OpenURL Connection Search

Select item for more details and to access through your institution.

Laquinimod rescues striatal, cortical and white matter pathology and results in modest behavioural improvements in the YAC128 model of Huntington disease.
Published in:
Scientific Reports, 2016, p. 31652, doi. 10.1038/srep31652
By:
- Garcia-Miralles, Marta;
- Hong, Xin;
- Tan, Liang Juin;
- Caron, Nicholas S.;
- Huang, Yihui;
- To, Xuan Vinh;
- Lin, Rachel Yanping;
- Franciosi, Sonia;
- Papapetropoulos, Spyros;
- Hayardeny, Liat;
- Hayden, Michael R.;
- Chuang, Kai-Hsiang;
- Pouladi, Mahmoud A.
Publication type:
Article
Elevated plasma and CSF neurofilament light chain concentrations are stabilized in response to mutant huntingtin lowering in the brains of Huntington's disease mice.
Published in:
Translational Neurodegeneration, 2024, v. 13, n. 1, p. 1, doi. 10.1186/s40035-024-00443-8
By:
- Caron, Nicholas S.;
- Byrne, Lauren M.;
- Lemarié, Fanny L.;
- Bone, Jeffrey N.;
- Aly, Amirah E.-E.;
- Ko, Seunghyun;
- Anderson, Christine;
- Casal, Lorenzo L.;
- Hill, Austin M.;
- Hawellek, David J.;
- McColgan, Peter;
- Wild, Edward J.;
- Leavitt, Blair R.;
- Hayden, Michael R.
Publication type:
Article
Using FLIM-FRET to Measure Conformational Changes of Transglutaminase Type 2 in Live Cells.
Published in:
PLoS ONE, 2012, v. 7, n. 8, p. 1, doi. 10.1371/journal.pone.0044159
By:
- Caron, Nicholas S.;
- Munsie, Lise N.;
- Keillor, Jeffrey W.;
- Truant, Ray;
- Strack, Stefan
Publication type:
Article
Preventing mutant huntingtin proteolysis and intermittent fasting promote autophagy in models of Huntington disease.
Published in:
Acta Neuropathologica Communications, 2018, v. 6, n. 1, p. 1, doi. 10.1186/s40478-018-0518-0
By:
- Ehrnhoefer, Dagmar E.;
- Martin, Dale D. O.;
- Schmidt, Mandi E.;
- Qiu, Xiaofan;
- Ladha, Safia;
- Caron, Nicholas S.;
- Skotte, Niels H.;
- Nguyen, Yen T. N.;
- Vaid, Kuljeet;
- Southwell, Amber L.;
- Engemann, Sabine;
- Franciosi, Sonia;
- Hayden, Michael R.
Publication type:
Article
Huntingtin suppression restores cognitive function in a mouse model of Huntington disease.
Published in:
Science Translational Medicine, 2018, v. 10, n. 461, p. 1, doi. 10.1126/scitranslmed.aar3959
By:
- Southwell, Amber L.;
- Kordasiewicz, Holly B.;
- Langbehn, Douglas;
- Skotte, Niels H.;
- Parsons, Matthew P.;
- Villanueva, Erika B.;
- Caron, Nicholas S.;
- Østergaard, Michael E.;
- Anderson, Lisa M.;
- Xie, Yuanyun;
- Cengio, Louisa Dal;
- Findlay-Black, Hailey;
- Doty, Crystal N.;
- Fitsimmons, Bethany;
- Swayze, Eric E.;
- Seth, Punit P.;
- Raymond, Lynn A.;
- Frank Bennett, C.;
- Hayden, Michael R.
Publication type:
Article
Cerebrospinal fluid biomarkers for assessing Huntington disease onset and severity.
Published in:
Brain Communications, 2022, v. 4, n. 6, p. 1, doi. 10.1093/braincomms/fcac309
By:
- Caron, Nicholas S.;
- Haqqani, Arsalan S.;
- Sandhu, Akshdeep;
- Aly, Amirah E.;
- Black, Hailey Findlay;
- Bone, Jeffrey N.;
- McBride, Jodi L.;
- Abulrob, Abedelnasser;
- Stanimirovic, Danica;
- Leavitt, Blair R.;
- Hayden, Michael R.
Publication type:
Article
Constitutive ablation of caspase-6 reduces the inflammatory response and behavioural changes caused by peripheral pro-inflammatory stimuli.
Published in:
Cell Death Discovery, 2018, v. 4, n. 1, p. N.PAG, doi. 10.1038/s41420-018-0043-8
By:
- Ladha, Safia;
- Qiu, Xiaofan;
- Casal, Lorenzo;
- Caron, Nicholas S.;
- Ehrnhoefer, Dagmar E.;
- Hayden, Michael R.
Publication type:
Article
Functional characterization of variants of unknown significance in a spinocerebellar ataxia patient using an unsupervised machine learning pipeline.
Published in:
Human Genome Variation, 2022, v. 9, n. 1, p. 1, doi. 10.1038/s41439-022-00188-8
By:
- Nath, Siddharth;
- Caron, Nicholas S.;
- May, Linda;
- Gluscencova, Oxana B.;
- Kolesar, Jill;
- Brady, Lauren;
- Kaufman, Brett A.;
- Boulianne, Gabrielle L.;
- Rodriguez, Amadeo R.;
- Tarnopolsky, Mark A.;
- Truant, Ray
Publication type:
Article
Gene expression profiles complement the analysis of genomic modifiers of the clinical onset of Huntington disease.
Published in:
Human Molecular Genetics, 2020, v. 29, n. 16, p. 2788, doi. 10.1093/hmg/ddaa184
By:
- Wright, Galen E. B.;
- Caron, Nicholas S.;
- Ng, Bernard;
- Casal, Lorenzo;
- Casazza, William;
- Xiaohong Xu;
- Ooi, Jolene;
- Pouladi, Mahmoud A.;
- Mostafavi, Sara;
- Ross, Colin J. D.;
- Hayden, Michael R.
Publication type:
Article
Live cell imaging and biophotonic methods reveal two types of mutant huntingtin inclusions.
Published in:
Human Molecular Genetics, 2014, v. 23, n. 9, p. 2324, doi. 10.1093/hmg/ddt625
By:
- Caron, Nicholas S.;
- Hung, Claudia L.;
- Atwal, Randy S.;
- Truant, Ray
Publication type:
Article
The Interaction of Aging and Cellular Stress Contributes to Pathogenesis in Mouse and Human Huntington Disease Neurons.
Published in:
Frontiers in Aging Neuroscience, 2020, v. 12, p. N.PAG, doi. 10.3389/fnagi.2020.524369
By:
- Machiela, Emily;
- Jeloka, Ritika;
- Caron, Nicholas S.;
- Mehta, Shagun;
- Schmidt, Mandi E.;
- Baddeley, Helen J. E.;
- Tom, Colton M.;
- Polturi, Nalini;
- Xie, Yuanyun;
- Mattis, Virginia B.;
- Hayden, Michael R.;
- Southwell, Amber L.
Publication type:
Article
Ultrasensitive measurement of huntingtin protein in cerebrospinal fluid demonstrates increase with Huntington disease stage and decrease following brain huntingtin suppression.
Published in:
Scientific Reports, 2015, p. 12166, doi. 10.1038/srep12166
By:
- Southwell, Amber L.;
- Caron, Nicholas S.;
- Villanueva, Erika B.;
- Xie, Yuanyun;
- Collins, Jennifer A.;
- Li Ye, Min;
- Sturrock, Aaron;
- Leavitt, Blair R.;
- Hayden, Michael R.;
- Smith, Stephen E.P.;
- Davis, Tessa R.;
- Schrum, Adam G.
Publication type:
Article
Potent and sustained huntingtin lowering via AAV5 encoding miRNA preserves striatal volume and cognitive function in a humanized mouse model of Huntington disease.
Published in:
Nucleic Acids Research, 2020, v. 48, n. 1, p. 36, doi. 10.1093/nar/gkz976
By:
- Caron, Nicholas S;
- Southwell, Amber L;
- Brouwers, Cynthia C;
- Cengio, Louisa Dal;
- Xie, Yuanyun;
- Black, Hailey Findlay;
- Anderson, Lisa M;
- Ko, Seunghyun;
- Zhu, Xiang;
- van Deventer, Sander J;
- Evers, Melvin M;
- Konstantinova, Pavlina;
- Hayden, Michael R
Publication type:
Article
DAPK1 Promotes Extrasynaptic GluN2B Phosphorylation and Striatal Spine Instability in the YAC128 Mouse Model of Huntington Disease.
Published in:
Frontiers in Cellular Neuroscience, 2020, v. 14, p. N.PAG, doi. 10.3389/fncel.2020.590569
By:
- Schmidt, Mandi E.;
- Caron, Nicholas S.;
- Aly, Amirah E.;
- Lemarié, Fanny L.;
- Dal Cengio, Louisa;
- Ko, Yun;
- Lazic, Nikola;
- Anderson, Lisa;
- Nguyen, Betty;
- Raymond, Lynn A.;
- Hayden, Michael R.
Publication type:
Article
Mutant Huntingtin Is Cleared from the Brain via Active Mechanisms in Huntington Disease.
Published in:
Journal of Neuroscience, 2021, v. 41, n. 4, p. 780, doi. 10.1523/JNEUROSCI.1865-20.2020
By:
- Caron, Nicholas S.;
- Banos, Raul;
- Yanick, Christopher;
- Aly, Amirah E.;
- Byrne, Lauren M.;
- Smith, Ethan D.;
- Yuanyun Xie;
- Smith, Stephen E. P.;
- Potluri, Nalini;
- Black, Hailey Findlay;
- Casal, Lorenzo;
- Seunghyun Ko;
- Daphne Cheung;
- Hyeongju Kim;
- Ihn Sik Seong;
- Wild, Edward J.;
- Ji-Joon Song;
- Hayden, Michael R.;
- Southwell, Amber L.
Publication type:
Article

Found: 15