Works by Cantley, Lewis C

Results: 121

An atlas of bacterial serine-threonine kinases reveals functional diversity and key distinctions from eukaryotic kinases.

Published in:

Science Signaling, 2025, v. 18, n. 885, p. 1, doi. 10.1126/scisignal.adt8686

By:

O'Boyle, Brady;
Yeung, Wayland;
Lu, Jason D.;
Katiyar, Samiksha;
Yaron-Barir, Tomer M.;
Johnson, Jared L.;
Cantley, Lewis C.;
Kannan, Natarajan

Publication type:

Article

Hem-1 Complexes Are Essential for Rac Activation, Actin Polymerization, and Myosin Regulation during Neutrophil Chemotaxis.

Published in:

PLoS Biology, 2006, v. 4, n. 2, p. e38, doi. 10.1371/journal.pbio.0040038

By:

Weiner, Orion D.;
Rentel, Maike C.;
Ott, Alex;
Brown, Glenn E.;
Jedrychowski, Mark;
Yaffe, Michael B.;
Gygi, Steven P.;
Cantley, Lewis C.;
Bourne, Henry R.;
Kirschner, Marc W.

Publication type:

Article

Signalling through the lipid products of phosphoinositide-3-OH kinase.

Published in:

Nature, 1997, v. 387, n. 6634, p. 673, doi. 10.1038/42648

By:

Toker, Alex;
Cantley, Lewis C.

Publication type:

Article

Scansite 2.0: proteome-wide prediction of cell signaling interactions using short sequence motifs.

Published in:

Nucleic Acids Research, 2003, v. 31, n. 13, p. 3635, doi. 10.1093/nar/gkg584

By:

Obenauer, John C.;
Cantley, Lewis C.;
Yaffe, Michael B.

Publication type:

Article

Tyrosine Kinase BMX Phosphorylates Phosphotyrosine-Primed Motif Mediating the Activation of Multiple Receptor Tyrosine Kinases.

Published in:

Science Signaling, 2013, v. 6, n. 277, p. 1, doi. 10.1126/scisignal.2003936

By:

Sen Chen;
Xinnong Jiang;
Gewinner, Christina A.;
Asara, John M.;
Simon, Nicholas I.;
Changmeng Cai;
Cantley, Lewis C.;
Balk, Steven P.

Publication type:

Article

Ubiquitination of K-Ras Enhances Activation and Facilitates Binding to Select Downstream Effectors.

Published in:

Science Signaling, 2011, v. 4, n. 163, p. 1, doi. 10.1126/scisignal.2001518

By:

Sasaki, Atsuo T.;
Carracedo, Arkaitz;
Locasale, Jason W.;
Anastasiou, Dimitrios;
Takeuchi, Koh;
Kahoud, Emily Rose;
Haviv, Sasson;
Asara, John M.;
Pandolfi, Pier Paolo;
Cantley, Lewis C.

Publication type:

Article

Akt-RSK-S6 Kinase Signaling Networks Activated by Oncogenic Receptor Tyrosine Kinases.

Published in:

Science Signaling, 2010, v. 3, n. 136, p. 1, doi. 10.1126/scisignal.2000998

By:

Moritz, Albrecht;
Yu Li;
Ailan Guo;
Villén, Judit;
Yi Wang;
MacNeill, Joan;
Kornhauser, Jon;
Sprott, Kam;
Jing Zhou;
Possemato, Anthony;
Jian Min Ren;
Hornbeck, Peter;
Cantley, Lewis C.;
Gygi, Steven P.;
Rush, John;
Comb, Michael J.

Publication type:

Article

Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth.

Published in:

Science Signaling, 2009, v. 2, n. 97, p. 1, doi. 10.1126/scisignal.2000431

By:

Hitosugi, Taro;
Kang, Sumin;
Vander Heiden, Matthew G.;
Chung, Tae-Wook;
Elf, Shannon;
Lythgoe, Katherine;
Dong, Shaozhong;
Lonial, Sagar;
Xu Wang;
Chen, Georgia Z.;
Xie, Jianxin;
Gu, Ting-Lei;
Polakiewicz, Roberto D.;
Roesel, Johannes L.;
Boggon, Titus J.;
Khuri, Fadlo R.;
Gilliland, D. Gary;
Cantley, Lewis C.;
Kaufman, Jonathan;
Chen, Jing

Publication type:

Article

Malic enzyme 1 knockout has no deleterious phenotype and is favored in the male germline under standard laboratory conditions.

Published in:

PLoS ONE, 2024, v. 19, n. 6, p. 1, doi. 10.1371/journal.pone.0303577

By:

Alektiar, Jonathan M.;
Shan, Mengrou;
Radyk, Megan D.;
Zhang, Li;
Halbrook, Christopher J.;
Lin, Lin;
Espinoza, Carlos;
Mier, Ivan F.;
Lavoie, Brooke L.;
Salvatore, Lucie;
Pasca di Magliano, Marina;
Cantley, Lewis C.;
Mueller, Jacob L.;
Lyssiotis, Costas A.

Publication type:

Article

Targeting the Dark Lipid Kinase PIP4K2C with a Potent and Selective Binder and Degrader.

Published in:

Angewandte Chemie International Edition, 2023, v. 62, n. 18, p. 1, doi. 10.1002/anie.202302364

By:

Teng, Mingxing;
Jiang, Jie;
Wang, Eric S.;
Geng, Qixiang;
Toenjes, Sean T.;
Donovan, Katherine A.;
Mageed, Nada;
Yue, Hong;
Nowak, Radosław P.;
Wang, Jinhua;
Manz, Theresa D.;
Fischer, Eric S.;
Cantley, Lewis C.;
Gray, Nathanael S.

Publication type:

Article

The Negative Regulation of Phosphoinositide 3-Kinase Signaling by p85 and Its Implication in Cancer.

Published in:

Cell Cycle, 2005, v. 4, n. 10, p. 1309, doi. 10.4161/cc.4.10.2062

By:

Luo, Ji;
Cantley, Lewis C.

Publication type:

Article

PTEN loss is a context-dependent outcome determinant in obese and non-obese endometrioid endometrial cancer patients.

Published in:

Molecular Oncology, 2015, v. 9, n. 8, p. 1694, doi. 10.1016/j.molonc.2015.04.014

By:

Westin, Shannon N.;
Ju, Zhenlin;
Broaddus, Russell R.;
Krakstad, Camilla;
Li, Jane;
Pal, Navdeep;
Lu, Karen H.;
Coleman, Robert L.;
Hennessy, Bryan T.;
Klempner, Samuel J.;
Werner, Henrica M.J.;
Salvesen, Helga B.;
Cantley, Lewis C.;
Mills, Gordon B.;
Myers, Andrea P.

Publication type:

Article

FoxO3 coordinates metabolic pathways to maintain redox balance in neural stem cells.

Published in:

EMBO Journal, 2013, v. 32, n. 19, p. 2589, doi. 10.1038/emboj.2013.186

By:

Yeo, Hyeonju;
Lyssiotis, Costas A;
Zhang, Yuqing;
Ying, Haoqiang;
Asara, John M;
Cantley, Lewis C;
Paik, Ji‐Hye

Publication type:

Article

Human pluripotent stem cells decouple respiration from energy production.

Published in:

EMBO Journal, 2011, v. 30, n. 24, p. 4851, doi. 10.1038/emboj.2011.436

By:

Shyh-Chang, Ng;
Zheng, Yuxiang;
Locasale, Jason W;
Cantley, Lewis C

Publication type:

Article

Breathless cancer cells get fat on glutamine.

Published in:

Cell Research, 2012, v. 22, n. 3, p. 443, doi. 10.1038/cr.2012.5

By:

Anastasiou, Dimitrios;
Cantley, Lewis C

Publication type:

Article

Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 1, p. 46, doi. 10.1038/nsmb.2430

By:

Baker, Rachael;
Lewis, Steven M;
Sasaki, Atsuo T;
Wilkerson, Emily M;
Locasale, Jason W;
Cantley, Lewis C;
Kuhlman, Brian;
Dohlman, Henrik G;
Campbell, Sharon L

Publication type:

Article

The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor.

Published in:

Nature Structural & Molecular Biology, 2004, v. 11, n. 1, p. 60, doi. 10.1038/nsmb708

By:

Turk, Benjamin E.;
Thiang Yian Wong;
Schwarzenbacher, RObert;
Jarrell, Emily T.;
Leppla, Stephen H.;
Collier, R. John;
Liddington, Robert C.;
Cantley, Lewis C.

Publication type:

Article

Identification of small molecule inhibitors of anthrax lethal factor.

Published in:

Nature Structural & Molecular Biology, 2004, v. 11, n. 1, p. 67, doi. 10.1038/nsmb711

By:

Panchal, Rekha G.;
Hermone, Ann R.;
Tam Luong Nguyen;
Tiang Yian Wong, Ann R.;
Schwarzenbacher, Robert;
Schmidt, James;
Lane, Douglas;
McGrath, Connor;
Turk, Benjamin E.;
Burnett, James;
Aman, M. Javad;
Little, Stephen;
Sausville, Edward A.;
Zaharevitz, Daniel W.;
Cantley, Lewis C.;
Liddington, Robert C.;
Gussio, Rick;
Bavari, Sina

Publication type:

Article

Distinct roles of class I and class III phosphatidylinositol 3-kinase in phagosome formation....

Published in:

Journal of Cell Biology, 2001, v. 155, n. 1, p. 19, doi. 10.1083/jcb.200107069

By:

Vieira, Otilia V.;
Botelho, Roberto J.;
Rameh, Lucia;
Brachmann, Saskia M.;
Matsuo, Tsuyoshi;
Davidson, Howard W.;
Schreiber, Alan;
Backer, Jonathan M.;
Cantley, Lewis C.;
Grinstein, Sergio

Publication type:

Article

GLUT5 (SLC2A5) enables fructose-mediated proliferation independent of ketohexokinase.

Published in:

Cancer & Metabolism, 2021, v. 9, n. 1, p. 1, doi. 10.1186/s40170-021-00246-9

By:

Liang, Roger J.;
Taylor, Samuel;
Nahiyaan, Navid;
Song, Junho;
Murphy, Charles J.;
Dantas, Ezequiel;
Cheng, Shuyuan;
Hsu, Ting-Wei;
Ramsamooj, Shakti;
Grover, Rahul;
Hwang, Seo-Kyoung;
Ngo, Bryan;
Cantley, Lewis C.;
Rhee, Kyu Y.;
Goncalves, Marcus D.

Publication type:

Article

Targeting glutamine metabolism sensitizes pancreatic cancer to PARP-driven metabolic catastrophe induced by β-lapachone.

Published in:

Cancer & Metabolism, 2015, v. 3, n. 1, p. 1, doi. 10.1186/s40170-015-0137-1

By:

Chakrabarti, Gaurab;
Moore, Zachary R.;
Xiuquan Luo;
Ilcheva, Mariya;
Ali, Aktar;
Padanad, Mahesh;
Yunyun Zhou;
Yang Xie;
Burma, Sandeep;
Scaglioni, Pier P.;
Cantley, Lewis C.;
DeBerardinis, Ralph J.;
Kimmelman, Alec C.;
Lyssiotis, Costas A.;
Boothman, David A.

Publication type:

Article

ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect.

Published in:

Nature Cell Biology, 2013, v. 15, n. 1, p. 124, doi. 10.1038/ncb2677

By:

Yang, Weiwei;
Zheng, Yanhua;
Xia, Yan;
Ji, Haitao;
Chen, Xiaomin;
Guo, Fang;
Lyssiotis, Costas A.;
Aldape, Kenneth;
Cantley, Lewis C.;
Lu, Zhimin

Publication type:

Article

ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect.

Published in:

Nature Cell Biology, 2012, v. 14, n. 12, p. 1295, doi. 10.1038/ncb2629

By:

Yang, Weiwei;
Zheng, Yanhua;
Xia, Yan;
Ji, Haitao;
Chen, Xiaomin;
Guo, Fang;
Lyssiotis, Costas A.;
Aldape, Kenneth;
Cantley, Lewis C.;
Lu, Zhimin

Publication type:

Article

A PtdInsP<sub>3</sub>- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity.

Published in:

Nature Cell Biology, 2002, v. 4, n. 7, p. 509, doi. 10.1038/ncb811

By:

Weiner, Orion D.;
Neilsen, Paul O.;
Prestwich, Glenn D.;
Kirschner, Marc W.;
Cantley, Lewis C.;
Bourne, Henry R.

Publication type:

Article

The PX domains of p47phox and p40phox bind to lipid products of PI(3)K.

Published in:

Nature Cell Biology, 2001, v. 3, n. 7, p. 675, doi. 10.1038/35083070

By:

Kanai, Fumihiko;
Liu, Hui;
Field, Seth J.;
Akbary, Hares;
Matsuo, Tsuyoshi;
Brown, Glenn E.;
Cantley, Lewis C.;
Yaffe, Michael B.

Publication type:

Article

Phosphoinositide biology ? messages from lipids.

Published in:

2000

By:

Luo, Ji;
Cantley, Lewis C.

Publication type:

Book Review

Insulin feedback is a targetable resistance mechanism of PI3K inhibition in glioblastoma.

Published in:

Neuro-Oncology, 2023, v. 25, n. 12, p. 2165, doi. 10.1093/neuonc/noad117

By:

Noch, Evan K;
Palma, Laura N;
Yim, Isaiah;
Bullen, Nayah;
Qiu, Yuqing;
Ravichandran, Hiranmayi;
Kim, Junbum;
Rendeiro, Andre;
Davis, Melissa B;
Elemento, Olivier;
Pisapia, David J;
Zhai, Kevin;
LeKaye, Hongbiao Carl;
Koutcher, Jason A;
Wen, Patrick Y;
Ligon, Keith L;
Cantley, Lewis C

Publication type:

Article

The chromatin remodeler RSF1 controls centromeric histone modifications to coordinate chromosome segregation.

Published in:

Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-06377-w

By:

Lee, Ho-Soo;
Lin, Zhonghui;
Chae, Sunyoung;
Yoo, Young-Suk;
Kim, Byung-Gyu;
Lee, Youngsoo;
Johnson, Jared L.;
Kim, You-Sun;
Cantley, Lewis C.;
Lee, Chang-Woo;
Yu, Hongtao;
Cho, Hyeseong

Publication type:

Article

Cancer, metabolism, fructose, artificial sweeteners, and going cold turkey on sugar.

Published in:

BMC Biology, 2013, v. 11, n. 1, p. 1, doi. 10.1186/1741-7007-12-8

By:

Cantley, Lewis C.

Publication type:

Article

Altered metabolism in cancer.

Published in:

BMC Biology, 2010, v. 8, p. 88, doi. 10.1186/1741-7007-8-88

By:

Locasale, Jason W.;
Cantley, Lewis C.

Publication type:

Article

Inhibition of lung cancer growth: ATP citrate lyase knockdown and statin treatment leads to dual blockade of mitogen-activated protein Kinase (MAPK) and Phosphatidylinositol-3-kinase (PI3K)/AKT pathways.

Published in:

Journal of Cellular Physiology, 2012, v. 227, n. 4, p. 1709, doi. 10.1002/jcp.22895

By:

Hanai, Jun-ichi;
Doro, Nathaniel;
Sasaki, Atsuo T.;
Kobayashi, Susumu;
Cantley, Lewis C.;
Seth, Pankaj;
Sukhatme, Vikas P.

Publication type:

Article

Metabolic syndrome: F stands for fructose and fat.

Published in:

Nature, 2013, v. 502, n. 7470, p. 181, doi. 10.1038/502181a

By:

Lyssiotis, Costas A.;
Cantley, Lewis C.

Publication type:

Article

Corrigendum: Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.

Published in:

Nature, 2013, v. 499, n. 7459, p. 504, doi. 10.1038/nature12317

By:

Son, Jaekyoung;
Lyssiotis, Costas A.;
Ying, Haoqiang;
Wang, Xiaoxu;
Hua, Sujun;
Ligorio, Matteo;
Perera, Rushika M.;
Ferrone, Cristina R.;
Mullarky, Edouard;
Shyh-Chang, Ng;
Kang, Ya'an;
Fleming, Jason B.;
Bardeesy, Nabeel;
Asara, John M.;
Haigis, Marcia C.;
DePinho, Ronald A.;
Cantley, Lewis C.;
Kimmelman, Alec C.

Publication type:

Article

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.

Published in:

Nature, 2013, v. 496, n. 7443, p. 101, doi. 10.1038/nature12040

By:

Son, Jaekyoung;
Lyssiotis, Costas A.;
Ying, Haoqiang;
Wang, Xiaoxu;
Hua, Sujun;
Ligorio, Matteo;
Perera, Rushika M.;
Ferrone, Cristina R.;
Mullarky, Edouard;
Shyh-Chang, Ng;
Kang, Ya'an;
Fleming, Jason B.;
Bardeesy, Nabeel;
Asara, John M.;
Haigis, Marcia C.;
DePinho, Ronald A.;
Cantley, Lewis C.;
Kimmelman, Alec C.

Publication type:

Article

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate.

Published in:

Nature, 2010, v. 465, n. 7300, p. 966, doi. 10.1038/nature09132

By:

Dang, Lenny;
White, David W.;
Gross, Stefan;
Bennett, Bryson D.;
Bittinger, Mark A.;
Driggers, Edward M.;
Fantin, Valeria R.;
Jang, Hyun Gyung;
Jin, Shengfang;
Keenan, Marie C.;
Marks, Kevin M.;
Prins, Robert M.;
Ward, Patrick S.;
Yen, Katharine E.;
Liau, Linda M.;
Rabinowitz, Joshua D.;
Cantley, Lewis C.;
Thompson, Craig B.;
Vander Heiden, Matthew G.;
Su, Shinsan M.

Publication type:

Article

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate.

Published in:

Nature, 2009, v. 462, n. 7274, p. 739, doi. 10.1038/nature08617

By:

Dang, Lenny;
White, David W.;
Gross, Stefan;
Bennett, Bryson D.;
Bittinger, Mark A.;
Driggers, Edward M.;
Fantin, Valeria R.;
Hyun Gyung Jang;
Shengfang Jin;
Keenan, Marie C.;
Marks, Kevin M.;
Prins, Robert M.;
Ward, Patrick S.;
Yen, Katharine E.;
Liau, Linda M.;
Rabinowitz, Joshua D.;
Cantley, Lewis C.;
Thompson, Craig B.;
Vander Heiden, Matthew G.;
Su, Shinsan M.

Publication type:

Article

Targeting a Common Collaborator in Cancer Development.

Published in:

Science Translational Medicine, 2010, v. 2, n. 48, p. 1, doi. 10.1126/scitranslmed.3001251

By:

Myers, Andrea P.;
Cantley, Lewis C.

Publication type:

Article

Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85α.

Published in:

Nature Genetics, 2000, v. 26, n. 3, p. 379, doi. 10.1038/81715

By:

Fruman, David A.;
Mauvais-Jarvis, Franck;
Pollard, Daniel A.;
Yballe, Claudine M.;
Brazil, Derek;
Bronson, Roderick T.;
Kahn, C. Ronald;
Cantley, Lewis C.

Publication type:

Article

Organ-specific lymphangiectasia, arrested lymphatic sprouting, and maturation defects resulting from gene-targeting of the PI3K regulatory isoforms p85α, p55α, and p50α.

Published in:

Developmental Dynamics, 2009, v. 238, n. 10, p. 2670, doi. 10.1002/dvdy.22078

By:

Mouta-Bellum, Carla;
Kirov, Aleksander;
Miceli-Libby, Laura;
Mancini, Maria L.;
Petrova, Tatiana V.;
Liaw, Lucy;
Prudovsky, Igor;
Thorpe, Philip E.;
Miura, Naoyuki;
Cantley, Lewis C.;
Alitalo, Kari;
Fruman, David A.;
Vary, Calvin P.H.

Publication type:

Article

Cancer metabolism: fatty acid oxidation in the limelight.

Published in:

Nature Reviews Cancer, 2013, v. 13, n. 4, p. 227, doi. 10.1038/nrc3483

By:

Carracedo, Arkaitz;
Cantley, Lewis C.;
Pandolfi, Pier Paolo

Publication type:

Article

PIK3CA and MAP3K1 alterations imply luminal A status and are associated with clinical benefit from pan-PI3K inhibitor buparlisib and letrozole in ER+ metastatic breast cancer.

Published in:

NPJ Breast Cancer, 2019, v. 5, n. 1, p. N.PAG, doi. 10.1038/s41523-019-0126-6

By:

Nixon, Mellissa J.;
Formisano, Luigi;
Mayer, Ingrid A.;
Estrada, M. Valeria;
González-Ericsson, Paula I.;
Isakoff, Steven J.;
Forero-Torres, Andrés;
Won, Helen;
Sanders, Melinda E.;
Solit, David B.;
Berger, Michael F.;
Cantley, Lewis C.;
Winer, Eric P.;
Arteaga, Carlos L.;
Balko, Justin M.

Publication type:

Article

Differential Effects of Gefitinib and Cetuximab on Non—small-cell Lung Cancers Bearing Epidermal Growth Factor Receptor Mutations.

Published in:

JNCI: Journal of the National Cancer Institute, 2005, v. 97, n. 16, p. 1185, doi. 10.1093/jnci/dji238

By:

Mukohara, Toru;
Engelman, Jeffrey A.;
Hanna, Nasser H.;
Yeap, Beow Y.;
Kobayashi, Susumu;
Lindeman, Neal;
Halmos, Balázs;
Peariberg, Joseph;
Tsuchihashi, Zenta;
Cantley, Lewis C.;
Tenen, Daniel G.;
Johnson, Bruce E.;
Janne, Pasi A.

Publication type:

Article

Competing paradigms of obesity pathogenesis: energy balance versus carbohydrate-insulin models.

Published in:

2022

By:

Ludwig, David S.;
Apovian, Caroline M.;
Aronne, Louis J.;
Astrup, Arne;
Cantley, Lewis C.;
Ebbeling, Cara B.;
Heymsfield, Steven B.;
Johnson, James D.;
King, Janet C.;
Krauss, Ronald M.;
Taubes, Gary;
Volek, Jeff S.;
Westman, Eric C.;
Willett, Walter C.;
Yancy Jr., William S.;
Friedman, Mark I.;
Yancy, William S Jr

Publication type:

journal article

Phase II, 2‐stage, 2‐arm, PIK3CA mutation stratified trial of MK‐2206 in recurrent endometrial cancer.

Published in:

International Journal of Cancer, 2020, v. 147, n. 2, p. 413, doi. 10.1002/ijc.32783

By:

Myers, Andrea P.;
Konstantinopoulos, Panagiotis A.;
Barry, William T.;
Luo, Weixiu;
Broaddus, Russell R.;
Makker, Vicky;
Drapkin, Ronny;
Liu, Joyce;
Doyle, Austin;
Horowitz, Neil S.;
Meric‐Bernstam, Funda;
Birrer, Michael;
Aghajanian, Carol;
Coleman, Robert L.;
Mills, Gordon B.;
Cantley, Lewis C.;
Matulonis, Ursula A.;
Westin, Shannon N.

Publication type:

Article

Phosphatidylinositol 3-kinase.

Published in:

BioEssays, 1994, v. 16, n. 8, p. 565, doi. 10.1002/bies.950160810

By:

Kapeller, Rosana;
Cantley, Lewis C.

Publication type:

Article

Rac-Mediated Macropinocytosis of Extracellular Protein Promotes Glucose Independence in Non-Small Cell Lung Cancer.

Published in:

Cancers, 2019, v. 11, n. 1, p. 37, doi. 10.3390/cancers11010037

By:

Hodakoski, Cindy;
Hopkins, Benjamin D.;
Zhang, Guoan;
Su, Taojunfeng;
Cheng, Zhe;
Morris, Roxanne;
Rhee, Kyu Y.;
Goncalves, Marcus D.;
Cantley, Lewis C.

Publication type:

Article

PHGDH amplification and altered glucose metabolism in human melanoma.

Published in:

Pigment Cell & Melanoma Research, 2011, v. 24, n. 6, p. 1112, doi. 10.1111/j.1755-148X.2011.00919.x

By:

Mullarky, Edouard;
Mattaini, Katherine R.;
Vander Heiden, Matthew G.;
Cantley, Lewis C.;
Locasale, Jason W.

Publication type:

Article

Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer.

Published in:

Nature Medicine, 2015, v. 21, n. 5, p. 457, doi. 10.1038/nm.3839

By:

Wei, Shuo;
Kozono, Shingo;
Kats, Lev;
Nechama, Morris;
Li, Wenzong;
Guarnerio, Jlenia;
Luo, Manli;
You, Mi-Hyeon;
Yao, Yandan;
Kondo, Asami;
Hu, Hai;
Bozkurt, Gunes;
Moerke, Nathan J;
Cao, Shugeng;
Reschke, Markus;
Chen, Chun-Hau;
Rego, Eduardo M;
Lo-Coco, Francesco;
Cantley, Lewis C;
Lee, Tae Ho

Publication type:

Article

A colorectal cancer classification system that associates cellular phenotype and responses to therapy.

Published in:

Nature Medicine, 2013, v. 19, n. 5, p. 619, doi. 10.1038/nm.3175

By:

Sadanandam, Anguraj;
Lyssiotis, Costas A;
Homicsko, Krisztian;
Collisson, Eric A;
Gibb, William J;
Wullschleger, Stephan;
Ostos, Liliane C Gonzalez;
Lannon, William A;
Grotzinger, Carsten;
Del Rio, Maguy;
Lhermitte, Benoit;
Olshen, Adam B;
Wiedenmann, Bertram;
Cantley, Lewis C;
Gray, Joe W;
Hanahan, Douglas

Publication type:

Article

Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers.

Published in:

Nature Medicine, 2008, v. 14, n. 12, p. 1351, doi. 10.1038/nm.1890

By:

Engelman, Jeffrey A.;
Chen, Liang;
Tan, Xiaohong;
Crosby, Katherine;
Guimaraes, Alexander R.;
Upadhyay, Rabi;
Maira, Michel;
McNamara, Kate;
Perera, Samanthi A.;
Song, Youngchul;
Chirieac, Lucian R.;
Kaur, Ramneet;
Lightbown, Angela;
Simendinger, Jessica;
Li, Timothy;
Padera, Robert F.;
García-Echeverría, Carlos;
Weissleder, Ralph;
Mahmood, Umar;
Cantley, Lewis C.

Publication type:

Article