Works by Caruana, Ignazio

Results: 23

Inhibition of autophagy enhances the antitumor efficacy of T/CAR T cell against neuroblastoma.

Published in:

Journal of Experimental & Clinical Cancer Research (17569966), 2025, v. 44, n. 1, p. 1, doi. 10.1186/s13046-025-03453-0

By:

De Mitri, Francesca;
Giansanti, Manuela;
Melaiu, Ombretta;
Haas, Dorothee;
Ebert, Stefan;
Tumino, Nicola;
Vulpis, Elisabetta;
Gatto, Francesca;
Martuscelli, Beatrice;
Antonioli, Manuela;
Sangiuliano, Elisabetta;
Caruso, Simona;
Marco, Scarsella;
De Stefanis, Cristiano;
Marabitti, Veronica;
Campello, Silvia;
Fruci, Doriana;
Vacca, Paola;
Caruana, Ignazio;
Nazio, Francesca

Publication type:

Article

LSD1 inhibition improves efficacy of adoptive T cell therapy by enhancing CD8+ T cell responsiveness.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-51500-9

By:

Pallavicini, Isabella;
Frasconi, Teresa Maria;
Catozzi, Carlotta;
Ceccacci, Elena;
Tiberti, Silvia;
Haas, Dorothee;
Samson, Jule;
Heuser-Loy, Christoph;
Nava Lauson, Carina B.;
Mangione, Marta;
Preto, Elisa;
Bigogno, Alberto;
Sala, Eleonora;
Iannacone, Matteo;
Mercurio, Ciro;
Gattinoni, Luca;
Caruana, Ignazio;
Kuka, Mirela;
Nezi, Luigi;
Minucci, Saverio

Publication type:

Article

Manipulating the Metabolism to Improve the Efficacy of CAR T-Cell Immunotherapy.

Published in:

Cells (2073-4409), 2021, v. 10, n. 1, p. 14, doi. 10.3390/cells10010014

By:

Pellegrino, Marsha;
Del Bufalo, Francesca;
De Angelis, Biagio;
Quintarelli, Concetta;
Caruana, Ignazio;
de Billy, Emmanuel

Publication type:

Article

Exploiting autophagy balance in T and NK cells as a new strategy to implement adoptive cell therapies.

Published in:

Molecular Cancer, 2023, v. 22, n. 1, p. 1, doi. 10.1186/s12943-023-01893-w

By:

Giansanti, Manuela;
Theinert, Tobias;
Boeing, Sarah Katharina;
Haas, Dorothee;
Schlegel, Paul-Gerhardt;
Vacca, Paola;
Nazio, Francesca;
Caruana, Ignazio

Publication type:

Article

Should I stay or should I go? Spatio-temporal control of cellular anchorage by hematopoietic factors orchestrates tumor metastatic cascade.

Published in:

Molecular Cancer, 2023, v. 22, n. 1, p. 1, doi. 10.1186/s12943-023-01851-6

By:

Marabitti, Veronica;
Caruana, Ignazio;
Nazio, Francesca

Publication type:

Article

Choice of costimulatory domains and of cytokines determines CAR T-cell activity in neuroblastoma.

Published in:

OncoImmunology, 2018, v. 7, n. 6, p. 1, doi. 10.1080/2162402X.2018.1433518

By:

Quintarelli, Concetta;
Orlando, Domenico;
Boffa, Iolanda;
Guercio, Marika;
Polito, Vinicia Assunta;
Petretto, Andrea;
Lavarello, Chiara;
Sinibaldi, Matilde;
Weber, Gerrit;
Del Bufalo, Francesca;
Giorda, Ezio;
Scarsella, Marco;
Petrini, Stefania;
Pagliara, Daria;
Locatelli, Franco;
De Angelis, Biagio;
Caruana, Ignazio

Publication type:

Article

Bevacizumab-mediated tumor vasculature remodelling improves tumor infiltration and antitumor efficacy of GD2-CAR T cells in a human neuroblastoma preclinical model.

Published in:

OncoImmunology, 2018, v. 7, n. 1, p. N.PAG, doi. 10.1080/2162402X.2017.1378843

By:

Bocca, Paola;
Carlo, Emma Di;
Caruana, Ignazio;
Emionite, Laura;
Cilli, Michele;
De Angelis, Biagio;
Quintarelli, Concetta;
Pezzolo, Annalisa;
Raffaghello, Lizzia;
Morandi, Fabio;
Locatelli, Franco;
Pistoia, Vito;
Prigione, Ignazia

Publication type:

Article

TFG binds LC3C to regulate ULK1 localization and autophagosome formation.

Published in:

EMBO Journal, 2021, v. 40, n. 10, p. 1, doi. 10.15252/embj.2019103563

By:

Carinci, Marianna;
Testa, Beatrice;
Bordi, Matteo;
Milletti, Giacomo;
Bonora, Massimo;
Antonucci, Laura;
Ferraina, Caterina;
Carro, Marta;
Kumar, Mukesh;
Ceglie, Donatella;
Eck, Franziska;
Nardacci, Roberta;
Guerroué, Francois;
Petrini, Stefania;
Soriano, Maria E;
Caruana, Ignazio;
Doria, Valentina;
Manifava, Maria;
Peron, Camille;
Lambrughi, Matteo

Publication type:

Article

Wilms' Tumor Primary Cells Display Potent Immunoregulatory Properties on NK Cells and Macrophages.

Published in:

Cancers, 2021, v. 13, n. 2, p. 224, doi. 10.3390/cancers13020224

By:

Fiore, Piera Filomena;
Vacca, Paola;
Tumino, Nicola;
Besi, Francesca;
Pelosi, Andrea;
Munari, Enrico;
Marconi, Marcella;
Caruana, Ignazio;
Pistoia, Vito;
Moretta, Lorenzo;
Azzarone, Bruno

Publication type:

Article

CD94-driven in vitro expansion of highly functional adaptive NKG2C+ NKG2A- CD57+ NK cells from CMV+ healthy donors.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1481745

By:

Giordano, Chiara;
Carlomagno, Simona;
Falco, Michela;
Cantoni, Claudia;
Vitale, Massimo;
Caruana, Ignazio;
Dirks, Johannes;
Serio, Alberto;
Muccio, Letizia;
Bartalucci, Giulia;
Bo, Alessandra;
Locatelli, Franco;
Bottino, Cristina;
Sivori, Simona;
Della Chiesa, Mariella

Publication type:

Article

Transition to a mesenchymal state in neuroblastoma may be characterized by a high expression of GD2 and by the acquisition of immune escape from NK cells.

Published in:

Frontiers in Immunology, 2024, p. 1, doi. 10.3389/fimmu.2024.1382931

By:

Di Matteo, Sabina;
Bilotta, Maria Teresa;
Pelosi, Andrea;
Haas, Dorothee;
Theinert, Tobias;
Weber, Gerrit;
Schlegel, Paul-Gerhardt;
Berg, Matthias;
Moretta, Lorenzo;
Maggi, Enrico;
Azzarone, Bruno;
Vacca, Paola;
Tumino, Nicola;
Caruana, Ignazio

Publication type:

Article

Polymorphonuclear myeloid-derived suppressor cells impair the anti-tumor efficacy of GD2.CAR T-cells in patients with neuroblastoma.

Published in:

Journal of Hematology & Oncology, 2021, v. 14, n. 1, p. 1, doi. 10.1186/s13045-021-01193-0

By:

Tumino, Nicola;
Weber, Gerrit;
Besi, Francesca;
Del Bufalo, Francesca;
Bertaina, Valentina;
Paci, Paola;
Quatrini, Linda;
Antonucci, Laura;
Sinibaldi, Matilde;
Quintarelli, Concetta;
Maggi, Enrico;
De Angelis, Biagio;
Locatelli, Franco;
Moretta, Lorenzo;
Vacca, Paola;
Caruana, Ignazio

Publication type:

Article

Targeting cancer stem cells in medulloblastoma by inhibiting AMBRA1 dual function in autophagy and STAT3 signalling.

Published in:

Acta Neuropathologica, 2021, v. 142, n. 3, p. 537, doi. 10.1007/s00401-021-02347-7

By:

Nazio, Francesca;
Po, Agnese;
Abballe, Luana;
Ballabio, Claudio;
Diomedi Camassei, Francesca;
Bordi, Matteo;
Camera, Antonio;
Caruso, Simona;
Caruana, Ignazio;
Pezzullo, Marco;
Ferraina, Caterina;
Milletti, Giacomo;
Gianesello, Matteo;
Reddel, Sofia;
De Luca, Carmen Dolores;
Ceglie, Donatella;
Marinelli, Sara;
Campello, Silvia;
Papaleo, Elena;
Miele, Evelina

Publication type:

Article

Identification of New Soluble Factors Correlated With the Development of Graft Failure After Haploidentical Hematopoietic Stem Cell Transplantation.

Published in:

Frontiers in Immunology, 2021, v. 11, p. N.PAG, doi. 10.3389/fimmu.2020.613644

By:

Weber, Gerrit;
Strocchio, Luisa;
Del Bufalo, Francesca;
Algeri, Mattia;
Pagliara, Daria;
Arnone, Claudia Manuela;
De Angelis, Biagio;
Quintarelli, Concetta;
Locatelli, Franco;
Merli, Pietro;
Caruana, Ignazio

Publication type:

Article

CAR-T-Derived Extracellular Vesicles: A Promising Development of CAR-T Anti-Tumor Therapy.

Published in:

Cancers, 2023, v. 15, n. 4, p. 1052, doi. 10.3390/cancers15041052

By:

Pagotto, Sara;
Simeone, Pasquale;
Brocco, Davide;
Catitti, Giulia;
De Bellis, Domenico;
Vespa, Simone;
Di Pietro, Natalia;
Marinelli, Lisa;
Di Stefano, Antonio;
Veschi, Serena;
De Lellis, Laura;
Verginelli, Fabio;
Kaitsas, Francesco;
Iezzi, Manuela;
Pandolfi, Assunta;
Visone, Rosa;
Tinari, Nicola;
Caruana, Ignazio;
Di Ianni, Mauro;
Cama, Alessandro

Publication type:

Article

Pediatric Tumors-Mediated Inhibitory Effect on NK Cells: The Case of Neuroblastoma and Wilms' Tumors.

Published in:

Cancers, 2021, v. 13, n. 10, p. 2374, doi. 10.3390/cancers13102374

By:

Pelosi, Andrea;
Fiore, Piera Filomena;
Di Matteo, Sabina;
Veneziani, Irene;
Caruana, Ignazio;
Ebert, Stefan;
Munari, Enrico;
Moretta, Lorenzo;
Maggi, Enrico;
Azzarone, Bruno;
Kluger, Harriet

Publication type:

Article

Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes.

Published in:

Nature Medicine, 2015, v. 21, n. 5, p. 524, doi. 10.1038/nm.3833

By:

Caruana, Ignazio;
Savoldo, Barbara;
Hoyos, Valentina;
Weber, Gerrit;
Liu, Hao;
Kim, Eugene S;
Ittmann, Michael M;
Marchetti, Dario;
Dotti, Gianpietro

Publication type:

Article

Preservation of antigen-specific Functions of αβ T cells and B cells removed from hematopoietic stem cell Transplants suggests Their Use as an alternative cell source for advanced Manipulation and adoptive immunotherapy.

Published in:

Frontiers in Immunology, 2017, v. 8, p. 1, doi. 10.3389/fimmu.2017.00332

By:

Li Pira, Giuseppina;
Di Cecca, Stefano;
Biagini, Simone;
Girolami, Elia;
Cicchetti, Elisabetta;
Bertaina, Valentina;
Quintarelli, Concetta;
Caruana, Ignazio;
Lucarelli, Barbarella;
Merli, Pietro;
Pagliara, Daria;
Brescia, Letizia Pomponia;
Bertaina, Alice;
Montanari, Mauro;
Locatelli, Franco

Publication type:

Article

Interaction between SNAI2 and MYOD enhances oncogenesis and suppresses differentiation in Fusion Negative Rhabdomyosarcoma.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-020-20386-8

By:

Pomella, Silvia;
Sreenivas, Prethish;
Gryder, Berkley E.;
Wang, Long;
Milewski, David;
Cassandri, Matteo;
Baxi, Kunal;
Hensch, Nicole R.;
Carcarino, Elena;
Song, Young;
Chou, Hsien-Chao;
Yohe, Marielle E.;
Stanton, Benjamin Z.;
Amadio, Bruno;
Caruana, Ignazio;
De Stefanis, Cristiano;
De Vito, Rita;
Locatelli, Franco;
Chen, Yidong;
Chen, Eleanor Y.

Publication type:

Article

Cytotoxic effects and tolerability of gemcitabine and axitinib in a xenograft model for c-myc amplified medulloblastoma.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-93586-x

By:

Schwinn, Stefanie;
Mokhtari, Zeinab;
Thusek, Sina;
Schneider, Theresa;
Sirén, Anna-Leena;
Tiemeyer, Nicola;
Caruana, Ignazio;
Miele, Evelina;
Schlegel, Paul G.;
Beilhack, Andreas;
Wölfl, Matthias

Publication type:

Article

TMOD-14. INNOVATIVE 3D MODEL FOR THE ESTABLISHMENT OF PRIMARY PAEDIATRIC LOW-GRADE GLIOMA (LGG) CULTURES: NEW PLATFORM FOR ADVANCED PRECLINICAL STUDIES OF INNOVATIVE AND IMMUNOTHERAPEUTIC APPROACHES.

Published in:

Neuro-Oncology, 2019, v. 21, p. ii123, doi. 10.1093/neuonc/noz036.251

By:

Belardinilli, Tamascia;
Arnone, Claudia Manuela;
Mastronuzzi, Angela;
Ceglie, Giulia;
Cacchione, Antonella;
Carai, Andrea;
Miele, Evelina;
Camassei, Francesca Diomedi;
Polito, Vinicia Assunta;
Stefanis, Cristiano De;
Quintarelli, Concetta;
Angelis, Biagio De;
Locatelli, Franco;
Caruana, Ignazio;
Bufalo, Francesca Del

Publication type:

Article

IMMU-12. NOVEL APPROACH FOR THE TREATMENT OF PEDIATRIC HIGH-GRADE GLIOMAS WITH THE COMBINATION OF ONCOLYTIC ADENOVIRUSES AND GENE THERAPY ENCODING A BiTE DIRECTED TO THE EphA2 TUMOR ANTIGEN.

Published in:

Neuro-Oncology, 2019, v. 21, p. ii95, doi. 10.1093/neuonc/noz036.133

By:

Arnone, Claudia Manuela;
Belardinilli, Tamascia;
Mastronuzzi, Angela;
Polito, Vinicia;
Cacchione, Antonella;
Carai, Andrea;
Camassei, Francesca Diomedi;
Scarsella, Marco;
Quintarelli, Concetta;
Angelis, Biagio De;
Locatelli, Franco;
Caruana, Ignazio;
Bufalo, Francesca Del

Publication type:

Article

Reversible induction of mitophagy by an optogenetic bimodular system.

Published in:

Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-09487-1

By:

D'Acunzo, Pasquale;
Strappazzon, Flavie;
Caruana, Ignazio;
Meneghetti, Giacomo;
Di Rita, Anthea;
Simula, Luca;
Weber, Gerrit;
Del Bufalo, Francesca;
Dalla Valle, Luisa;
Campello, Silvia;
Locatelli, Franco;
Cecconi, Francesco

Publication type:

Article

Works by Caruana, Ignazio

Inhibition of autophagy enhances the antitumor efficacy of T/CAR T cell against neuroblastoma.

LSD1 inhibition improves efficacy of adoptive T cell therapy by enhancing CD8<sup>+</sup> T cell responsiveness.

Manipulating the Metabolism to Improve the Efficacy of CAR T-Cell Immunotherapy.

Exploiting autophagy balance in T and NK cells as a new strategy to implement adoptive cell therapies.

Should I stay or should I go? Spatio-temporal control of cellular anchorage by hematopoietic factors orchestrates tumor metastatic cascade.

Choice of costimulatory domains and of cytokines determines CAR T-cell activity in neuroblastoma.

Bevacizumab-mediated tumor vasculature remodelling improves tumor infiltration and antitumor efficacy of GD2-CAR T cells in a human neuroblastoma preclinical model.

TFG binds LC3C to regulate ULK1 localization and autophagosome formation.

Wilms' Tumor Primary Cells Display Potent Immunoregulatory Properties on NK Cells and Macrophages.

CD94-driven in vitro expansion of highly functional adaptive NKG2C<sup>+</sup> NKG2A<sup>-</sup> CD57<sup>+</sup> NK cells from CMV<sup>+</sup> healthy donors.

Transition to a mesenchymal state in neuroblastoma may be characterized by a high expression of GD2 and by the acquisition of immune escape from NK cells.

Polymorphonuclear myeloid-derived suppressor cells impair the anti-tumor efficacy of GD2.CAR T-cells in patients with neuroblastoma.

Targeting cancer stem cells in medulloblastoma by inhibiting AMBRA1 dual function in autophagy and STAT3 signalling.

Identification of New Soluble Factors Correlated With the Development of Graft Failure After Haploidentical Hematopoietic Stem Cell Transplantation.

CAR-T-Derived Extracellular Vesicles: A Promising Development of CAR-T Anti-Tumor Therapy.

Pediatric Tumors-Mediated Inhibitory Effect on NK Cells: The Case of Neuroblastoma and Wilms' Tumors.

Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes.

Preservation of antigen-specific Functions of αβ T cells and B cells removed from hematopoietic stem cell Transplants suggests Their Use as an alternative cell source for advanced Manipulation and adoptive immunotherapy.

Interaction between SNAI2 and MYOD enhances oncogenesis and suppresses differentiation in Fusion Negative Rhabdomyosarcoma.

Cytotoxic effects and tolerability of gemcitabine and axitinib in a xenograft model for c-myc amplified medulloblastoma.

TMOD-14. INNOVATIVE 3D MODEL FOR THE ESTABLISHMENT OF PRIMARY PAEDIATRIC LOW-GRADE GLIOMA (LGG) CULTURES: NEW PLATFORM FOR ADVANCED PRECLINICAL STUDIES OF INNOVATIVE AND IMMUNOTHERAPEUTIC APPROACHES.

IMMU-12. NOVEL APPROACH FOR THE TREATMENT OF PEDIATRIC HIGH-GRADE GLIOMAS WITH THE COMBINATION OF ONCOLYTIC ADENOVIRUSES AND GENE THERAPY ENCODING A BiTE DIRECTED TO THE EphA2 TUMOR ANTIGEN.

Reversible induction of mitophagy by an optogenetic bimodular system.