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Impact of Large Granular Lymphocyte Leukemia on Blood DNA Methylation and Epigenetic Clock Modeling in Fischer 344 Rats.
Published in:
2022
By:
- Finesso, Giovanni E;
- McDevitt, Ross A;
- Roy, Roshni;
- Brinster, Lauren R;
- Francesco, Andrea Di;
- Meade, Theresa;
- Cabo, Rafael de;
- Ferrucci, Luigi;
- Perdue, Kathy A;
- Di Francesco, Andrea;
- de Cabo, Rafael
Publication type:
journal article
Polypharmacy Results in Functional Impairment in Mice: Novel Insights Into Age and Sex Interactions.
Published in:
2021
By:
- Wu, Harry;
- Mach, John;
- Gemikonakli, Gizem;
- Tran, Trang;
- Allore, Heather;
- Gnjidic, Danijela;
- Howlett, Susan E;
- Cabo, Rafael de;
- Couteur, David G Le;
- Hilmer, Sarah N;
- de Cabo, Rafael;
- Le Couteur, David G
Publication type:
journal article
Chronic Polypharmacy with Increasing Drug Burden Index Exacerbates Frailty and Impairs Physical Function, with Effects Attenuated by Deprescribing, in Aged Mice.
Published in:
2021
By:
- Mach, John;
- Gemikonakli, Gizem;
- Logan, Caitlin;
- Wyk, Brent Vander;
- Allore, Heather;
- Ekambareshwar, Swathi;
- Kane, Alice E;
- Howlett, Susan E;
- Cabo, Rafael de;
- Couteur, David G Le;
- Hilmer, Sarah N;
- Vander Wyk, Brent;
- de Cabo, Rafael;
- Le Couteur, David G
Publication type:
journal article
Study of Longitudinal Aging in Mice: Presentation of Experimental Techniques.
Published in:
2021
By:
- Palliyaguru, Dushani L;
- Teixeira, Camila Vieira Ligo;
- Duregon, Eleonora;
- Germanio, Clara di;
- Alfaras, Irene;
- Mitchell, Sarah J;
- Navas-Enamorado, Ignacio;
- Shiroma, Eric J;
- Studenski, Stephanie;
- Bernier, Michel;
- Camandola, Simonetta;
- Price, Nathan L;
- Ferrucci, Luigi;
- Cabo, Rafael de;
- Vieira Ligo Teixeira, Camila;
- di Germanio, Clara;
- de Cabo, Rafael
Publication type:
journal article
Combining a High Dose of Metformin With the SIRT1 Activator, SRT1720, Reduces Life Span in Aged Mice Fed a High-Fat Diet.
Published in:
2020
By:
- Palliyaguru, Dushani L;
- Minor, Robin K;
- Mitchell, Sarah J;
- Palacios, Hector H;
- Licata, Jordan J;
- Ward, Theresa M;
- Abulwerdi, Gelareh;
- Elliott, Peter;
- Westphal, Christoph;
- Ellis, James L;
- Sinclair, David A;
- Price, Nathan L;
- Bernier, Michel;
- Cabo, Rafael de;
- Palacio, Hector H;
- de Cabo, Rafael
Publication type:
journal article
A Glance Back at the Journal of Gerontology-Coffee, Dietary Interventions and Life Span.
Published in:
2020
By:
- Duregon, Eleonora;
- Bernier, Michel;
- Cabo, Rafael de;
- de Cabo, Rafael
Publication type:
journal article
Of Aging Mice and Men: Gait Speed Decline Is a Translatable Trait, With Species-Specific Underlying Properties.
Published in:
2019
By:
- Bair, Woei-Nan;
- Petr, Michael;
- Alfaras, Irene;
- Mitchell, Sarah J;
- Bernier, Michel;
- Ferrucci, Luigi;
- Studenski, Stephanie A;
- Cabo, Rafael De;
- de Cabo, Rafael
Publication type:
journal article
The Impact of Aging, Calorie Restriction and Dietary Fat on Autophagy Markers and Mitochondrial Ultrastructure and Dynamics in Mouse Skeletal Muscle.
Published in:
2019
By:
- Gutiérrez-Casado, Elena;
- López-Domínguez, José A;
- Montero-Guisado, Jesús;
- González-Reyes, José A;
- Villalba, José M;
- Khraiwesh, Husam;
- López-Lluch, Guillermo;
- Navas, Plácido;
- Cabo, Rafael de;
- Ramsey, Jon J;
- de Cabo, Rafael
Publication type:
journal article
Corrigendum to: The Effect of Aging on Acetaminophen Pharmacokinetics, Toxicity and Nrf2 in Fischer 344 Rats.
Published in:
2019
By:
- Mach, John;
- Huizer-Pajkos, Aniko;
- Cogger, Victoria C;
- McKenzie, Catriona;
- Couteur, David G Le;
- Jones, Brett E;
- Cabo, Rafael de;
- Hilmer, Sarah N;
- Le Couteur, David G;
- de Cabo, Rafael
Publication type:
journal article
Benefits of Caloric Restriction in Longevity and Chemical-Induced Tumorigenesis Are Transmitted Independent of NQO1.
Published in:
2019
By:
- Diaz-Ruiz, Alberto;
- Francesco, Andrea Di;
- Carboneau, Bethany A;
- Levan, Sophia R;
- Pearson, Kevin J;
- Price, Nathan L;
- Ward, Theresa M;
- Bernier, Michel;
- Cabo, Rafael de;
- Mercken, Evi M;
- Di Francesco, Andrea;
- de Cabo, Rafael
Publication type:
journal article
Long-term Dietary Macronutrients and Hepatic Gene Expression in Aging Mice.
Published in:
2018
By:
- Gokarn, Rahul;
- Solon-Biet, Samantha M;
- Cogger, Victoria C;
- Cooney, Gregory J;
- Wahl, Devin;
- McMahon, Aisling C;
- Mitchell, James R;
- Mitchell, Sarah J;
- Hine, Christopher;
- Cabo, Rafael de;
- de Cabo, Rafael;
- Raubenheimer, David;
- Simpson, Stephen J;
- Le Couteur, David G
Publication type:
journal article
Breaking the Ceiling of Human Maximal Life span.
Published in:
2018
By:
- Ben-Haim, Moshe Shay;
- Kanfi, Yariv;
- Mitchell, Sarah J;
- Maoz, Noam;
- Vaughan, Kelli L;
- Amariglio, Ninette;
- Lerrer, Batia;
- Cabo, Rafael de;
- Rechavi, Gideon;
- Cohen, Haim Y;
- de Cabo, Rafael
Publication type:
journal article
Sex and Aging.
Published in:
2018
By:
- Le Couteur, David G.;
- Anderson, Rozalyn M.;
- Cabo, Rafael de;
- de Cabo, Rafael
Publication type:
journal article
Are sirtuins viable targets for improving healthspan and lifespan?
Published in:
Nature Reviews Drug Discovery, 2012, v. 11, n. 6, p. 443, doi. 10.1038/nrd3738
By:
- Baur, Joseph A.;
- Ungvari, Zoltan;
- Minor, Robin K.;
- Le Couteur, David G.;
- de Cabo, Rafael
Publication type:
Article
Drugs Targeting Mechanisms of Aging to Delay Age-Related Disease and Promote Healthspan: Proceedings of a National Institute on Aging Workshop.
Published in:
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2023, v. 78, p. 53, doi. 10.1093/gerona/glad034
By:
- Espinoza, Sara E;
- Khosla, Sundeep;
- Baur, Joseph A;
- Cabo, Rafael de;
- Musi, Nicolas
Publication type:
Article
Serum Concentrations of Losartan Metabolites Correlate With Improved Physical Function in a Pilot Study of Prefrail Older Adults.
Published in:
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2022, v. 77, n. 12, p. 2356, doi. 10.1093/gerona/glac102
By:
- Lee, Jessica L;
- Zhang, Cissy;
- Westbrook, Reyhan;
- Gabrawy, Mariann M;
- Nidadavolu, Lolita;
- Yang, Huanle;
- Marx, Ruth;
- Wu, Yuqiong;
- Anders, Nicole M;
- Ma, Lina;
- Bichara, Marcela-Dávalos;
- Kwak, Min-Ji;
- Buta, Brian;
- Khadeer, Mohammed;
- Yenokyan, Gayane;
- Tian, Jing;
- Xue, Qian-Li;
- Siragy, Helmy M;
- Carey, Robert M;
- Cabo, Rafael de
Publication type:
Article
Chronic Polypharmacy with Increasing Drug Burden Index Exacerbates Frailty and Impairs Physical Function, with Effects Attenuated by Deprescribing, in Aged Mice.
Published in:
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2021, v. 76, n. 6, p. 1010, doi. 10.1093/gerona/glaa060
By:
- Mach, John;
- Gemikonakli, Gizem;
- Logan, Caitlin;
- Wyk, Brent Vander;
- Allore, Heather;
- Ekambareshwar, Swathi;
- Kane, Alice E;
- Howlett, Susan E;
- Cabo, Rafael de;
- Couteur, David G Le;
- Hilmer, Sarah N
Publication type:
Article
Intermittent mTOR Inhibition Reverses Kidney Aging in Old Rats.
Published in:
2018
By:
- Di Francesco, Andrea;
- Diaz-Ruiz, Alberto;
- de Cabo, Rafael;
- Bernier, Michel
Publication type:
Editorial
Nrf2 Deficiency Exacerbates Obesity-Induced Oxidative Stress, Neurovascular Dysfunction, Blood-Brain Barrier Disruption, Neuroinflammation, Amyloidogenic Gene Expression, and Cognitive Decline in Mice, Mimicking the Aging Phenotype.
Published in:
2018
By:
- Tarantini, Stefano;
- Valcarcel-Ares, M. Noa;
- Yabluchanskiy, Andriy;
- Tucsek, Zsuzsanna;
- Hertelendy, Peter;
- Kiss, Tamas;
- Gautam, Tripti;
- Zhang, Xin A.;
- Sonntag, William E.;
- de Cabo, Rafael;
- Farkas, Eszter;
- Elliott, Michael H.;
- Kinter, Michael T.;
- Deak, Ferenc;
- Ungvari, Zoltan;
- Csiszar, Anna
Publication type:
journal article
Caloric Restriction Study Design Limitations in Rodent and Nonhuman Primate Studies.
Published in:
2018
By:
- Vaughan, Kelli L.;
- Kaiser, Tamzin;
- Peaden, Robert;
- Anson, R. Michael;
- de Cabo, Rafael;
- Mattison, Julie A.
Publication type:
journal article
Caloric Restriction Research: New Perspectives on the Biology of Aging.
Published in:
2018
By:
- Anderson, Rozalyn M.;
- Le Couteur, David G.;
- de Cabo, Rafael
Publication type:
journal article
Stem Cell Transplantation for Frailty.
Published in:
2017
By:
- Le Couteur, David G.;
- Anderson, Rozalyn M.;
- Newman, Anne B.;
- de Cabo, Rafael
Publication type:
journal article
A Comparison of Two Mouse Frailty Assessment Tools.
Published in:
2017
By:
- Kane, Alice E.;
- Huizer-Pajkos, Aniko;
- Mach, John;
- Mitchell, Sarah J.;
- de Cabo, Rafael;
- Le Couteur, David G.;
- Howlett, Susan E.;
- Hilmer, Sarah N.
Publication type:
journal article
SIRT1 Polymorphisms and Serum-Induced SIRT1 Protein Expression in Aging and Frailty: The CHAMP Study.
Published in:
2017
By:
- Razi, Shajjia;
- Cogger, Victoria C.;
- Kennerson, Marina;
- Benson, Vicky L.;
- McMahon, Aisling C.;
- Fiona M. Blyth, Fiona M. x;
- Handelsman, David J.;
- Seibel, Markus J.;
- Hirani, Vasant;
- Naganathan, Vasikaran;
- Waite, Louise;
- de Cabo, Rafael;
- Cumming, Robert G.;
- Le Couteur, David G.;
- Blyth, Fiona M
Publication type:
journal article
17α-Estradiol: A Novel Therapeutic Intervention to Target Age-related Chronic Inflammation.
Published in:
2017
By:
- Gonzalez-Freire, Marta;
- Diaz-Ruiz, Alberto;
- de Cabo, Rafael
Publication type:
Editorial
Adverse Geriatric Outcomes Secondary to Polypharmacy in a Mouse Model: The Influence of Aging.
Published in:
2016
By:
- Huizer-Pajkos, Aniko;
- Kane, Alice E.;
- Howlett, Susan E.;
- Mach, John;
- Mitchell, Sarah J.;
- de Cabo, Rafael;
- Le Couteur, David G.;
- Hilmer, Sarah N.
Publication type:
journal article
Measures of Healthspan as Indices of Aging in Mice-A Recommendation.
Published in:
2016
By:
- Richardson, Arlan;
- Fischer, Kathleen E.;
- Speakman, John R.;
- de Cabo, Rafael;
- Mitchell, Sarah J.;
- Peterson, Charlotte A.;
- Rabinovitch, Peter;
- Chiao, Ying A.;
- Taffet, George;
- Miller, Richard A.;
- Rentería, René C.;
- Bower, James;
- Ingram, Donald K.;
- Ladiges, Warren C.;
- Yuji Ikeno;
- Sierra, Felipe;
- Austad, Steven N.;
- Ikeno, Yuji
Publication type:
journal article
Impact of Longevity Interventions on a Validated Mouse Clinical Frailty Index.
Published in:
2016
By:
- Kane, Alice E.;
- Hilmer, Sarah N.;
- Boyer, Dawn;
- Gavin, Kristan;
- Nines, Dawn;
- Howlett, Susan E.;
- de Cabo, Rafael;
- Mitchell, Sarah J.
Publication type:
journal article
Reconsidering the Role of Mitochondria in Aging.
Published in:
2015
By:
- Gonzalez-Freire, Marta;
- de Cabo, Rafael;
- Bernier, Michel;
- Sollott, Steven J.;
- Fabbri, Elisa;
- Navas, Placido;
- Ferrucci, Luigi
Publication type:
journal article
Energy - A Hallmark of Physical Function.
Published in:
2015
By:
- Kritchevsky, Stephen B.;
- de Cabo, Rafael
Publication type:
Editorial
Two-Year Trial of Human Caloric Restriction.
Published in:
2015
By:
- Di Francesco, Andrea;
- de Cabo, Rafael
Publication type:
commentary
Factors that Impact on Interrater Reliability of the Mouse Clinical Frailty Index.
Published in:
2015
By:
- Kane, Alice E;
- Hilmer, Sarah N;
- Huizer-Pajkos, Aniko;
- Mach, John;
- Nines, Dawn;
- Boyer, Dawn;
- Gavin, Kristan;
- Mitchell, Sarah J;
- de Cabo, Rafael
Publication type:
commentary
Dietary Fat and Aging Modulate Apoptotic Signaling in Liver of Calorie-Restricted Mice.
Published in:
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2015, v. 70, n. 4, p. 399, doi. 10.1093/gerona/glu045
By:
- López-Domínguez, José Alberto;
- Khraiwesh, Husam;
- González-Reyes, José Antonio;
- López-Lluch, Guillermo;
- Navas, Plácido;
- Ramsey, Jon Jay;
- de Cabo, Rafael;
- Burón, María Isabel;
- Villalba, José Manuel
Publication type:
Article
Are Glycans the Holy Grail for Biomarkers of Aging? (Comment on: Glycans Are a Novel Biomarker of Chronological and Biological Age by Kristic et al.)
Published in:
2014
By:
- Le Couteur, David G;
- Simpson, Stephen J;
- de Cabo, Rafael
Publication type:
Journal Article
Are Glycans the Holy Grail for Biomarkers of Aging? (Comment on: Glycans Are a Novel Biomarker of Chronological and Biological Age by Kristic et al.).
Published in:
2014
By:
- Le Couteur, David G.;
- Simpson, Stephen J.;
- de Cabo, Rafael
Publication type:
Editorial
Age-Related Loss of Responsiveness to 2,5-Dimethoxy-4-Iodoamphetamine in Liver Sinusoidal Endothelial Cells.
Published in:
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2014, v. 69, n. 5, p. 514, doi. 10.1093/gerona/glt124
By:
- Cogger, Victoria C.;
- Mitchell, Sarah J.;
- Warren, Alessandra;
- de Cabo, Rafael;
- Le Couteur, David G.
Publication type:
Article
Longitudinal Analysis of Calorie Restriction on Rat Taste Bud Morphology and Expression of Sweet Taste Modulators.
Published in:
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2014, v. 69, n. 5, p. 532, doi. 10.1093/gerona/glt129
By:
- Cai, Huan;
- Daimon, Caitlin M.;
- Cong, Wei-na;
- Wang, Rui;
- Chirdon, Patrick;
- de Cabo, Rafael;
- Sévigny, Jean;
- Maudsley, Stuart;
- Martin, Bronwen
Publication type:
Article
The Effect of Aging on Acetaminophen Pharmacokinetics, Toxicity and Nrf2 in Fischer 344 Rats.
Published in:
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2014, v. 69, n. 4, p. 387, doi. 10.1093/gerona/glt095
By:
- Mach, John;
- Huizer-Pajkos, Aniko;
- Cogger, Victoria C.;
- McKenzie, Catriona;
- Le Couteur, David G.;
- Jones, Brett E.;
- de Cabo, Rafael;
- Hilmer, Sarah N.
Publication type:
Article
The evolution of research on ageing and nutrition.
Published in:
2014
By:
- Le Couteur, David G;
- Wilder, Shawn M;
- de Cabo, Rafael;
- Simpson, Stephen J
Publication type:
Journal Article
The Evolution of Research on Ageing and Nutrition.
Published in:
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2014, v. 69, n. 1, p. 1, doi. 10.1093/gerona/glt130
By:
- Le Couteur, David G.;
- Wilder, Shawn M.;
- de Cabo, Rafael;
- Simpson, Stephen J.
Publication type:
Article
Alterations of Ultrastructural and Fission/Fusion Markers in Hepatocyte Mitochondria From Mice Following Calorie Restriction With Different Dietary Fats.
Published in:
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2013, v. 68, n. 9, p. 1023, doi. 10.1093/gerona/glt006
By:
- Khraiwesh, Husam;
- López-Domínguez, José A.;
- López-Lluch, Guillermo;
- Navas, Plácido;
- de Cabo, Rafael;
- Ramsey, Jon J.;
- Villalba, José M.;
- González-Reyes, José A.
Publication type:
Article
Sirtuin Activation: A Role for Plasma Membrane in the Cell Growth Puzzle.
Published in:
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2013, v. 68, n. 4, p. 368, doi. 10.1093/gerona/gls184
By:
- Crane, Frederick L.;
- Navas, Plácido;
- Low, Hans;
- Sun, Iris L.;
- de Cabo, Rafael
Publication type:
Article
Evaluation of Resveratrol, Green Tea Extract, Curcumin, Oxaloacetic Acid, and Medium-Chain Triglyceride Oil on Life Span of Genetically Heterogeneous Mice.
Published in:
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2013, v. 68, n. 1, p. 6, doi. 10.1093/gerona/gls070
By:
- Strong, Randy;
- Miller, Richard A.;
- Astle, Clinton M.;
- Baur, Joseph A.;
- de Cabo, Rafael;
- Fernandez, Elizabeth;
- Guo, Wen;
- Javors, Martin;
- Kirkland, James L.;
- Nelson, James F.;
- Sinclair, David A.;
- Teter, Bruce;
- Williams, David;
- Zaveri, Nurulain;
- Nadon, Nancy L.;
- Harrison, David E.
Publication type:
Article
Disruption of Nrf2 Signaling Impairs Angiogenic Capacity of Endothelial Cells: Implications for Microvascular Aging.
Published in:
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2012, v. 67, n. 8, p. 821, doi. 10.1093/gerona/glr229
By:
- Valcarcel-Ares, M. Noa;
- Gautam, Tripti;
- Warrington, Junie P.;
- Bailey-Downs, Lora;
- Sosnowska, Danuta;
- de Cabo, Rafael;
- Losonczy, Gyorgy;
- Sonntag, William E.;
- Ungvari, Zoltan;
- Csiszar, Anna
Publication type:
Article
Aging, Drugs, and Drug Metabolism.
Published in:
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2012, v. 67A, n. 2, p. 137, doi. 10.1093/gerona/glr084
By:
- Le Couteur, David G.;
- McLachlan, Andrew J.;
- de Cabo, Rafael
Publication type:
Article
Aging Biology and Novel Targets for Drug Discovery.
Published in:
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2012, v. 67A, n. 2, p. 168, doi. 10.1093/gerona/glr095
By:
- Le Couteur, David G.;
- McLachlan, Andrew J.;
- Quinn, Ronald J.;
- Simpson, Stephen J.;
- de Cabo, Rafael
Publication type:
Article
Age-Related Pseudocapillarization of the Liver Sinusoidal Endothelium Impairs the Hepatic Clearance of Acetaminophen in Rats.
Published in:
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2011, v. 66A, n. 4, p. 400, doi. 10.1093/gerona/glq221
By:
- Mitchell, Sarah J.;
- Huizer-Pajkos, Aniko;
- Cogger, Victoria C.;
- McLachlan, Andrew J.;
- Le Couteur, David G.;
- Jones, Brett;
- de Cabo, Rafael;
- Hilmer, Sarah N.
Publication type:
Article
Genetic Deletion of Nrf2 Promotes Immortalization and Decreases Life Span of Murine Embryonic Fibroblasts.
Published in:
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2011, v. 66A, n. 3, p. 247, doi. 10.1093/gerona/glq181
By:
- Jódar, Laura;
- Mercken, Evi M.;
- Ariza, Julia;
- Younts, Caitlin;
- González-Reyes, José A.;
- Alcaín, Francisco J.;
- Burón, Isabel;
- de Cabo, Rafael;
- Villalba, José M.
Publication type:
Article
Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice.
Published in:
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2011, v. 66A, n. 2, p. 191, doi. 10.1093/gerona/glq178
By:
- Miller, Richard A.;
- Harrison, David E.;
- Astle, C. M.;
- Baur, Joseph A.;
- Boyd, Angela Rodriguez;
- de Cabo, Rafael;
- Fernandez, Elizabeth;
- Flurkey, Kevin;
- Javors, Martin A.;
- Nelson, James F.;
- Orihuela, Carlos J.;
- Pletcher, Scott;
- Sharp, Zelton Dave;
- Sinclair, David;
- Starnes, Joseph W.;
- Wilkinson, J. Erby;
- Nadon, Nancy L.;
- Strong, Randy
Publication type:
Article
Determinants of serum-induced SIRT1 expression in older men: the CHAMP study.
Published in:
2011
By:
- Le Couteur, David G;
- Benson, Vicky L;
- McMahon, Aisling C;
- Blyth, Fiona;
- Handelsman, David J;
- Seibel, Markus J;
- Kennerson, Marina;
- Naganathan, Vasi;
- Cumming, Robert G;
- de Cabo, Rafael
Publication type:
journal article

Found: 156