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Tumour-on-chip microfluidic platform for assessment of drug pharmacokinetics and treatment response.
Published in:
Communications Biology, 2021, v. 4, n. 1, p. 1, doi. 10.1038/s42003-021-02526-y
By:
- Petreus, Tudor;
- Cadogan, Elaine;
- Hughes, Gareth;
- Smith, Aaron;
- Pilla Reddy, Venkatesh;
- Lau, Alan;
- O'Connor, Mark James;
- Critchlow, Susan;
- Ashford, Marianne;
- Oplustil O'Connor, Lenka
Publication type:
Article
Targeting the kinase activities of ATR and ATM exhibits antitumoral activity in mouse models of MLL-rearranged AML.
Published in:
Science Signaling, 2016, v. 9, n. 445, p. 1, doi. 10.1126/scisignal.aad8243
By:
- Morgado-Palacin, Isabel;
- Day, Amanda;
- Murga, Matilde;
- Lafarga, Vanesa;
- Anton, Marta Elena;
- Tubbs, Anthony;
- Hua-Tang Chen;
- Ergan, Aysegul;
- Anderson, Rhonda;
- Bhandoola, Avinash;
- Pike, Kurt G.;
- Barlaam, Bernard;
- Cadogan, Elaine;
- Xi Wang;
- Pierce, Andrew J.;
- Hubbard, Chad;
- Armstrong, Scott A.;
- Nussenzweig, André;
- Fernandez-Capetillo, Oscar
Publication type:
Article
Type 2 nitric oxide synthase and protein nitration in chronic lung infection.
Published in:
Journal of Pathology, 2003, v. 199, n. 1, p. 122, doi. 10.1002/path.1256
By:
- Hopkins, Natalie;
- Cadogan, Elaine;
- Giles, Shay;
- Bannigan, John;
- McLoughlin, Paul
Publication type:
Article
Pharmacologic ATM but not ATR kinase inhibition abrogates p21-dependent G1 arrest and promotes gastrointestinal syndrome after total body irradiation.
Published in:
Scientific Reports, 2017, p. 41892, doi. 10.1038/srep41892
By:
- Vendetti, Frank P.;
- Leibowitz, Brian J.;
- Barnes, Jennifer;
- Schamus, Sandy;
- Kiesel, Brian F.;
- Abberbock, Shira;
- Conrads, Thomas;
- Clump, David Andy;
- Cadogan, Elaine;
- O'Connor, Mark J.;
- Yu, Jian;
- Beumer, Jan H.;
- Bakkenist, Christopher J.
Publication type:
Article
Relevance of ATM Status in Driving Sensitivity to DNA Damage Response Inhibitors in Patient-Derived Xenograft Models.
Published in:
Cancers, 2023, v. 15, n. 16, p. 4195, doi. 10.3390/cancers15164195
By:
- Karmokar, Ankur;
- Sargeant, Rebecca;
- Hughes, Adina M.;
- Baakza, Hana;
- Wilson, Zena;
- Talbot, Sara;
- Bloomfield, Sarah;
- Leo, Elisabetta;
- Jones, Gemma N.;
- Likhatcheva, Maria;
- Tobalina, Luis;
- Dean, Emma;
- Cadogan, Elaine B.;
- Lau, Alan
Publication type:
Article
A microfluidic system that replicates pharmacokinetic (PK) profiles in vitro improves prediction of in vivo efficacy in preclinical models.
Published in:
PLoS Biology, 2022, v. 20, n. 5, p. 1, doi. 10.1371/journal.pbio.3001624
By:
- Singh, Dharaminder;
- Deosarkar, Sudhir P.;
- Cadogan, Elaine;
- Flemington, Vikki;
- Bray, Alysha;
- Zhang, Jingwen;
- Reiserer, Ronald S.;
- Schaffer, David K.;
- Gerken, Gregory B.;
- Britt, Clayton M.;
- Werner, Erik M.;
- Gibbons, Francis D.;
- Kostrzewski, Tomasz;
- Chambers, Christopher E.;
- Davies, Emma J.;
- Montoya, Antonio Ramos;
- Fok, Jacqueline H. L.;
- Hughes, David;
- Fabre, Kristin;
- Wagoner, Matthew P.
Publication type:
Article
Aurora kinase inhibitor nanoparticles target tumors with favorable therapeutic index in vivo.
Published in:
Science Translational Medicine, 2016, v. 8, n. 325, p. 1, doi. 10.1126/scitranslmed.aad2355
By:
- Ashton, Susan;
- Young Ho Song;
- Nolan, Jim;
- Cadogan, Elaine;
- Murray, Jim;
- Odedra, Rajesh;
- Foster, John;
- Hall, Peter A.;
- Low, Susan;
- Taylor, Paula;
- Ellston, Rebecca;
- Polanska, Urszula M.;
- Wilson, Joanne;
- Howes, Colin;
- Smith, Aaron;
- Goodwin, Richard J. A.;
- Swales, John G.;
- Strittmatter, Nicole;
- Takáts, Zoltán;
- Nilsson, Anna
Publication type:
Article
pRAD50: a novel and clinically applicable pharmacodynamic biomarker of both ATM and ATR inhibition identified using mass spectrometry and immunohistochemistry.
Published in:
2018
By:
- Jones, Gemma N.;
- Rooney, Claire;
- Griffin, Nicola;
- Roudier, Martine;
- Young, Lucy A.;
- Garcia-Trinidad, Antonio;
- Hughes, Gareth D.;
- Whiteaker, Jeffrey R.;
- Wilson, Zena;
- Odedra, Rajesh;
- Zhao, Lei;
- Ivey, Richard G.;
- Howat, William J.;
- Harrington, Elizabeth A.;
- Barrett, J. Carl;
- Ramos-Montoya, Antonio;
- Lau, Alan;
- Paulovich, Amanda G.;
- Cadogan, Elaine B.;
- Pierce, Andrew J.
Publication type:
journal article
Late Intervention with a Myeloperoxidase Inhibitor Stops Progression of Experimental Chronic Obstructive Pulmonary Disease.
Published in:
American Journal of Respiratory & Critical Care Medicine, 2012, v. 185, n. 1, p. 34, doi. 10.1164/rccm.201103-0468OC
By:
- Churg, Andrew;
- Marshall, Caroline V.;
- Sin, Don D.;
- Bolton, Sarah;
- Zhou, Steven;
- Thain, Katherine;
- Cadogan, Elaine B.;
- Maltby, Justine;
- Soars, Matthew G.;
- Mallinder, Philip R.;
- Wright, Joanne L.
Publication type:
Article
Mixed effects modeling of radiotherapy in combination with immune checkpoint blockade or inhibitors of the DNA damage response pathway.
Published in:
CPT: Pharmacometrics & Systems Pharmacology, 2023, v. 12, n. 11, p. 1640, doi. 10.1002/psp4.13026
By:
- Hodson, David;
- Mistry, Hitesh;
- Guzzetti, Sofia;
- Davies, Michael;
- Staniszewska, Anna;
- Farrington, Paul;
- Cadogan, Elaine;
- Yates, James;
- Aarons, Leon;
- Ogungbenro, Kayode
Publication type:
Article
Complete loss of ATM function augments replication catastrophe induced by ATR inhibition and gemcitabine in pancreatic cancer models.
Published in:
2020
By:
- Dunlop, Charles R.;
- Wallez, Yann;
- Johnson, Timothy Isaac;
- Bernaldo de Quirós Fernández, Sandra;
- Durant, Stephen T.;
- Cadogan, Elaine B.;
- Lau, Alan;
- Richards, Frances M.;
- Jodrell, Duncan I.
Publication type:
journal article
ATM kinase inhibitor AZD0156 in combination with irinotecan and 5-fluorouracil in preclinical models of colorectal cancer.
Published in:
2022
By:
- Davis, S. Lindsey;
- Hartman, Sarah J.;
- Bagby, Stacey M.;
- Schlaepfer, Marina;
- Yacob, Betelehem W.;
- Tse, Tonia;
- Simmons, Dennis M.;
- Diamond, Jennifer R.;
- Lieu, Christopher H.;
- Leal, Alexis D.;
- Cadogan, Elaine B.;
- Hughes, Gareth D.;
- Durant, Stephen T.;
- Messersmith, Wells A.;
- Pitts, Todd M.
Publication type:
journal article
ALT neuroblastoma chemoresistance due to telomere dysfunction–induced ATM activation is reversible with ATM inhibitor AZD0156.
Published in:
Science Translational Medicine, 2021, v. 13, n. 607, p. 1, doi. 10.1126/scitranslmed.abd5750
By:
- Koneru, Balakrishna;
- Farooqi, Ahsan;
- Nguyen, Thinh H.;
- Chen, Wan Hsi;
- Hindle, Ashly;
- Eslinger, Cody;
- Makena, Monish Ram;
- Burrow, Trevor A.;
- Wilson, Joanne;
- Smith, Aaron;
- Pilla Reddy, Venkatesh;
- Cadogan, Elaine;
- Durant, Stephen T.;
- Reynolds, C. Patrick
Publication type:
Article

Found: 13