Works by CHINI, Eduardo N.

Results: 30

APOE genotype modifies benefits of calorie restriction against aging.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, p. 1, doi. 10.1002/alz.085702

By:

Qiao, Wenhui;
Chen, Yixing;
Ren, Yingxue;
Ikezu, Tadafumi C;
Johnson, Stephen;
Li, Fuyao;
Chen, Kai;
Pan, Meixia;
Kashyap, Sonu;
Bueser, Katrina Rae;
Wetmore, Allison;
Kurti, Aishe I.;
Meneses, Axel D.;
Owens, Jada A.;
Chini, Eduardo N.;
Chen, Jun;
Han, Xianlin;
Bu, Guojun;
Zhao, Na

Publication type:

Article

Role of Transient Receptor Potential C3 in TNF-α-Enhanced Calcium Influx in Human Airway Myocytes.

Published in:

American Journal of Respiratory Cell & Molecular Biology, 2006, v. 35, n. 2, p. 243, doi. 10.1165/rcmb.2006-0003OC

By:

White, Thomas A.;
Ailing Xue;
Chini, Eduardo N.;
Thompson, Michael;
Sieck, Gary C.;
Wylam, Mark E.

Publication type:

Article

Abscisic acid controls calcium-dependent egress and development in Toxoplasma gondii.

Published in:

Nature, 2008, v. 451, n. 7175, p. 207, doi. 10.1038/nature06478

By:

Nagamune, Kisaburo;
Hicks, Leslie M.;
Fux, Blima;
Brossier, Fabien;
Chini, Eduardo N.;
Sibley, L. David

Publication type:

Article

Methylglyoxal Reshapes Hepatic and Adipose Tissue Metabolism and Increases Viability of Lymphocytes.

Published in:

Cellular Physiology & Biochemistry (Cell Physiol Biochem Press GmbH & Co. KG), 2025, v. 59, n. 2, p. 174, doi. 10.33594/000000770

By:

Lucredi, Naiara Cristina;
Saavedra, Lucas Paulo J.;
Piovan, Silvano;
Lima, Emanuele P.;
Godoy, Mariane Aparecida F.;
Marchiosi, Rogério;
Vicentini, Verônica Elisa P.;
Mathias, Paulo Cezar F.;
Sá-Nakanishi, Anacharis B.;
Bracht, Lívia;
Chini, Claudia C. S.;
Chini, Eduardo N.;
Bracht, Adelar;
Comar, Jurandir F.

Publication type:

Article

CD38 expression, function, and gene resequencing in a human lymphoblastoid cell line-based model system.

Published in:

Leukemia & Lymphoma, 2010, v. 51, n. 7, p. 1315, doi. 10.3109/10428194.2010.483299

By:

Hartman, William R.;
Pelleymounter, Linda L.;
Moon, Irene;
Kalari, Krishna;
Liu, Mohan;
Wu, Tse-Yu;
Escande, Carlos;
Nin, Veronica;
Chini, Eduardo N.;
Weinshilboum, Richard M.

Publication type:

Article

Rho GTPase effectors and NAD metabolism in cancer immune suppression.

Published in:

Expert Opinion on Therapeutic Targets, 2018, v. 22, n. 1, p. 9, doi. 10.1080/14728222.2018.1413091

By:

Chaker, Mahmoud;
Minden, Audrey;
Chen, Suzie;
Weiss, Robert H;
Chini, Eduardo N.;
Mahipal, Amit;
Azmi, Asfar S.

Publication type:

Article

Correction: SIRT1 Activity Is Linked to Its Brain Region-Specific Phosphorylation and Is Impaired in Huntington's Disease Mice.

Published in:

PLoS ONE, 2016, v. 11, n. 2, p. 1, doi. 10.1371/journal.pone.0150682

By:

Tulino, Raffaella;
Benjamin, Agnesska C.;
Jolinon, Nelly;
Smith, Donna L.;
Chini, Eduardo N.;
Carnemolla, Alisia;
Bates, Gillian P.

Publication type:

Article

SIRT1 Activity Is Linked to Its Brain Region-Specific Phosphorylation and Is Impaired in Huntington’s Disease Mice.

Published in:

PLoS ONE, 2016, v. 11, n. 1, p. 1, doi. 10.1371/journal.pone.0145425

By:

Tulino, Raffaella;
Benjamin, Agnesska C.;
Jolinon, Nelly;
Smith, Donna L.;
Chini, Eduardo N.;
Carnemolla, Alisia;
Bates, Gillian P.

Publication type:

Article

Critical Role of Astrocyte NAD1 Glycohydrolase in Myelin Injury and Regeneration.

Published in:

Journal of Neuroscience, 2021, v. 41, n. 41, p. 8644, doi. 10.1523/JNEUROSCI.2264-20.2021

By:

Langley, Monica R.;
Chan-Il Choi;
Peclat, Thais R.;
Yong Guo;
Simon, Whitney L.;
Hyesook Yoon;
Kleppe, Laurel;
Lucchinetti, Claudia F.;
Chini, Claudia C. S.;
Chini, Eduardo N.;
Scarisbrick, Isobel A.

Publication type:

Article

A stress-induced cilium-to-PML-NB route drives senescence initiation.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-37362-7

By:

Ma, Xiaoyu;
Zhang, Yingyi;
Zhang, Yuanyuan;
Zhang, Xu;
Huang, Yan;
He, Kai;
Chen, Chuan;
Hao, Jielu;
Zhao, Debiao;
LeBrasseur, Nathan K.;
Kirkland, James L.;
Chini, Eduardo N.;
Wei, Qing;
Ling, Kun;
Hu, Jinghua

Publication type:

Article

A novel form of Deleted in breast cancer 1 (DBC1) lacking the N-terminal domain does not bind SIRT1 and is dynamically regulated in vivo.

Published in:

Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-50789-7

By:

Santos, Leonardo;
Colman, Laura;
Contreras, Paola;
Chini, Claudia C.;
Carlomagno, Adriana;
Leyva, Alejandro;
Bresque, Mariana;
Marmisolle, Inés;
Quijano, Celia;
Durán, Rosario;
Irigoín, Florencia;
Prieto-Echagüe, Victoria;
Vendelbo, Mikkel H.;
Sotelo-Silveira, José R.;
Chini, Eduardo N.;
Badano, Jose L.;
Calliari, Aldo J.;
Escande, Carlos

Publication type:

Article

Low NAD+ Levels Are Associated With a Decline of Spermatogenesis in Transgenic ANDY and Aging Mice.

Published in:

Frontiers in Endocrinology, 2022, v. 13, p. 1, doi. 10.3389/fendo.2022.896356

By:

Meyer-Ficca, Mirella L.;
Zwerdling, Alexie E.;
Swanson, Corey A.;
Tucker, Abby G.;
Lopez, Sierra A.;
Wandersee, Miles K.;
Warner, Gina M.;
Thompson, Katie L.;
Chini, Claudia C.S.;
Chen, Haolin;
Chini, Eduardo N.;
Meyer, Ralph G.

Publication type:

Article

CD38 inhibitor 78c increases mice lifespan and healthspan in a model of chronological aging.

Published in:

Aging Cell, 2022, v. 21, n. 4, p. 1, doi. 10.1111/acel.13589

By:

Peclat, Thais R.;
Thompson, Katie L.;
Warner, Gina M.;
Chini, Claudia C.S.;
Tarragó, Mariana G.;
Mazdeh, Delaram Z.;
Zhang, Chunlian;
Zavala‐Solorio, Jose;
Kolumam, Ganesh;
Liang Wong, Yao;
Cohen, Robert L.;
Chini, Eduardo N.

Publication type:

Article

Targeting senescent cells alleviates obesity‐induced metabolic dysfunction.

Published in:

Aging Cell, 2019, v. 18, n. 3, p. 1, doi. 10.1111/acel.12950

By:

Palmer, Allyson K.;
Xu, Ming;
Zhu, Yi;
Pirtskhalava, Tamar;
Weivoda, Megan M.;
Hachfeld, Christine M.;
Prata, Larissa G.;
Dijk, Theo H.;
Verkade, Esther;
Casaclang‐Verzosa, Grace;
Johnson, Kurt O.;
Cubro, Hajrunisa;
Doornebal, Ewald J.;
Ogrodnik, Mikolaj;
Jurk, Diana;
Jensen, Michael D.;
Chini, Eduardo N.;
Miller, Jordan D.;
Matveyenko, Aleksey;
Stout, Michael B.

Publication type:

Article

Deleted in Breast Cancer 1 regulates cellular senescence during obesity.

Published in:

Aging Cell, 2014, v. 13, n. 5, p. 951, doi. 10.1111/acel.12235

By:

Escande, Carlos;
Nin, Veronica;
Pirtskhalava, Tamar;
Chini, Claudia C.;
Thereza Barbosa, Maria;
Mathison, Angela;
Urrutia, Raul;
Tchkonia, Tamar;
Kirkland, James L.;
Chini, Eduardo N.

Publication type:

Article

Selective decrease of mRNAs encoding plasma membrane calcium pump isoforms 2 and 3 in rat kidney.

Published in:

Kidney International, 1999, v. 56, n. 5, p. 1818, doi. 10.1046/j.1523-1755.1999.00736.x

By:

Caride, Ariel J.;
Chini, Eduardo N.;
Penniston, John T.;
Dousa, Thomas P.

Publication type:

Article

Cytoprotective effects of adrenomedullin in glomerular cell injury: Central role of cAMP signaling pathway.

Published in:

Kidney International, 1997, v. 52, n. 4, p. 917, doi. 10.1038/ki.1997.413

By:

Chini, Eduardo N.;
Chini, Claudia C. S.;
Bolliger, Chad;
Jougasaki, Michihisa;
Grande, Joseph P.;
Burnett, John C.;
Jr.;
P. Dousa, Thomas

Publication type:

Article

Cyclic ADP-ribose metabolism in rat kidney: High capacity for synthesis in glomeruli.

Published in:

Kidney International, 1997, v. 51, n. 5, p. 1500, doi. 10.1038/ki.1997.206

By:

Chini, Eduardo N.;
Klener Jr., Pavel;
Beers, Kelly W.;
Chini, Claudla C. S.;
Grande, Joseph P.;
Dousa, Thomas P.

Publication type:

Article

Formation of reactive oxygen metabolites in glomeruli is suppressed by inhibition of cAMP phosphodiesterase isozyme type IV.

Published in:

Kidney International, 1994, v. 46, n. 1, p. 28, doi. 10.1038/ki.1994.241

By:

Chini, Claudia C. S.;
Chini, Eduardo N.;
Williams, Josie M.;
Matoušovic, Karel;
Dousa, Thomas P.

Publication type:

Article

Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity.

Published in:

Diabetes, 2015, v. 64, n. 7, p. 2289, doi. 10.2337/db14-1820

By:

Palmer, Allyson K.;
Tchkonia, Tamara;
LeBrasseur, Nathan K.;
Chini, Eduardo N.;
Ming Xu;
Kirkland, James L.

Publication type:

Article

Deleted in Breast Cancer 1 Limits Adipose Tissue Fat Accumulation and Plays a Key Role in the Development of Metabolic Syndrome Phenotype.

Published in:

Diabetes, 2015, v. 64, n. 1, p. 12, doi. 10.2337/db14-0192

By:

Escande, Carlos;
Nin, Veronica;
Pirtskhalava, Tamar;
Chini, Claudia C. S.;
Tchkonia, Tamar;
Kirkland, James L.;
Chini, Eduardo N.

Publication type:

Article

Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome.

Published in:

2013

By:

Escande, Carlos;
Nin, Veronica;
Price, Nathan L;
Capellini, Verena;
Gomes, Ana P;
Barbosa, Maria Thereza;
O'Neil, Luke;
White, Thomas A;
Sinclair, David A;
Chini, Eduardo N

Publication type:

journal article

Flavonoid Apigenin Is an Inhibitor of the NAD+ ase CD38.

Published in:

Diabetes, 2013, v. 62, n. 4, p. 1084, doi. 10.2337/db12-1139

By:

Escande, Carlos;
Nin, Veronica;
Price, Nathan L.;
Capellini, Verena;
Gomes, Ana P.;
Barbosa, Maria Thereza;
O'Neil, Luke;
White, Thomas A.;
Sinclair, David A.;
Chini, Eduardo N.

Publication type:

Article

DBC1 (Deleted in Breast Cancer 1) modulates the stability and function of the nuclear receptor Rev-erba.

Published in:

Biochemical Journal, 2013, v. 451, n. 3, p. 453, doi. 10.1042/BJ20121085

By:

CHINI, Claudia C. S.;
ESCANDE, Carlos;
NIN, Veronica;
CHINI, Eduardo N.

Publication type:

Article

Tissue-resident CD8+ T cells drive age-associated chronic lung sequelae after viral pneumonia.

Published in:

Science Immunology, 2020, v. 5, n. 53, p. 1, doi. 10.1126/sciimmunol.abc4557

By:

Goplen, Nick P.;
Wu, Yue;
Son, Young Min;
Li, Chaofan;
Wang, Zheng;
Cheon, In Su;
Jiang, Li;
Zhu, Bibo;
Ayasoufi, Katayoun;
Chini, Eduardo N.;
Johnson, Aaron J.;
Vassallo, Robert;
Limper, Andrew H.;
Zhang, Nu;
Sun, Jie

Publication type:

Article

Endurance Capacity, Not Body Size, Determines Physical Activity Levels: Role of Skeletal Muscle PEPCK.

Published in:

PLoS ONE, 2009, v. 4, n. 6, p. 1, doi. 10.1371/journal.pone.0005869

By:

Novak, Colleen M.;
Escande, Carlos;
Gerber, Susan M.;
Chini, Eduardo N.;
Minzhi Zhang;
Britton, Steven L.;
Koch, Lauren G.;
Levine, James A.

Publication type:

Article

The Multi-faceted Ecto-enzyme CD38: Roles in Immunomodulation, Cancer, Aging, and Metabolic Diseases.

Published in:

Frontiers in Immunology, 2019, p. N.PAG, doi. 10.3389/fimmu.2019.01187

By:

Hogan, Kelly A.;
Chini, Claudia C. S.;
Chini, Eduardo N.

Publication type:

Article

mRNAs Coding for the Calcium-Sensing Receptor along the Rat Nephron: Effect of a Low-Phosphate Diet.

Published in:

Kidney & Blood Pressure Research, 1998, v. 21, n. 5, p. 305, doi. 10.1159/000025886

By:

Caride, Ariel J.;
Chini, Eduardo N.;
Homma, Sumiko;
Dousa, Thomas P.;
Penniston, John T.

Publication type:

Article

Dihydronicotinamide Riboside Is a Potent NAD+ Precursor Promoting a Pro-Inflammatory Phenotype in Macrophages.

Published in:

Frontiers in Immunology, 2022, v. 13, p. 1, doi. 10.3389/fimmu.2022.840246

By:

Chini, Claudia C. S.;
Peclat, Thais R.;
Gomez, Lilian S.;
Zeidler, Julianna D.;
Warner, Gina M.;
Kashyap, Sonu;
Mazdeh, Delaram Z.;
Hayat, Faisal;
Migaud, Marie E.;
Paulus, Aneel;
Chanan-Khan, Asher A.;
Chini, Eduardo N.

Publication type:

Article

TNB-738, a biparatopic antibody, boosts intracellular NAD+ by inhibiting CD38 ecto-enzyme activity.

Published in:

2022

By:

Ugamraj, Harshad S.;
Dang, Kevin;
Ouisse, Laure-Hélène;
Buelow, Benjamin;
Chini, Eduardo N.;
Castello, Giulia;
Allison, James;
Clarke, Starlynn C;
Davison, Laura M.;
Buelow, Roland;
Deng, Rong;
Iyer, Suhasini;
Schellenberger, Ute;
Manika, Sankar N.;
Bijpuria, Shipra;
Musnier, Astrid;
Poupon, Anne;
Cuturi, Maria Cristina;
van Schooten, Wim;
Dalvi, Pranjali

Publication type:

Report

Works by CHINI, Eduardo N.

APOE genotype modifies benefits of calorie restriction against aging.

Role of Transient Receptor Potential C3 in TNF-α-Enhanced Calcium Influx in Human Airway Myocytes.

Abscisic acid controls calcium-dependent egress and development in Toxoplasma gondii.

Methylglyoxal Reshapes Hepatic and Adipose Tissue Metabolism and Increases Viability of Lymphocytes.

CD38 expression, function, and gene resequencing in a human lymphoblastoid cell line-based model system.

Rho GTPase effectors and NAD metabolism in cancer immune suppression.

Correction: SIRT1 Activity Is Linked to Its Brain Region-Specific Phosphorylation and Is Impaired in Huntington's Disease Mice.

SIRT1 Activity Is Linked to Its Brain Region-Specific Phosphorylation and Is Impaired in Huntington’s Disease Mice.

Critical Role of Astrocyte NAD1 Glycohydrolase in Myelin Injury and Regeneration.

A stress-induced cilium-to-PML-NB route drives senescence initiation.

A novel form of Deleted in breast cancer 1 (DBC1) lacking the N-terminal domain does not bind SIRT1 and is dynamically regulated in vivo.

Low NAD<sup>+</sup> Levels Are Associated With a Decline of Spermatogenesis in Transgenic ANDY and Aging Mice.

CD38 inhibitor 78c increases mice lifespan and healthspan in a model of chronological aging.

Targeting senescent cells alleviates obesity‐induced metabolic dysfunction.

Deleted in Breast Cancer 1 regulates cellular senescence during obesity.

Selective decrease of mRNAs encoding plasma membrane calcium pump isoforms 2 and 3 in rat kidney.

Cytoprotective effects of adrenomedullin in glomerular cell injury: Central role of cAMP signaling pathway.

Cyclic ADP-ribose metabolism in rat kidney: High capacity for synthesis in glomeruli.

Formation of reactive oxygen metabolites in glomeruli is suppressed by inhibition of cAMP phosphodiesterase isozyme type IV.

Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity.

Deleted in Breast Cancer 1 Limits Adipose Tissue Fat Accumulation and Plays a Key Role in the Development of Metabolic Syndrome Phenotype.

Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome.

Flavonoid Apigenin Is an Inhibitor of the NAD<sup>+</sup> ase CD38.

DBC1 (Deleted in Breast Cancer 1) modulates the stability and function of the nuclear receptor Rev-erba.

Tissue-resident CD8<sup>+</sup> T cells drive age-associated chronic lung sequelae after viral pneumonia.

Endurance Capacity, Not Body Size, Determines Physical Activity Levels: Role of Skeletal Muscle PEPCK.

The Multi-faceted Ecto-enzyme CD38: Roles in Immunomodulation, Cancer, Aging, and Metabolic Diseases.

mRNAs Coding for the Calcium-Sensing Receptor along the Rat Nephron: Effect of a Low-Phosphate Diet.

Dihydronicotinamide Riboside Is a Potent NAD<sup>+</sup> Precursor Promoting a Pro-Inflammatory Phenotype in Macrophages.

TNB-738, a biparatopic antibody, boosts intracellular NAD+ by inhibiting CD38 ecto-enzyme activity.