Works by Caplen, Natasha

Results: 30

In situ generation of pseudotyped retroviral progeny by adenovirus-mediated transduction of tumor cells enhances the killing effect of HSV-tk suicide gene therapy in vitro and in vivo.

Published in:

Journal of Gene Medicine, 2004, v. 6, n. 3, p. 288, doi. 10.1002/jgm.490

By:

Takashi Okada;
Natasha J. Caplen;
W. Jay Ramsey;
Masafumi Onodera;
Kuniko Shimazaki;
Tatsuya Nomoto;
Rahim Ajalli;
Oliver Wildner;
John Morris;
Akihiro Kume;
Hirofumi Hamada;
R. Michael Blaese;
Keiya Ozawa

Publication type:

Article

RNAi quashes polyQ.

Published in:

Nature Medicine, 2004, v. 10, n. 8, p. 775, doi. 10.1038/nm0804-775

By:

Caplen, Natasha J.

Publication type:

Article

DNAJC9 prevents CENP-A mislocalization and chromosomal instability by maintaining the fidelity of histone supply chains.

Published in:

EMBO Journal, 2024, v. 43, n. 11, p. 2166, doi. 10.1038/s44318-024-00093-6

By:

Balachandra, Vinutha;
Shrestha, Roshan L;
Hammond, Colin M;
Lin, Shinjen;
Hendriks, Ivo A;
Sethi, Subhash Chandra;
Chen, Lu;
Sevilla, Samantha;
Caplen, Natasha J;
Chari, Raj;
Karpova, Tatiana S;
McKinnon, Katherine;
Todd, Matthew AM;
Koparde, Vishal;
Cheng, Ken Chih-Chien;
Nielsen, Michael L;
Groth, Anja;
Basrai, Munira A

Publication type:

Article

RNAi Screen Reveals Candidate miRNAs Associated with the NF‐κB Pathway.

Published in:

FASEB Journal, 2013, v. 27, p. 780.1, doi. 10.1096/fasebj.27.1_supplement.780.1

By:

Redan, Benjamin W.;
Motobar, Omid;
Tuzmen, Pinar;
Guha, Rajarshi;
Caplen, Natasha;
Martin, Scott E.

Publication type:

Article

Allele-specific silencing of the dominant disease allele in sialuria by RNA interference.

Published in:

FASEB Journal, 2008, v. 22, n. 11, p. 3846, doi. 10.1096/fj.08-110890

By:

Klootwijk, Riko D.;
Savelkoul, Paul J. M.;
Ciccone, Carla;
Manoli, Irini;
Caplen, Natasha J.;
Krasnewich, Donna M.;
Gahl, William A.;
Huizing, Marjan

Publication type:

Article

Identification of therapeutic targets applicable to clinical strategies in ovarian cancer.

Published in:

2016

By:

Kim, Marianne K.;
Caplen, Natasha;
Chakka, Sirisha;
Hernandez, Lidia;
House, Carrie;
Pongas, Georgios;
Jordan, Elizabeth;
Annunziata, Christina M.

Publication type:

journal article

Comprehensive profiling of mRNA splicing indicates that GC content signals altered cassette exon inclusion in Ewing sarcoma.

Published in:

NAR Cancer, 2022, v. 4, n. 1, p. 1, doi. 10.1093/narcan/zcab052

By:

Graham, Garrett T.;
Selvanathan, Saravana P.;
Zöllner, Stefan K.;
Stahl, Emily;
Shlien, Adam;
Caplen, Natasha J.;
Üren, Aykut;
Toretsky, Jeffrey A.

Publication type:

Article

The HNRNPF/H RNA binding proteins and disease.

Published in:

Wiley Interdisciplinary Reviews: RNA, 2023, v. 14, n. 5, p. 1, doi. 10.1002/wrna.1788

By:

Brownmiller, Tayvia;
Caplen, Natasha J.

Publication type:

Article

Fusion transcripts: Unexploited vulnerabilities in cancer?

Published in:

Wiley Interdisciplinary Reviews: RNA, 2020, v. 11, n. 1, p. N.PAG, doi. 10.1002/wrna.1562

By:

Neckles, Carla;
Sundara Rajan, Soumya;
Caplen, Natasha J.

Publication type:

Article

A genomic strategy for the functional validation of colorectal cancer genes identifies potential therapeutic targets.

Published in:

International Journal of Cancer, 2011, v. 128, n. 5, p. 1069, doi. 10.1002/ijc.25453

By:

Grade, Marian;
Hummon, Amanda B.;
Camps, Jordi;
Emons, Georg;
Spitzner, Melanie;
Gaedcke, Jochen;
Hoermann, Patrick;
Ebner, Reinhard;
Becker, Heinz;
Difilippantonio, Michael J.;
Ghadimi, B. Michael;
Beissbarth, Tim;
Caplen, Natasha J.;
Ried, Thomas

Publication type:

Article

Mismatched siRNAs downregulate mRNAs as a function of target site location

Published in:

FEBS Letters, 2006, v. 580, n. 15, p. 3694, doi. 10.1016/j.febslet.2006.05.056

By:

Martin, Scott E.;
Caplen, Natasha J.

Publication type:

Article

Inefficient cationic lipid-mediated siRNA and antisense oligonucleotide transfer to airway epithelial cells in vivo.

Published in:

Respiratory Research, 2006, v. 7, p. 26, doi. 10.1186/1465-9921-7-26

By:

Griesenbach, Uta;
Kitson, Chris;
Garcia, Sara Escudero;
Farley, Raymond;
Singh, Charanjit;
Somerton, Luci;
Painter, Hazel;
Smith, Rbecca L.;
Gill, Deborah R.;
Hyde, Stephen C.;
Yu-Hua Chow;
Hu, Jim;
Gray, Mike;
Edbrooke, Mark;
Ogilvie, Varrie;
MacGregor, Gordon;
Scheule, Ronald K;
Cheng, Seng H.;
Caplen, Natasha J.;
Alton, Eric W. F. W.

Publication type:

Article

Identification and validation of genes with expression patterns inverse to multiple metastasis suppressor genes in breast cancer cell lines.

Published in:

Clinical & Experimental Metastasis, 2014, v. 31, n. 7, p. 771, doi. 10.1007/s10585-014-9667-0

By:

Marino, Natascia;
Collins, Joshua;
Shen, Changyu;
Caplen, Natasha;
Merchant, Anand;
Gökmen-Polar, Yesim;
Goswami, Chirayu;
Hoshino, Takashi;
Qian, Yongzhen;
Sledge, George;
Steeg, Patricia

Publication type:

Article

Inhibition of Viral Gene Expression and Replication in Mosquito Cells by dsRNA-Triggered RNA Interference

Published in:

Molecular Therapy, 2002, v. 6, n. 2, p. 243, doi. 10.1006/mthe.2002.0652

By:

Caplen, Natasha J.;
Zheng, Zhili;
Falgout, Barry;
Morgan, Richard A.

Publication type:

Article

Identification of the receptor tyrosine kinase AXL in breast cancer as a target for the human miR- 34a microRNA.

Published in:

2011

By:

Mackiewicz, Mark;
Huppi, Konrad;
Pitt, Jason;
Dorsey, Tiffany;
Ambs, Stefan;
Caplen, Natasha

Publication type:

Report

Identification of WEE1 as a potential molecular target in cancer cells by RNAi screening of the human tyrosine kinome.

Published in:

Breast Cancer Research & Treatment, 2010, v. 122, n. 2, p. 347, doi. 10.1007/s10549-009-0571-2

By:

Murrow, Lyndsay;
Garimella, Sireesha;
Jones, Tamara;
Caplen, Natasha;
Lipkowitz, Stanley

Publication type:

Article

HNRNPH1 destabilizes the G-quadruplex structures formed by G-rich RNA sequences that regulate the alternative splicing of an oncogenic fusion transcript.

Published in:

Nucleic Acids Research, 2022, v. 50, n. 11, p. 6474, doi. 10.1093/nar/gkac409

By:

Vo, Tam;
Brownmiller, Tayvia;
Hall, Katherine;
Jones, Tamara L;
Choudhari, Sulbha;
Grammatikakis, Ioannis;
Ludwig, Katelyn R;
Caplen, Natasha J

Publication type:

Article

Identification of novel molecular regulators of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)-induced apoptosis in breast cancer cells by RNAi screening.

Published in:

Breast Cancer Research, 2014, v. 16, n. 2, p. 1, doi. 10.1186/bcr3645

By:

Garimella, Sireesha V.;
Gehlhaus, Kristie;
Dine, Jennifer L.;
Pitt, Jason J.;
Grandin, Magdalena;
Chakka, Sirisha;
Nau, Marion M.;
Caplen, Natasha J.;
Lipkowitz, Stanley

Publication type:

Article

Cross-species genomic and functional analyses identify a combination therapy using a CHK1 inhibitor and a ribonucleotide reductase inhibitor to treat triple-negative breast cancer.

Published in:

2012

By:

Bennett, Christina N;
Tomlinson, Christine C;
Michalowski, Aleksandra M;
Chu, Isabel M;
Luger, Dror;
Mittereder, Lara R;
Aprelikova, Olga;
Shou, James;
Piwinica-Worms, Helen;
Caplen, Natasha J;
Hollingshead, Melinda G;
Green, Jeffrey E

Publication type:

journal article

Pvt1-encoded microRNAs in oncogenesis.

Published in:

Retrovirology, 2008, v. 5, p. 1, doi. 10.1186/1742-4690-5-4

By:

Beck-Engeser, Gabriele B.;
Lum, Amy M.;
Huppi, Konrad;
Caplen, Natasha J.;
Wang, Bruce B.;
Wabl, Matthias

Publication type:

Article

Systems-wide RNAi analysis of CASP8AP2/FLASH shows transcriptional deregulation of the replication-dependent histone genes and extensive effects on the transcriptome of colorectal cancer cells.

Published in:

Molecular Cancer, 2012, v. 11, n. 1, p. 1, doi. 10.1186/1476-4598-11-1

By:

Hummon, Amanda B.;
Pitt, Jason J.;
Camps, Jordi;
Emons, Georg;
Skube, Susan B.;
Huppi, Konrad;
Jones, Tamara L.;
Beissbarth, Tim;
Kramer, Frank;
Grade, Marian;
Difilippantonio, Michael J.;
Ried, Thomas;
Caplen, Natasha J.

Publication type:

Article

SpliceCenter: A suite of web-based bioinformatic applications for evaluating the impact of alternative splicing on RT-PCR, RNAi, microarray, and peptide-based studies.

Published in:

BMC Bioinformatics, 2008, v. 9, p. 1, doi. 10.1186/1471-2105-9-313

By:

Ryan, Michael C.;
Zeeberg, Barry R.;
Caplen, Natasha J.;
Cleland, James A.;
Kahn, Ari B.;
Liu, Hongfang;
Weinstein, John N.

Publication type:

Article

Short Interfering RNA (siRNA)-Mediated RNA Interference (RNAi) in Human Cells.

Published in:

Annals of the New York Academy of Sciences, 2003, v. 1002, n. 1, p. 56, doi. 10.1196/annals.1281.007

By:

CAPLEN, NATASHA J.;
MOUSSES, SPYRO

Publication type:

Article

Cancer biology functional genomics: From small RNAs to big dreams.

Published in:

Molecular Carcinogenesis, 2020, v. 59, n. 12, p. 1343, doi. 10.1002/mc.23260

By:

Sundara Rajan, Soumya;
Ludwig, Katelyn R.;
Hall, Katherine L.;
Jones, Tamara L.;
Caplen, Natasha J.

Publication type:

Article

EWS‐FLI1 reprograms the metabolism of Ewing sarcoma cells via positive regulation of glutamine import and serine‐glycine biosynthesis.

Published in:

Molecular Carcinogenesis, 2018, v. 57, n. 10, p. 1342, doi. 10.1002/mc.22849

By:

Sen, Nirmalya;
Cross, Allison M.;
Lorenzi, Philip L.;
Khan, Javed;
Gryder, Berkley E.;
Kim, Suntae;
Caplen, Natasha J.

Publication type:

Article

Localization and up-regulation of Mucin ( MUC2) gene expression in human nasal biopsies of patients with cystic fibrosis.

Published in:

Journal of Pathology, 1997, v. 181, n. 3, p. 305, doi. 10.1002/(SICI)1096-9896(199703)181:3<305::AID-PATH774>3.0.CO;2-D

By:

Li, Dechun;
Wang, Danming;
Majumdar, Swati;
Jany, Berthold;
Durham, Stephen R.;
Cottrell, Janet;
Caplen, Natasha;
Geddes, Duncan M.;
Alton, Eric W. F. W.;
Jeffrey, Peter K.

Publication type:

Article

Genomic instability and mouse microRNAs.

Published in:

Toxicology Mechanisms & Methods, 2011, v. 21, n. 4, p. 325, doi. 10.3109/15376516.2011.562759

By:

Huppi, Konrad;
Pitt, Jason;
Wahlberg, Brady;
Caplen, Natasha J.

Publication type:

Article

Multiplexing siRNAs to compress RNAi-based screen size in human cells.

Published in:

Nucleic Acids Research, 2007, v. 35, n. 8, p. e57, doi. 10.1093/nar/gkm141

By:

Martin, Scott E.;
Jones, Tamara L.;
Thomas, Cheryl L.;
Lorenzi, Philip L.;
Nguyen, Dac A.;
Runfola, Timothy;
Gunsior, Michele;
Weinstein, John N.;
Goldsmith, Paul K.;
Lader, Eric;
Huppi, Konrad;
Caplen, Natasha J.

Publication type:

Article

Protein Phosphatase 1 Regulatory Subunit PNUTS Prevents CENP-A Mislocalization and Chromosomal Instability.

Published in:

Molecular & Cellular Biology, 2025, v. 45, n. 5, p. 185, doi. 10.1080/10985549.2025.2487010

By:

Balachandra, Vinutha;
Thomas, Makenzie;
Shrestha, Roshan L.;
Sethi, Subhash Chandra;
Chari, Raj;
Lin, Shinjen;
Chih-Chien Cheng, Ken;
Karpova, Tatiana S.;
Caplen, Natasha J.;
Basrai, Munira A.

Publication type:

Article

Endogenous EWSR1 Exists in Two Visual Modalities That Reflect Its Associations with Nucleic Acids and Concentration at Sites of Active Transcription.

Published in:

Molecular & Cellular Biology, 2024, v. 44, n. 3, p. 103, doi. 10.1080/10985549.2024.2315425

By:

Sundara Rajan, Soumya;
Ebegboni, Vernon J.;
Pichling, Patricio;
Ludwig, Katelyn R.;
Jones, Tamara L.;
Chari, Raj;
Tran, Andy;
Kruhlak, Michael J.;
Loncarek, Jadranka;
Caplen, Natasha J.

Publication type:

Article