Works matching AU COFFER, Paul J.

Results: 40

Epigenetic changes in inflammatory arthritis monocytes contribute to disease and can be targeted by JAK inhibition.

Published in:

Rheumatology, 2023, v. 62, n. 8, p. 2887, doi. 10.1093/rheumatology/kead001

By:

Peeters, Janneke G C;
Boltjes, Arjan;
Scholman, Rianne C;
Vervoort, Stephin J;
Coffer, Paul J;
Mokry, Michal;
Vastert, Sebastiaan J;
Wijk, Femke van;
Loosdregt, Jorg van

Publication type:

Article

Autophagy Proteins ATG5 and ATG7 Are Essential for the Maintenance of Human CD34+ Hematopoietic Stem-Progenitor Cells.

Published in:

Stem Cells, 2016, v. 34, n. 6, p. 1651, doi. 10.1002/stem.2347

By:

Gomez-Puerto, Maria Catalina;
Folkerts, Hendrik;
Wierenga, Albertus T.J.;
Schepers, Koen;
Schuringa, Jan Jacob;
Coffer, Paul J.;
Vellenga, Edo

Publication type:

Article

Epigenetic drug screen identifies the histone deacetylase inhibitor NSC3852 as a potential novel drug for the treatment of pediatric acute myeloid leukemia.

Published in:

Pediatric Blood & Cancer, 2019, v. 66, n. 8, p. N.PAG, doi. 10.1002/pbc.27785

By:

Wiggers, Caroline R.M.;
Govers, Anita M.A.P.;
Lelieveld, Daphne;
Egan, David A.;
Zwaan, C. Michel;
Sonneveld, Edwin;
Coffer, Paul J.;
Bartels, Marije

Publication type:

Article

Epigenetic drug screen identifies the histone deacetylase inhibitor NSC3852 as a potential novel drug for the treatment of pediatric acute myeloid leukemia.

Published in:

2019

By:

Wiggers, Caroline R M;
Govers, Anita M A P;
Lelieveld, Daphne;
Egan, David A;
Zwaan, C Michel;
Sonneveld, Edwin;
Coffer, Paul J;
Bartels, Marije

Publication type:

journal article

PD-1+CD8+ T cells are clonally expanding effectors in human chronic inflammation.

Published in:

2018

By:

Petrelli, Alessandra;
Mijnheer, Gerdien;
Hoytema van Konijnenburg, David P.;
van der Wal, Maria M.;
Giovannone, Barbara;
Mocholi, Enric;
Vazirpanah, Nadia;
Broen, Jasper C.;
Hijnen, Dirkjan;
Oldenburg, Bas;
Coffer, Paul J.;
Vastert, Sebastian J.;
Prakken, Berent J.;
Spierings, Eric;
Pandit, Aridaman;
Mokry, Michal;
van Wijk, Femke;
van Konijnenburg, David P Hoytema

Publication type:

journal article

Signal inhibitory receptor on leukocytes-1 ( SIRL-1) negatively regulates the oxidative burst in human phagocytes.

Published in:

European Journal of Immunology, 2013, v. 43, n. 5, p. 1297, doi. 10.1002/eji.201242916

By:

Steevels, Tessa A. M.;
Avondt, Kristof;
Westerlaken, Geertje H. A.;
Stalpers, Femke;
Walk, Jona;
Bont, Louis;
Coffer, Paul J.;
Meyaard, Linde

Publication type:

Article

Interferon-gamma induces epithelial reprogramming driving CXCL11-mediated T-cell migration.

Published in:

Journal of Leukocyte Biology, 2025, v. 117, n. 2, p. 1, doi. 10.1093/jleuko/qiae205

By:

Cutilli, Alessandro;
Jansen, Suze A;
Paolucci, Francesca;
Hoesel, Marliek van;
Frederiks, Cynthia L;
Mulder, Tessa A M;
Chalkiadakis, Theofilos;
Mokry, Michal;
Prekovic, Stefan;
Mocholi, Enric;
Lindemans, Caroline A;
Coffer, Paul J

Publication type:

Article

N6-methyladenosine promotes TNF mRNA degradation in CD4+ T lymphocytes.

Published in:

Journal of Leukocyte Biology, 2024, v. 116, n. 4, p. 807, doi. 10.1093/jleuko/qiae087

By:

Vroonhoven, Ellen C N van;
Picavet, Lucas W;
Scholman, Rianne C;
Sijbers, Lyanne J P M;
Kievit, Corlinda R E;
Dungen, Noortje A M van den;
Mokry, Michal;
Evers, Anouk;
Lebbink, Robert J;
Mocholi, Enric;
Coffer, Paul J;
Calis, Jorg J A;
Vastert, Sebastiaan J;
Loosdregt, Jorg van

Publication type:

Article

Forkhead-box transcription factors and their role in the immune system.

Published in:

Nature Reviews Immunology, 2004, v. 4, n. 11, p. 889, doi. 10.1038/nri1488

By:

Coffer, Paul J.;
Burgering, Boudewijn M. T.

Publication type:

Article

FoxO3a regulates erythroid differentiation and induces BTG1, an activator of protein arginine methyl transferase 1.

Published in:

Journal of Cell Biology, 2004, v. 164, n. 2, p. 175, doi. 10.1083/jcb.200307056

By:

Walbert J. Bakker, Noriyuki;
Montserrat Bláizquez-Domingo, Noriyuki;
Kolbus, Andrea;
Besooyren, Janeyr;
Steinlein, Peter;
Beug, Hartmut;
Coffer, Paul J.;
Löwenberg, Bob;
Lindern, Marieke von;
Dijk, Thamar B. van

Publication type:

Article

FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons.

Published in:

Journal of Cell Biology, 2003, v. 162, n. 4, p. 613, doi. 10.1083/jcb.200303026

By:

Gilley, Jonathan;
Coffer, Paul J.;
Ham, Jonathan

Publication type:

Article

FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B—enhanced cell survival through maintenance of mitochondrial integrity.

Published in:

Journal of Cell Biology, 2002, v. 156, n. 3, p. 531, doi. 10.1083/jcb.200108084

By:

Dijkers, Pascale F.;
Birkenkamp, Kim U.;
Lam, Eric W.-F.;
Thomas, N. Shaun B.;
Lammers, Jan-Willem J.;
Koenderman, Leo;
Coffer, Paul J.

Publication type:

Article

Insulin activates Stat3 independently of p21ras-ERK and PI-3K signal transduction.

Published in:

Oncogene, 1997, v. 15, n. 21, p. 2529, doi. 10.1038/sj.onc.1201429

By:

Coffer, Paul J;
van Puijenbroek, André;
Burgering, Boudewijn MTh;
Jonge, Marjolijn Klop-de;
Koenderman, Leo;
Bos, Johannes L;
Kruijer, Wiebe

Publication type:

Article

The role of the PI3K-PKB signaling module in regulation of hematopoiesis.

Published in:

Cell Cycle, 2009, v. 8, n. 4, p. 560, doi. 10.4161/cc.8.4.7654

By:

Buitenhuis, Miranda;
Coffer, Paul J.

Publication type:

Article

Cytokine mediated suppression of TF-1 apoptosis requires PI3K activation and inhibition of Bim expression

Published in:

FEBS Letters, 2005, v. 579, n. 1, p. 191, doi. 10.1016/j.febslet.2004.11.074

By:

Rosas, Marcela;
Birkenkamp, Kim U.;
Lammers, Jan-Willem J.;
Koenderman, Leo;
Coffer, Paul J.

Publication type:

Article

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction.

Published in:

Nature, 1995, v. 376, n. 6541, p. 599, doi. 10.1038/376599a0

By:

Burgering, Boudewijn M. Th;
Coffer, Paul J.

Publication type:

Article

Early adipogenesis is regulated through USP7-mediated deubiquitination of the histone acetyltransferase TIP60.

Published in:

Nature Communications, 2013, v. 4, n. 10, p. 2656, doi. 10.1038/ncomms3656

By:

Gao, Yuan;
Koppen, Arjen;
Rakhshandehroo, Maryam;
Tasdelen, Ismayil;
van de Graaf, Stan F.;
van Loosdregt, Jorg;
van Beekum, Olivier;
Hamers, Nicole;
van Leenen, Dik;
Berkers, Celia R.;
Berger, Ruud;
Holstege, Frank C.P.;
Coffer, Paul J.;
Brenkman, Arjan B.;
Ovaa, Huib;
Kalkhoven, Eric

Publication type:

Article

Glutamine metabolism links growth factor signaling to the regulation of autophagy.

Published in:

Autophagy, 2012, v. 8, n. 12, p. 1862, doi. 10.4161/auto.22152

By:

van der Vos, Kristan E.;
Coffer, Paul J.

Publication type:

Article

The role of STATs in myeloid differentiation and leukemia.

Published in:

Oncogene, 2000, v. 19, n. 21, p. 2511, doi. 10.1038/sj.onc.1203479

By:

Coffer, Paul J;
Koenderman, Leo;
de Groot, Rolf P

Publication type:

Article

Association of RACK1 and PKCβ with the common β-chain of the IL-5/IL-3/GM-CSF receptor.

Published in:

Oncogene, 1999, v. 18, n. 36, p. 5126, doi. 10.1038/sj.onc.1202896

By:

Geijsen, Niels;
Spaargaren, Marcel;
Raaijmakers, Jan AM;
Lammers, Jan-Willem J;
Koenderman, Leo;
Coffer, Paul J

Publication type:

Article

Regulation and function of protein kinase B and MAP kinase activation by the IL-5/GM-CSF/IL-3 receptor.

Published in:

Oncogene, 1999, v. 18, n. 22, p. 3334, doi. 10.1038/sj.onc.1202678

By:

Dijkers, Pascale F;
van Dijk, Thamar B;
de Groot, Rolf P;
Raaijmakers, Jan AM;
Lammers, Jan-Willem J;
Koenderman, Leo;
Coffer, Paul J

Publication type:

Article

Forkhead transcriptions factor FOXO3a protects quiescent cells from oxidative stress.

Published in:

Nature, 2002, v. 419, n. 6904, p. 316, doi. 10.1038/nature01036

By:

Kops, Geert J.P.L.;
Dansen, Tobias B.;
Polderman, Paulien E.;
Saarloos, Ingrid;
Wirtz, Karel W.A.;
Coffer, Paul J.;
Huang, Ting-T.;
Bos, Johannes L.;
Medema, René H.;
Burgering, Boudewijn M.T.

Publication type:

Article

The expression of the tumour suppressor HBP1 is down-regulated by growth factors via the PI3K/PKB/FOXO pathway.

Published in:

Biochemical Journal, 2014, v. 460, n. 1, p. 25, doi. 10.1042/BJ20131467

By:

COOMANS DE BRACHÈNE, Alexandra;
BOLLAERT, Emeline;
EIJKELENBOOM, Astrid;
DE ROCCA SERRA, Audrey;
VAN DER VOS, Kristan E.;
BURGERING, Boudewijn M. T.;
COFFER, Paul J.;
ESSAGHIR, Ahmed;
DEMOULIN, Jean-Baptiste

Publication type:

Article

The serine/threonine phosphatase PPM1B (PP2Cß) selectively modulates PPARγ activity.

Published in:

Biochemical Journal, 2013, v. 451, n. 1, p. 45, doi. 10.1042/BJ20121113

By:

TASDELEN, Ismayil;
VAN BEEKUM, Olivier;
GORBENKO, Olena;
FLESKENS, Veerle;
VAN DEN BROEK, Niels J. F.;
KOPPEN, Arjen;
HAMERS, Nicole;
BERGER, Ruud;
COFFER, Paul J.;
BRENKMAN, Arjan B.;
KALKHOVEN, Eric

Publication type:

Article

Modulation of glutamine metabolism by the PI(3)K-PKB-FOXO network regulates autophagy.

Published in:

Nature Cell Biology, 2012, v. 14, n. 8, p. 829, doi. 10.1038/ncb2536

By:

van der Vos, Kristan E.;
Eliasson, Pernilla;
Proikas-Cezanne, Tassula;
Vervoort, Stephin J.;
van Boxtel, Ruben;
Putker, Marrit;
van Zutphen, Iris J.;
Mauthe, Mario;
Zellmer, Sebastian;
Pals, Cornelieke;
Verhagen, Liesbeth P.;
Groot Koerkamp, Marian J. A.;
Braat, A. Koen;
Dansen, Tobias B.;
Holstege, Frank C.;
Gebhardt, Rolf;
Burgering, Boudewijn M.;
Coffer, Paul J.

Publication type:

Article

Stressed marrow: FoxOs stem tumour growth.

Published in:

Nature Cell Biology, 2007, v. 9, n. 3, p. 251, doi. 10.1038/ncb0307-251

By:

Coffer, Paul J.;
Burgering, Boudewijn M. T.

Publication type:

Article

In Vitro Evaluation of Spider Silk Meshes as a Potential Biomaterial for Bladder Reconstruction.

Published in:

PLoS ONE, 2015, v. 10, n. 12, p. 1, doi. 10.1371/journal.pone.0145240

By:

Steins, Anne;
Dik, Pieter;
Müller, Wally H.;
Vervoort, Stephin J.;
Reimers, Kerstin;
Kuhbier, Jörn W.;
Vogt, Peter M.;
van Apeldoorn, Aart A.;
Coffer, Paul J.;
Schepers, Koen

Publication type:

Article

Differential Effects of Nitrostyrene Derivatives on Myelopoiesis Involve Regulation of C/EBPα and p38MAPK Activity.

Published in:

PLoS ONE, 2014, v. 9, n. 3, p. 1, doi. 10.1371/journal.pone.0090586

By:

Bartels, Marije;
Calgarotto, Andrana K.;
Martens, Anton C.;
Maso, Victor;
da Silva, Saulo L.;
Bierings, Marc B.;
de Souza Queiroz, Mary L.;
Coffer, Paul J.

Publication type:

Article

SOX4 Mediates TGF-β-Induced Expression of Mesenchymal Markers during Mammary Cell Epithelial to Mesenchymal Transition.

Published in:

PLoS ONE, 2013, v. 8, n. 1, p. 1, doi. 10.1371/journal.pone.0053238

By:

Vervoort, Stephin J.;
Lourenço, Ana Rita;
van Boxtel, Ruben;
Coffer, Paul J.

Publication type:

Article

STAT3 Regulates Monocyte TNF-Alpha Production in Systemic Inflammation Caused by Cardiac Surgery with Cardiopulmonary Bypass.

Published in:

PLoS ONE, 2012, v. 7, n. 4, p. 1, doi. 10.1371/journal.pone.0035070

By:

Jong, Petrus R. de;
Schadenberg, Alvin W. L.;
van den Broek, Theo;
Beekman, Jeffrey M.;
van Wijk, Femke;
Coffer, Paul J.;
Prakken, Berent J.;
Jansen, Nicolaas J. G.

Publication type:

Article

Rapid Temporal Control of Foxp3 Protein Degradation by Sirtuin-1.

Published in:

PLoS ONE, 2011, v. 6, n. 4, p. 1, doi. 10.1371/journal.pone.0019047

By:

van Loosdregt, Jorg;
Brunen, Diede;
Fleskens, Veerle;
Pals, Cornelieke E. G. M.;
Lam, Eric W. F.;
Coffer, Paul J.

Publication type:

Article

p38 MAP Kinase Inhibits Neutrophil Development Through Phosphorylation of C/EBPa on Serine 21.

Published in:

Stem Cells, 2009, v. 27, n. 9, p. 2271, doi. 10.1002/stem.152

By:

Geest, Christian R.;
Buitenhuis, Miranda;
Laarhoven, Annemieke G.;
Bierings, Marc B.;
Bruin, Marrie C. A.;
Vellenga, Edo;
Coffer, Paul J.

Publication type:

Article

When less is more: the PI3K pathway as a determinant of tumor response to dietary restriction.

Published in:

Cell Research, 2009, v. 19, n. 7, p. 797, doi. 10.1038/cr.2009.81

By:

Coffer, Paul J.

Publication type:

Article

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation.

Published in:

Nature, 2013, v. 504, n. 7480, p. 451, doi. 10.1038/nature12726

By:

Arpaia, Nicholas;
Campbell, Clarissa;
Fan, Xiying;
Dikiy, Stanislav;
van der Veeken, Joris;
deRoos, Paul;
Liu, Hui;
Cross, Justin R.;
Pfeffer, Klaus;
Coffer, Paul J.;
Rudensky, Alexander Y.

Publication type:

Article

Hepatic autophagy is differentially regulated in periportal and pericentral zones - a general mechanism relevant for other tissues?

Published in:

Cell Communication & Signaling, 2013, v. 11, n. 1, p. 1, doi. 10.1186/1478-811X-11-21

By:

Gebhardt, Rolf;
Coffer, Paul J.

Publication type:

Article

FoxO3a and BCR-ABL Regulate cyclin D2 Transcription through a STAT5/BCL6-Dependent Mechanism.

Published in:

Molecular & Cellular Biology, 2004, v. 24, n. 22, p. 10058, doi. 10.1128/MCB.24.22.10058-10071.2004

By:

de Mattos, Silvia Fernández;
Essafi, Abdelkader;
Soeiro, Inês;
Pietersen, Alexandra M.;
Birkenkamp, Kim U.;
Edwards, Corinne S.;
Martino, Anthony;
Nelson, Brad H.;
Francis, Julia M.;
Jones, Marius C.;
Brosens, Jan J.;
Coffer, Paul J.;
Lam, Eric W.-F.

Publication type:

Article

Colorectal Cancer-Infiltrating Regulatory T Cells: Functional Heterogeneity, Metabolic Adaptation, and Therapeutic Targeting.

Published in:

Frontiers in Immunology, 2022, v. 13, p. 1, doi. 10.3389/fimmu.2022.903564

By:

Revilla, Sonia Aristin;
Kranenburg, Onno;
Coffer, Paul J.

Publication type:

Article

Induction of prosurvival molecules by apoptotic stimuli: involvement of FOXO3a and ROS.

Published in:

Oncogene, 2005, v. 24, n. 12, p. 2020, doi. 10.1038/sj.onc.1208385

By:

Liu, Jun-Wei;
Chandra, Dhyan;
Rudd, Michael D.;
Butler, Andrew P.;
Pallotta, Vincent;
Brown, David;
Coffer, Paul J.;
Tang, Dean G.

Publication type:

Article

c-Jun activating binding protein 1 binds to the IgA receptor and modulates protein levels of FcαRI and FcRγ-chain.

Published in:

European Journal of Immunology, 2010, v. 40, n. 7, p. 2035, doi. 10.1002/eji.200939985

By:

Bakema, Jantine E.;
Hiemstra, Ida H.;
Bakker, Johanna;
de Haij, Simone;
Kok, Yvonne;
Adema, Gosse;
van Egmond, Marjolein;
Coffer, Paul J.;
van de Winkel, Jan G. J.;
Leusen, Jeanette H. W.

Publication type:

Article

C/EBPɑ is crucial determinant of epithelial maintenance by preventing epithelial-to-mesenchymal transition.

Published in:

Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-14556-x

By:

Lourenço, Ana Rita;
Roukens, M. Guy;
Seinstra, Danielle;
Frederiks, Cynthia L.;
Pals, Cornelieke E.;
Vervoort, Stephin J.;
Margarido, Andreia S.;
van Rheenen, Jacco;
Coffer, Paul J.

Publication type:

Article