Works matching AU Cantley, Lewis C

Results: 121

Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 1, p. 46, doi. 10.1038/nsmb.2430

By:

Baker, Rachael;
Lewis, Steven M;
Sasaki, Atsuo T;
Wilkerson, Emily M;
Locasale, Jason W;
Cantley, Lewis C;
Kuhlman, Brian;
Dohlman, Henrik G;
Campbell, Sharon L

Publication type:

Article

Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer.

Published in:

Nature Medicine, 2015, v. 21, n. 5, p. 457, doi. 10.1038/nm.3839

By:

Wei, Shuo;
Kozono, Shingo;
Kats, Lev;
Nechama, Morris;
Li, Wenzong;
Guarnerio, Jlenia;
Luo, Manli;
You, Mi-Hyeon;
Yao, Yandan;
Kondo, Asami;
Hu, Hai;
Bozkurt, Gunes;
Moerke, Nathan J;
Cao, Shugeng;
Reschke, Markus;
Chen, Chun-Hau;
Rego, Eduardo M;
Lo-Coco, Francesco;
Cantley, Lewis C;
Lee, Tae Ho

Publication type:

Article

A colorectal cancer classification system that associates cellular phenotype and responses to therapy.

Published in:

Nature Medicine, 2013, v. 19, n. 5, p. 619, doi. 10.1038/nm.3175

By:

Sadanandam, Anguraj;
Lyssiotis, Costas A;
Homicsko, Krisztian;
Collisson, Eric A;
Gibb, William J;
Wullschleger, Stephan;
Ostos, Liliane C Gonzalez;
Lannon, William A;
Grotzinger, Carsten;
Del Rio, Maguy;
Lhermitte, Benoit;
Olshen, Adam B;
Wiedenmann, Bertram;
Cantley, Lewis C;
Gray, Joe W;
Hanahan, Douglas

Publication type:

Article

Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers.

Published in:

Nature Medicine, 2008, v. 14, n. 12, p. 1351, doi. 10.1038/nm.1890

By:

Engelman, Jeffrey A.;
Chen, Liang;
Tan, Xiaohong;
Crosby, Katherine;
Guimaraes, Alexander R.;
Upadhyay, Rabi;
Maira, Michel;
McNamara, Kate;
Perera, Samanthi A.;
Song, Youngchul;
Chirieac, Lucian R.;
Kaur, Ramneet;
Lightbown, Angela;
Simendinger, Jessica;
Li, Timothy;
Padera, Robert F.;
García-Echeverría, Carlos;
Weissleder, Ralph;
Mahmood, Umar;
Cantley, Lewis C.

Publication type:

Article

A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer.

Published in:

Nature Genetics, 2013, v. 45, n. 7, p. 747, doi. 10.1038/ng.2650

By:

Lunardi, Andrea;
Ala, Ugo;
Epping, Mirjam T;
Salmena, Leonardo;
Clohessy, John G;
Webster, Kaitlyn A;
Wang, Guocan;
Mazzucchelli, Roberta;
Bianconi, Maristella;
Stack, Edward C;
Lis, Rosina;
Patnaik, Akash;
Cantley, Lewis C;
Bubley, Glenn;
Cordon-Cardo, Carlos;
Gerald, William L;
Montironi, Rodolfo;
Signoretti, Sabina;
Loda, Massimo;
Nardella, Caterina

Publication type:

Article

Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85α.

Published in:

Nature Genetics, 2000, v. 26, n. 3, p. 379, doi. 10.1038/81715

By:

Fruman, David A.;
Mauvais-Jarvis, Franck;
Pollard, Daniel A.;
Yballe, Claudine M.;
Brazil, Derek;
Bronson, Roderick T.;
Kahn, C. Ronald;
Cantley, Lewis C.

Publication type:

Article

The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex.

Published in:

Journal of Cell Biology, 2005, v. 170, n. 3, p. 455, doi. 10.1083/jcb.200503088

By:

Ji Luo;
Field, Seth J.;
Lee, Jennifer Y.;
Engelman, Jeffrey A.;
Cantley, Lewis C.

Publication type:

Article

A novel phosphatidylinositol (3,4,5) P<sub>3</sub> pathway in fission yeast.

Published in:

Journal of Cell Biology, 2004, v. 166, n. 2, p. 205, doi. 10.1083/jcb.200404150

By:

Mitra, Prasenjit;
Zhang, Yingjie;
Rameh, Lucia E.;
Ivsnina, Maria P.;
McCollum, Dannel;
Nunnari, John J.;
Hendricks, Gregory M.;
Kerr, Monica L.;
Field, Seth J.;
Cantley, Lewis C.;
Ross, Alonzo H.

Publication type:

Article

Blocking ActRIIB and restoring appetite reverses cachexia and improves survival in mice with lung cancer.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-32135-0

By:

Queiroz, Andre Lima;
Dantas, Ezequiel;
Ramsamooj, Shakti;
Murthy, Anirudh;
Ahmed, Mujmmail;
Zunica, Elizabeth R. M.;
Liang, Roger J.;
Murphy, Jessica;
Holman, Corey D.;
Bare, Curtis J.;
Ghahramani, Gregory;
Wu, Zhidan;
Cohen, David E.;
Kirwan, John P.;
Cantley, Lewis C.;
Axelrod, Christopher L.;
Goncalves, Marcus D.

Publication type:

Article

Phosphatidylinositol 3-kinase.

Published in:

BioEssays, 1994, v. 16, n. 8, p. 565, doi. 10.1002/bies.950160810

By:

Kapeller, Rosana;
Cantley, Lewis C.

Publication type:

Article

A Homogeneous, High-Throughput Assay for Phosphatidylinositol 5-Phosphate 4-Kinase with a Novel, Rapid Substrate Preparation.

Published in:

PLoS ONE, 2013, v. 8, n. 1, p. 1, doi. 10.1371/journal.pone.0054127

By:

Davis, Mindy I.;
Sasaki, Atsuo T.;
Min Shen;
Emerling, Brooke M.;
Thorne, Natasha;
Michael, Sam;
Pragani, Rajan;
Boxer, Matthew;
Sumita, Kazutaka;
Koh Takeuchi;
Auld, Douglas S.;
Zhuyin Li;
Cantley, Lewis C.;
Simeonov, Anton

Publication type:

Article

Somatic Mutations of PIK3R1 Promote Gliomagenesis.

Published in:

PLoS ONE, 2012, v. 7, n. 11, p. 1, doi. 10.1371/journal.pone.0049466

By:

Quayle, Steven N.;
Lee, Jennifer Y.;
Cheung, Lydia W. T.;
Li Ding;
Wiedemeyer, Ruprecht;
Dewan, Robert W.;
Huang-Hobbs, Emmet;
Li Zhuang;
Wilson, Richard K.;
Ligon, Keith L.;
Mills, Gordon B.;
Cantley, Lewis C.;
Chin, Lynda

Publication type:

Article

Development of a High-Throughput Assay for Identifying Inhibitors of TBK1 and IKKϵ.

Published in:

PLoS ONE, 2012, v. 7, n. 7, p. 1, doi. 10.1371/journal.pone.0041494

By:

Hutti, Jessica E.;
Porter, Melissa A.;
Cheely, Adam W.;
Cantley, Lewis C.;
Wang, Xiaodong;
Kireev, Dmitri;
Baldwin, Albert S.;
Janzen, William P.

Publication type:

Article

Designed Inhibitors of Insulin-Degrading Enzyme Regulate the Catabolism and Activity of Insulin.

Published in:

PLoS ONE, 2010, v. 5, n. 5, p. 1, doi. 10.1371/journal.pone.0010504

By:

Leissring, Malcolm A.;
Malito, Enrico;
Hedouin, Sabrine;
Reinstatler, Lael;
Sahara, Tomoko;
Abdul-Hay, Samer O.;
Choudhry, Shakeel;
Maharvi, Ghulam M.;
Fauq, Abdul H.;
Huzarska, Malwina;
May, Philip S.;
Sungwoon Choi;
Logan, Todd P.;
Turk, Benjamin E.;
Cantley, Lewis C.;
Manolopoulou, Marika;
Wei-Jen Tang;
Stein, Ross L.;
Cuny, Gregory D.;
Selkoe, Dennis J.

Publication type:

Article

Ras Activity Regulation by Monoubiquitination.

Published in:

FASEB Journal, 2013, v. 27, p. 1046.3, doi. 10.1096/fasebj.27.1_supplement.1046.3

By:

Campbell, Sharon L;
Baker, Rachael;
Lewis, Steven;
Sasaki, Atsuo;
Wilkerson, Emily M;
Locasale, Jason;
Cantley, Lewis C;
Kuhlman, Brian;
Dohlman, Henrik

Publication type:

Article

Cancer, metabolism, fructose, artificial sweeteners, and going cold turkey on sugar.

Published in:

BMC Biology, 2013, v. 11, n. 1, p. 1, doi. 10.1186/1741-7007-12-8

By:

Cantley, Lewis C.

Publication type:

Article

Altered metabolism in cancer.

Published in:

BMC Biology, 2010, v. 8, p. 88, doi. 10.1186/1741-7007-8-88

By:

Locasale, Jason W.;
Cantley, Lewis C.

Publication type:

Article

The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor.

Published in:

Nature Structural & Molecular Biology, 2004, v. 11, n. 1, p. 60, doi. 10.1038/nsmb708

By:

Turk, Benjamin E.;
Thiang Yian Wong;
Schwarzenbacher, RObert;
Jarrell, Emily T.;
Leppla, Stephen H.;
Collier, R. John;
Liddington, Robert C.;
Cantley, Lewis C.

Publication type:

Article

Identification of small molecule inhibitors of anthrax lethal factor.

Published in:

Nature Structural & Molecular Biology, 2004, v. 11, n. 1, p. 67, doi. 10.1038/nsmb711

By:

Panchal, Rekha G.;
Hermone, Ann R.;
Tam Luong Nguyen;
Tiang Yian Wong, Ann R.;
Schwarzenbacher, Robert;
Schmidt, James;
Lane, Douglas;
McGrath, Connor;
Turk, Benjamin E.;
Burnett, James;
Aman, M. Javad;
Little, Stephen;
Sausville, Edward A.;
Zaharevitz, Daniel W.;
Cantley, Lewis C.;
Liddington, Robert C.;
Gussio, Rick;
Bavari, Sina

Publication type:

Article

Characterization of monovalent ion transport systems in an insect cell line ( Manduca sexta embryonic cell line che).

Published in:

Journal of Cellular Physiology, 1984, v. 121, n. 1, p. 125, doi. 10.1002/jcp.1041210115

By:

English, Leigh H.;
Cantley, Lewis C.

Publication type:

Article

Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-33862-0

By:

Li, Zhongchi;
Low, Vivien;
Luga, Valbona;
Sun, Janet;
Earlie, Ethan;
Parang, Bobak;
Shobana Ganesh, Kripa;
Cho, Sungyun;
Endress, Jennifer;
Schild, Tanya;
Hu, Mengying;
Lyden, David;
Jin, Wenbing;
Guo, Chunjun;
Dephoure, Noah;
Cantley, Lewis C.;
Laughney, Ashley M.;
Blenis, John

Publication type:

Article

Tyrosine Kinase BMX Phosphorylates Phosphotyrosine-Primed Motif Mediating the Activation of Multiple Receptor Tyrosine Kinases.

Published in:

Science Signaling, 2013, v. 6, n. 277, p. 1, doi. 10.1126/scisignal.2003936

By:

Sen Chen;
Xinnong Jiang;
Gewinner, Christina A.;
Asara, John M.;
Simon, Nicholas I.;
Changmeng Cai;
Cantley, Lewis C.;
Balk, Steven P.

Publication type:

Article

Ubiquitination of K-Ras Enhances Activation and Facilitates Binding to Select Downstream Effectors.

Published in:

Science Signaling, 2011, v. 4, n. 163, p. 1, doi. 10.1126/scisignal.2001518

By:

Sasaki, Atsuo T.;
Carracedo, Arkaitz;
Locasale, Jason W.;
Anastasiou, Dimitrios;
Takeuchi, Koh;
Kahoud, Emily Rose;
Haviv, Sasson;
Asara, John M.;
Pandolfi, Pier Paolo;
Cantley, Lewis C.

Publication type:

Article

Akt-RSK-S6 Kinase Signaling Networks Activated by Oncogenic Receptor Tyrosine Kinases.

Published in:

Science Signaling, 2010, v. 3, n. 136, p. 1, doi. 10.1126/scisignal.2000998

By:

Moritz, Albrecht;
Yu Li;
Ailan Guo;
Villén, Judit;
Yi Wang;
MacNeill, Joan;
Kornhauser, Jon;
Sprott, Kam;
Jing Zhou;
Possemato, Anthony;
Jian Min Ren;
Hornbeck, Peter;
Cantley, Lewis C.;
Gygi, Steven P.;
Rush, John;
Comb, Michael J.

Publication type:

Article

Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth.

Published in:

Science Signaling, 2009, v. 2, n. 97, p. 1, doi. 10.1126/scisignal.2000431

By:

Hitosugi, Taro;
Kang, Sumin;
Vander Heiden, Matthew G.;
Chung, Tae-Wook;
Elf, Shannon;
Lythgoe, Katherine;
Dong, Shaozhong;
Lonial, Sagar;
Xu Wang;
Chen, Georgia Z.;
Xie, Jianxin;
Gu, Ting-Lei;
Polakiewicz, Roberto D.;
Roesel, Johannes L.;
Boggon, Titus J.;
Khuri, Fadlo R.;
Gilliland, D. Gary;
Cantley, Lewis C.;
Kaufman, Jonathan;
Chen, Jing

Publication type:

Article

Targeting the Dark Lipid Kinase PIP4K2C with a Potent and Selective Binder and Degrader.

Published in:

Angewandte Chemie International Edition, 2023, v. 62, n. 18, p. 1, doi. 10.1002/anie.202302364

By:

Teng, Mingxing;
Jiang, Jie;
Wang, Eric S.;
Geng, Qixiang;
Toenjes, Sean T.;
Donovan, Katherine A.;
Mageed, Nada;
Yue, Hong;
Nowak, Radosław P.;
Wang, Jinhua;
Manz, Theresa D.;
Fischer, Eric S.;
Cantley, Lewis C.;
Gray, Nathanael S.

Publication type:

Article

Receptor tyrosine kinases exert dominant control over PI3K signaling in human KRAS mutant colorectal cancers.

Published in:

2011

By:

Ebi, Hiromichi;
Corcoran, Ryan B.;
Singh, Anurag;
Zhao Chen;
Song, Youngchul;
Lifshits, Eugene;
Ryan, David P.;
Meyerhardt, Jeffrey A.;
Benes, Cyril;
Settleman, Jeffrey;
Wong, Kwok.-Kin.;
Cantley, Lewis C.;
Engelman, Jeffrey A.;
Chen, Zhao

Publication type:

journal article

Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer.

Published in:

2008

By:

Carracedo, Arkaitz;
Li Ma;
Teruya-Feldstein, Julie;
Rojo, Federico;
Salmena, Leonardo;
Alimonti, Andrea;
Egia, Ainara;
Sasaki, Atsuo T.;
Thomas, George;
Kozma, Sara C.;
Papa, Antonella;
Nardella, Caterina;
Cantley, Lewis C.;
Baselga, Jose;
Pandolfi, Pier Paolo;
Ma, Li

Publication type:

journal article

Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice.

Published in:

2008

By:

Hill, Jennifer W.;
Williams, Kevin W.;
Chianping Ye;
Ji Luo;
Balthasar, Nina;
Coppari, Roberto;
Cowley, Michael A.;
Cantley, Lewis C.;
Lowell, Bradford B.;
Elmquist, Joel K.;
Ye, Chianping;
Luo, Ji

Publication type:

journal article

Allelic dilution obscures detection of biologically significant resistance mutation in EGFR-amplified lung cancer.

Published in:

Journal of Clinical Investigation, 2006, v. 116, n. 10, p. 2695, doi. 10.1172/JCI28656

By:

Engelman, Jeffrey A.;
Mukohara, Toru;
Zejnullahu, Kreshnik;
Lifshits, Eugene;
Borrás, Ana M.;
Gale, Christopher-Michael;
Naumov, George N.;
Yeap, Beow Y.;
Jarrell, Emily;
Sun, Jason;
Tracy, Sean;
Xiaojun Zhao;
Heymach, John V.;
Johnson, Bruce E.;
Cantley, Lewis C.;
Jänne, Pasi A.

Publication type:

Article

Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancer.

Published in:

2006

By:

Engelman, Jeffrey A.;
Mukohara, Toru;
Zejnullahu, Kreshnik;
Lifshits, Eugene;
Borrás, Ana M.;
Gale, Christopher-Michael;
Naumov, George N.;
Yeap, Beow Y.;
Jarrell, Emily;
Sun, Jason;
Tracy, Sean;
Xiaojun Zhao;
Heymach, John V.;
Johnson, Bruce E.;
Cantley, Lewis C.;
Jänne, Pasi A.;
Borrás, Ana M;
Zhao, Xiaojun;
Jänne, Pasi A

Publication type:

journal article

Differential Effects of Gefitinib and Cetuximab on Non—small-cell Lung Cancers Bearing Epidermal Growth Factor Receptor Mutations.

Published in:

JNCI: Journal of the National Cancer Institute, 2005, v. 97, n. 16, p. 1185, doi. 10.1093/jnci/dji238

By:

Mukohara, Toru;
Engelman, Jeffrey A.;
Hanna, Nasser H.;
Yeap, Beow Y.;
Kobayashi, Susumu;
Lindeman, Neal;
Halmos, Balázs;
Peariberg, Joseph;
Tsuchihashi, Zenta;
Cantley, Lewis C.;
Tenen, Daniel G.;
Johnson, Bruce E.;
Janne, Pasi A.

Publication type:

Article

A Cross-Species Study of PI3K Protein-Protein Interactions Reveals the Direct Interaction of P85 and SHP2.

Published in:

Scientific Reports, 2016, p. 20471, doi. 10.1038/srep20471

By:

Breitkopf, Susanne B.;
Yang, Xuemei;
Begley, Michael J.;
Kulkarni, Meghana;
Chiu, Yu-Hsin;
Turke, Alexa B.;
Lauriol, Jessica;
Yuan, Min;
Qi, Jie;
Engelman, Jeffrey A.;
Hong, Pengyu;
Kontaridis, Maria I.;
Cantley, Lewis C.;
Perrimon, Norbert;
Asara, John M.

Publication type:

Article

The chromatin remodeler RSF1 controls centromeric histone modifications to coordinate chromosome segregation.

Published in:

Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-06377-w

By:

Lee, Ho-Soo;
Lin, Zhonghui;
Chae, Sunyoung;
Yoo, Young-Suk;
Kim, Byung-Gyu;
Lee, Youngsoo;
Johnson, Jared L.;
Kim, You-Sun;
Cantley, Lewis C.;
Lee, Chang-Woo;
Yu, Hongtao;
Cho, Hyeseong

Publication type:

Article

Cancer's insatiable appetite.

Published in:

Nature Biotechnology, 2009, v. 27, n. 10, p. 916, doi. 10.1038/nbt1009-916

By:

Locasale, Jason W;
Cantley, Lewis C;
Heiden, Matthew G vander

Publication type:

Article

In vivo near-infrared fluorescence imaging of osteoblastic activity.

Published in:

Nature Biotechnology, 2001, v. 19, n. 12, p. 1148, doi. 10.1038/nbt1201-1148

By:

Zaheer, Atif;
Lenkinski, Robert E.;
Mahmood, Ashfaq;
Jones, Alun G.;
Cantley, Lewis C.;
Frangioni, John V.

Publication type:

Article

Determination of protease cleavage site motifs using mixture-based oriented peptide libraries.

Published in:

Nature Biotechnology, 2001, v. 19, n. 7, p. 661, doi. 10.1038/90273

By:

Turk, Benjamin E.;
Huang, Lisa L.;
Piro, Elizabeth T.;
Cantley, Lewis C.

Publication type:

Article

A motif-based profile scanning approach for genome-wide prediction of signaling pathways.

Published in:

Nature Biotechnology, 2001, v. 19, n. 4, p. 348, doi. 10.1038/86737

By:

Yaffe, Michael B.;
Leparc, German G.;
Lai, Jack;
Obata, Toshiyuki;
Volinia, Stefano;
Cantley, Lewis C.

Publication type:

Article

Minimal activators that bind to the KIX domain of p300/CBP identified by phage display screening.

Published in:

Nature Biotechnology, 2000, v. 18, n. 10, p. 1080, doi. 10.1038/80280

By:

Frangioni, John V.;
LaRiccia, Leah M.;
Cantley, Lewis C.;
Montminy, Marc R.

Publication type:

Article

IκB Kinase α Phosphorylation of TRAF4 Downregulates Innate Immune Signaling.

Published in:

Molecular & Cellular Biology, 2012, v. 32, n. 13, p. 2479, doi. 10.1128/MCB.00106-12

By:

Marinis, Jill M.;
Hutti, Jessica E.;
Homer, Craig R.;
Cobb, Brian A.;
Cantley, Lewis C.;
McDonald, Christine;
Abbott, Derek W.

Publication type:

Article

Characterization of PXK as a Protein Involved in Epidermal Growth Factor Receptor Trafficking.

Published in:

Molecular & Cellular Biology, 2010, v. 30, n. 7, p. 10, doi. 10.1128/MCB.01105-09

By:

Takeuchi, Hiroshi;
Takeuchi, Takako;
Jing Gao;
Cantley, Lewis C.;
Hirata, Masato

Publication type:

Article

IκB Kinase β Phosphorylates the K63 Deubiquitinase A20 To Cause Feedback Inhibition of the NF-κB Pathway.

Published in:

Molecular & Cellular Biology, 2007, v. 27, n. 21, p. 9, doi. 10.1128/MCB.01101-07

By:

Hutti, Jessica E.;
Turk, Benjamin E.;
Asara, John M.;
Ma, Averil;
Cantley, Lewis C.;
Abbott, Derek W.

Publication type:

Article

Coordinated Regulation of Toll-Like Receptor and NOD2 Signaling by K63-Linked Polyubiquitin Chains.

Published in:

Molecular & Cellular Biology, 2007, v. 27, n. 17, p. 7, doi. 10.1128/MCB.00270-07

By:

Abbott, Derek W.;
Yibin Yang;
Hutti, Jessica E.;
Madhavarapu, Swetha;
Kelliher, Michelle A.;
Cantley, Lewis C.

Publication type:

Article

The p85α Regulatory Subunit of Phosphoinositide 3-Kinase Potentiates c-Jun N-Terminal Kinase-Mediated Insulin Resistance.

Published in:

Molecular & Cellular Biology, 2007, v. 27, n. 8, p. 5, doi. 10.1128/MCB.00079-07

By:

Taniguchi, Cullen M.;
Aleman, José O.;
Ueki, Kohjiro;
Ji Luo;
Asano, Tomoichiro;
Kaneto, Hideaki;
Stephanopoulos, Gregory;
Cantley, Lewis C.;
Kahn, C. Ronald

Publication type:

Article

Hem-1 Complexes Are Essential for Rac Activation, Actin Polymerization, and Myosin Regulation during Neutrophil Chemotaxis.

Published in:

PLoS Biology, 2006, v. 4, n. 2, p. e38, doi. 10.1371/journal.pbio.0040038

By:

Weiner, Orion D.;
Rentel, Maike C.;
Ott, Alex;
Brown, Glenn E.;
Jedrychowski, Mark;
Yaffe, Michael B.;
Gygi, Steven P.;
Cantley, Lewis C.;
Bourne, Henry R.;
Kirschner, Marc W.

Publication type:

Article

Targeting the Dark Lipid Kinase PIP4K2C with a Potent and Selective Binder and Degrader.

Published in:

Angewandte Chemie, 2023, v. 135, n. 18, p. 1, doi. 10.1002/ange.202302364

By:

Teng, Mingxing;
Jiang, Jie;
Wang, Eric S.;
Geng, Qixiang;
Toenjes, Sean T.;
Donovan, Katherine A.;
Mageed, Nada;
Yue, Hong;
Nowak, Radosław P.;
Wang, Jinhua;
Manz, Theresa D.;
Fischer, Eric S.;
Cantley, Lewis C.;
Gray, Nathanael S.

Publication type:

Article

A Bad kinase makes good.

Published in:

Nature, 1997, v. 390, n. 6656, p. 116, doi. 10.1038/36442

By:

Franke, Thomas F.;
Cantley, Lewis C.

Publication type:

Article

Signalling through the lipid products of phosphoinositide-3-OH kinase.

Published in:

Nature, 1997, v. 387, n. 6634, p. 673, doi. 10.1038/42648

By:

Toker, Alex;
Cantley, Lewis C.

Publication type:

Article

The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.

Published in:

2006

By:

Engelman, Jeffrey A.;
Ji Luo;
Cantley, Lewis C.;
Luo, Ji

Publication type:

journal article

Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins.

Published in:

Oncogene, 1998, v. 16, n. 7, p. 891, doi. 10.1038/sj.onc.1201607

By:

Welsh, Michael;
Songyang, Zhou;
Frantz, J Daniel;
Trüb, Thomas;
Reedquist, Kris A;
Karlsson, Torbjörn;
Miyazaki, Masaya;
Cantley, Lewis C;
Band, Hamid;
Shoelson, Steven E

Publication type:

Article