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Progress on early diagnosing Alzheimer's disease.
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- Frontiers of Medicine, 2024, v. 18, n. 3, p. 446, doi. 10.1007/s11684-023-1047-1
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- Article
Nicastrin Is Required for Assembly of Presenilin/ϒ-Secretase Complexes to Mediate Notch Signaling and for Processing and Trafficking of Β-Amyloid Precursor Protein in Mammals.
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- Journal of Neuroscience, 2003, v. 23, n. 8, p. 3272, doi. 10.1523/JNEUROSCI.23-08-03272.2003
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- Article
The Crucial Roles of Pitx3 in Midbrain Dopaminergic Neuron Development and Parkinson's Disease-Associated Neurodegeneration.
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- International Journal of Molecular Sciences, 2023, v. 24, n. 10, p. 8614, doi. 10.3390/ijms24108614
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- Article
Aldehyde dehydrogenase 1 defines and protects a nigrostriatal dopaminergic neuron subpopulation.
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- Journal of Clinical Investigation, 2014, v. 124, n. 7, p. 3032, doi. 10.1172/JCI72176
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- Article
Nurr1<sup>Cd11bcre</sup> conditional knockout mice display inflammatory injury to nigrostriatal dopaminergic neurons.
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- Glia, 2020, v. 68, n. 10, p. 2057, doi. 10.1002/glia.23826
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- Article
Amyloid plaque pathogenesis in 5XFAD mouse spinal cord: retrograde transneuronal modulation after peripheral nerve injury.
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- Neurotoxicity Research, 2013, v. 24, n. 1, p. 1, doi. 10.1007/s12640-012-9355-2
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- Article
BACE1 Elevation is Involved in Amyloid Plaque Development in the Triple Transgenic Model of Alzheimer's Disease: Differential Aβ Antibody Labeling of Early-Onset Axon Terminal Pathology.
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- Neurotoxicity Research, 2012, v. 21, n. 2, p. 160, doi. 10.1007/s12640-011-9256-9
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- Article
Lack of human-like extracellular sortilin neuropathology in transgenic Alzheimer's disease model mice and macaques.
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- Alzheimer's Research & Therapy, 2018, v. 10, n. 1, p. N.PAG, doi. 10.1186/s13195-018-0370-2
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- Article
Sortilin Fragments Deposit at Senile Plaques in Human Cerebrum.
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- Frontiers in Neuroanatomy, 2017, p. 1, doi. 10.3389/fnana.2017.00045
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- Article
P4-257: Activation of protein kinase C suppresses the β-secretase activity through regulation of the degradation and translocation of BACE1
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- 2006
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- Abstract
P4-257: Activation of protein kinase C suppresses the β-secretase activity through regulation of the degradation and translocation of BACE1
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- 2006
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- Publication type:
- Abstract
Genetically engineered models relevant to neurodegenerative disorders.
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- Journal of Molecular Neuroscience, 2001, v. 17, n. 2, p. 233, doi. 10.1385/JMN:17:2:233
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- Article
Acute Hypoxia Induced an Imbalanced M1/M2 Activation of Microglia through NF-κB Signaling in Alzheimer's Disease Mice and Wild-Type Littermates.
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- Frontiers in Aging Neuroscience, 2017, p. 1, doi. 10.3389/fnagi.2017.00282
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- Article
Longitudinal Metabolomics Profiling of Parkinson’s Disease-Related α-Synuclein A53T Transgenic Mice.
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- PLoS ONE, 2015, v. 10, n. 8, p. 1, doi. 10.1371/journal.pone.0136612
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- Article
Leucine-Rich Repeat Kinase 2 (Lrrk2) Deficiency Diminishes the Development of Experimental Autoimmune Uveitis (EAU) and the Adaptive Immune Response.
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- PLoS ONE, 2015, v. 10, n. 6, p. 1, doi. 10.1371/journal.pone.0128906
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- Article
Optogenetic Measurement of Presynaptic Calcium Transients Using Conditional Genetically Encoded Calcium Indicator Expression in Dopaminergic Neurons.
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- PLoS ONE, 2014, v. 9, n. 10, p. 1, doi. 10.1371/journal.pone.0111749
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- Article
Chronic Temporal Lobe Epilepsy Is Associated with Enhanced Alzheimer-Like Neuropathology in 3 x Tg-AD Mice.
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- PLoS ONE, 2012, v. 7, n. 11, p. 1, doi. 10.1371/journal.pone.0048782
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- Article
Biochemical Characterization and Cellular Effects of CADASIL Mutants of NOTCH3.
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- PLoS ONE, 2012, v. 7, n. 9, p. 1, doi. 10.1371/journal.pone.0044964
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- Article
Transcriptome Analysis of a Rotenone Model of Parkinsonism Reveals Complex I-Tied and -Untied Toxicity Mechanisms Common to Neurodegenerative Diseases.
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- PLoS ONE, 2012, v. 7, n. 9, p. 1, doi. 10.1371/journal.pone.0044700
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- Article
Cytosolic Phospholipase A<sub>2</sub> alpha/Arachidonic Acid Signaling Mediates Depolarization-Induced Suppression of Excitation in the Cerebellum.
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- PLoS ONE, 2012, v. 7, n. 8, p. 1, doi. 10.1371/journal.pone.0041499
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- Article
The IkappaB Kinase Family Phosphorylates the Parkinson's Disease Kinase LRRK2 at Ser935 and Ser910 during Toll-Like Receptor Signaling.
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- PLoS ONE, 2012, v. 7, n. 6, p. 1, doi. 10.1371/journal.pone.0039132
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- Article
ALS2/Alsin Knockout Mice and Motor Neuron Diseases.
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- Neurodegenerative Diseases, 2008, v. 5, n. 6, p. 359, doi. 10.1159/000151295
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- Article
Non-neuronal and neuronal BACE1 elevation in association with angiopathic and leptomeningeal β-amyloid deposition in the human brain
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- BMC Neurology, 2015, v. 15, n. 1, p. 71, doi. 10.1186/s12883-015-0327-z
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- Article
Non-neuronal and neuronal BACE1 elevation in association with angiopathic and leptomeningeal β-amyloid deposition in the human brain.
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- BMC Neurology, 2015, v. 15, n. 1, p. 1, doi. 10.1186/s12883-015-0327-z
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- Article
Phosphorylation of Ezrin/Radixin/Moesin Proteins by LRRK2 Promotes the Rearrangement of Actin Cytoskeleton in Neuronal Morphogenesis.
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- Journal of Neuroscience, 2009, v. 29, n. 44, p. 13971, doi. 10.1523/JNEUROSCI.3799-09.2009
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- Article
The Chaperone Activity of Heat Shock Protein 90 Is Critical for Maintaining the Stability of Leucine-Rich Repeat Kinase 2.
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- Journal of Neuroscience, 2008, v. 28, n. 13, p. 3384, doi. 10.1523/JNEUROSCI.0185-08.2008
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- Article
The G59S Mutation in p150<sup>glued</sup> Causes Dysfunction of Dynactin in Mice.
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- Journal of Neuroscience, 2007, v. 27, n. 51, p. 13982, doi. 10.1523/JNEUROSCI.4226-07.2007
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- Article
Amyotrophic Lateral Sclerosis 2-Deficiency Leads to Neuronal Degeneration in Amyotrophic Lateral Sclerosis through Altered AMPA Receptor Trafficking.
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- Journal of Neuroscience, 2006, v. 26, n. 45, p. 29, doi. 10.1523/JNEUROSCI.2084-06.2006
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- Article
BACE1, a Major Determinant of Selective Vulnerability of the Brain to Amyloid-β Amyloidogenesis, is Essential for Cognitive, Emotional, and Synaptic Functions.
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- Journal of Neuroscience, 2005, v. 25, n. 50, p. 11693, doi. 10.1523/JNEUROSCI.2766-05.2005
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- Article
Loss of ALS2 Function Is Insufficient to Trigger Motor Neuron Degeneration in Knock-Out Mice But Predisposes Neurons to Oxidative Stress.
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- Journal of Neuroscience, 2005, v. 25, n. 33, p. 7567, doi. 10.1523/JNEUROSCI.1645-05.2005
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- Article
Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi export.
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- EMBO Journal, 2014, v. 33, n. 20, p. 2314, doi. 10.15252/embj.201487807
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- Article
DJ-1 is Essential for Long-Term Depression at Hippocampal CA1 Synapses.
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- NeuroMolecular Medicine, 2008, v. 10, n. 1, p. 40, doi. 10.1007/s12017-008-8023-4
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- Article
Tau knockout exacerbates degeneration of parvalbumin-positive neurons in substantia nigra pars reticulata in Parkinson's disease-related α-synuclein A53T mice.
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- FASEB Journal, 2020, v. 34, n. 9, p. 12239, doi. 10.1096/fj.202000017RR
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- Article
Tau haploinsufficiency causes prenatal loss of dopaminergic neurons in the ventral tegmental area and reduction of transcription factor orthodenticle homeobox 2 expression.
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- FASEB Journal, 2017, v. 31, n. 8, p. 3349, doi. 10.1096/fj.201601303R
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- Article
The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease.
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- Nature Immunology, 2011, v. 12, n. 11, p. 1063, doi. 10.1038/ni.2113
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- Article
Deficiency of Perry syndrome-associated p150<sup>Glued</sup> in midbrain dopaminergic neurons leads to progressive neurodegeneration and endoplasmic reticulum abnormalities.
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- NPJ Parkinson's Disease, 2023, v. 9, n. 1, p. 1, doi. 10.1038/s41531-023-00478-0
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- Article
Autophagy in neurodegenerative diseases: pathogenesis and therapy.
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- Brain Pathology, 2018, v. 28, n. 1, p. 3, doi. 10.1111/bpa.12545
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- Article
Mitochondrial respiratory inhibition and oxidative stress elevate β-secretase (BACE1) proteins and activity in vivo in the rat retina.
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- Experimental Brain Research, 2007, v. 181, n. 3, p. 435, doi. 10.1007/s00221-007-0943-y
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- Article
LRRK2 modulates microglial activity through regulation of chemokine (C-X3-C) receptor 1 -mediated signalling pathways.
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- Human Molecular Genetics, 2016, v. 25, n. 16, p. 3515, doi. 10.1093/hmg/ddw194
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- Article
NEDD4-mediated HSF1 degradation underlies α-synucleinopathy.
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- Human Molecular Genetics, 2016, v. 25, n. 2, p. 211, doi. 10.1093/hmg/ddv445
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- Article
Selective expression of Parkinson's disease-related Leucine-rich repeat kinase 2 G2019Smissensemutation in midbrain dopaminergic neurons impairs dopamine release and dopaminergic gene expression.
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- Human Molecular Genetics, 2015, v. 24, n. 18, p. 5299, doi. 10.1093/hmg/ddv249
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- Article
A calcineurin- and NFAT-dependent pathway is involved in α-synuclein-induced degeneration of midbrain dopaminergic neurons.
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- Human Molecular Genetics, 2014, v. 23, n. 24, p. 6567, doi. 10.1093/hmg/ddu377
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- Article
Amyotrophic lateral sclerosis-related VAPB P56S mutation differentially affects the function and survival of corticospinal and spinal motor neurons.
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- Human Molecular Genetics, 2014, v. 23, n. 11, p. 3069, doi. 10.1093/hmg/ddu098
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- Article
Amyotrophic lateral sclerosis-related VAPB P56S mutation differentially affects the function and survival of corticospinal and spinal motor neurons.
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- Human Molecular Genetics, 2013, v. 22, n. 21, p. 4293, doi. 10.1093/hmg/ddt279
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- Article
MicroRNA-205 regulates the expression of Parkinson's disease-related leucine-rich repeat kinase 2 protein.
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- Human Molecular Genetics, 2013, v. 22, n. 3, p. 608, doi. 10.1093/hmg/dds470
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- Article
The essential role of transcription factor Pitx3 in preventing mesodiencephalic dopaminergic neurodegeneration and maintaining neuronal subtype identities during aging.
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- Cell Death & Disease, 2021, v. 12, n. 11, p. 1, doi. 10.1038/s41419-021-04319-x
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- Article
Astrocytic expression of Parkinson's disease-related A53T α-synuclein causes neurodegeneration in mice.
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- Molecular Brain, 2010, v. 3, p. 12, doi. 10.1186/1756-6606-3-12
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- Article
α-Synuclein Negatively Regulates Nurr1 Expression Through NF-κB-Related Mechanism.
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- Frontiers in Molecular Neuroscience, 2020, v. 13, p. 1, doi. 10.3389/fnmol.2020.00064
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- Article
Corrigendum: LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity.
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- Nature Neuroscience, 2014, v. 17, n. 9, p. 1287, doi. 10.1038/nn0914-1287b
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- Article
Corrigendum: LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity.
- Published in:
- Nature Neuroscience, 2014, v. 17, n. 9, p. 1287, doi. 10.1038/nn0914-1287c
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- Article