Works by COFFER, Paul J.

Results: 40

Interferon-gamma induces epithelial reprogramming driving CXCL11-mediated T-cell migration.
Published in:
Journal of Leukocyte Biology, 2025, v. 117, n. 2, p. 1, doi. 10.1093/jleuko/qiae205
By:
- Cutilli, Alessandro;
- Jansen, Suze A;
- Paolucci, Francesca;
- Hoesel, Marliek van;
- Frederiks, Cynthia L;
- Mulder, Tessa A M;
- Chalkiadakis, Theofilos;
- Mokry, Michal;
- Prekovic, Stefan;
- Mocholi, Enric;
- Lindemans, Caroline A;
- Coffer, Paul J
Publication type:
Article
The role of the PI3K-PKB signaling module in regulation of hematopoiesis.
Published in:
Cell Cycle, 2009, v. 8, n. 4, p. 560, doi. 10.4161/cc.8.4.7654
By:
- Buitenhuis, Miranda;
- Coffer, Paul J.
Publication type:
Article
Cytokine mediated suppression of TF-1 apoptosis requires PI3K activation and inhibition of Bim expression
Published in:
FEBS Letters, 2005, v. 579, n. 1, p. 191, doi. 10.1016/j.febslet.2004.11.074
By:
- Rosas, Marcela;
- Birkenkamp, Kim U.;
- Lammers, Jan-Willem J.;
- Koenderman, Leo;
- Coffer, Paul J.
Publication type:
Article
Epigenetic drug screen identifies the histone deacetylase inhibitor NSC3852 as a potential novel drug for the treatment of pediatric acute myeloid leukemia.
Published in:
Pediatric Blood & Cancer, 2019, v. 66, n. 8, p. N.PAG, doi. 10.1002/pbc.27785
By:
- Wiggers, Caroline R.M.;
- Govers, Anita M.A.P.;
- Lelieveld, Daphne;
- Egan, David A.;
- Zwaan, C. Michel;
- Sonneveld, Edwin;
- Coffer, Paul J.;
- Bartels, Marije
Publication type:
Article
Epigenetic drug screen identifies the histone deacetylase inhibitor NSC3852 as a potential novel drug for the treatment of pediatric acute myeloid leukemia.
Published in:
2019
By:
- Wiggers, Caroline R M;
- Govers, Anita M A P;
- Lelieveld, Daphne;
- Egan, David A;
- Zwaan, C Michel;
- Sonneveld, Edwin;
- Coffer, Paul J;
- Bartels, Marije
Publication type:
journal article
Forkhead-box transcription factors and their role in the immune system.
Published in:
Nature Reviews Immunology, 2004, v. 4, n. 11, p. 889, doi. 10.1038/nri1488
By:
- Coffer, Paul J.;
- Burgering, Boudewijn M. T.
Publication type:
Article
Induction of prosurvival molecules by apoptotic stimuli: involvement of FOXO3a and ROS.
Published in:
Oncogene, 2005, v. 24, n. 12, p. 2020, doi. 10.1038/sj.onc.1208385
By:
- Liu, Jun-Wei;
- Chandra, Dhyan;
- Rudd, Michael D.;
- Butler, Andrew P.;
- Pallotta, Vincent;
- Brown, David;
- Coffer, Paul J.;
- Tang, Dean G.
Publication type:
Article
When less is more: the PI3K pathway as a determinant of tumor response to dietary restriction.
Published in:
Cell Research, 2009, v. 19, n. 7, p. 797, doi. 10.1038/cr.2009.81
By:
- Coffer, Paul J.
Publication type:
Article
Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation.
Published in:
Nature, 2013, v. 504, n. 7480, p. 451, doi. 10.1038/nature12726
By:
- Arpaia, Nicholas;
- Campbell, Clarissa;
- Fan, Xiying;
- Dikiy, Stanislav;
- van der Veeken, Joris;
- deRoos, Paul;
- Liu, Hui;
- Cross, Justin R.;
- Pfeffer, Klaus;
- Coffer, Paul J.;
- Rudensky, Alexander Y.
Publication type:
Article
Colorectal Cancer-Infiltrating Regulatory T Cells: Functional Heterogeneity, Metabolic Adaptation, and Therapeutic Targeting.
Published in:
Frontiers in Immunology, 2022, v. 13, p. 1, doi. 10.3389/fimmu.2022.903564
By:
- Revilla, Sonia Aristin;
- Kranenburg, Onno;
- Coffer, Paul J.
Publication type:
Article
Insulin activates Stat3 independently of p21ras-ERK and PI-3K signal transduction.
Published in:
Oncogene, 1997, v. 15, n. 21, p. 2529, doi. 10.1038/sj.onc.1201429
By:
- Coffer, Paul J;
- van Puijenbroek, André;
- Burgering, Boudewijn MTh;
- Jonge, Marjolijn Klop-de;
- Koenderman, Leo;
- Bos, Johannes L;
- Kruijer, Wiebe
Publication type:
Article
The expression of the tumour suppressor HBP1 is down-regulated by growth factors via the PI3K/PKB/FOXO pathway.
Published in:
Biochemical Journal, 2014, v. 460, n. 1, p. 25, doi. 10.1042/BJ20131467
By:
- COOMANS DE BRACHÈNE, Alexandra;
- BOLLAERT, Emeline;
- EIJKELENBOOM, Astrid;
- DE ROCCA SERRA, Audrey;
- VAN DER VOS, Kristan E.;
- BURGERING, Boudewijn M. T.;
- COFFER, Paul J.;
- ESSAGHIR, Ahmed;
- DEMOULIN, Jean-Baptiste
Publication type:
Article
The serine/threonine phosphatase PPM1B (PP2Cß) selectively modulates PPARγ activity.
Published in:
Biochemical Journal, 2013, v. 451, n. 1, p. 45, doi. 10.1042/BJ20121113
By:
- TASDELEN, Ismayil;
- VAN BEEKUM, Olivier;
- GORBENKO, Olena;
- FLESKENS, Veerle;
- VAN DEN BROEK, Niels J. F.;
- KOPPEN, Arjen;
- HAMERS, Nicole;
- BERGER, Ruud;
- COFFER, Paul J.;
- BRENKMAN, Arjan B.;
- KALKHOVEN, Eric
Publication type:
Article
Epigenetic changes in inflammatory arthritis monocytes contribute to disease and can be targeted by JAK inhibition.
Published in:
Rheumatology, 2023, v. 62, n. 8, p. 2887, doi. 10.1093/rheumatology/kead001
By:
- Peeters, Janneke G C;
- Boltjes, Arjan;
- Scholman, Rianne C;
- Vervoort, Stephin J;
- Coffer, Paul J;
- Mokry, Michal;
- Vastert, Sebastiaan J;
- Wijk, Femke van;
- Loosdregt, Jorg van
Publication type:
Article
Early adipogenesis is regulated through USP7-mediated deubiquitination of the histone acetyltransferase TIP60.
Published in:
Nature Communications, 2013, v. 4, n. 10, p. 2656, doi. 10.1038/ncomms3656
By:
- Gao, Yuan;
- Koppen, Arjen;
- Rakhshandehroo, Maryam;
- Tasdelen, Ismayil;
- van de Graaf, Stan F.;
- van Loosdregt, Jorg;
- van Beekum, Olivier;
- Hamers, Nicole;
- van Leenen, Dik;
- Berkers, Celia R.;
- Berger, Ruud;
- Holstege, Frank C.P.;
- Coffer, Paul J.;
- Brenkman, Arjan B.;
- Ovaa, Huib;
- Kalkhoven, Eric
Publication type:
Article
In Vitro Evaluation of Spider Silk Meshes as a Potential Biomaterial for Bladder Reconstruction.
Published in:
PLoS ONE, 2015, v. 10, n. 12, p. 1, doi. 10.1371/journal.pone.0145240
By:
- Steins, Anne;
- Dik, Pieter;
- Müller, Wally H.;
- Vervoort, Stephin J.;
- Reimers, Kerstin;
- Kuhbier, Jörn W.;
- Vogt, Peter M.;
- van Apeldoorn, Aart A.;
- Coffer, Paul J.;
- Schepers, Koen
Publication type:
Article
Hepatic autophagy is differentially regulated in periportal and pericentral zones - a general mechanism relevant for other tissues?
Published in:
Cell Communication & Signaling, 2013, v. 11, n. 1, p. 1, doi. 10.1186/1478-811X-11-21
By:
- Gebhardt, Rolf;
- Coffer, Paul J.
Publication type:
Article
Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction.
Published in:
Nature, 1995, v. 376, n. 6541, p. 599, doi. 10.1038/376599a0
By:
- Burgering, Boudewijn M. Th;
- Coffer, Paul J.
Publication type:
Article
FoxO3a regulates erythroid differentiation and induces BTG1, an activator of protein arginine methyl transferase 1.
Published in:
Journal of Cell Biology, 2004, v. 164, n. 2, p. 175, doi. 10.1083/jcb.200307056
By:
- Walbert J. Bakker, Noriyuki;
- Montserrat Bláizquez-Domingo, Noriyuki;
- Kolbus, Andrea;
- Besooyren, Janeyr;
- Steinlein, Peter;
- Beug, Hartmut;
- Coffer, Paul J.;
- Löwenberg, Bob;
- Lindern, Marieke von;
- Dijk, Thamar B. van
Publication type:
Article
FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons.
Published in:
Journal of Cell Biology, 2003, v. 162, n. 4, p. 613, doi. 10.1083/jcb.200303026
By:
- Gilley, Jonathan;
- Coffer, Paul J.;
- Ham, Jonathan
Publication type:
Article
FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B—enhanced cell survival through maintenance of mitochondrial integrity.
Published in:
Journal of Cell Biology, 2002, v. 156, n. 3, p. 531, doi. 10.1083/jcb.200108084
By:
- Dijkers, Pascale F.;
- Birkenkamp, Kim U.;
- Lam, Eric W.-F.;
- Thomas, N. Shaun B.;
- Lammers, Jan-Willem J.;
- Koenderman, Leo;
- Coffer, Paul J.
Publication type:
Article
PD-1+CD8+ T cells are clonally expanding effectors in human chronic inflammation.
Published in:
2018
By:
- Petrelli, Alessandra;
- Mijnheer, Gerdien;
- Hoytema van Konijnenburg, David P.;
- van der Wal, Maria M.;
- Giovannone, Barbara;
- Mocholi, Enric;
- Vazirpanah, Nadia;
- Broen, Jasper C.;
- Hijnen, Dirkjan;
- Oldenburg, Bas;
- Coffer, Paul J.;
- Vastert, Sebastian J.;
- Prakken, Berent J.;
- Spierings, Eric;
- Pandit, Aridaman;
- Mokry, Michal;
- van Wijk, Femke;
- van Konijnenburg, David P Hoytema
Publication type:
journal article
Modulation of glutamine metabolism by the PI(3)K-PKB-FOXO network regulates autophagy.
Published in:
Nature Cell Biology, 2012, v. 14, n. 8, p. 829, doi. 10.1038/ncb2536
By:
- van der Vos, Kristan E.;
- Eliasson, Pernilla;
- Proikas-Cezanne, Tassula;
- Vervoort, Stephin J.;
- van Boxtel, Ruben;
- Putker, Marrit;
- van Zutphen, Iris J.;
- Mauthe, Mario;
- Zellmer, Sebastian;
- Pals, Cornelieke;
- Verhagen, Liesbeth P.;
- Groot Koerkamp, Marian J. A.;
- Braat, A. Koen;
- Dansen, Tobias B.;
- Holstege, Frank C.;
- Gebhardt, Rolf;
- Burgering, Boudewijn M.;
- Coffer, Paul J.
Publication type:
Article
Stressed marrow: FoxOs stem tumour growth.
Published in:
Nature Cell Biology, 2007, v. 9, n. 3, p. 251, doi. 10.1038/ncb0307-251
By:
- Coffer, Paul J.;
- Burgering, Boudewijn M. T.
Publication type:
Article
N6-methyladenosine promotes TNF mRNA degradation in CD4+ T lymphocytes.
Published in:
Journal of Leukocyte Biology, 2024, v. 116, n. 4, p. 807, doi. 10.1093/jleuko/qiae087
By:
- Vroonhoven, Ellen C N van;
- Picavet, Lucas W;
- Scholman, Rianne C;
- Sijbers, Lyanne J P M;
- Kievit, Corlinda R E;
- Dungen, Noortje A M van den;
- Mokry, Michal;
- Evers, Anouk;
- Lebbink, Robert J;
- Mocholi, Enric;
- Coffer, Paul J;
- Calis, Jorg J A;
- Vastert, Sebastiaan J;
- Loosdregt, Jorg van
Publication type:
Article
Autophagy Proteins ATG5 and ATG7 Are Essential for the Maintenance of Human CD34+ Hematopoietic Stem-Progenitor Cells.
Published in:
Stem Cells, 2016, v. 34, n. 6, p. 1651, doi. 10.1002/stem.2347
By:
- Gomez-Puerto, Maria Catalina;
- Folkerts, Hendrik;
- Wierenga, Albertus T.J.;
- Schepers, Koen;
- Schuringa, Jan Jacob;
- Coffer, Paul J.;
- Vellenga, Edo
Publication type:
Article
p38 MAP Kinase Inhibits Neutrophil Development Through Phosphorylation of C/EBPa on Serine 21.
Published in:
Stem Cells, 2009, v. 27, n. 9, p. 2271, doi. 10.1002/stem.152
By:
- Geest, Christian R.;
- Buitenhuis, Miranda;
- Laarhoven, Annemieke G.;
- Bierings, Marc B.;
- Bruin, Marrie C. A.;
- Vellenga, Edo;
- Coffer, Paul J.
Publication type:
Article
C/EBPɑ is crucial determinant of epithelial maintenance by preventing epithelial-to-mesenchymal transition.
Published in:
Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-14556-x
By:
- Lourenço, Ana Rita;
- Roukens, M. Guy;
- Seinstra, Danielle;
- Frederiks, Cynthia L.;
- Pals, Cornelieke E.;
- Vervoort, Stephin J.;
- Margarido, Andreia S.;
- van Rheenen, Jacco;
- Coffer, Paul J.
Publication type:
Article
Forkhead transcriptions factor FOXO3a protects quiescent cells from oxidative stress.
Published in:
Nature, 2002, v. 419, n. 6904, p. 316, doi. 10.1038/nature01036
By:
- Kops, Geert J.P.L.;
- Dansen, Tobias B.;
- Polderman, Paulien E.;
- Saarloos, Ingrid;
- Wirtz, Karel W.A.;
- Coffer, Paul J.;
- Huang, Ting-T.;
- Bos, Johannes L.;
- Medema, René H.;
- Burgering, Boudewijn M.T.
Publication type:
Article
The role of STATs in myeloid differentiation and leukemia.
Published in:
Oncogene, 2000, v. 19, n. 21, p. 2511, doi. 10.1038/sj.onc.1203479
By:
- Coffer, Paul J;
- Koenderman, Leo;
- de Groot, Rolf P
Publication type:
Article
Association of RACK1 and PKCβ with the common β-chain of the IL-5/IL-3/GM-CSF receptor.
Published in:
Oncogene, 1999, v. 18, n. 36, p. 5126, doi. 10.1038/sj.onc.1202896
By:
- Geijsen, Niels;
- Spaargaren, Marcel;
- Raaijmakers, Jan AM;
- Lammers, Jan-Willem J;
- Koenderman, Leo;
- Coffer, Paul J
Publication type:
Article
Regulation and function of protein kinase B and MAP kinase activation by the IL-5/GM-CSF/IL-3 receptor.
Published in:
Oncogene, 1999, v. 18, n. 22, p. 3334, doi. 10.1038/sj.onc.1202678
By:
- Dijkers, Pascale F;
- van Dijk, Thamar B;
- de Groot, Rolf P;
- Raaijmakers, Jan AM;
- Lammers, Jan-Willem J;
- Koenderman, Leo;
- Coffer, Paul J
Publication type:
Article
Signal inhibitory receptor on leukocytes-1 ( SIRL-1) negatively regulates the oxidative burst in human phagocytes.
Published in:
European Journal of Immunology, 2013, v. 43, n. 5, p. 1297, doi. 10.1002/eji.201242916
By:
- Steevels, Tessa A. M.;
- Avondt, Kristof;
- Westerlaken, Geertje H. A.;
- Stalpers, Femke;
- Walk, Jona;
- Bont, Louis;
- Coffer, Paul J.;
- Meyaard, Linde
Publication type:
Article
c-Jun activating binding protein 1 binds to the IgA receptor and modulates protein levels of FcαRI and FcRγ-chain.
Published in:
European Journal of Immunology, 2010, v. 40, n. 7, p. 2035, doi. 10.1002/eji.200939985
By:
- Bakema, Jantine E.;
- Hiemstra, Ida H.;
- Bakker, Johanna;
- de Haij, Simone;
- Kok, Yvonne;
- Adema, Gosse;
- van Egmond, Marjolein;
- Coffer, Paul J.;
- van de Winkel, Jan G. J.;
- Leusen, Jeanette H. W.
Publication type:
Article
Differential Effects of Nitrostyrene Derivatives on Myelopoiesis Involve Regulation of C/EBPα and p38MAPK Activity.
Published in:
PLoS ONE, 2014, v. 9, n. 3, p. 1, doi. 10.1371/journal.pone.0090586
By:
- Bartels, Marije;
- Calgarotto, Andrana K.;
- Martens, Anton C.;
- Maso, Victor;
- da Silva, Saulo L.;
- Bierings, Marc B.;
- de Souza Queiroz, Mary L.;
- Coffer, Paul J.
Publication type:
Article
SOX4 Mediates TGF-β-Induced Expression of Mesenchymal Markers during Mammary Cell Epithelial to Mesenchymal Transition.
Published in:
PLoS ONE, 2013, v. 8, n. 1, p. 1, doi. 10.1371/journal.pone.0053238
By:
- Vervoort, Stephin J.;
- Lourenço, Ana Rita;
- van Boxtel, Ruben;
- Coffer, Paul J.
Publication type:
Article
STAT3 Regulates Monocyte TNF-Alpha Production in Systemic Inflammation Caused by Cardiac Surgery with Cardiopulmonary Bypass.
Published in:
PLoS ONE, 2012, v. 7, n. 4, p. 1, doi. 10.1371/journal.pone.0035070
By:
- Jong, Petrus R. de;
- Schadenberg, Alvin W. L.;
- van den Broek, Theo;
- Beekman, Jeffrey M.;
- van Wijk, Femke;
- Coffer, Paul J.;
- Prakken, Berent J.;
- Jansen, Nicolaas J. G.
Publication type:
Article
Rapid Temporal Control of Foxp3 Protein Degradation by Sirtuin-1.
Published in:
PLoS ONE, 2011, v. 6, n. 4, p. 1, doi. 10.1371/journal.pone.0019047
By:
- van Loosdregt, Jorg;
- Brunen, Diede;
- Fleskens, Veerle;
- Pals, Cornelieke E. G. M.;
- Lam, Eric W. F.;
- Coffer, Paul J.
Publication type:
Article
Glutamine metabolism links growth factor signaling to the regulation of autophagy.
Published in:
Autophagy, 2012, v. 8, n. 12, p. 1862, doi. 10.4161/auto.22152
By:
- van der Vos, Kristan E.;
- Coffer, Paul J.
Publication type:
Article
FoxO3a and BCR-ABL Regulate cyclin D2 Transcription through a STAT5/BCL6-Dependent Mechanism.
Published in:
Molecular & Cellular Biology, 2004, v. 24, n. 22, p. 10058, doi. 10.1128/MCB.24.22.10058-10071.2004
By:
- de Mattos, Silvia Fernández;
- Essafi, Abdelkader;
- Soeiro, Inês;
- Pietersen, Alexandra M.;
- Birkenkamp, Kim U.;
- Edwards, Corinne S.;
- Martino, Anthony;
- Nelson, Brad H.;
- Francis, Julia M.;
- Jones, Marius C.;
- Brosens, Jan J.;
- Coffer, Paul J.;
- Lam, Eric W.-F.
Publication type:
Article