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RRx-001 protects normal tissues but not tumors via Nrf2 induction and Bcl-2 inhibition.
- Published in:
- Journal of Cancer Research & Clinical Oncology, 2019, v. 145, n. 8, p. 2045, doi. 10.1007/s00432-019-02958-4
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- Article
RRx-001 protects against cisplatin-induced toxicities.
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- Journal of Cancer Research & Clinical Oncology, 2017, v. 143, n. 9, p. 1671, doi. 10.1007/s00432-017-2416-4
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- Article
Replacing the Transfusion of 1-2 Units of Blood with Plasma Expanders that Increase Oxygen Delivery Capacity: Evidence from Experimental Studies.
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- Journal of Functional Biomaterials, 2014, v. 5, n. 4, p. 232, doi. 10.3390/jfb5040232
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- Article
The direct NLRP3 inhibitor and Phase 3 small molecule anticancer agent, RRx‐001, protects aged triple transgenic Alzheimer's disease model mice from CNS degeneration and cognitive decline.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 10, p. 1, doi. 10.1002/alz.061516
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- Article
Modelo de hemodilución normovolémica extrema en porcinos conscientes para evaluar soluciones de reanimación.
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- Revista de Ingeniería, 2012, n. 36, p. 25, doi. 10.16924/revinge.36.3
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- Article
RRx-001 Increases Erythrocyte Preferential Adhesion to the Tumor Vasculature.
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- International Journal of Molecular Sciences, 2021, v. 22, n. 9, p. 4713, doi. 10.3390/ijms22094713
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- Article
Transport of nitric oxide by perfluorocarbon emulsion.
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- Biotechnology Progress, 2013, v. 29, n. 6, p. 1565, doi. 10.1002/btpr.1797
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- Article
Hemorheological implications of perfluorocarbon based oxygen carrier interaction with colloid plasma expanders and blood.
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- Biotechnology Progress, 2013, v. 29, n. 3, p. 796, doi. 10.1002/btpr.1724
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- Article
Synthesis, biophysical properties, and oxygenation potential of variable molecular weight glutaraldehyde-polymerized bovine hemoglobins with low and high oxygen affinity.
- Published in:
- Biotechnology Progress, 2011, v. 27, n. 4, p. 1172, doi. 10.1002/btpr.624
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- Article
Synthesis and biophysical properties of polymerized human serum albumin.
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- Biotechnology Progress, 2011, v. 27, n. 1, p. 290, doi. 10.1002/btpr.531
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- Article
GBT440 improves red blood cell deformability and reduces viscosity of sickle cell blood under deoxygenated conditions.
- Published in:
- Clinical Hemorheology & Microcirculation, 2018, v. 70, n. 1, p. 95, doi. 10.3233/CH-170340
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- Article
Rat red blood cell storage lesions in various additive solutions.
- Published in:
- Clinical Hemorheology & Microcirculation, 2017, v. 67, n. 1, p. 45, doi. 10.3233/CH-170248
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- Article
Nonlinear cardiovascular regulation consequent to changes in blood viscosity.
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- Clinical Hemorheology & Microcirculation, 2011, v. 49, n. 1-4, p. 29
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- Article
Blood pressure directly correlates with blood viscosity in diabetes type 1 children but not in normals.
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- Clinical Hemorheology & Microcirculation, 2010, v. 44, n. 1, p. 55, doi. 10.3233/CH-2010-1252
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- Article
Increased hematocrit and reduced blood pressure following control of glycemia in diabetes.
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- Clinical Hemorheology & Microcirculation, 2008, v. 38, n. 1, p. 67
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- Publication type:
- Article
Application of negative tissue interstitial pressure improves functional capillary density after hemorrhagic shock in the absence of volume resuscitation.
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- Physiological Reports, 2021, v. 9, n. 5, p. 1, doi. 10.14814/phy2.14783
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- Article
Safety and efficacy of human polymerized hemoglobin on guinea pig resuscitation from hemorrhagic shock.
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- Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-23926-y
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- Article
RRx-001: a chimeric triple action NLRP3 inhibitor, Nrf2 inducer, and nitric oxide superagonist.
- Published in:
- Frontiers in Oncology, 2023, p. 1, doi. 10.3389/fonc.2023.1204143
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- Article
Influence of serological factors and BMI on the blood pressure/hematocrit association in healthy young men and women.
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- 2014
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- Publication type:
- journal article
Influence of serological factors and BMI on the blood pressure/hematocrit association in healthy young men and women.
- Published in:
- Vascular Health & Risk Management, 2014, v. 10, p. 271, doi. 10.2147/VHRM.S60130
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- Article
Nonobese, exercising children diagnosed with dyslipidemia have normal C-reactive protein.
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- 2009
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- Publication type:
- journal article
Hematocrit and mean arterial blood pressure in pre- and postmenopause women.
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- 2009
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- Publication type:
- journal article
Hematocrit and mean arterial blood pressure in pre- and postmenopause women.
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- Vascular Health & Risk Management, 2009, v. 5, p. 483
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- Publication type:
- Article
Nonobese, exercising children diagnosed with dyslipidemia have normal C-reactive protein.
- Published in:
- Vascular Health & Risk Management, 2009, v. 5, p. 65
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- Publication type:
- Article
Blood pressure reduction due to hemoglobin glycosylation in type 2 diabetic patients.
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- 2008
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- Publication type:
- journal article
Blood pressure reduction due to hemoglobin glycosylation in type 2 diabetic patients.
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- Vascular Health & Risk Management, 2008, v. 4, n. 4, p. 917
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- Publication type:
- Article
GBT021601 improves red blood cell health and the pathophysiology of sickle cell disease in a murine model.
- Published in:
- British Journal of Haematology, 2023, v. 202, n. 1, p. 173, doi. 10.1111/bjh.18771
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- Article
RRx-001, A novel dinitroazetidine radiosensitizer.
- Published in:
- Investigational New Drugs, 2016, v. 34, n. 3, p. 371, doi. 10.1007/s10637-016-0326-y
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- Publication type:
- Article
A Review of RRx-001: A Late-Stage Multi-Indication Inhibitor of NLRP3 Activation and Chronic Inflammation.
- Published in:
- Drugs, 2023, v. 83, n. 5, p. 389, doi. 10.1007/s40265-023-01838-z
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- Publication type:
- Article
Nitric Oxide Protection Against Murine Cerebral Malaria Is Associated With Improved Cerebral Microcirculatory Physiology.
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- Journal of Infectious Diseases, 2011, v. 203, n. 10, p. 1454, doi. 10.1093/infdis/jir058
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- Publication type:
- Article
Conversion of Platinum-Etoposide-Resistant to Sensitive SCLC after Treatment with the Epi-Immunotherapeutic RRx-001: A Case Report.
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- Oncology Research & Treatment, 2016, v. 39, n. 11, p. 720, doi. 10.1159/000449432
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- Publication type:
- Article
Turning on the Radio: Epigenetic Inhibitors as Potential Radiopriming Agents.
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- Biomolecules (2218-273X), 2016, v. 6, n. 3, p. 32, doi. 10.3390/biom6030032
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- Article
Microvascular perfusion upon exchange transfusion with stored red blood cells in normovolemic anemic conditions.
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- 2004
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- Publication type:
- journal article
Modulation of Perfusion and Oxygenation by Red Blood Cell Oxygen Affinity during Acute Anemia.
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- American Journal of Respiratory Cell & Molecular Biology, 2008, v. 38, n. 3, p. 354, doi. 10.1165/rcmb.2007-0292OC
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- Publication type:
- Article
Lowering of Blood Pressure by Increasing Hematocrit with Non-Nitric Oxide--Scavenging Red Blood Cells.
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- American Journal of Respiratory Cell & Molecular Biology, 2008, v. 38, n. 2, p. 135, doi. 10.1165/rcmb.2007-0081OC
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- Publication type:
- Article
Exogenous nitric oxide decreases brain vascular inflammation, leakage and venular resistance during Plasmodium berghei ANKA infection in mice.
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- Journal of Neuroinflammation, 2011, v. 8, n. 1, p. 66, doi. 10.1186/1742-2094-8-66
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- Publication type:
- Article
Phase 1 pilot study of RRx-001 + nivolumab in patients with advanced metastatic cancer (PRIMETIME).
- Published in:
- Frontiers in Immunology, 2023, v. 14, p. 01, doi. 10.3389/fimmu.2023.1104753
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- Article
Platelet inhibitory effects of the Phase 3 anticancer and normal tissue cytoprotective agent, RRx‐001.
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- Journal of Cellular & Molecular Medicine, 2018, v. 22, n. 10, p. 5076, doi. 10.1111/jcmm.13791
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- Article
Impact of hemoglobin nitrite to nitric oxide reductase on blood transfusion for resuscitation from hemorrhagic shock.
- Published in:
- Asian Journal of Transfusion Science, 2015, v. 9, n. 1, p. 55, doi. 10.4103/0973-6247.150952
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- Article
Effects of plasma viscosity modulation on cardiac function during moderate hemodilution.
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- Asian Journal of Transfusion Science, 2010, v. 4, n. 2, p. 102, doi. 10.4103/0973-6247.67034
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- Publication type:
- Article
Safety profile and efficacy of low and high oxygen affinity polymerized human hemoglobin in trauma model.
- Published in:
- FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.R4206
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- Publication type:
- Article
Drag Reducing Polymers Improves Microvascular Perfusion After Extracorporeal Circulation.
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- FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.R6230
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- Publication type:
- Article
Apohemoglobin‐haptoglobin (Apohb‐Hp) Complex as a Vasculo‐protective Agent in Hypoxia Induced Vaso‐occlusion in Sickle Cell Disease.
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- FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.R6339
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- Publication type:
- Article
Human polymerized hemoglobin as an alternative to blood in resuscitation from hemorrhagic shock.
- Published in:
- FASEB Journal, 2021, v. 35, p. N.PAG, doi. 10.1096/fasebj.2021.35.S1.05273
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- Publication type:
- Article
Quantifying the Reduction in Microcirculation Perfusion After Extracorporeal Circulation.
- Published in:
- FASEB Journal, 2021, v. 35, p. N.PAG, doi. 10.1096/fasebj.2021.35.S1.05477
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- Article
Hemorrhagic shock resuscitation using a polymerized hemoglobin oxygen carrier versus whole blood (707.5).
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- FASEB Journal, 2014, v. 28, p. N.PAG, doi. 10.1096/fasebj.28.1_supplement.707.5
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- Publication type:
- Article
Quantification of microvascular hemodynamic using cross correlation analysis of intravital microscopy videos (678.11).
- Published in:
- FASEB Journal, 2014, v. 28, p. N.PAG, doi. 10.1096/fasebj.28.1_supplement.678.11
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- Publication type:
- Article
Difference between hemoglobin‐based oxygen carrier and non‐oxygen carrying plasma expander on cardiac function during hemorrhagic shock resuscitation (545.1).
- Published in:
- FASEB Journal, 2014, v. 28, p. N.PAG, doi. 10.1096/fasebj.28.1_supplement.545.1
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- Publication type:
- Article
Notch-independent RBPJ controls angiogenesis in the adult heart.
- Published in:
- Nature Communications, 2016, v. 7, n. 6, p. 12088, doi. 10.1038/ncomms12088
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- Article
Nitric Oxide Synthase Dysfunction Contributes to Impaired Cerebroarteriolar Reactivity in Experimental Cerebral Malaria.
- Published in:
- PLoS Pathogens, 2013, v. 9, n. 6, p. 1, doi. 10.1371/journal.ppat.1003444
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- Publication type:
- Article