
- Cross, Darren;
- Eyers, Patrick A;
- Alessi, Dario R
Publication type:
Article
Clinical and genetic evaluation of six children with diffuse capillary malformation and undergrowth.
Published in:
Pediatric Dermatology, 2020, v. 37, n. 5, p. 833, doi. 10.1111/pde.14252
By:
- Cubiró, Xavier;
- Rozas‐Muñoz, Eduardo;
- Castel, Pau;
- Roé Crespo, Esther;
- Garcia‐Melendo, Cristina;
- Puig, Lluis;
- Baselga, Eulalia
Publication type:
Article
Somatic PIK3CA mutations as a driver of sporadic venous malformations.
Published in:
Science Translational Medicine, 2016, v. 8, n. 332, p. 1, doi. 10.1126/scitranslmed.aaf1164
By:
- Castel, Pau;
- Carmona, F. Javier;
- Grego-Bessa, Joaquim;
- Berger, Michael F.;
- Viale, Agnès;
- Anderson, Kathryn V.;
- Bague, Silvia;
- Scaltriti, Maurizio;
- Antonescu, Cristina R.;
- Baselga, Eulàlia;
- Baselga, José
Publication type:
Article
PI3K inhibition results in enhanced estrogen receptor function and dependence in hormone receptor–positive breast cancer.
Published in:
Science Translational Medicine, 2015, v. 7, n. 283, p. 1, doi. 10.1126/scitranslmed.aaa4442
By:
- Bosch, Ana;
- Zhiqiang Li;
- Bergamaschi, Anna;
- Ellis, Haley;
- Toska, Eneda;
- Prat, Aleix;
- Tao, Jessica J.;
- Spratt, Daniel E.;
- Viola-Villegas, Nerissa T.;
- Castel, Pau;
- Minuesa, Gerard;
- Morse, Natasha;
- Rodón, Jordi;
- Ibrahim, Yasir;
- Cortes, Javier;
- Perez-Garcia, Jose;
- Galvan, Patricia;
- Grueso, Judit;
- Guzman, Marta;
- Katzenellenbogen, John A.
Publication type:
Article
Convergent loss of PTEN leads to clinical resistance to a PI(3)Kα inhibitor.
Published in:
Nature, 2015, v. 518, n. 7538, p. 240, doi. 10.1038/nature13948
By:
- Juric, Dejan;
- Castel, Pau;
- Griffith, Malachi;
- Griffith, Obi L.;
- Won, Helen H.;
- Ellis, Haley;
- Ebbesen, Saya H.;
- Ainscough, Benjamin J.;
- Ramu, Avinash;
- Iyer, Gopa;
- Shah, Ronak H.;
- Huynh, Tiffany;
- Mino-Kenudson, Mari;
- Sgroi, Dennis;
- Isakoff, Steven;
- Thabet, Ashraf;
- Elamine, Leila;
- Solit, David B.;
- Lowe, Scott W.;
- Quadt, Cornelia
Publication type:
Article

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