Works matching AU Byrne, Dominic P.

Results: 31

Mechanistic and evolutionary insights into isoform-specific 'supercharging' in DCLK family kinases.

Published in:

eLife, 2023, p. 1, doi. 10.7554/eLife.87958

By:

Venkat, Aarya;
Watterson, Grace;
Byrne, Dominic P.;
O'Boyle, Brady;
Shrestha, Safal;
Gravel, Nathan;
Fairweather, Emma E.;
Daly, Leonard A.;
Bunn, Claire;
Yeung, Wayland;
Aggarwal, Ishan;
Katiyar, Samiksha;
Eyers, Claire E.;
Eyers, Patrick A.;
Kannan, Natarajan

Publication type:

Article

Breakdown of albumin and haemalbumin by the cysteine protease interpain A, an albuminase of Prevotella intermedia.

Published in:

BMC Microbiology, 2015, v. 15, n. 1, p. 1, doi. 10.1186/s12866-015-0516-3

By:

Byrne, Dominic P.;
Manandhar, Surya P.;
Potempa, Jan;
Smalley, John W.

Publication type:

Article

KinOrtho: a method for mapping human kinase orthologs across the tree of life and illuminating understudied kinases.

Published in:

BMC Bioinformatics, 2021, v. 22, n. 1, p. 1, doi. 10.1186/s12859-021-04358-3

By:

Huang, Liang-Chin;
Taujale, Rahil;
Gravel, Nathan;
Venkat, Aarya;
Yeung, Wayland;
Byrne, Dominic P.;
Eyers, Patrick A.;
Kannan, Natarajan

Publication type:

Article

Correction: Pyocycanin, a Contributory Factor in Haem Acquisition and Virulence Enhancement of Porphyromonas gingivalis in the Lung.

Published in:

PLoS ONE, 2016, v. 11, n. 1, p. 1, doi. 10.1371/journal.pone.0148008

By:

Benedyk, Malgorzata;
Byrne, Dominic P.;
Glowczyk, Izabela;
Potempa, Jan;
Olczak, Mariusz;
Olczak, Teresa;
Smalley, John W.

Publication type:

Article

Strong anion exchange‐mediated phosphoproteomics reveals extensive human non‐canonical phosphorylation.

Published in:

EMBO Journal, 2019, v. 38, n. 21, p. N.PAG, doi. 10.15252/embj.2018100847

By:

Hardman, Gemma;
Perkins, Simon;
Brownridge, Philip J;
Clarke, Christopher J;
Byrne, Dominic P;
Campbell, Amy E;
Kalyuzhnyy, Anton;
Myall, Ashleigh;
Eyers, Patrick A;
Jones, Andrew R;
Eyers, Claire E

Publication type:

Article

Correction: Hydrophobic Core Variations Provide a Structural Framework for Tyrosine Kinase Evolution and Functional Specialization.

Published in:

2016

By:

Mohanty, Smita;
Oruganty, Krishnadev;
Kwon, Annie;
Byrne, Dominic P.;
Ferries, Samantha;
Ruan, Zheng;
Hanold, Laura E.;
Katiyar, Samiksha;
Kennedy, Eileen J.;
Eyers, Patrick A.;
Kannan, Natarajan

Publication type:

Correction Notice

Hydrophobic Core Variations Provide a Structural Framework for Tyrosine Kinase Evolution and Functional Specialization.

Published in:

PLoS Genetics, 2016, v. 12, n. 2, p. 1, doi. 10.1371/journal.pgen.1005885

By:

Mohanty, Smita;
Oruganty, Krishnadev;
Kwon, Annie;
Byrne, Dominic P.;
Ferries, Samantha;
Ruan, Zheng;
Hanold, Laura E.;
Katiyar, Samiksha;
Kennedy, Eileen J.;
Eyers, Patrick A.;
Kannan, Natarajan

Publication type:

Article

Redox regulation and dynamic control of brain-selective kinases BRSK1/2 in the AMPK family through cysteine-based mechanisms.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.92536

By:

Bendzunas, George N.;
Byrne, Dominic P.;
Shrestha, Safal;
Daly, Leonard A.;
Oswald, Sally O.;
Katiyar, Samiksha;
Venkat, Aarya;
Yeung, Wayland;
Eyers, Claire E.;
Eyers, Patrick A.;
Kannan, Natarajan

Publication type:

Article

Classification of Cushing’s syndrome PKAc mutants based upon their ability to bind PKI.

Published in:

Biochemical Journal, 2023, v. 480, n. 12, p. 875, doi. 10.1042/BCJ20230183

By:

Omar, Mitchell H.;
Kihiu, Maryanne;
Byrne, Dominic P.;
Lee, Kyung-Soon;
Lakey, Tyler M.;
Butcher, Erik;
Eyers, Patrick A.;
Scott, John D.

Publication type:

Article

ERK1/2 inhibitors act as monovalent degraders inducing ubiquitylation and proteasome-dependent turnover of ERK2, but not ERK1.

Published in:

Biochemical Journal, 2023, v. 480, n. 9, p. 587, doi. 10.1042/BCJ20220598

By:

Balmanno, Kathryn;
Kidger, Andrew M.;
Byrne, Dominic P.;
Sale, Matthew J.;
Nassman, Nejma;
Eyers, Patrick A.;
Cook, Simon J.

Publication type:

Article

Evolutionary and cellular analysis of the 'dark' pseudokinase PSKH2.

Published in:

Biochemical Journal, 2023, v. 480, n. 2, p. 141, doi. 10.1042/BCJ20220474

By:

Byrne, Dominic P.;
Shrestha, Safal;
Daly, Leonard A.;
Marensi, Vanessa;
Ramakrishnan, Krithika;
Eyers, Claire E.;
Kannan, Natarajan;
Eyers, Patrick A.

Publication type:

Article

Impact of fluoroquinolones and aminoglycosides on P. aeruginosa virulence factor production and cytotoxicity.

Published in:

Biochemical Journal, 2022, v. 479, n. 24, p. 2511, doi. 10.1042/BCJ20220527

By:

Foulkes, Daniel M.;
McLean, Keri;
Sloniecka, Marta;
Rustidge, Sophie;
Byrne, Dominic P.;
Haneef, Atikah S.;
Winstanley, Craig;
Berry, Neil;
Fernig, David G.;
Kaye, Stephen B.

Publication type:

Article

Correction: Mobility shift-based electrophoresis coupled with fluorescent detection enables realtime enzyme analysis of carbohydrate sulfatase activity.

Published in:

Biochemical Journal, 2021, v. 478, n. 13, p. 2537, doi. 10.1042/bcj-2020-0952_cor

By:

Byrne, Dominic P.;
London, James A.;
Eyers, Patrick A.;
Yates, Edwin A.;
Cartmell, Alan

Publication type:

Article

Mobility shift-based electrophoresis coupled with fluorescent detection enables real-time enzyme analysis of carbohydrate sulfatase activity.

Published in:

Biochemical Journal, 2021, v. 478, n. 4, p. 735, doi. 10.1042/BCJ20200952

By:

Byrne, Dominic P.;
London, James A.;
Eyers, Patrick A.;
Yates, Edwin A.;
Cartmell, Alan

Publication type:

Article

Use of the Polo-like kinase 4 (PLK4) inhibitor centrinone to investigate intracellular signalling networks using SILAC-based phosphoproteomics.

Published in:

Biochemical Journal, 2020, v. 477, n. 13, p. 2451, doi. 10.1042/BCJ20200309

By:

Byrne, Dominic P.;
Clarke, Christopher J.;
Brownridge, Philip J.;
Kalyuzhnyy, Anton;
Perkins, Simon;
Campbell, Amy;
Mason, David;
Jones, Andrew R.;
Eyers, Patrick A.;
Eyers, Claire E.

Publication type:

Article

New tools for evaluating protein tyrosine sulfation: tyrosylprotein sulfotransferases (TPSTs) are novel targets for RAF protein kinase inhibitors.

Published in:

Biochemical Journal, 2018, v. 475, n. 15, p. 2435, doi. 10.1042/BCJ20180266

By:

Byrne, Dominic P.;
Yong Li;
Ngamlert, Pawin;
Ramakrishnan, Krithika;
Eyers, Claire E.;
Wells, Carrow;
Drewry, David H.;
Zuercher, William J.;
Berry, Neil G.;
Fernig, David G.;
Eyers, Patrick A.

Publication type:

Article

New tools for carbohydrate sulfation analysis: heparan sulfate 2-O-sulfotransferase (HS2ST) is a target for small-molecule protein kinase inhibitors.

Published in:

Biochemical Journal, 2018, v. 475, n. 15, p. 2417, doi. 10.1042/BCJ20180265

By:

Byrne, Dominic P.;
Yong Li;
Ramakrishnan, Krithika;
Barsukov, Igor L.;
Yates, Edwin A.;
Eyers, Claire E.;
Papy-Garcia, Dulcé;
Chantepie, Sandrine;
Pagadala, Vijayakanth;
Jian Liu;
Wells, Carrow;
Drewry, David H.;
Zuercher, William J.;
Berry, Neil G.;
Fernig, David G.;
Eyers, Patrick A.

Publication type:

Article

cAMP-dependent protein kinase (PKA) complexes probed by complementary differential scanning fluorimetry and ion mobility-mass spectrometry.

Published in:

Biochemical Journal, 2016, v. 473, n. 19, p. 3159, doi. 10.1042/BCJ20160648

By:

Byrne, Dominic P.;
Vonderach, Matthias;
Ferries, Samantha;
Brownridge, Philip J.;
Eyers, Claire E.;
Eyers, Patrick A.

Publication type:

Article

The Tribbles 2 (TRB2) pseudokinase binds to ATP and autophosphorylates in a metal-independent manner.

Published in:

Biochemical Journal, 2015, v. 467, n. 1, p. 47, doi. 10.1042/BJ20141441

By:

Bailey, Fiona P.;
Byrne, Dominic P.;
Oruganty, Krishnadev;
Eyers, Claire E.;
Novotny, Christopher J.;
Shokat, Kevan M.;
Kannan, Natarajan;
Eyers, Patrick A.

Publication type:

Article

Going for broke: targeting the human cancer pseudokinome.

Published in:

Biochemical Journal, 2015, v. 465, n. 2, p. 195, doi. 10.1042/BJ20141060

By:

Bailey, Fiona P.;
Byrne, Dominic P.;
McSkimming, Daniel;
Kannan, Natarajan;
Eyers, Patrick A.

Publication type:

Article

A redox-active switch in fructosamine-3-kinases expands the regulatory repertoire of the protein kinase superfamily.

Published in:

Science Signaling, 2020, v. 13, n. 639, p. 1, doi. 10.1126/scisignal.aax6313

By:

Shrestha, Safal;
Katiyar, Samiksha;
Sanz-Rodriguez, Carlos E.;
Kemppinen, Nolan R.;
Kim, Hyun W.;
Kadirvelraj, Renuka;
Panagos, Charalampos;
Keyhaninejad, Neda;
Colonna, Maxwell;
Chopra, Pradeep;
Byrne, Dominic P.;
Boons, Geert J.;
van der Knaap, Esther;
Eyers, Patrick A.;
Edison, Arthur S.;
Wood, Zachary A.;
Kannan, Natarajan

Publication type:

Article

Aurora A regulation by reversible cysteine oxidation reveals evolutionarily conserved redox control of Ser/Thr protein kinase activity.

Published in:

Science Signaling, 2020, v. 13, n. 639, p. 1, doi. 10.1126/scisignal.aax2713

By:

Byrne, Dominic P.;
Shrestha, Safal;
Galler, Martin;
Cao, Min;
Daly, Leonard A.;
Campbell, Amy E.;
Eyers, Claire E.;
Veal, Elizabeth A.;
Kannan, Natarajan;
Eyers, Patrick A.

Publication type:

Article

Covalent inhibitors of EGFR family protein kinases induce degradation of human Tribbles 2 (TRIB2) pseudokinase in cancer cells.

Published in:

Science Signaling, 2018, v. 11, n. 549, p. 1, doi. 10.1126/scisignal.aat7951

By:

Foulkes, Daniel M.;
Byrne, Dominic P.;
Yeung, Wayland;
Shrestha, Safal;
Bailey, Fiona P.;
Ferries, Samantha;
Eyers, Claire E.;
Keeshan, Karen;
Wells, Carrow;
Drewry, David H.;
Zuercher, William J.;
Kannan, Natarajan;
Eyers, Patrick A.

Publication type:

Article

Pyocycanin, a Contributory Factor in Haem Acquisition and Virulence Enhancement of Porphyromonas gingivalis in the Lung.

Published in:

PLoS ONE, 2015, v. 10, n. 2, p. 1, doi. 10.1371/journal.pone.0118319

By:

Benedyk, Malgorzata;
Byrne, Dominic P.;
Glowczyk, Izabela;
Potempa, Jan;
Olczak, Mariusz;
Olczak, Teresa;
Smalley, John W.

Publication type:

Article

Evaluating Caveolin Interactions: Do Proteins Interact with the Caveolin Scaffolding Domain through a Widespread Aromatic Residue-Rich Motif?

Published in:

PLoS ONE, 2012, v. 7, n. 9, p. 1, doi. 10.1371/journal.pone.0044879

By:

Byrne, Dominic P.;
Dart, Caroline;
Rigden, Daniel J.;
Haslam, Niall James

Publication type:

Article

HmuY Haemophore and Gingipain Proteases Constitute a Unique Syntrophic System of Haem Acquisition by Porphyromonas gingivalis.

Published in:

PLoS ONE, 2011, v. 6, n. 2, p. 1, doi. 10.1371/journal.pone.0017182

By:

Smalley, John W.;
Byrne, Dominic P.;
Birss, Andrew J.;
Wojtowicz, Halina;
Sroka, Aneta;
Potempa, Jan;
Olczak, Teresa

Publication type:

Article

Mitotic phosphotyrosine network analysis reveals that tyrosine phosphorylation regulates Polo-like kinase 1 (PLK1).

Published in:

Science Signaling, 2016, v. 9, n. 458, p. 1, doi. 10.1126/scisignal.aah3525

By:

Caron, Danielle;
Byrne, Dominic P.;
Thebault, Philippe;
Soulet, Denis;
Landry, Christian R.;
Eyers, Patrick A.;
Elowe, Sabine

Publication type:

Article

DRP-1 is required for BH3 mimetic-mediated mitochondrial fragmentation and apoptosis.

Published in:

Cell Death & Disease, 2017, v. 8, n. 1, p. e2552, doi. 10.1038/cddis.2016.485

By:

Milani, Mateus;
Byrne, Dominic P;
Greaves, Georgia;
Butterworth, Michael;
Cohen, Gerald M;
Eyers, Patrick A;
Varadarajan, Shankar

Publication type:

Article

Polysaccharide sulfotransferases: the identification of putative sequences and respective functional characterisation.

Published in:

Essays in Biochemistry, 2024, v. 68, n. 4, p. 431, doi. 10.1042/EBC20230094

By:

Mistry, Ravina;
Byrne, Dominic P.;
Starns, David;
Barsukov, Igor L.;
Yates, Edwin A.;
Fernig, David G.

Publication type:

Article

Tribbles pseudokinases: novel targets for chemical biology and drug discovery?

Published in:

Biochemical Society Transactions, 2015, v. 43, n. 5, p. 1095, doi. 10.1042/BST20150109

By:

Foulkes, Daniel M.;
Byrne, Dominic P.;
Bailey, Fiona P.;
Eyers, Patrick A.

Publication type:

Article

Cataloguing the dead: breathing new life into pseudokinase research.

Published in:

FEBS Journal, 2020, v. 287, n. 19, p. 4150, doi. 10.1111/febs.15246

By:

Shrestha, Safal;
Byrne, Dominic P.;
Harris, John A.;
Kannan, Natarajan;
Eyers, Patrick A.

Publication type:

Article